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The map label for this gene is nadA1 [H]

Identifier: 21228175

GI number: 21228175

Start: 2471811

End: 2472725

Strand: Direct

Name: nadA1 [H]

Synonym: MM_2073

Alternate gene names: 21228175

Gene position: 2471811-2472725 (Clockwise)

Preceding gene: 21228174

Following gene: 21228177

Centisome position: 60.34

GC content: 46.67

Gene sequence:

>915_bases
ATGCAGCAAGCAGACCTTACAAAAAGGATTAATGAATTGAAGTTAAAACGAAACGCAGTAATTCTTTCTCATTATTATTC
ACGCCCCGAAGTCCAGGACATTGCAGATTTTGTCGGTGACTCCCTTGCCCTGAGCCAGGAAGCCGTACGCCAGGACGCTG
ATGTTATTGTCTTCTGCGGCGTCCATTTTATGGGGGAAAGCGCTGCAATCCTTTCCCCTAATAAAACGGTTTTGTTGCCT
GAAATTGATGCTACCTGCCCGATGGCAGATATGGTCAATGTTGAAGGCCTTAAAATATTGAAAGAAAAACACCCTGAAGC
CCCTGTTGTCTCTTATGTAAACAGCTCGGCTGCAATAAAGGCAGAATCCTATATATGCTGCACCTCTGCCAACGCTGTGG
AAGTTGTAAACTCCCTGGACGCAGACGAGGTCATCTTTGTGCCTGACAAGAACCTGGCTGCTTATGTTGCGTCCCGGACT
GACAAGAAAATCATTCCCTGGGAAGGGCACTGCCCGACACACCACCAGATCCTTCGGGAAGATGTCCTGAAAATGAAAGA
AAAGCATCCTCGGGCTGAATTTATAGCTCATCCCGAGTGCCGCCCTGATGTCCTTGAACTTGCAGACCATGTGGCAAGCA
CGCGGGGCATGATCGTACACGCAGAGAGATCGCCTGCAAAGGAGTTTATAATAGGTACGGAGTGCGGGCTTATTCATGGG
CTTCTTAAAGCAGTTCCTGAAAAAACATACTACTGCGTCTCTGAATTTGCCTGCTGCCCGAGCATGAAAATGGTCAACCT
TGAAAAAGTCCTGACTTCCCTTGAAAAAATGCAGCAAAGAGTAATTGTTCCCGAAGATGTTAGAGCCAGGGCAAAAGAAG
CCCTTGATAGAATGCTTGCAGTAAAAATAAATTAA

Upstream 100 bases:

>100_bases
AAAATGCCAGTAAATCAAATATCACCGGAGCTTCCTGAGCTTGAGAACCTCTCTGCTAAAAAATAGCTCTGTTTAATTAC
TCTAATATTATGGTGGTCCC

Downstream 100 bases:

>100_bases
TTATTTGAATCTTTTTTCGCTACATTTTGCCGCGTCTATTTTGGCGAAGGCTATTTTTTATCCTTTTTTCCTTAGGGCAT
AACTCATCCAAGATTTCATA

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MQQADLTKRINELKLKRNAVILSHYYSRPEVQDIADFVGDSLALSQEAVRQDADVIVFCGVHFMGESAAILSPNKTVLLP
EIDATCPMADMVNVEGLKILKEKHPEAPVVSYVNSSAAIKAESYICCTSANAVEVVNSLDADEVIFVPDKNLAAYVASRT
DKKIIPWEGHCPTHHQILREDVLKMKEKHPRAEFIAHPECRPDVLELADHVASTRGMIVHAERSPAKEFIIGTECGLIHG
LLKAVPEKTYYCVSEFACCPSMKMVNLEKVLTSLEKMQQRVIVPEDVRARAKEALDRMLAVKIN

Sequences:

