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The map label for this gene is trkA

Identifier: 21228605

GI number: 21228605

Start: 2983776

End: 2985122

Strand: Reverse

Name: trkA

Synonym: MM_2503

Alternate gene names: 21228605

Gene position: 2985122-2983776 (Counterclockwise)

Preceding gene: 21228606

Following gene: 21228604

Centisome position: 72.87

GC content: 45.21

Gene sequence:

>1347_bases
ATGAAAGCTGTAATTATTGGTGCAGGGGAAGTGGGCTACCATATTGCAAAAGCCCTCTCTCCTAAAAATGATGTGGTAAT
TATAGATAAAGATGAAGAAGCAGCAAAAAGAGCTGACGAACTTGACGTGCTCGTAATTGAAGGAAACGGAGCAAACGCAG
AGATCCTTTCAAGAGTTCTGCAGAATGCTGATCTTCTTGTAGCTGTTACCGGGGTTGATGAGGTTAACATTGTCGCCTGT
ATGACAGCAAAACTGATTATGAAAAATAAAAACGGCTGGAAAGATACAAAGACCATAGCAAGGGTCAGTAACCCCGATTA
CATAGACTCTCCGGTTACATCAAGAGCCCAGGTCGGCGTTGACCTTATGATCTGCCCGGAACTTGCGCTTGCTTCTGAAG
TTGCCGATATACTCTCAAGTCCCTCCGCAATAGATGCGGAAATGTTTGCCGAAGGAAAGGTAAGGATGACTGAGTTTGCA
ATAAGTCCTGAAAGCAAACTTGTAGGAAAACATATGCAGGACCTCAAGCTTGCCGACTGCTGCATTGTCAGCGCGGTTTT
CAGGGAAGACCAGATAATAATTCCCCATGGAGACGACCTGATCAAAGCAAACGACCATATGGTAGTTGTGGGCAAGCCGG
AGTCCATGGAAGATCTTGAGAGCGTCTTCGGAAGTAAGGTGTCTCATAGAACCAGAATTCTCCTTATCGGATGCGGAATT
GTAGGGATGTATCTGGCAAAACTGATCGATAAAGAGGAAAATGCAGATCTGAGAATTATCGAGCACAGCAAAAGCCGCTG
CATAGAAGTGGCAGAGATACTGGAAAATGCCCTTGTACTTAATGGAGACGGCACTGATGTCAGCCTTCTCAGAGAGGAAA
ATATTGAAGATATGGATGTTGTTGTTGCGGTTACGGACAGCGATGAAAAGAACCTTCTCTGTTCCCTGCTTGCAAAGCAG
CTCGGTGCAAAAAAGGTAATTGCAAGGGCTGACCGCTCGGACTACCTGCCTCTTTTTGAGATGGTAGGGATAGACATGGC
TGTAAGCCCGAGAGAAGCAACCGTAAACGAAGTCCTCAAGCTTACCATGGGAAGAGGTATACAGACACTTACGACCATTG
AGGGTGAAAGAGCTGAGATTATAGAATATACGGCCTCCGAGAAGTCCAGAATTGTGGGCAAGCCCTTAAACAAAGTAAAG
TTCCCCAAAGGAGCTCTTATTAACATGGTGGTGCGCGGAAAGGAGACTATAATCCCAAGAGGGGATTTCATTGTCAATGA
AGGAGACCGTGTAGTTATTTTCTCAATGGCTTCGGCAGCATCGGAAGTAGAAAAATATTTCAAGTAA

Upstream 100 bases:

>100_bases
TTTCCCGGTATTATACCGTTCAGTCCTATGCTGGTTGCTTCTCGTTCAGGAATCCGTGCAGTGGCGGGTTCATTGATAAC
AGTTTTTTTGAAGGTGTTCT

Downstream 100 bases:

