Click here to switch to the map view.

The map label for this gene is mre11

Identifier: 21228295

GI number: 21228295

Start: 2601848

End: 2603701

Strand: Direct

Name: mre11

Synonym: MM_2193

Alternate gene names: 21228295

Gene position: 2601848-2603701 (Clockwise)

Preceding gene: 21228294

Following gene: 21228296

Centisome position: 63.52

GC content: 48.33

Gene sequence:

>1854_bases
ATGGACCGGGAAATAAGGATACTCCACACAGCAGACACGCACCTGGGATACCGGCAGTACCACAGCGAGGTACGTAGGCA
GGACTTTTTTAAGGCTTTTGAGACGGTCATAAAGGATGCGGTTGACATGCAGGTTGATGCTGTCGTGCATGCGGGGGATC
TTTTTGATTCACGGAACCCGACCCTTGAAGACCTCCTTGAGACTATGAACGTCCTTTCCCGGTTAAAGGTCGCAAACATA
CCTTTTTTCGGAATTGTCGGGAACCACGAGAGCAAGCAAAGTACCCAGTGGCTTGACCTCTTTGAGGAAATGGGGCTTGC
GGGGAGGCTCGGGAAAGCCCCGAAGATGGTCGGGGATGTAGCAATCTATGGGATTGACAGTGTCCCGAAATCAAAAATTC
CTCTTTTCGATTATTCTGGATTTGAAATTCCGGAGTCTCTGCCTGAAAATTGCAGGAAGCTGCTTGTAATGCACCAGATC
ATGCAGCCTTCCCCGTTTCCGGACTGGGACTGTGCTGAGGTGATAGAAAATCTTCCTTTTAAGGCTGATGCAGTTCTCCT
CGGTGACTACCATGAATATGAGAAAATAAAGGTGGGGGAGTCATGGGTCACATACTCGGGGAGCACGGAACGCAACAGCG
CATCTGAAAAAGAGCCCCGTTCTTACAGCATTATCACTCTTTCCGGGGAAGGGCTGGAAATCAGTAGACGGACGATCCCT
ACCCGAAATTTCCTTTTCATTACTGCAAAAGTTGACGGGGAAGAAAAGCCCTTCGAACAGATTTTTTCTACCGTAAATGA
GCACCTCGAAGAGATTCCTGAATCCGTAGTATTTCTGGATGTTTCAGGAGACTCGAGTTCGGTCCTCTCCTTCAGTGAAA
TCGAAGAATACCTCCTGAGCAAAGGAGCTCTTGTGGTAAAGGTCAAAGATGCAAGGGTGAAAGAGGGGATTCCGGAAGAA
GTTATTAAAGTCGCATTTCATGACCCCGACAGGGCTGTTGCCGAAGAGCTCCGCAGGATGAGCCTGAACGACGGCGGTCT
GATAGTCGATGAGGTTATCCGGAGCCCGGATGTGCCCAGGTCAAGGGTTGATGAAGAGACCGAGAACCGGCTTCTCGGGT
TGATTGAGGCAATAGATTTCAAAGACCCGGATTTCATGATAAAAATCCCTGTCAGTCATGTCAGTCCGGTCGATCCCTCC
AGCTCTGTCAGCTCAATCGAGTCTTCCGGTTCTGTCAGCCCGATCGACTCTGTCAGTACTGTTAGTCCTTCCAGTCCTTC
CAGCTCTGCCATAATCAAAGAGCCTGAAGAACTTAAACCGCCAGGTGCAGCTGAAGAAATTGAAAATCCCAAGCCTGCGG
GAGTAACTGAGTTTACGGCAGCAGTAGCAGCGAAATCCGAAACCCTGATGCCTCCTGTGAGAATTCAAAGGTCTGAATCT
CTCAACGAATCTCTCAATAAGATTTTTGAAAAACATGATGTAGTCCCCGAATCGCCTGAAACCGCCGGTTCAATTGCCGG
TTCTGTGGAAACAGCTGTAGAAGATGAAATTTCTAAAGTAACTCCTGATTCCGGAGTCATTACTGCTCCCCAATCCAGTT
CACCGGTTAGTTTCTCAGATAACTCCCAGACTGGTTTCTCAGCTATTTCTCCGCCTGAAAGCATTCCGTCGCCTGAAATT
TTGAAGGAAAATTCTGAAGCAGATGCAGACGAAAAGCCTGTTGACGGAAAGCTTTCTGAAGAAAAGCCTGTTGGGGTTCC
GGATAAAGCCACAAAAACTGTAAAGCAGAGCCATAGGAAAGGAAAAGAAAAATCTGCCGTTCCCAGACAGTATAACCTTG
GTGATTACCTGTGA

Upstream 100 bases:

>100_bases
GAGACAACCTGTTAATACTCACTCTTAACCGCGAGTCTGTGGAAATCAGTTAAATACTAATATACAAATCCCTATACCGT
AAAAACTAGAGACTGATACC

Downstream 100 bases:

>100_bases
AGCTGAAAAACCTGTACATAGAAAATATTCGGAGCTATAAAAAGCTGGACTTCACCTTCGAAGACGGAGTAACTGTAATT
TCCGGGGTAAACGGAAGTGG

Product: DNA repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MDREIRILHTADTHLGYRQYHSEVRRQDFFKAFETVIKDAVDMQVDAVVHAGDLFDSRNPTLEDLLETMNVLSRLKVANI
PFFGIVGNHESKQSTQWLDLFEEMGLAGRLGKAPKMVGDVAIYGIDSVPKSKIPLFDYSGFEIPESLPENCRKLLVMHQI
MQPSPFPDWDCAEVIENLPFKADAVLLGDYHEYEKIKVGESWVTYSGSTERNSASEKEPRSYSIITLSGEGLEISRRTIP
TRNFLFITAKVDGEEKPFEQIFSTVNEHLEEIPESVVFLDVSGDSSSVLSFSEIEEYLLSKGALVVKVKDARVKEGIPEE
VIKVAFHDPDRAVAEELRRMSLNDGGLIVDEVIRSPDVPRSRVDEETENRLLGLIEAIDFKDPDFMIKIPVSHVSPVDPS
SSVSSIESSGSVSPIDSVSTVSPSSPSSSAIIKEPEELKPPGAAEEIENPKPAGVTEFTAAVAAKSETLMPPVRIQRSES
LNESLNKIFEKHDVVPESPETAGSIAGSVETAVEDEISKVTPDSGVITAPQSSSPVSFSDNSQTGFSAISPPESIPSPEI
LKENSEADADEKPVDGKLSEEKPVGVPDKATKTVKQSHRKGKEKSAVPRQYNLGDYL

Sequences:

>Translated_617_residues
MDREIRILHTADTHLGYRQYHSEVRRQDFFKAFETVIKDAVDMQVDAVVHAGDLFDSRNPTLEDLLETMNVLSRLKVANI
PFFGIVGNHESKQSTQWLDLFEEMGLAGRLGKAPKMVGDVAIYGIDSVPKSKIPLFDYSGFEIPESLPENCRKLLVMHQI
MQPSPFPDWDCAEVIENLPFKADAVLLGDYHEYEKIKVGESWVTYSGSTERNSASEKEPRSYSIITLSGEGLEISRRTIP
TRNFLFITAKVDGEEKPFEQIFSTVNEHLEEIPESVVFLDVSGDSSSVLSFSEIEEYLLSKGALVVKVKDARVKEGIPEE
VIKVAFHDPDRAVAEELRRMSLNDGGLIVDEVIRSPDVPRSRVDEETENRLLGLIEAIDFKDPDFMIKIPVSHVSPVDPS
SSVSSIESSGSVSPIDSVSTVSPSSPSSSAIIKEPEELKPPGAAEEIENPKPAGVTEFTAAVAAKSETLMPPVRIQRSES
LNESLNKIFEKHDVVPESPETAGSIAGSVETAVEDEISKVTPDSGVITAPQSSSPVSFSDNSQTGFSAISPPESIPSPEI
LKENSEADADEKPVDGKLSEEKPVGVPDKATKTVKQSHRKGKEKSAVPRQYNLGDYL
>Mature_617_residues
MDREIRILHTADTHLGYRQYHSEVRRQDFFKAFETVIKDAVDMQVDAVVHAGDLFDSRNPTLEDLLETMNVLSRLKVANI
PFFGIVGNHESKQSTQWLDLFEEMGLAGRLGKAPKMVGDVAIYGIDSVPKSKIPLFDYSGFEIPESLPENCRKLLVMHQI
MQPSPFPDWDCAEVIENLPFKADAVLLGDYHEYEKIKVGESWVTYSGSTERNSASEKEPRSYSIITLSGEGLEISRRTIP
TRNFLFITAKVDGEEKPFEQIFSTVNEHLEEIPESVVFLDVSGDSSSVLSFSEIEEYLLSKGALVVKVKDARVKEGIPEE
VIKVAFHDPDRAVAEELRRMSLNDGGLIVDEVIRSPDVPRSRVDEETENRLLGLIEAIDFKDPDFMIKIPVSHVSPVDPS
SSVSSIESSGSVSPIDSVSTVSPSSPSSSAIIKEPEELKPPGAAEEIENPKPAGVTEFTAAVAAKSETLMPPVRIQRSES
LNESLNKIFEKHDVVPESPETAGSIAGSVETAVEDEISKVTPDSGVITAPQSSSPVSFSDNSQTGFSAISPPESIPSPEI
LKENSEADADEKPVDGKLSEEKPVGVPDKATKTVKQSHRKGKEKSAVPRQYNLGDYL

