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The map label for this gene is hisC [H]

Identifier: 21228162

GI number: 21228162

Start: 2454369

End: 2455859

Strand: Reverse

Name: hisC [H]

Synonym: MM_2060

Alternate gene names: 21228162

Gene position: 2455859-2454369 (Counterclockwise)

Preceding gene: 21228169

Following gene: 21228161

Centisome position: 59.95

GC content: 46.55

Gene sequence:

>1491_bases
GTGTCAGAGCAAAGAAGTGTACCTTTAAGGGAGCATCTGCTGGCCCTGAAGCCCTGCAGACATGGAGGGCTAATCCAGGA
AACTTCGGAGACGTACGGGATCCCCGAAAACGAAATCCTCGACTTCAGTGCAAACTTTAACCCACTGGGAAGTCCCTTTG
ACTATCCGGAAAACGGGCTAAACTTTGAAGATATTATCAAGAAGAGTTGTGGAAAACTCCTGGAATACCCTGATAACAGG
TATGTAGAGTTCAGGGAAGCTGCTGCAAGGTTTGTAGGACTTGGAGTAACACCGCAGAGCATTGTTCCTGGAAACGGTTC
AACGGAAATAGTAAGGCTGGTAGTCGAATCCGTGATAGAAAAGGGAGATAAAGTCCTTTTACCCTGGCCCACTTTCGGAG
AATACGAAATGCAGTGCCGGATCACAGGAGCTGAACCCGTATGTCCTTCACAGGAAGAAGTAAATACACTCCCTGATGAG
GTGCTGGAAGAAGCAAAAATCCTTTTTATCTGTAATCCTAACAACCCCACAGGAAAACTCCGCACCAGGGAAGAACTTAA
AGTCCTTGCGGAACGCTGCAGAGAACATAAGACCCTCCTCTATGTGGATGAAGCATTCATAGAGCTTTCAGACCCTTCAC
AGAGTGTTGCAGACCTTCCTGCAGAAAATAATTATGTTTTTGTCATGCGTTCCCTTACAAAAGACTTTGCAATTCCCGGA
ATCAGAATGGGCTTCGGAATAGCTCCTCCGGCTATGGCTGATATACTTAACACAGCAAGGCTGTCCTGGAACCTGGGAGC
TATTGCAAACAATACAGGAATTGCGCTTCTTAATATCGAAGGCGGAATTGACAGCCCTTACCTGAAAAAAGCAAGGGAAA
TGATACTCAAAGAAGGAGAAACCCTCAAAGCCAAAATCGATAGGATAAGGGGTTTTGAAGCCGGAGAAGTGAATGTTAAC
TTCATACTGGTTGATGTAAGCAAGTTCATGCTTAATTCAAGCGAATTAACTGCACGCCTTGCAGCACGAGGAGTCCTTGT
CCGGGACTGTGTTTCCTTTCACGGCCTTGGAAAGAATTACATACGGGTTGCAGTCAGGACAGAAAAAGAAAACGACAGGC
TCATTGCTGCAATCGGGGACGTTATCACCGAATGGGGCAGAGAACAGGCAAAGAACGAACTGCAGCACGTAATCGAAAAA
GCCAGTGAAGAAGGCATCGGAGGCAGAAAGACCTGCGAATACTATCCGTGCCATTTCGAAGGCCAGAACTGCACATTCTG
CTTCTGTCCGTTTTACCCCTGTGAAAACGAAAAAACCGGAGGGAAATGGATACAGAGTTCAAGAGGAGGCAGGGTATGGA
GTTGCGTTGACTGCCACCTTGTCCATAAAAAGGAGATAGCCCAGAAAATCCTTGACTGCCTTATGCACGAAGGGGATACT
GACGAACTCGTAAAAGTAGCCTGGAAAGAAGTGATGGAGCCTATCTTATGA

Upstream 100 bases:

>100_bases
CGCAATCAAATAACCATAAAGCAAATAAAGGCATGTTTGCACGAGCTAATATAATAAACAACTTAATATACAGGCTTCAC
GCTAAATATTTGCGATCAAC

Downstream 100 bases:

>100_bases
TCATACCGGACAGCGGGCACCTCGCTCTGGTACTTCTGCTAGCTGCAGTCATAGACATAGTTTTCGGGGAACCTCCTGCT
GCTGTCCACCCGGTCGTCTG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MSEQRSVPLREHLLALKPCRHGGLIQETSETYGIPENEILDFSANFNPLGSPFDYPENGLNFEDIIKKSCGKLLEYPDNR
YVEFREAAARFVGLGVTPQSIVPGNGSTEIVRLVVESVIEKGDKVLLPWPTFGEYEMQCRITGAEPVCPSQEEVNTLPDE
VLEEAKILFICNPNNPTGKLRTREELKVLAERCREHKTLLYVDEAFIELSDPSQSVADLPAENNYVFVMRSLTKDFAIPG
IRMGFGIAPPAMADILNTARLSWNLGAIANNTGIALLNIEGGIDSPYLKKAREMILKEGETLKAKIDRIRGFEAGEVNVN
FILVDVSKFMLNSSELTARLAARGVLVRDCVSFHGLGKNYIRVAVRTEKENDRLIAAIGDVITEWGREQAKNELQHVIEK
ASEEGIGGRKTCEYYPCHFEGQNCTFCFCPFYPCENEKTGGKWIQSSRGGRVWSCVDCHLVHKKEIAQKILDCLMHEGDT
DELVKVAWKEVMEPIL

Sequences:

>Translated_496_residues
MSEQRSVPLREHLLALKPCRHGGLIQETSETYGIPENEILDFSANFNPLGSPFDYPENGLNFEDIIKKSCGKLLEYPDNR
YVEFREAAARFVGLGVTPQSIVPGNGSTEIVRLVVESVIEKGDKVLLPWPTFGEYEMQCRITGAEPVCPSQEEVNTLPDE
VLEEAKILFICNPNNPTGKLRTREELKVLAERCREHKTLLYVDEAFIELSDPSQSVADLPAENNYVFVMRSLTKDFAIPG
IRMGFGIAPPAMADILNTARLSWNLGAIANNTGIALLNIEGGIDSPYLKKAREMILKEGETLKAKIDRIRGFEAGEVNVN
FILVDVSKFMLNSSELTARLAARGVLVRDCVSFHGLGKNYIRVAVRTEKENDRLIAAIGDVITEWGREQAKNELQHVIEK
ASEEGIGGRKTCEYYPCHFEGQNCTFCFCPFYPCENEKTGGKWIQSSRGGRVWSCVDCHLVHKKEIAQKILDCLMHEGDT
DELVKVAWKEVMEPIL
>Mature_495_residues
SEQRSVPLREHLLALKPCRHGGLIQETSETYGIPENEILDFSANFNPLGSPFDYPENGLNFEDIIKKSCGKLLEYPDNRY
VEFREAAARFVGLGVTPQSIVPGNGSTEIVRLVVESVIEKGDKVLLPWPTFGEYEMQCRITGAEPVCPSQEEVNTLPDEV
LEEAKILFICNPNNPTGKLRTREELKVLAERCREHKTLLYVDEAFIELSDPSQSVADLPAENNYVFVMRSLTKDFAIPGI
RMGFGIAPPAMADILNTARLSWNLGAIANNTGIALLNIEGGIDSPYLKKAREMILKEGETLKAKIDRIRGFEAGEVNVNF
ILVDVSKFMLNSSELTARLAARGVLVRDCVSFHGLGKNYIRVAVRTEKENDRLIAAIGDVITEWGREQAKNELQHVIEKA
SEEGIGGRKTCEYYPCHFEGQNCTFCFCPFYPCENEKTGGKWIQSSRGGRVWSCVDCHLVHKKEIAQKILDCLMHEGDTD
ELVKVAWKEVMEPIL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=344, Percent_Identity=26.7441860465116, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788627, Length=164, Percent_Identity=28.0487804878049, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17567369, Length=156, Percent_Identity=29.4871794871795, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71994472, Length=154, Percent_Identity=29.8701298701299, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994476, Length=154, Percent_Identity=29.8701298701299, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=359, Percent_Identity=25.3481894150418, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 55532; Mature: 55401