>100_bases
GAAAATATTTCAAGTAAGTTTTACGGGACAGGGGTTTTTCTGTGAATAAAAAAGCTATTTATAATGCGCTTGGGAAAATT
CTTATACTTCTGGCTTTTAC

Product: potassium transporter peripheral membrane component

Products: NA

Alternate protein names: K(+)-uptake protein trkA homolog 1

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MKAVIIGAGEVGYHIAKALSPKNDVVIIDKDEEAAKRADELDVLVIEGNGANAEILSRVLQNADLLVAVTGVDEVNIVAC
MTAKLIMKNKNGWKDTKTIARVSNPDYIDSPVTSRAQVGVDLMICPELALASEVADILSSPSAIDAEMFAEGKVRMTEFA
ISPESKLVGKHMQDLKLADCCIVSAVFREDQIIIPHGDDLIKANDHMVVVGKPESMEDLESVFGSKVSHRTRILLIGCGI
VGMYLAKLIDKEENADLRIIEHSKSRCIEVAEILENALVLNGDGTDVSLLREENIEDMDVVVAVTDSDEKNLLCSLLAKQ
LGAKKVIARADRSDYLPLFEMVGIDMAVSPREATVNEVLKLTMGRGIQTLTTIEGERAEIIEYTASEKSRIVGKPLNKVK
FPKGALINMVVRGKETIIPRGDFIVNEGDRVVIFSMASAASEVEKYFK

Sequences:

>Translated_448_residues
MKAVIIGAGEVGYHIAKALSPKNDVVIIDKDEEAAKRADELDVLVIEGNGANAEILSRVLQNADLLVAVTGVDEVNIVAC
MTAKLIMKNKNGWKDTKTIARVSNPDYIDSPVTSRAQVGVDLMICPELALASEVADILSSPSAIDAEMFAEGKVRMTEFA
ISPESKLVGKHMQDLKLADCCIVSAVFREDQIIIPHGDDLIKANDHMVVVGKPESMEDLESVFGSKVSHRTRILLIGCGI
VGMYLAKLIDKEENADLRIIEHSKSRCIEVAEILENALVLNGDGTDVSLLREENIEDMDVVVAVTDSDEKNLLCSLLAKQ
LGAKKVIARADRSDYLPLFEMVGIDMAVSPREATVNEVLKLTMGRGIQTLTTIEGERAEIIEYTASEKSRIVGKPLNKVK
FPKGALINMVVRGKETIIPRGDFIVNEGDRVVIFSMASAASEVEKYFK
>Mature_448_residues
MKAVIIGAGEVGYHIAKALSPKNDVVIIDKDEEAAKRADELDVLVIEGNGANAEILSRVLQNADLLVAVTGVDEVNIVAC
MTAKLIMKNKNGWKDTKTIARVSNPDYIDSPVTSRAQVGVDLMICPELALASEVADILSSPSAIDAEMFAEGKVRMTEFA
ISPESKLVGKHMQDLKLADCCIVSAVFREDQIIIPHGDDLIKANDHMVVVGKPESMEDLESVFGSKVSHRTRILLIGCGI
VGMYLAKLIDKEENADLRIIEHSKSRCIEVAEILENALVLNGDGTDVSLLREENIEDMDVVVAVTDSDEKNLLCSLLAKQ
LGAKKVIARADRSDYLPLFEMVGIDMAVSPREATVNEVLKLTMGRGIQTLTTIEGERAEIIEYTASEKSRIVGKPLNKVK
FPKGALINMVVRGKETIIPRGDFIVNEGDRVVIFSMASAASEVEKYFK

Specific function: Part of a potassium transport system

COG id: COG0569

COG function: function code P; K+ transport systems, NAD-binding component

Gene ontology:

Cell location: Peripherally Bound To The Inner Side Of The Inner Membrane Via The Trkg And Trkh Proteins [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 RCK N-terminal domains

Homologues:

Organism=Escherichia coli, GI1789685, Length=461, Percent_Identity=32.3210412147505, Blast_Score=233, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRKA1_METMA (P39449)

Other databases:

- EMBL:   X74307
- EMBL:   AE008384
- PIR:   S39806
- RefSeq:   NP_634527.1
- ProteinModelPortal:   P39449
- SMR:   P39449
- GeneID:   1480845
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_2503
- NMPDR:   fig|192952.1.peg.2503
- HOGENOM:   HBG697234
- OMA:   LMICPEL
- ProtClustDB:   PRK09496
- BioCyc:   MMAZ192952:MM2503-MONOMER
- GO:   GO:0005488
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR006037
- InterPro:   IPR003148
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00335

