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The map label for this gene is serA [H]

Identifier: 21240796

GI number: 21240796

Start: 23093

End: 24085

Strand: Direct

Name: serA [H]

Synonym: XAC0022

Alternate gene names: 21240796

Gene position: 23093-24085 (Clockwise)

Preceding gene: 21240795

Following gene: 21240799

Centisome position: 0.45

GC content: 69.39

Gene sequence:

>993_bases
ATGCGCATTGTGGTGCCCGACGACTACCAGGGCGCCGTTGCGCAGCTGCCCTGCCTGCAGCAACTGCAGGACCACCAGGT
GCAGGTGCTGGGCGCGTTGGATGCGGAGCTCGATGCGCGCGCCGCATGCCTGGCCGACGCCGACGCGTTGGTGTTGATCC
GCGAACGCACGCGGGTGGATGCGGCGCTGCTGCAACGGCTGCCACGGCTGAAACTGATCAGCCAGACCGGGCGCGTGGGT
GCGCATGTGGATGTTGCGGCGTGCACTGCGTTGGGTGTGGCGGTGGCCGAAGGCGTCGGCTCGCCGGTGGCGCCGGCCGA
GCTGACCTGGGCGCTGATCCTGTCGGCCAGCCGTCGGCTGACCGACTACCAGCATGCATTGCAACAGGGACGCTGGCAGG
CGCTTGGCGATCCCGGCTTGGGCCGCGTGCTGCATGGGCGCACGTTGGGGATCTGGAGTTACGGGCGAATCGGCCAACGC
GTGGCCGGCTTTGGGCGCGCCTTCGGCATGCAGGTGGTGGTGTGGGGCGGCGAGGCGTCCTGTGCGCAGGCAGCGCGCGA
TGGGTTCGCGGTTGCGGGCAGTCGCGAGGACCTGTTCGAACGCAGCGACGTGCTGTCGCTGCATCGGCGTCTGACTGCGC
AGACACGGCATGACGTCACCGCCCAGGATCTGGCGCGCATGCGCGCCGACGCGTTGCTGGTCAACACCAGCCGCGCCGAG
TTGATTGCGCCTGGCGCCTTGCTCGCTGCGTTGGACGCGGGCCGGCCGGCGCAGGCCGCGCTGGATGTGTTCGAGCACGA
GCCGGTGCTGGACCCGCGCGATCCGCTGCTGCGGCATGCGCGCGTGCTGGCGACACCGCATCTGGGATACGTGGAGCGCG
ACAGCTACGCGCTGTATTTCGATGCGGCGTTCGACAATGTGCTGGCGTTCGCGGCGGGCACACCGCGCAACCTGGTCAAT
CCCGAGGTGTTGGCAACAACGCAGCGGGTGTGA

Upstream 100 bases:

>100_bases
GGATCGAAGAAGTCGAGAAAAAGGGCCAGTCGGTGATTCGCGATGCCACCACCGGCGACAAGGTGGTCACCCCGTTCCCC
TCGCCGATCAAGCCACGCTG

Downstream 100 bases:

>100_bases
TTCCCCGCTGGGTCAGCGCGGTCTTGAAGCAGCCAGCAAGCCGCGCGCGCTGCTGCCAGGTCAGCGAGGCCCGAGGCTCG
GTGTGGCATGTACCACTCCT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MRIVVPDDYQGAVAQLPCLQQLQDHQVQVLGALDAELDARAACLADADALVLIRERTRVDAALLQRLPRLKLISQTGRVG
AHVDVAACTALGVAVAEGVGSPVAPAELTWALILSASRRLTDYQHALQQGRWQALGDPGLGRVLHGRTLGIWSYGRIGQR
VAGFGRAFGMQVVVWGGEASCAQAARDGFAVAGSREDLFERSDVLSLHRRLTAQTRHDVTAQDLARMRADALLVNTSRAE
LIAPGALLAALDAGRPAQAALDVFEHEPVLDPRDPLLRHARVLATPHLGYVERDSYALYFDAAFDNVLAFAAGTPRNLVN
PEVLATTQRV

Sequences:

>Translated_330_residues
MRIVVPDDYQGAVAQLPCLQQLQDHQVQVLGALDAELDARAACLADADALVLIRERTRVDAALLQRLPRLKLISQTGRVG
AHVDVAACTALGVAVAEGVGSPVAPAELTWALILSASRRLTDYQHALQQGRWQALGDPGLGRVLHGRTLGIWSYGRIGQR
VAGFGRAFGMQVVVWGGEASCAQAARDGFAVAGSREDLFERSDVLSLHRRLTAQTRHDVTAQDLARMRADALLVNTSRAE
LIAPGALLAALDAGRPAQAALDVFEHEPVLDPRDPLLRHARVLATPHLGYVERDSYALYFDAAFDNVLAFAAGTPRNLVN
PEVLATTQRV
>Mature_330_residues
MRIVVPDDYQGAVAQLPCLQQLQDHQVQVLGALDAELDARAACLADADALVLIRERTRVDAALLQRLPRLKLISQTGRVG
AHVDVAACTALGVAVAEGVGSPVAPAELTWALILSASRRLTDYQHALQQGRWQALGDPGLGRVLHGRTLGIWSYGRIGQR
VAGFGRAFGMQVVVWGGEASCAQAARDGFAVAGSREDLFERSDVLSLHRRLTAQTRHDVTAQDLARMRADALLVNTSRAE
LIAPGALLAALDAGRPAQAALDVFEHEPVLDPRDPLLRHARVLATPHLGYVERDSYALYFDAAFDNVLAFAAGTPRNLVN
PEVLATTQRV

