Click here to switch to the map view.

The map label for this gene is ubiB [H]

Identifier: 21228412

GI number: 21228412

Start: 2765668

End: 2767341

Strand: Direct

Name: ubiB [H]

Synonym: MM_2310

Alternate gene names: 21228412

Gene position: 2765668-2767341 (Clockwise)

Preceding gene: 21228410

Following gene: 21228413

Centisome position: 67.52

GC content: 44.8

Gene sequence:

>1674_bases
ATGACCAATTCATTATGGATGCTGGGGAAGACAAAGCGCTATCTTGAGGTCACACGAGTTCTTTTCAAATATAATCTCAT
CCCGGAACTCTACCATGACCTGCGGACTGAATATATATCCAATCCTGACTGCACCTGCACTTTTGATCTCGAAAATCGGG
AGACAGCTGCAAAACTCAGGCAGGCTTTCGAAGAGCTGGGTCCCACTTTTATCAAGATGGGGCAGACAATGAGTAAAAGG
CCTGATCTTGTGCCCCAGCCATATGTTGTTGAAATGGCAAATTTGCAGGACAGAGTCAAACCTGTGCCTTTTGAAGAGAT
GGCTGAGTCTCTTGACCTTGCATGTGTATGTGAATATCAGACTCGTGAGGAAAGGAAAAGGAAGAAAAGCGAGGAGGAGC
TCAAGGCTGCAAGGGAGAGAAAAGCAAAAGCTTTTATTGATATTTTTGACAGCTTTGACCCTGAGCCGATCGCCTGCGGC
TCTATTGCTCAGGTCTATAAAGGTGTTCTCGAAGGCAAGCCCGTAGCCGTTAAGATACTTCGACCGCACCTGATTGACAT
CATAAATATCGACCTTTCCATACTGGACGACTTTAAACCTGTTATGAAAAAGGTTATGGGCGTGGGAAAGAATTTTGACA
TCGATGCTTTTCTTCTGGAAATTCGGGAAATGCTTACCCGGGAAGTTGACCTCAGGATTGAAGCTGTCAACATGAGGCGT
TTTGAAGATAATTTCAAGAATGTGAAAAATGTTTCTGTGCCTAAAATTTATCCGGATTACTGCTCTGCAAATGTCCTTAC
AATGGAATTTATTCAGGGGACGCAGGTTAAAGACATAATTGATACGCCTCTGCCCCAGAGTAAAAAGTCGGAATATACGC
GTACAATTACAAAGAGTTACCTGAAGCAGGTTTATATAGATGGTTTTTATCATGCAGATCCCCACGGCGGCAATATGCTG
GTTGAAGAGAACGATACTGTTTCTTTCATCGATTTTGGGGCAGTTGGCAGCATAGATGACGAACTCAAAAGGAATATGCT
GGAGTTCTATTACGCTATCAATAACAGGGATGTTGAAGGGGCAACGCAGGGTTTTCTTAAAATCGGGGGAGCAGACTCAA
GAGATGTGGATGTTCGCAGGCTCAGGAAGGATATGGACGAACTGATCGCAAACCAGAACTACGGGCTTGAAGGCAGGCAG
AGCGACAATTACGCAAAACTGGGCCTGAAATATGATATCCGGCTCCCGGGGGAATTTTCCACCCTTCAGAGGGCGATCCT
GCTTATAGAAGGAGTTTGCCTTGAACTTGACCCCAGGTACAATATTAAAAGCATCGCAATTCCTGTCCTTATGGATGCTT
ACAAAAAACTCAATACTCCAAAGGGAGCTGCACTTCATATCGAATTTTCCTCCGAGCCAGTGGATGAAAAAGCCGAGATG
AGGGCTGCGATCAGGGAGGTTGCCGACAAAATGGAAGGCATGGGGGACAGGTTCCTTGAGGTAAGGCAGAAAGATAAAAG
GCGTGAAGTTTTTTCAAAGGAAATTTTCCTTGCTGTTCTGCTTGTAGTCTCTGCCTATATATTGCTATACGGGGAGGTAT
TTTACTGGGTTGGACTTGCAGGATTTGGTGGAGCAATCCTCATAGCAGTTATTGCTTCACTGAAAGGGAAGTGA

Upstream 100 bases:

>100_bases
CAGTAAAATTGTTTAATTCTCCAGTAAAATTGTTTAATTCTCCAGTAAATTTGCTTAATCCTCCAGAAACTGGTATCCTT
AGAAACTCTATTAAACAATA

Downstream 100 bases:

>100_bases
AGAATGAAATCAGATCCCAATAAAAAGTTCTGATAACCGGAAATTAAGATAATAATGTGCCTGATAATACCAGGTATCCA
GTAGTAATTACAATATTCAT

Product: ubiquinone biosynthesis protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MTNSLWMLGKTKRYLEVTRVLFKYNLIPELYHDLRTEYISNPDCTCTFDLENRETAAKLRQAFEELGPTFIKMGQTMSKR
PDLVPQPYVVEMANLQDRVKPVPFEEMAESLDLACVCEYQTREERKRKKSEEELKAARERKAKAFIDIFDSFDPEPIACG
SIAQVYKGVLEGKPVAVKILRPHLIDIINIDLSILDDFKPVMKKVMGVGKNFDIDAFLLEIREMLTREVDLRIEAVNMRR
FEDNFKNVKNVSVPKIYPDYCSANVLTMEFIQGTQVKDIIDTPLPQSKKSEYTRTITKSYLKQVYIDGFYHADPHGGNML
VEENDTVSFIDFGAVGSIDDELKRNMLEFYYAINNRDVEGATQGFLKIGGADSRDVDVRRLRKDMDELIANQNYGLEGRQ
SDNYAKLGLKYDIRLPGEFSTLQRAILLIEGVCLELDPRYNIKSIAIPVLMDAYKKLNTPKGAALHIEFSSEPVDEKAEM
RAAIREVADKMEGMGDRFLEVRQKDKRREVFSKEIFLAVLLVVSAYILLYGEVFYWVGLAGFGGAILIAVIASLKGK

Sequences:

>Translated_557_residues
MTNSLWMLGKTKRYLEVTRVLFKYNLIPELYHDLRTEYISNPDCTCTFDLENRETAAKLRQAFEELGPTFIKMGQTMSKR
PDLVPQPYVVEMANLQDRVKPVPFEEMAESLDLACVCEYQTREERKRKKSEEELKAARERKAKAFIDIFDSFDPEPIACG
SIAQVYKGVLEGKPVAVKILRPHLIDIINIDLSILDDFKPVMKKVMGVGKNFDIDAFLLEIREMLTREVDLRIEAVNMRR
FEDNFKNVKNVSVPKIYPDYCSANVLTMEFIQGTQVKDIIDTPLPQSKKSEYTRTITKSYLKQVYIDGFYHADPHGGNML
VEENDTVSFIDFGAVGSIDDELKRNMLEFYYAINNRDVEGATQGFLKIGGADSRDVDVRRLRKDMDELIANQNYGLEGRQ
SDNYAKLGLKYDIRLPGEFSTLQRAILLIEGVCLELDPRYNIKSIAIPVLMDAYKKLNTPKGAALHIEFSSEPVDEKAEM
RAAIREVADKMEGMGDRFLEVRQKDKRREVFSKEIFLAVLLVVSAYILLYGEVFYWVGLAGFGGAILIAVIASLKGK
>Mature_556_residues
TNSLWMLGKTKRYLEVTRVLFKYNLIPELYHDLRTEYISNPDCTCTFDLENRETAAKLRQAFEELGPTFIKMGQTMSKRP
DLVPQPYVVEMANLQDRVKPVPFEEMAESLDLACVCEYQTREERKRKKSEEELKAARERKAKAFIDIFDSFDPEPIACGS
IAQVYKGVLEGKPVAVKILRPHLIDIINIDLSILDDFKPVMKKVMGVGKNFDIDAFLLEIREMLTREVDLRIEAVNMRRF
EDNFKNVKNVSVPKIYPDYCSANVLTMEFIQGTQVKDIIDTPLPQSKKSEYTRTITKSYLKQVYIDGFYHADPHGGNMLV
EENDTVSFIDFGAVGSIDDELKRNMLEFYYAINNRDVEGATQGFLKIGGADSRDVDVRRLRKDMDELIANQNYGLEGRQS
DNYAKLGLKYDIRLPGEFSTLQRAILLIEGVCLELDPRYNIKSIAIPVLMDAYKKLNTPKGAALHIEFSSEPVDEKAEMR
AAIREVADKMEGMGDRFLEVRQKDKRREVFSKEIFLAVLLVVSAYILLYGEVFYWVGLAGFGGAILIAVIASLKGK

