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The map label for this gene is prs

Identifier: 21228307

GI number: 21228307

Start: 2620308

End: 2621195

Strand: Reverse

Name: prs

Synonym: MM_2205

Alternate gene names: 21228307

Gene position: 2621195-2620308 (Counterclockwise)

Preceding gene: 21228308

Following gene: 21228299

Centisome position: 63.99

GC content: 49.1

Gene sequence:

>888_bases
ATGGAATATATCAAGACGGCAACTGAGGTATATATCTTGAAGATCATAGGTGGACCAGCATCACAGTTACTTGCCAGCCG
CACAGCCAGAGCTCTGGGGACAGAGCCTGTTCTCTGCGAGTTTAACCGCTTCCCTGACGGGGAACTTTATCTTAGGATAG
CAGAGGAAATAGAAAACGAAAAAGTTACCCTCATCCAGAGCACGCCCACTGACTCTGATTTTGTCGCCCTGCTTCAGCTT
ATCGATGCCTGTGAAGGGGCAGCCGAAATAAATGTTGTGATCCCTTACATGGGCTATGCCAGGCAGGACAAGAAATTCAA
GTCAGGAGAACCCGTAAGTGCCCGTGCAATTGCCCGCTGTATCAATGCTGACAGGGTTTTTACAATAAATATCCATGAAA
AGAGCGTGCTTGAACACTTCCCTTGCCCCGCAGAAAATCTTGACGCAGCAGCCCTTATCGGCTCATATGTTGCAGGTTTC
GGCCTTGAGCGCCCCATGCTGGTCGCTCCCGATGAAGGAGCACGGGGGCTTGTGAAGAATGTGGCTTCAGGACACGGTTT
TGACCATGACCACCTTCAGAAGACAAGGCTCAGCGGAGATACAGTTGTAATCAAAACAAAGAACCTTGATGTAACAGGCA
GGCACGTTGTCCTTGTGGACGATATGATTGCAACCGGAGGGACAATGGCTGAGTCGATACGGATGCTTAAATCCCAGGGA
GCAATTGATGTCCACCTTGCCTGTGTACACCCTGTCCTTACAAGAAATGCAGCTTTAAGGCTCTTCCATGCAGGTGTAAA
AGACATAATAGGAACCGACACGCTTGAAAAAGCCGAAAGCAAACTGAGTGTTGCCCCTCTTATTGCAGAAGCCCTTTCCG
GGTACTAA

Upstream 100 bases:

>100_bases
GGTGCTTGAGAAGCTAAAGGGTAAAGCTTGAAAAGATAAAAATGGCATTGAAAAGCTAGAGCCTGAAAAGCAGGGTCCAT
AAAAATAAGTTTTTTAAAGG

Downstream 100 bases:

>100_bases
ACTCTGAGTCAAAAGCTATATCTATGAATCAAAAAAACGTTACTTTATTTAAACGTTTTTTGATCCAACGAAACACAGGT
GCTTCCCGCCTGGGAAGTAC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MEYIKTATEVYILKIIGGPASQLLASRTARALGTEPVLCEFNRFPDGELYLRIAEEIENEKVTLIQSTPTDSDFVALLQL
IDACEGAAEINVVIPYMGYARQDKKFKSGEPVSARAIARCINADRVFTINIHEKSVLEHFPCPAENLDAAALIGSYVAGF
GLERPMLVAPDEGARGLVKNVASGHGFDHDHLQKTRLSGDTVVIKTKNLDVTGRHVVLVDDMIATGGTMAESIRMLKSQG
AIDVHLACVHPVLTRNAALRLFHAGVKDIIGTDTLEKAESKLSVAPLIAEALSGY

Sequences:

>Translated_295_residues
MEYIKTATEVYILKIIGGPASQLLASRTARALGTEPVLCEFNRFPDGELYLRIAEEIENEKVTLIQSTPTDSDFVALLQL
IDACEGAAEINVVIPYMGYARQDKKFKSGEPVSARAIARCINADRVFTINIHEKSVLEHFPCPAENLDAAALIGSYVAGF
GLERPMLVAPDEGARGLVKNVASGHGFDHDHLQKTRLSGDTVVIKTKNLDVTGRHVVLVDDMIATGGTMAESIRMLKSQG
AIDVHLACVHPVLTRNAALRLFHAGVKDIIGTDTLEKAESKLSVAPLIAEALSGY
>Mature_295_residues
MEYIKTATEVYILKIIGGPASQLLASRTARALGTEPVLCEFNRFPDGELYLRIAEEIENEKVTLIQSTPTDSDFVALLQL
IDACEGAAEINVVIPYMGYARQDKKFKSGEPVSARAIARCINADRVFTINIHEKSVLEHFPCPAENLDAAALIGSYVAGF
GLERPMLVAPDEGARGLVKNVASGHGFDHDHLQKTRLSGDTVVIKTKNLDVTGRHVVLVDDMIATGGTMAESIRMLKSQG
AIDVHLACVHPVLTRNAALRLFHAGVKDIIGTDTLEKAESKLSVAPLIAEALSGY

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family

Homologues:

Organism=Homo sapiens, GI4506127, Length=297, Percent_Identity=29.2929292929293, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI4506129, Length=274, Percent_Identity=28.8321167883212, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI28557709, Length=276, Percent_Identity=28.9855072463768, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI84875539, Length=277, Percent_Identity=28.8808664259928, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1787458, Length=294, Percent_Identity=31.6326530612245, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI25149168, Length=277, Percent_Identity=29.6028880866426, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17554702, Length=277, Percent_Identity=29.6028880866426, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71989924, Length=277, Percent_Identity=29.6028880866426, Blast_Score=110, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17554704, Length=275, Percent_Identity=29.4545454545455, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319403, Length=296, Percent_Identity=28.3783783783784, Blast_Score=105, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6320946, Length=295, Percent_Identity=28.4745762711864, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321776, Length=286, Percent_Identity=26.2237762237762, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322667, Length=151, Percent_Identity=29.8013245033113, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355239, Length=274, Percent_Identity=27.3722627737226, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI45551540, Length=295, Percent_Identity=25.4237288135593, Blast_Score=91, Evalue=7e-19,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KPRS_METMA (Q8PUX3)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_634229.1
- ProteinModelPortal:   Q8PUX3
- SMR:   Q8PUX3
- GeneID:   1480547
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_2205
- NMPDR:   fig|192952.1.peg.2205
- HOGENOM:   HBG519284
- OMA:   YARQDRT
- ProtClustDB:   PRK00934
- BioCyc:   MMAZ192952:MM2205-MONOMER
- BRENDA:   2.7.6.1
- GO:   GO:0005737
- HAMAP:   MF_00583_A
- InterPro:   IPR005946
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01251

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.7.6.1

Molecular weight: Translated: 31877; Mature: 31877

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00114 PRPP_SYNTHASE; PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYIKTATEVYILKIIGGPASQLLASRTARALGTEPVLCEFNRFPDGELYLRIAEEIENE
CCCHHHHCEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEHHHCCCC
KVTLIQSTPTDSDFVALLQLIDACEGAAEINVVIPYMGYARQDKKFKSGEPVSARAIARC
EEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHH
INADRVFTINIHEKSVLEHFPCPAENLDAAALIGSYVAGFGLERPMLVAPDEGARGLVKN
HCCCEEEEEEECHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHH
VASGHGFDHDHLQKTRLSGDTVVIKTKNLDVTGRHVVLVDDMIATGGTMAESIRMLKSQG
HHCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECHHHCCCHHHHHHHHHHHCC
AIDVHLACVHPVLTRNAALRLFHAGVKDIIGTDTLEKAESKLSVAPLIAEALSGY
CEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEYIKTATEVYILKIIGGPASQLLASRTARALGTEPVLCEFNRFPDGELYLRIAEEIENE
CCCHHHHCEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEHHHCCCC
KVTLIQSTPTDSDFVALLQLIDACEGAAEINVVIPYMGYARQDKKFKSGEPVSARAIARC
EEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHH
INADRVFTINIHEKSVLEHFPCPAENLDAAALIGSYVAGFGLERPMLVAPDEGARGLVKN
HCCCEEEEEEECHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHH
VASGHGFDHDHLQKTRLSGDTVVIKTKNLDVTGRHVVLVDDMIATGGTMAESIRMLKSQG
HHCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECHHHCCCHHHHHHHHHHHCC
AIDVHLACVHPVLTRNAALRLFHAGVKDIIGTDTLEKAESKLSVAPLIAEALSGY
CEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824