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MRE11/RAD32 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRE11_METMA (Q8PUY5)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_634217.1
- ProteinModelPortal:   Q8PUY5
- GeneID:   1480535
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_2193
- NMPDR:   fig|192952.1.peg.2193
- HOGENOM:   HBG122182
- OMA:   YSGSTER
- ProtClustDB:   CLSK492509
- BioCyc:   MMAZ192952:MM2193-MONOMER
- InterPro:   IPR004843

Pfam domain/function: PF00149 Metallophos

EC number: NA

Molecular weight: Translated: 67782; Mature: 67782

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: ACT_SITE 89-89

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDREIRILHTADTHLGYRQYHSEVRRQDFFKAFETVIKDAVDMQVDAVVHAGDLFDSRNP
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHCCCCC
TLEDLLETMNVLSRLKVANIPFFGIVGNHESKQSTQWLDLFEEMGLAGRLGKAPKMVGDV
CHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHCE
AIYGIDSVPKSKIPLFDYSGFEIPESLPENCRKLLVMHQIMQPSPFPDWDCAEVIENLPF
EEEECCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCC
KADAVLLGDYHEYEKIKVGESWVTYSGSTERNSASEKEPRSYSIITLSGEGLEISRRTIP
CCCEEEECCCCCCCEEEECCCEEEECCCCCCCCCCCCCCCCEEEEEEECCCCEEHHHCCC
TRNFLFITAKVDGEEKPFEQIFSTVNEHLEEIPESVVFLDVSGDSSSVLSFSEIEEYLLS
CCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEHHHHHHHHHC
KGALVVKVKDARVKEGIPEEVIKVAFHDPDRAVAEELRRMSLNDGGLIVDEVIRSPDVPR
CCCEEEEEECCHHHCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEHHHHHCCCCCCH
SRVDEETENRLLGLIEAIDFKDPDFMIKIPVSHVSPVDPSSSVSSIESSGSVSPIDSVST
HHCCHHHHHHHHHHHHHHCCCCCCEEEEEEHHHCCCCCCCHHHHHHHCCCCCCCCCCCCC
VSPSSPSSSAIIKEPEELKPPGAAEEIENPKPAGVTEFTAAVAAKSETLMPPVRIQRSES
CCCCCCCCCCCCCCHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHH
LNESLNKIFEKHDVVPESPETAGSIAGSVETAVEDEISKVTPDSGVITAPQSSSPVSFSD
HHHHHHHHHHHHCCCCCCCCHHHHHHCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCC
NSQTGFSAISPPESIPSPEILKENSEADADEKPVDGKLSEEKPVGVPDKATKTVKQSHRK
CCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
GKEKSAVPRQYNLGDYL
CCHHHCCCCCCCCCCCC
>Mature Secondary Structure
MDREIRILHTADTHLGYRQYHSEVRRQDFFKAFETVIKDAVDMQVDAVVHAGDLFDSRNP
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHCCCCC
TLEDLLETMNVLSRLKVANIPFFGIVGNHESKQSTQWLDLFEEMGLAGRLGKAPKMVGDV
CHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHCE
AIYGIDSVPKSKIPLFDYSGFEIPESLPENCRKLLVMHQIMQPSPFPDWDCAEVIENLPF
EEEECCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCC
KADAVLLGDYHEYEKIKVGESWVTYSGSTERNSASEKEPRSYSIITLSGEGLEISRRTIP
CCCEEEECCCCCCCEEEECCCEEEECCCCCCCCCCCCCCCCEEEEEEECCCCEEHHHCCC
TRNFLFITAKVDGEEKPFEQIFSTVNEHLEEIPESVVFLDVSGDSSSVLSFSEIEEYLLS
CCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEHHHHHHHHHC
KGALVVKVKDARVKEGIPEEVIKVAFHDPDRAVAEELRRMSLNDGGLIVDEVIRSPDVPR
CCCEEEEEECCHHHCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEHHHHHCCCCCCH
SRVDEETENRLLGLIEAIDFKDPDFMIKIPVSHVSPVDPSSSVSSIESSGSVSPIDSVST
HHCCHHHHHHHHHHHHHHCCCCCCEEEEEEHHHCCCCCCCHHHHHHHCCCCCCCCCCCCC
VSPSSPSSSAIIKEPEELKPPGAAEEIENPKPAGVTEFTAAVAAKSETLMPPVRIQRSES
CCCCCCCCCCCCCCHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHH
LNESLNKIFEKHDVVPESPETAGSIAGSVETAVEDEISKVTPDSGVITAPQSSSPVSFSD
HHHHHHHHHHHHCCCCCCCCHHHHHHCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCC
NSQTGFSAISPPESIPSPEILKENSEADADEKPVDGKLSEEKPVGVPDKATKTVKQSHRK
CCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
GKEKSAVPRQYNLGDYL
CCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12125824