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The map label for this gene is msrA

Identifier: 21228501

GI number: 21228501

Start: 2860819

End: 2861454

Strand: Reverse

Name: msrA

Synonym: MM_2399

Alternate gene names: 21228501

Gene position: 2861454-2860819 (Counterclockwise)

Preceding gene: 21228502

Following gene: 21228500

Centisome position: 69.85

GC content: 42.92

Gene sequence:

>636_bases
ATGATATACCTGAAATATAATTGTCCTTTAACATATCTGATTTTATTGAAGCTTGAAGGGGGGAAGACGGTGGAAGAAAA
GACAGACGCCGAACAGAGAAACGCAACATCTGAAGAGGATACTGAGATATTTGAAAATCCTGGAGAAGGTCTGGAAAAAG
CGACCTTTGCAGCAGGCTGCTTCTGGGGAATTGAAGAGGCATTCCGGCAGATTAAAGGTGTGGTTGCAACTGCAGTTGGC
TATAGCGGAGGTCATTTTAAAAGACCTACCTATGAGCAGGTCTGTACCCTTGACACCGGACATGCAGAAGCCGTAAGGGT
TATTTTTGATCCTGAAATAGTCTCATATAAGACCCTGCTGGATGTTTTCTGGAAGATCCATGACCCGACAACAAAAGACA
GGCAGGGACCTGATGTAGGAAAACAGTACCGTTCCGTGATCTTTTACCACAGCGACGAGCAAAAGGCTGCTGCCCTTGCC
TCAAAAGAAGAACTGGAAAAGTCAGGGGCTTTCAAAAATCCGGTAGTAACCGAGATAGTGCCGGTTTCCGAATTTTATAT
GGCAGAAGACTATCACCAGCAGTATTTTGAAAAAAAAGGATTTTTACAGAATATATTCAGGAGCTTTAAAAAATAA

Upstream 100 bases:

>100_bases
CCTGATCAGAGAAAAAGTCGATTTTCAAGTAAAATAGATTATAAACTATATTATTGGCGGTATATCCTGATCAAAAGATT
ATACTCAATGTTTTGATCAC

Downstream 100 bases:

>100_bases
TTCTGAAAACAGGTTACAGGGACGAAAAGAGCTGGATAAGAGCTTTGCATAACCATAACCTGGTGAAAAGCCAGTCCAGA
AAAGATGCATGAAAACGTAA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MIYLKYNCPLTYLILLKLEGGKTVEEKTDAEQRNATSEEDTEIFENPGEGLEKATFAAGCFWGIEEAFRQIKGVVATAVG
YSGGHFKRPTYEQVCTLDTGHAEAVRVIFDPEIVSYKTLLDVFWKIHDPTTKDRQGPDVGKQYRSVIFYHSDEQKAAALA
SKEELEKSGAFKNPVVTEIVPVSEFYMAEDYHQQYFEKKGFLQNIFRSFKK

Sequences:

>Translated_211_residues
MIYLKYNCPLTYLILLKLEGGKTVEEKTDAEQRNATSEEDTEIFENPGEGLEKATFAAGCFWGIEEAFRQIKGVVATAVG
YSGGHFKRPTYEQVCTLDTGHAEAVRVIFDPEIVSYKTLLDVFWKIHDPTTKDRQGPDVGKQYRSVIFYHSDEQKAAALA
SKEELEKSGAFKNPVVTEIVPVSEFYMAEDYHQQYFEKKGFLQNIFRSFKK
>Mature_211_residues
MIYLKYNCPLTYLILLKLEGGKTVEEKTDAEQRNATSEEDTEIFENPGEGLEKATFAAGCFWGIEEAFRQIKGVVATAVG
YSGGHFKRPTYEQVCTLDTGHAEAVRVIFDPEIVSYKTLLDVFWKIHDPTTKDRQGPDVGKQYRSVIFYHSDEQKAAALA
SKEELEKSGAFKNPVVTEIVPVSEFYMAEDYHQQYFEKKGFLQNIFRSFKK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=153, Percent_Identity=50.9803921568627, Blast_Score=155, Evalue=2e-38,
Organism=Homo sapiens, GI208609995, Length=153, Percent_Identity=50.9803921568627, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI208609993, Length=103, Percent_Identity=52.4271844660194, Blast_Score=102, Evalue=3e-22,
Organism=Escherichia coli, GI1790665, Length=157, Percent_Identity=50.3184713375796, Blast_Score=164, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17533973, Length=153, Percent_Identity=40.5228758169935, Blast_Score=109, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6320881, Length=152, Percent_Identity=40.1315789473684, Blast_Score=118, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24664627, Length=144, Percent_Identity=41.6666666666667, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24664631, Length=144, Percent_Identity=40.9722222222222, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI45553131, Length=137, Percent_Identity=40.1459854014599, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_METMA (Q8PUD6)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_634423.1
- ProteinModelPortal:   Q8PUD6
- SMR:   Q8PUD6
- GeneID:   1480741
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_2399
- NMPDR:   fig|192952.1.peg.2399
- HOGENOM:   HBG748152
- OMA:   YHQQYFE
- ProtClustDB:   PRK14054
- BioCyc:   MMAZ192952:MM2399-MONOMER
- BRENDA:   1.8.4.11
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 24048; Mature: 24048

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: ACT_SITE 60-60

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYLKYNCPLTYLILLKLEGGKTVEEKTDAEQRNATSEEDTEIFENPGEGLEKATFAAGC
CEEEEECCCEEEEEEEEECCCCCCHHHHCHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHH
FWGIEEAFRQIKGVVATAVGYSGGHFKRPTYEQVCTLDTGHAEAVRVIFDPEIVSYKTLL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCEEEEEECCCHHHHHHHH
DVFWKIHDPTTKDRQGPDVGKQYRSVIFYHSDEQKAAALASKEELEKSGAFKNPVVTEIV
HHHHHHCCCCCCCCCCCCHHHHHHHEEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHEE
PVSEFYMAEDYHQQYFEKKGFLQNIFRSFKK
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure
MIYLKYNCPLTYLILLKLEGGKTVEEKTDAEQRNATSEEDTEIFENPGEGLEKATFAAGC
CEEEEECCCEEEEEEEEECCCCCCHHHHCHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHH
FWGIEEAFRQIKGVVATAVGYSGGHFKRPTYEQVCTLDTGHAEAVRVIFDPEIVSYKTLL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCEEEEEECCCHHHHHHHH
DVFWKIHDPTTKDRQGPDVGKQYRSVIFYHSDEQKAAALASKEELEKSGAFKNPVVTEIV
HHHHHHCCCCCCCCCCCCHHHHHHHEEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHEE
PVSEFYMAEDYHQQYFEKKGFLQNIFRSFKK
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824