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The map label for this gene is cobY [H]

Identifier: 21228158

GI number: 21228158

Start: 2451045

End: 2451656

Strand: Reverse

Name: cobY [H]

Synonym: MM_2056

Alternate gene names: 21228158

Gene position: 2451656-2451045 (Counterclockwise)

Preceding gene: 21228159

Following gene: 21228157

Centisome position: 59.85

GC content: 45.26

Gene sequence:

>612_bases
ATGGACGCTATTGTAATGGCAGGAGGGTTCGGGCAGAGGCTTGGTATGGGGGAAAAGCCCTGCGTAGAATTGCTCGGAAA
GCCGCTTATTACCTATGTAATAGATAACCTTAGAGCTTCAAAAAATATAGACCGGGTTTTCGTAGCGGTCTCGCCTGTTA
CCCCGAAAACCGAAATTATGATTCAAGAACGTTATAAGGGAGAGGTACAGGTAATCAGGACATTCGGCGGAAACTATGTG
GGAGACATGATTCACGCAGTAGAGACTTCAAATACTGCAGGCCCGGTAATGATCATCATGTCCGACCTGCCGCTGGTGAA
TCCTGACCTTATTGATTCGGTGATAGAGAAATACAGGGAAGAAGGAAAACCTGCACTTTCCGTTTATGTCCCTATCAATG
TCTGCAGAGGAACCGGGACCAGGCCTGACACAGTATTTAATAAGGACGGAAAACTCATCGTGCCTGCTGGAGTTAATATC
CTTGACAGTTCTCAAATCAGGAAAGAACAGGAAGACTTTAATCTCATACTTGATAATCCCAGACTAGCAATAAACGTAAA
TACCGTTAAAGACCTGCAGCGCTGCAAGGATTTACTGCAGTGCTCCAACTAA

Upstream 100 bases:

>100_bases
ACGGAATCGGTACAGCCAACGAGATTGGGAGGATAACTGCCCTGATTGTAATCGCAGTTACCCTTAAACTTTCATTAAAT
GGATACCTTGGAGGTTTAGA

Downstream 100 bases:

>100_bases
AATTTGCTAGAGGTGTCATAGATTCTATCCTTAAAAAACCTGATATTGAGCCGCGATGGGAAAAAAATTCTTCGTGGTAT
TAACCTTGAGGTAGGTGACC

Product: putative nucleotidyltransferase

Products: NA

Alternate protein names: AdoCbi-P guanylyltransferase [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MDAIVMAGGFGQRLGMGEKPCVELLGKPLITYVIDNLRASKNIDRVFVAVSPVTPKTEIMIQERYKGEVQVIRTFGGNYV
GDMIHAVETSNTAGPVMIIMSDLPLVNPDLIDSVIEKYREEGKPALSVYVPINVCRGTGTRPDTVFNKDGKLIVPAGVNI
LDSSQIRKEQEDFNLILDNPRLAINVNTVKDLQRCKDLLQCSN

Sequences:

>Translated_203_residues
MDAIVMAGGFGQRLGMGEKPCVELLGKPLITYVIDNLRASKNIDRVFVAVSPVTPKTEIMIQERYKGEVQVIRTFGGNYV
GDMIHAVETSNTAGPVMIIMSDLPLVNPDLIDSVIEKYREEGKPALSVYVPINVCRGTGTRPDTVFNKDGKLIVPAGVNI
LDSSQIRKEQEDFNLILDNPRLAINVNTVKDLQRCKDLLQCSN
>Mature_203_residues
MDAIVMAGGFGQRLGMGEKPCVELLGKPLITYVIDNLRASKNIDRVFVAVSPVTPKTEIMIQERYKGEVQVIRTFGGNYV
GDMIHAVETSNTAGPVMIIMSDLPLVNPDLIDSVIEKYREEGKPALSVYVPINVCRGTGTRPDTVFNKDGKLIVPAGVNI
LDSSQIRKEQEDFNLILDNPRLAINVNTVKDLQRCKDLLQCSN

Specific function: Guanylyltransferase that catalyzes the synthesis of adenosylcobinamide-GDP (AdoCbi-GDP) from adenosylcobinamide- phosphate (AdoCbi-P) and GTP. Is involved in adenosylcobalamin biosynthesis. Binds one GTP per dimer. Can not use other NTPs or GDP. Does not

COG id: COG2266

COG function: function code H; GTP:adenosylcobinamide-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005245
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.62 [H]

Molecular weight: Translated: 22360; Mature: 22360

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAIVMAGGFGQRLGMGEKPCVELLGKPLITYVIDNLRASKNIDRVFVAVSPVTPKTEIM
CCEEEEECCCCHHCCCCCCHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHEE
IQERYKGEVQVIRTFGGNYVGDMIHAVETSNTAGPVMIIMSDLPLVNPDLIDSVIEKYRE
EECCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHH
EGKPALSVYVPINVCRGTGTRPDTVFNKDGKLIVPAGVNILDSSQIRKEQEDFNLILDNP
CCCCEEEEEEEEEEECCCCCCCCCEECCCCCEEEECCCCEECCHHHHHHHCCCEEEECCC
RLAINVNTVKDLQRCKDLLQCSN
EEEEEEHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDAIVMAGGFGQRLGMGEKPCVELLGKPLITYVIDNLRASKNIDRVFVAVSPVTPKTEIM
CCEEEEECCCCHHCCCCCCHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHEE
IQERYKGEVQVIRTFGGNYVGDMIHAVETSNTAGPVMIIMSDLPLVNPDLIDSVIEKYRE
EECCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHH
EGKPALSVYVPINVCRGTGTRPDTVFNKDGKLIVPAGVNILDSSQIRKEQEDFNLILDNP
CCCCEEEEEEEEEEECCCCCCCCCEECCCCCEEEECCCCEECCHHHHHHHCCCEEEECCC
RLAINVNTVKDLQRCKDLLQCSN
EEEEEEHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]