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=285, Percent_Identity=30.1754385964912, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI145580578, Length=282, Percent_Identity=32.9787234042553, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI4557499, Length=282, Percent_Identity=32.9787234042553, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI61743967, Length=265, Percent_Identity=32.4528301886792, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4557497, Length=272, Percent_Identity=32.7205882352941, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI145580575, Length=282, Percent_Identity=32.9787234042553, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI6912396, Length=211, Percent_Identity=30.3317535545024, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI87082289, Length=314, Percent_Identity=31.8471337579618, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1789279, Length=270, Percent_Identity=28.8888888888889, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1787645, Length=188, Percent_Identity=30.3191489361702, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081824, Length=194, Percent_Identity=31.9587628865979, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=324, Percent_Identity=29.6296296296296, Blast_Score=121, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI25147481, Length=284, Percent_Identity=30.6338028169014, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320925, Length=255, Percent_Identity=29.4117647058824, Blast_Score=92, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=182, Percent_Identity=31.3186813186813, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6322116, Length=255, Percent_Identity=28.6274509803922, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19921140, Length=324, Percent_Identity=28.0864197530864, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24646446, Length=277, Percent_Identity=31.0469314079422, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646448, Length=277, Percent_Identity=31.0469314079422, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646452, Length=277, Percent_Identity=31.0469314079422, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646450, Length=277, Percent_Identity=31.0469314079422, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI62472511, Length=275, Percent_Identity=30.9090909090909, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI28574286, Length=251, Percent_Identity=29.8804780876494, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI45552429, Length=254, Percent_Identity=28.3464566929134, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24585514, Length=254, Percent_Identity=28.3464566929134, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28574282, Length=254, Percent_Identity=28.3464566929134, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45551003, Length=254, Percent_Identity=28.3464566929134, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28574284, Length=254, Percent_Identity=28.3464566929134, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571528, Length=254, Percent_Identity=27.1653543307087, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35500; Mature: 35500

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVVPDDYQGAVAQLPCLQQLQDHQVQVLGALDAELDARAACLADADALVLIRERTRVD
CEEECCCCCCCHHHHHHHHHHHHHHHEEEEEHHCCCHHHHHHHHCCCCEEEEEHHHHHHH
AALLQRLPRLKLISQTGRVGAHVDVAACTALGVAVAEGVGSPVAPAELTWALILSASRRL
HHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
TDYQHALQQGRWQALGDPGLGRVLHGRTLGIWSYGRIGQRVAGFGRAFGMQVVVWGGEAS
HHHHHHHHCCCEEECCCCCCCHHHCCCEEEECCCHHHHHHHHHHHHHCCCEEEEECCCHH
CAQAARDGFAVAGSREDLFERSDVLSLHRRLTAQTRHDVTAQDLARMRADALLVNTSRAE
HHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCHH
LIAPGALLAALDAGRPAQAALDVFEHEPVLDPRDPLLRHARVLATPHLGYVERDSYALYF
HCCCHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEECCCEEEEE
DAAFDNVLAFAAGTPRNLVNPEVLATTQRV
ECHHHHHHHHCCCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure
MRIVVPDDYQGAVAQLPCLQQLQDHQVQVLGALDAELDARAACLADADALVLIRERTRVD
CEEECCCCCCCHHHHHHHHHHHHHHHEEEEEHHCCCHHHHHHHHCCCCEEEEEHHHHHHH
AALLQRLPRLKLISQTGRVGAHVDVAACTALGVAVAEGVGSPVAPAELTWALILSASRRL
HHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
TDYQHALQQGRWQALGDPGLGRVLHGRTLGIWSYGRIGQRVAGFGRAFGMQVVVWGGEAS
HHHHHHHHCCCEEECCCCCCCHHHCCCEEEECCCHHHHHHHHHHHHHCCCEEEEECCCHH
CAQAARDGFAVAGSREDLFERSDVLSLHRRLTAQTRHDVTAQDLARMRADALLVNTSRAE
HHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCHH
LIAPGALLAALDAGRPAQAALDVFEHEPVLDPRDPLLRHARVLATPHLGYVERDSYALYF
HCCCHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEECCCEEEEE
DAAFDNVLAFAAGTPRNLVNPEVLATTQRV
ECHHHHHHHHCCCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]