>Translated_304_residues
MQQADLTKRINELKLKRNAVILSHYYSRPEVQDIADFVGDSLALSQEAVRQDADVIVFCGVHFMGESAAILSPNKTVLLP
EIDATCPMADMVNVEGLKILKEKHPEAPVVSYVNSSAAIKAESYICCTSANAVEVVNSLDADEVIFVPDKNLAAYVASRT
DKKIIPWEGHCPTHHQILREDVLKMKEKHPRAEFIAHPECRPDVLELADHVASTRGMIVHAERSPAKEFIIGTECGLIHG
LLKAVPEKTYYCVSEFACCPSMKMVNLEKVLTSLEKMQQRVIVPEDVRARAKEALDRMLAVKIN
>Mature_304_residues
MQQADLTKRINELKLKRNAVILSHYYSRPEVQDIADFVGDSLALSQEAVRQDADVIVFCGVHFMGESAAILSPNKTVLLP
EIDATCPMADMVNVEGLKILKEKHPEAPVVSYVNSSAAIKAESYICCTSANAVEVVNSLDADEVIFVPDKNLAAYVASRT
DKKIIPWEGHCPTHHQILREDVLKMKEKHPRAEFIAHPECRPDVLELADHVASTRGMIVHAERSPAKEFIIGTECGLIHG
LLKAVPEKTYYCVSEFACCPSMKMVNLEKVLTSLEKMQQRVIVPEDVRARAKEALDRMLAVKIN

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate [H]

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 2 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786964, Length=316, Percent_Identity=34.8101265822785, Blast_Score=189, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003473
- InterPro:   IPR023066 [H]

Pfam domain/function: PF02445 NadA [H]

EC number: =2.5.1.72 [H]

Molecular weight: Translated: 33801; Mature: 33801

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQADLTKRINELKLKRNAVILSHYYSRPEVQDIADFVGDSLALSQEAVRQDADVIVFCG
CCCHHHHHHHHHHHHHHCEEEEEHHCCCCCHHHHHHHHCCHHHHHHHHHHCCCCEEEEEC
VHFMGESAAILSPNKTVLLPEIDATCPMADMVNVEGLKILKEKHPEAPVVSYVNSSAAIK
CEECCCCCEEECCCCEEEEECCCCCCCHHHHCCCCHHHHHHHCCCCCHHHHHCCCCCEEE
AESYICCTSANAVEVVNSLDADEVIFVPDKNLAAYVASRTDKKIIPWEGHCPTHHQILRE
ECCEEEECCCCHHHHHHCCCCCCEEEECCCCHHHHHHCCCCCEECCCCCCCCHHHHHHHH
DVLKMKEKHPRAEFIAHPECRPDVLELADHVASTRGMIVHAERSPAKEFIIGTECGLIHG
HHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHEEECCHHHHHHH
LLKAVPEKTYYCVSEFACCPSMKMVNLEKVLTSLEKMQQRVIVPEDVRARAKEALDRMLA
HHHHCCCHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHE
VKIN
EECC
>Mature Secondary Structure
MQQADLTKRINELKLKRNAVILSHYYSRPEVQDIADFVGDSLALSQEAVRQDADVIVFCG
CCCHHHHHHHHHHHHHHCEEEEEHHCCCCCHHHHHHHHCCHHHHHHHHHHCCCCEEEEEC
VHFMGESAAILSPNKTVLLPEIDATCPMADMVNVEGLKILKEKHPEAPVVSYVNSSAAIK
CEECCCCCEEECCCCEEEEECCCCCCCHHHHCCCCHHHHHHHCCCCCHHHHHCCCCCEEE
AESYICCTSANAVEVVNSLDADEVIFVPDKNLAAYVASRTDKKIIPWEGHCPTHHQILRE
ECCEEEECCCCHHHHHHCCCCCCEEEECCCCHHHHHHCCCCCEECCCCCCCCHHHHHHHH
DVLKMKEKHPRAEFIAHPECRPDVLELADHVASTRGMIVHAERSPAKEFIIGTECGLIHG
HHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHEEECCHHHHHHH
LLKAVPEKTYYCVSEFACCPSMKMVNLEKVLTSLEKMQQRVIVPEDVRARAKEALDRMLA
HHHHCCCHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHE
VKIN
EECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]