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=310, Percent_Identity=24.5161290322581, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI32261307, Length=489, Percent_Identity=22.9038854805726, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI217035081, Length=232, Percent_Identity=26.7241379310345, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI41393593, Length=296, Percent_Identity=25, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI34147522, Length=215, Percent_Identity=26.5116279069767, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI2367309, Length=461, Percent_Identity=26.8980477223427, Blast_Score=152, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17559152, Length=337, Percent_Identity=24.9258160237389, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI32565180, Length=192, Percent_Identity=29.6875, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17555620, Length=352, Percent_Identity=24.4318181818182, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6325148, Length=467, Percent_Identity=24.4111349036403, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6321319, Length=225, Percent_Identity=27.1111111111111, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323282, Length=277, Percent_Identity=23.4657039711191, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI22024280, Length=308, Percent_Identity=25.974025974026, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24662575, Length=339, Percent_Identity=23.598820058997, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 63625; Mature: 63494

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSLWMLGKTKRYLEVTRVLFKYNLIPELYHDLRTEYISNPDCTCTFDLENRETAAKLR
CCCCEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHH
QAFEELGPTFIKMGQTMSKRPDLVPQPYVVEMANLQDRVKPVPFEEMAESLDLACVCEYQ
HHHHHHCHHHHHHCCHHHCCCCCCCCCHHHHHHCHHHHCCCCCHHHHHHHCCEEEEECHH
TREERKRKKSEEELKAARERKAKAFIDIFDSFDPEPIACGSIAQVYKGVLEGKPVAVKIL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEEC
RPHLIDIINIDLSILDDFKPVMKKVMGVGKNFDIDAFLLEIREMLTREVDLRIEAVNMRR
CCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEHHHH
FEDNFKNVKNVSVPKIYPDYCSANVLTMEFIQGTQVKDIIDTPLPQSKKSEYTRTITKSY
HHHHHHHCCCCCCCCCCCCCCCCCEEEHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHH
LKQVYIDGFYHADPHGGNMLVEENDTVSFIDFGAVGSIDDELKRNMLEFYYAINNRDVEG
HHHHHHCCEEECCCCCCCEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCH
ATQGFLKIGGADSRDVDVRRLRKDMDELIANQNYGLEGRQSDNYAKLGLKYDIRLPGEFS
HHCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECEEEEEECCCCHH
TLQRAILLIEGVCLELDPRYNIKSIAIPVLMDAYKKLNTPKGAALHIEFSSEPVDEKAEM
HHHHHHHHHHCHHEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHH
RAAIREVADKMEGMGDRFLEVRQKDKRREVFSKEIFLAVLLVVSAYILLYGEVFYWVGLA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFGGAILIAVIASLKGK
HCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TNSLWMLGKTKRYLEVTRVLFKYNLIPELYHDLRTEYISNPDCTCTFDLENRETAAKLR
CCCEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHH
QAFEELGPTFIKMGQTMSKRPDLVPQPYVVEMANLQDRVKPVPFEEMAESLDLACVCEYQ
HHHHHHCHHHHHHCCHHHCCCCCCCCCHHHHHHCHHHHCCCCCHHHHHHHCCEEEEECHH
TREERKRKKSEEELKAARERKAKAFIDIFDSFDPEPIACGSIAQVYKGVLEGKPVAVKIL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEEC
RPHLIDIINIDLSILDDFKPVMKKVMGVGKNFDIDAFLLEIREMLTREVDLRIEAVNMRR
CCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEHHHH
FEDNFKNVKNVSVPKIYPDYCSANVLTMEFIQGTQVKDIIDTPLPQSKKSEYTRTITKSY
HHHHHHHCCCCCCCCCCCCCCCCCEEEHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHH
LKQVYIDGFYHADPHGGNMLVEENDTVSFIDFGAVGSIDDELKRNMLEFYYAINNRDVEG
HHHHHHCCEEECCCCCCCEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCH
ATQGFLKIGGADSRDVDVRRLRKDMDELIANQNYGLEGRQSDNYAKLGLKYDIRLPGEFS
HHCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECEEEEEECCCCHH
TLQRAILLIEGVCLELDPRYNIKSIAIPVLMDAYKKLNTPKGAALHIEFSSEPVDEKAEM
HHHHHHHHHHCHHEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHH
RAAIREVADKMEGMGDRFLEVRQKDKRREVFSKEIFLAVLLVVSAYILLYGEVFYWVGLA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFGGAILIAVIASLKGK
HCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]