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The map label for this gene is 21228571

Identifier: 21228571

GI number: 21228571

Start: 2942284

End: 2943768

Strand: Reverse

Name: 21228571

Synonym: MM_2469

Alternate gene names: NA

Gene position: 2943768-2942284 (Counterclockwise)

Preceding gene: 21228572

Following gene: 21228569

Centisome position: 71.86

GC content: 44.31

Gene sequence:

>1485_bases
ATGAATCATTTATCGGGAATAAATTTAATTCTGGCACTGGGTCTGTTTTTTTGCTTTATTTCGAGTGCTGAAGCCGCAGA
CCCACTTGCTTTGGATGACGGAGATGTGAATCTTTCGGAACTCAGGGCTTTTGACCTGCTGGGCAGATGTGAAACAGGGT
CTATAGTAAATACTGTATCACTTTCTTCTACAGGCAATTATCTTGCAGCCGGAGGGTTTGATCACAAAGTTTATTATTAT
GATTCCAGGGGGACGCAACTATGGAATTATACTACAGGAGATATTGTTTATACTGTATCGATTTCTTCAGATGGATCTCG
AATTGCAGCAGGAAGCAATGATAGAAAAGTGTACTTCTTTAACCGGGAAGGAGAACTCCTGTGGAGCCGAAAAACCGGAG
GCAATATTAATAGTGTAGCAGTCTCTTCTGAAGGGCTTTACATTGCAACAGGCGGCGAGGACGGAAAGGTATATTTCCTG
GACAAAGATGGTAAACTTTTATGGAGCTTTAATTCAGGAGATGCTGTCCGCAGCGTAGCTATTTCCAGAGACGGGGATTA
CGTGGCAACAGGAAGCGCTAATAATTATGTTTACCTCCTTGACAGTGAGGGAAAAACCCTCTGGGGGAAAAAAACAGGAA
GCCTGATCAACAGTGTAACCATGACCCCTAATGCTTACTATGTGGCTGCAGGAGGGTCCAATTATAACGTTTATCTTTTT
GACCGTAAAGGGGAATTTTCATGGATGCATAATCCCGGTTACTGGGTCAGCAGTGTTTCTTTAAGCAGCAATGGATCCCA
TCTAGCTGCAGGAAGTTTCGACGACAGGATTTACCTCTTCAACCTTACAGGCGCAAAACTATGGGACTACCAGGTAAAAG
ATGACGTTTATGCTGTGGAGATAGCGCCGGATTCATCTTTCATTGCAGCCGGGAGCTGGGACGATAGCATCTATGCACTT
AATATGAGCGGAAAAGAACTCTGGAACTGCAGCTGCGGAGGGAACATCAACAGCCTGGATGTTTCACGCGACAGTTCGAC
CATTGCTGCAGGGAGTGAAGCAGGAGCAGTATATATATTTAAACGGAACGCAACCGCTTTTGCACTGCTATCCGGGGATG
CAAGTTTCCTGCCAGAAGAGCCTGTAAAGACAGAAGATTCCTCTCTTGAAGAAAATATCCAGCCCGTAGAAGAAACCCCC
GTAGATACAGGAGGTATTGAAAACCTGGTAGAAGATGCTGCAGCTTCATCAGGTGATAAGAAAGAAAACATAAAAACCGG
GGGTAAGCTGGGAATGGAGGAGTTGCCTTCAGAAAAAAGTTCTTCAAGCATTTTTGGGATATTTGATTCAATAAAGTTTC
CGCTTGCCCTTCTGATCGGGTCCATGGCAGGTACGGTTTTCTTCTTAAAAAGAAGGCTTACCAAACGTCAGGAGATGGAT
GAGAATACCGAGGACTTTGAAAACCTTGAAGAGAGTGATACATGA

Upstream 100 bases:

>100_bases
TATTTTTTTTGGTTTAATCTCATTATATACCTAAATTTACATCTGGAAAACAACTGTATCAAAAAATTCATGTGTAATAA
AGTACTTCATTATAAATTAT

Downstream 100 bases:

>100_bases
GGGAATGATTGAGAAACACATAGGGATAACTCCGGAAAGGAGTTTCCCAAAAACAGAACATTTTCTGCAATATTTAATTT
TGAATGGAATGACGGACCCT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MNHLSGINLILALGLFFCFISSAEAADPLALDDGDVNLSELRAFDLLGRCETGSIVNTVSLSSTGNYLAAGGFDHKVYYY
DSRGTQLWNYTTGDIVYTVSISSDGSRIAAGSNDRKVYFFNREGELLWSRKTGGNINSVAVSSEGLYIATGGEDGKVYFL
DKDGKLLWSFNSGDAVRSVAISRDGDYVATGSANNYVYLLDSEGKTLWGKKTGSLINSVTMTPNAYYVAAGGSNYNVYLF
DRKGEFSWMHNPGYWVSSVSLSSNGSHLAAGSFDDRIYLFNLTGAKLWDYQVKDDVYAVEIAPDSSFIAAGSWDDSIYAL
NMSGKELWNCSCGGNINSLDVSRDSSTIAAGSEAGAVYIFKRNATAFALLSGDASFLPEEPVKTEDSSLEENIQPVEETP
VDTGGIENLVEDAAASSGDKKENIKTGGKLGMEELPSEKSSSSIFGIFDSIKFPLALLIGSMAGTVFFLKRRLTKRQEMD
ENTEDFENLEESDT

Sequences:

>Translated_494_residues
MNHLSGINLILALGLFFCFISSAEAADPLALDDGDVNLSELRAFDLLGRCETGSIVNTVSLSSTGNYLAAGGFDHKVYYY
DSRGTQLWNYTTGDIVYTVSISSDGSRIAAGSNDRKVYFFNREGELLWSRKTGGNINSVAVSSEGLYIATGGEDGKVYFL
DKDGKLLWSFNSGDAVRSVAISRDGDYVATGSANNYVYLLDSEGKTLWGKKTGSLINSVTMTPNAYYVAAGGSNYNVYLF
DRKGEFSWMHNPGYWVSSVSLSSNGSHLAAGSFDDRIYLFNLTGAKLWDYQVKDDVYAVEIAPDSSFIAAGSWDDSIYAL
NMSGKELWNCSCGGNINSLDVSRDSSTIAAGSEAGAVYIFKRNATAFALLSGDASFLPEEPVKTEDSSLEENIQPVEETP
VDTGGIENLVEDAAASSGDKKENIKTGGKLGMEELPSEKSSSSIFGIFDSIKFPLALLIGSMAGTVFFLKRRLTKRQEMD
ENTEDFENLEESDT
>Mature_494_residues
MNHLSGINLILALGLFFCFISSAEAADPLALDDGDVNLSELRAFDLLGRCETGSIVNTVSLSSTGNYLAAGGFDHKVYYY
DSRGTQLWNYTTGDIVYTVSISSDGSRIAAGSNDRKVYFFNREGELLWSRKTGGNINSVAVSSEGLYIATGGEDGKVYFL
DKDGKLLWSFNSGDAVRSVAISRDGDYVATGSANNYVYLLDSEGKTLWGKKTGSLINSVTMTPNAYYVAAGGSNYNVYLF
DRKGEFSWMHNPGYWVSSVSLSSNGSHLAAGSFDDRIYLFNLTGAKLWDYQVKDDVYAVEIAPDSSFIAAGSWDDSIYAL
NMSGKELWNCSCGGNINSLDVSRDSSTIAAGSEAGAVYIFKRNATAFALLSGDASFLPEEPVKTEDSSLEENIQPVEETP
VDTGGIENLVEDAAASSGDKKENIKTGGKLGMEELPSEKSSSSIFGIFDSIKFPLALLIGSMAGTVFFLKRRLTKRQEMD
ENTEDFENLEESDT

Specific function: Unknown

COG id: COG2319

COG function: function code R; FOG: WD40 repeat

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 13 WD repeats [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=240, Percent_Identity=27.9166666666667, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17533647, Length=256, Percent_Identity=30.078125, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020472
- InterPro:   IPR011600
- InterPro:   IPR015943
- InterPro:   IPR001680
- InterPro:   IPR011046
- InterPro:   IPR019782
- InterPro:   IPR019775
- InterPro:   IPR017986
- InterPro:   IPR019781 [H]

Pfam domain/function: PF00656 Peptidase_C14; PF00400 WD40 [H]

