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The map label for this gene is nadC [H]

Identifier: 21228172

GI number: 21228172

Start: 2465579

End: 2466412

Strand: Reverse

Name: nadC [H]

Synonym: MM_2070

Alternate gene names: 21228172

Gene position: 2466412-2465579 (Counterclockwise)

Preceding gene: 21228173

Following gene: 21228171

Centisome position: 60.21

GC content: 45.08

Gene sequence:

>834_bases
ATGTTTATCAGAGAAATTGAAAGCTTCATAGAAGAAGACCTTGGGTACGATGACGTTTCATGCACTATTGTCCCGGACAG
GCCTGCTGAAGCCATTATTTTTACGAAAGAAGACTGCACGGTTGCAGGGATAGATGAGGCAGTATCAATATTTTATTATT
TTGGGATTCAGGCTGAAACTGATTTTAAAGATGGGGACCAGCTAAAGAAGGGAGACATAATTTTCAGGCTTAAGGGAGGA
GCCGTTTCCATTCTAAGGGCAGAGCGCATCAGCCTCAACTTCCTGGGACACCTCAGCGGAATTGCAACCCTGACAAGAAA
ATGCATGGACATTGCTAGAAAGCACTCTGAGACTGTGAGGGTCGCCTGCACAAGAAAGACAACTCCCGGAATCAGGAAAT
TCGAAAAGCTGGCTGTTGCCGCAGGTGGGGGAGATACACACAGGTTTAACCTCTCGGATGCGGTCATGATAAAAGATAAC
CATGTGAAACTTATGGGGATAGAAGCCGCAATCAAAGAAGCCCGGAAAACCAGCTTTACACGGAAAATTGAGGTTGAAGT
TGAATCTGCAGAAGATGCGGTCTTTGCCGCAGAGCTGGGAGCTGACATAATAATGCTTGACAATATGCAGCCTGATGGGG
TTAAAGAAACTATTTCCATACTTAACGGAAAAGGGCTCAGAGAATCAGTTCTTATAGAAGCTTCAGGAGGGATTTCTCTG
GAAAACCTGGAAGCTTATGCAAAAACAGGAGTGGATGTAATATCCATGGGCTTACTGATCCACAGATCAAGATGGATAGA
TGTCAGCCTGGAAATAGTCCGCCCTGAGAGCTAA

Upstream 100 bases:

>100_bases
TATATATTTCAAGAAAATAGCCACTGGAAAGAGATAGAAAAACCCGAAATGCCCGCGATTCTTATAAATGCAGGAGACAT
AAAATAGCGGGGTAAAAATT

Downstream 100 bases:

>100_bases
AATATATTCTGGAAATTGGAGACATAAGTTAGCTCCAAATAGAAATCAGAACCGAAAAAGCTGCACAGGGCAAGAAAATT
AAAAAAACAGCATATAGGTA

Product: nicotinate-nucleotide pyrophosphate carboxylating protein

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MFIREIESFIEEDLGYDDVSCTIVPDRPAEAIIFTKEDCTVAGIDEAVSIFYYFGIQAETDFKDGDQLKKGDIIFRLKGG
AVSILRAERISLNFLGHLSGIATLTRKCMDIARKHSETVRVACTRKTTPGIRKFEKLAVAAGGGDTHRFNLSDAVMIKDN
HVKLMGIEAAIKEARKTSFTRKIEVEVESAEDAVFAAELGADIIMLDNMQPDGVKETISILNGKGLRESVLIEASGGISL
ENLEAYAKTGVDVISMGLLIHRSRWIDVSLEIVRPES

Sequences:

>Translated_277_residues
MFIREIESFIEEDLGYDDVSCTIVPDRPAEAIIFTKEDCTVAGIDEAVSIFYYFGIQAETDFKDGDQLKKGDIIFRLKGG
AVSILRAERISLNFLGHLSGIATLTRKCMDIARKHSETVRVACTRKTTPGIRKFEKLAVAAGGGDTHRFNLSDAVMIKDN
HVKLMGIEAAIKEARKTSFTRKIEVEVESAEDAVFAAELGADIIMLDNMQPDGVKETISILNGKGLRESVLIEASGGISL
ENLEAYAKTGVDVISMGLLIHRSRWIDVSLEIVRPES
>Mature_277_residues
MFIREIESFIEEDLGYDDVSCTIVPDRPAEAIIFTKEDCTVAGIDEAVSIFYYFGIQAETDFKDGDQLKKGDIIFRLKGG
AVSILRAERISLNFLGHLSGIATLTRKCMDIARKHSETVRVACTRKTTPGIRKFEKLAVAAGGGDTHRFNLSDAVMIKDN
HVKLMGIEAAIKEARKTSFTRKIEVEVESAEDAVFAAELGADIIMLDNMQPDGVKETISILNGKGLRESVLIEASGGISL
ENLEAYAKTGVDVISMGLLIHRSRWIDVSLEIVRPES

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=269, Percent_Identity=36.8029739776952, Blast_Score=163, Evalue=1e-40,
Organism=Escherichia coli, GI1786299, Length=271, Percent_Identity=33.5793357933579, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321162, Length=280, Percent_Identity=38.2142857142857, Blast_Score=171, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30457; Mature: 30457

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIREIESFIEEDLGYDDVSCTIVPDRPAEAIIFTKEDCTVAGIDEAVSIFYYFGIQAET
CCHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCCEEECHHHHEEEEEEEEEEEEC
DFKDGDQLKKGDIIFRLKGGAVSILRAERISLNFLGHLSGIATLTRKCMDIARKHSETVR
CCCCCCCCCCCCEEEEECCCEEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEE
VACTRKTTPGIRKFEKLAVAAGGGDTHRFNLSDAVMIKDNHVKLMGIEAAIKEARKTSFT
EEEECCCCCCHHHHHHEEEEECCCCCEEEECCCEEEEECCCEEEEEHHHHHHHHHHCCCE
RKIEVEVESAEDAVFAAELGADIIMLDNMQPDGVKETISILNGKGLRESVLIEASGGISL
EEEEEEEECCCCEEEEHHHCCCEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCH
ENLEAYAKTGVDVISMGLLIHRSRWIDVSLEIVRPES
HHHHHHHHCCHHHHHHHHHHCCCEEEEEEEEEECCCC
>Mature Secondary Structure
MFIREIESFIEEDLGYDDVSCTIVPDRPAEAIIFTKEDCTVAGIDEAVSIFYYFGIQAET
CCHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCCEEECHHHHEEEEEEEEEEEEC
DFKDGDQLKKGDIIFRLKGGAVSILRAERISLNFLGHLSGIATLTRKCMDIARKHSETVR
CCCCCCCCCCCCEEEEECCCEEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEE
VACTRKTTPGIRKFEKLAVAAGGGDTHRFNLSDAVMIKDNHVKLMGIEAAIKEARKTSFT
EEEECCCCCCHHHHHHEEEEECCCCCEEEECCCEEEEECCCEEEEEHHHHHHHHHHCCCE
RKIEVEVESAEDAVFAAELGADIIMLDNMQPDGVKETISILNGKGLRESVLIEASGGISL
EEEEEEEECCCCEEEEHHHCCCEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCH
ENLEAYAKTGVDVISMGLLIHRSRWIDVSLEIVRPES
HHHHHHHHCCHHHHHHHHHHCCCEEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]