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQRSVPLREHLLALKPCRHGGLIQETSETYGIPENEILDFSANFNPLGSPFDYPENGL
CCCCCCCCHHHHHHHHCCCCCCCCEEECHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCC
NFEDIIKKSCGKLLEYPDNRYVEFREAAARFVGLGVTPQSIVPGNGSTEIVRLVVESVIE
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
KGDKVLLPWPTFGEYEMQCRITGAEPVCPSQEEVNTLPDEVLEEAKILFICNPNNPTGKL
CCCEEEECCCCCCCEEEEEEEECCCCCCCCHHHHHCCHHHHHCCCEEEEEECCCCCCCCC
RTREELKVLAERCREHKTLLYVDEAFIELSDPSQSVADLPAENNYVFVMRSLTKDFAIPG
CCHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCHHHHCCCCCCCEEEEEEHHHHHHCCCC
IRMGFGIAPPAMADILNTARLSWNLGAIANNTGIALLNIEGGIDSPYLKKAREMILKEGE
EEECCCCCCHHHHHHHHHHHHEEECCEEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCC
TLKAKIDRIRGFEAGEVNVNFILVDVSKFMLNSSELTARLAARGVLVRDCVSFHGLGKNY
HHHHHHHHHCCCCCCCEEEEEEEEEEHHHHHCCHHHHHHHHHCCHHHHHHHHHHCCCCCE
IRVAVRTEKENDRLIAAIGDVITEWGREQAKNELQHVIEKASEEGIGGRKTCEYYPCHFE
EEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCEEC
GQNCTFCFCPFYPCENEKTGGKWIQSSRGGRVWSCVDCHLVHKKEIAQKILDCLMHEGDT
CCCCEEEEECCCCCCCCCCCCHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCH
DELVKVAWKEVMEPIL
HHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEQRSVPLREHLLALKPCRHGGLIQETSETYGIPENEILDFSANFNPLGSPFDYPENGL
CCCCCCCHHHHHHHHCCCCCCCCEEECHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCC
NFEDIIKKSCGKLLEYPDNRYVEFREAAARFVGLGVTPQSIVPGNGSTEIVRLVVESVIE
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
KGDKVLLPWPTFGEYEMQCRITGAEPVCPSQEEVNTLPDEVLEEAKILFICNPNNPTGKL
CCCEEEECCCCCCCEEEEEEEECCCCCCCCHHHHHCCHHHHHCCCEEEEEECCCCCCCCC
RTREELKVLAERCREHKTLLYVDEAFIELSDPSQSVADLPAENNYVFVMRSLTKDFAIPG
CCHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCHHHHCCCCCCCEEEEEEHHHHHHCCCC
IRMGFGIAPPAMADILNTARLSWNLGAIANNTGIALLNIEGGIDSPYLKKAREMILKEGE
EEECCCCCCHHHHHHHHHHHHEEECCEEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCC
TLKAKIDRIRGFEAGEVNVNFILVDVSKFMLNSSELTARLAARGVLVRDCVSFHGLGKNY
HHHHHHHHHCCCCCCCEEEEEEEEEEHHHHHCCHHHHHHHHHCCHHHHHHHHHHCCCCCE
IRVAVRTEKENDRLIAAIGDVITEWGREQAKNELQHVIEKASEEGIGGRKTCEYYPCHFE
EEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCEEC
GQNCTFCFCPFYPCENEKTGGKWIQSSRGGRVWSCVDCHLVHKKEIAQKILDCLMHEGDT
CCCCEEEEECCCCCCCCCCCCHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCH
DELVKVAWKEVMEPIL
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]