EC number: NA

Molecular weight: Translated: 53463; Mature: 53463

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHLSGINLILALGLFFCFISSAEAADPLALDDGDVNLSELRAFDLLGRCETGSIVNTVS
CCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEE
LSSTGNYLAAGGFDHKVYYYDSRGTQLWNYTTGDIVYTVSISSDGSRIAAGSNDRKVYFF
ECCCCCEEEECCCCCEEEEECCCCCEEEEEECCCEEEEEEECCCCCEEECCCCCCEEEEE
NREGELLWSRKTGGNINSVAVSSEGLYIATGGEDGKVYFLDKDGKLLWSFNSGDAVRSVA
CCCCCEEEEECCCCCCEEEEEECCCEEEEECCCCCEEEEEECCCCEEEEECCCCCEEEEE
ISRDGDYVATGSANNYVYLLDSEGKTLWGKKTGSLINSVTMTPNAYYVAAGGSNYNVYLF
EECCCCEEEECCCCCEEEEEECCCCEEECCCCCCCEEEEEECCCEEEEEECCCCEEEEEE
DRKGEFSWMHNPGYWVSSVSLSSNGSHLAAGSFDDRIYLFNLTGAKLWDYQVKDDVYAVE
ECCCCEEEEECCCEEEEEEEECCCCCEEEECCCCCEEEEEEECCCEEEEEEECCCEEEEE
IAPDSSFIAAGSWDDSIYALNMSGKELWNCSCGGNINSLDVSRDSSTIAAGSEAGAVYIF
ECCCCCEEEECCCCCCEEEEECCCCCEEEEECCCCCCEEEECCCCCEEECCCCCCEEEEE
KRNATAFALLSGDASFLPEEPVKTEDSSLEENIQPVEETPVDTGGIENLVEDAAASSGDK
ECCCEEEEEEECCCCCCCCCCCCCCCCCHHHCCCCHHHCCCCCCCHHHHHHHHHCCCCCC
KENIKTGGKLGMEELPSEKSSSSIFGIFDSIKFPLALLIGSMAGTVFFLKRRLTKRQEMD
HHHCCCCCCCCHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ENTEDFENLEESDT
CCHHHHHHHHHCCC
>Mature Secondary Structure
MNHLSGINLILALGLFFCFISSAEAADPLALDDGDVNLSELRAFDLLGRCETGSIVNTVS
CCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEE
LSSTGNYLAAGGFDHKVYYYDSRGTQLWNYTTGDIVYTVSISSDGSRIAAGSNDRKVYFF
ECCCCCEEEECCCCCEEEEECCCCCEEEEEECCCEEEEEEECCCCCEEECCCCCCEEEEE
NREGELLWSRKTGGNINSVAVSSEGLYIATGGEDGKVYFLDKDGKLLWSFNSGDAVRSVA
CCCCCEEEEECCCCCCEEEEEECCCEEEEECCCCCEEEEEECCCCEEEEECCCCCEEEEE
ISRDGDYVATGSANNYVYLLDSEGKTLWGKKTGSLINSVTMTPNAYYVAAGGSNYNVYLF
EECCCCEEEECCCCCEEEEEECCCCEEECCCCCCCEEEEEECCCEEEEEECCCCEEEEEE
DRKGEFSWMHNPGYWVSSVSLSSNGSHLAAGSFDDRIYLFNLTGAKLWDYQVKDDVYAVE
ECCCCEEEEECCCEEEEEEEECCCCCEEEECCCCCEEEEEEECCCEEEEEEECCCEEEEE
IAPDSSFIAAGSWDDSIYALNMSGKELWNCSCGGNINSLDVSRDSSTIAAGSEAGAVYIF
ECCCCCEEEECCCCCCEEEEECCCCCEEEEECCCCCCEEEECCCCCEEECCCCCCEEEEE
KRNATAFALLSGDASFLPEEPVKTEDSSLEENIQPVEETPVDTGGIENLVEDAAASSGDK
ECCCEEEEEEECCCCCCCCCCCCCCCCCHHHCCCCHHHCCCCCCCHHHHHHHHHCCCCCC
KENIKTGGKLGMEELPSEKSSSSIFGIFDSIKFPLALLIGSMAGTVFFLKRRLTKRQEMD
HHHCCCCCCCCHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ENTEDFENLEESDT
CCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]