Pfam domain/function: PF02080 TrkA_C; PF02254 TrkA_N

EC number: NA

Molecular weight: Translated: 48775; Mature: 48775

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS51202 RCK_C; PS51201 RCK_N

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVIIGAGEVGYHIAKALSPKNDVVIIDKDEEAAKRADELDVLVIEGNGANAEILSRVL
CCEEEEECCHHHHHHHHHCCCCCCEEEEECCHHHHHCCCCCEEEEEECCCCCHHHHHHHH
QNADLLVAVTGVDEVNIVACMTAKLIMKNKNGWKDTKTIARVSNPDYIDSPVTSRAQVGV
CCCCEEEEEECCCCCEEHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHCCE
DLMICPELALASEVADILSSPSAIDAEMFAEGKVRMTEFAISPESKLVGKHMQDLKLADC
EEEECCCHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHH
CIVSAVFREDQIIIPHGDDLIKANDHMVVVGKPESMEDLESVFGSKVSHRTRILLIGCGI
HHHHHHHCCCEEEEECCCCEEECCCCEEEEECCCCHHHHHHHHCCCCCCCEEEEEEECCH
VGMYLAKLIDKEENADLRIIEHSKSRCIEVAEILENALVLNGDGTDVSLLREENIEDMDV
HHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCEEECCCCCCEEEEECCCCCCEEE
VVAVTDSDEKNLLCSLLAKQLGAKKVIARADRSDYLPLFEMVGIDMAVSPREATVNEVLK
EEEEECCCCHHHHHHHHHHHHCHHHHHHHCCCCCCCCHHHHHCCCEEECCCHHHHHHHHH
LTMGRGIQTLTTIEGERAEIIEYTASEKSRIVGKPLNKVKFPKGALINMVVRGKETIIPR
HHHCCCCEEEEECCCCCHHEEEECCCCCCCCCCCCHHHCCCCCCCEEEEEEECCEEECCC
GDFIVNEGDRVVIFSMASAASEVEKYFK
CCEEEECCCEEEEEEEHHHHHHHHHHCC
>Mature Secondary Structure
MKAVIIGAGEVGYHIAKALSPKNDVVIIDKDEEAAKRADELDVLVIEGNGANAEILSRVL
CCEEEEECCHHHHHHHHHCCCCCCEEEEECCHHHHHCCCCCEEEEEECCCCCHHHHHHHH
QNADLLVAVTGVDEVNIVACMTAKLIMKNKNGWKDTKTIARVSNPDYIDSPVTSRAQVGV
CCCCEEEEEECCCCCEEHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHCCE
DLMICPELALASEVADILSSPSAIDAEMFAEGKVRMTEFAISPESKLVGKHMQDLKLADC
EEEECCCHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHH
CIVSAVFREDQIIIPHGDDLIKANDHMVVVGKPESMEDLESVFGSKVSHRTRILLIGCGI
HHHHHHHCCCEEEEECCCCEEECCCCEEEEECCCCHHHHHHHHCCCCCCCEEEEEEECCH
VGMYLAKLIDKEENADLRIIEHSKSRCIEVAEILENALVLNGDGTDVSLLREENIEDMDV
HHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCEEECCCCCCEEEEECCCCCCEEE
VVAVTDSDEKNLLCSLLAKQLGAKKVIARADRSDYLPLFEMVGIDMAVSPREATVNEVLK
EEEEECCCCHHHHHHHHHHHHCHHHHHHHCCCCCCCCHHHHHCCCEEECCCHHHHHHHHH
LTMGRGIQTLTTIEGERAEIIEYTASEKSRIVGKPLNKVKFPKGALINMVVRGKETIIPR
HHHCCCCEEEEECCCCCHHEEEECCCCCCCCCCCCHHHCCCCCCCEEEEEEECCEEECCC
GDFIVNEGDRVVIFSMASAASEVEKYFK
CCEEEECCCEEEEEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8268235; 12125824