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The map label for this gene is fwdA [H]

Identifier: 21228081

GI number: 21228081

Start: 2351646

End: 2353364

Strand: Reverse

Name: fwdA [H]

Synonym: MM_1979

Alternate gene names: 21228081

Gene position: 2353364-2351646 (Counterclockwise)

Preceding gene: 21228082

Following gene: 21228080

Centisome position: 57.45

GC content: 49.85

Gene sequence:

>1719_bases
ATGTCGGAAATCCTGATTAAAAACGCCAGCGTCTGTGACCCGGCACAGGGAATTAACTGCGAGACCATGGACATCTGCAT
AAGAGACGGAAAGATTGTGGAGAGCGTCTCCGGAAGTGCAGAGGTTATTGATGCAGAGGGCAGGCTCACCATGGCAGGAG
GCTTTGACGGGCACACACACAGCGCGGGAAAGATCAACGTAGGACGTTTCATCAACCCAAACGATGCAAGGAAAAACCCT
GTACCCGGGCTTTCTGGCCAGGTCGCACGTACCGAAAAGACAAGAGCTCAGGTAGGGTATAATACCCCAAACACTTACGC
AATCGGATACAGGTATGCAAAACTGGGGTATACAACCATCTGTGAAGCTGCAATCCCCCTGCTTGCTGCAAGGCATACCC
ATGAAGAATTCAAGGAAATCCCTATCCTTGACAAAATGGGGCTGTCACTCTTCGGGAGCAACTGGCAGGTCATGGAGTAC
ATCCGTGACAAGGAGCCTGAAAAACTTGCAGCATACATTGCCTGGGGATTGAAAGCCTCAAGAGGATATGGAGTAAAGAT
TGTAAACCCCGGAGGAGGAGAAGCCTGGGGCTGGGGAAGAAACGTAAGCGGACTTTATGACCCTGTACCCAACTTTGATG
TAACTCCTGCAGAGATCCTTCTGGGGCTTGCAGAAGCTAATGAGCGCCTTCAGCTCCCTCACTCCATACACGTGCACTGC
AACAACCTCGGAAAGCCAGGAAACTATGCTACAACCATAGAGACCATGAAGCTTCTGGAAAAGGTTAAGCCCAGCAGGGA
CAGGCAGGCTCTTCACGTAACCCACGTTCAGTTCAATGCTTATGCAGGGACTTCCTGGAGGGACTTTGAGACAGGAGCCC
CAATGGTTGCAGATTACATTAACGGAGCAAACCACCTGACCTTCGACCTGGGACAGGTAATCTTCGGACCCGCAGTTACA
ATGACCGCAGACGGGCCTGTTGAGTATGCAAACTCAAGAATGCTGCACGAGAAGTGGAGCAACCAGGACATTGAACTGGA
AGATGCTTCCGGAGTCGTACCCCTGTTCTACTCACCAAAAAGCTTTGTGAACGCGGTCCAGTGGGCAATAGGGCTTGAAC
TCGCCCTGCTTGTAAAAGACCCCTGGAAAGTCATGTTTACAACTGACAGCCCCAACGGCGGGTCTTTTGTCAACTATCCT
GAAGCCTTTACCTACCTTATGAGTGCAAAGAGAAGAGAAGAAGTTATCTCGGGATTCTCTAAGATGGCACTCGACAGGAT
GGTACTGCCCGGAATCGACAGGGAACTTGACTTTTATGAGCTTGCTGTCATGACAAGGAGCACACAGTCAAAGATGTACA
GCATGCCTGAGAAAGGAAACCTTAAAGTGGGCTCTGACGCTGACATTGCTATCTATGACATCCTTCCGGGGCAGGTTGAC
CCCTCGACAGAGTATGCAAAGGTCAAGAAAGCTTTCTCTGCTGCATCATATACCCTGAAGAGCGGAGAGGTCGTTGTAAA
AGACGGAGAGATCGAAGAGACCCCGAAAGGAAAGACTTACTGGGTTAACGCAAAGATTCCGGAGAGCATCGATACCGCAA
TGCAGAAAGATATAGACCGCAAATTCAGGAAGTATTACACTGTGAGCAAATCCAATTACATGGTTGAAGACTCGTATATC
CAGAAGCCTGTCGAGATCGGCACAGAGGGGGTTTTCTAA

Upstream 100 bases:

>100_bases
CTCCGCATGAAGAAACTGATTGATACAGAGTTCAAGACCGACGAAGAGATCGTAAAAGACCTGACTGCAAAAGTAAGGGA
AATGAAGAGAGGTGTATAAG

Downstream 100 bases:

>100_bases
ATGCAGATTGTAAAACTCTCCCTCAAAAAAGCAAACAAAATTCCAATTGAAGCCGATAACATAAACCCTGACAACTTTGC
CGGCAAAACTGCAGAAGAAA

Product: tungsten formylmethanofuran dehydrogenase subunit A

Products: CO2; methanofuran; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 572; Mature: 571

Protein sequence:

>572_residues
MSEILIKNASVCDPAQGINCETMDICIRDGKIVESVSGSAEVIDAEGRLTMAGGFDGHTHSAGKINVGRFINPNDARKNP
VPGLSGQVARTEKTRAQVGYNTPNTYAIGYRYAKLGYTTICEAAIPLLAARHTHEEFKEIPILDKMGLSLFGSNWQVMEY
IRDKEPEKLAAYIAWGLKASRGYGVKIVNPGGGEAWGWGRNVSGLYDPVPNFDVTPAEILLGLAEANERLQLPHSIHVHC
NNLGKPGNYATTIETMKLLEKVKPSRDRQALHVTHVQFNAYAGTSWRDFETGAPMVADYINGANHLTFDLGQVIFGPAVT
MTADGPVEYANSRMLHEKWSNQDIELEDASGVVPLFYSPKSFVNAVQWAIGLELALLVKDPWKVMFTTDSPNGGSFVNYP
EAFTYLMSAKRREEVISGFSKMALDRMVLPGIDRELDFYELAVMTRSTQSKMYSMPEKGNLKVGSDADIAIYDILPGQVD
PSTEYAKVKKAFSAASYTLKSGEVVVKDGEIEETPKGKTYWVNAKIPESIDTAMQKDIDRKFRKYYTVSKSNYMVEDSYI
QKPVEIGTEGVF

Sequences:

>Translated_572_residues
MSEILIKNASVCDPAQGINCETMDICIRDGKIVESVSGSAEVIDAEGRLTMAGGFDGHTHSAGKINVGRFINPNDARKNP
VPGLSGQVARTEKTRAQVGYNTPNTYAIGYRYAKLGYTTICEAAIPLLAARHTHEEFKEIPILDKMGLSLFGSNWQVMEY
IRDKEPEKLAAYIAWGLKASRGYGVKIVNPGGGEAWGWGRNVSGLYDPVPNFDVTPAEILLGLAEANERLQLPHSIHVHC
NNLGKPGNYATTIETMKLLEKVKPSRDRQALHVTHVQFNAYAGTSWRDFETGAPMVADYINGANHLTFDLGQVIFGPAVT
MTADGPVEYANSRMLHEKWSNQDIELEDASGVVPLFYSPKSFVNAVQWAIGLELALLVKDPWKVMFTTDSPNGGSFVNYP
EAFTYLMSAKRREEVISGFSKMALDRMVLPGIDRELDFYELAVMTRSTQSKMYSMPEKGNLKVGSDADIAIYDILPGQVD
PSTEYAKVKKAFSAASYTLKSGEVVVKDGEIEETPKGKTYWVNAKIPESIDTAMQKDIDRKFRKYYTVSKSNYMVEDSYI
QKPVEIGTEGVF
>Mature_571_residues
SEILIKNASVCDPAQGINCETMDICIRDGKIVESVSGSAEVIDAEGRLTMAGGFDGHTHSAGKINVGRFINPNDARKNPV
PGLSGQVARTEKTRAQVGYNTPNTYAIGYRYAKLGYTTICEAAIPLLAARHTHEEFKEIPILDKMGLSLFGSNWQVMEYI
RDKEPEKLAAYIAWGLKASRGYGVKIVNPGGGEAWGWGRNVSGLYDPVPNFDVTPAEILLGLAEANERLQLPHSIHVHCN
NLGKPGNYATTIETMKLLEKVKPSRDRQALHVTHVQFNAYAGTSWRDFETGAPMVADYINGANHLTFDLGQVIFGPAVTM
TADGPVEYANSRMLHEKWSNQDIELEDASGVVPLFYSPKSFVNAVQWAIGLELALLVKDPWKVMFTTDSPNGGSFVNYPE
AFTYLMSAKRREEVISGFSKMALDRMVLPGIDRELDFYELAVMTRSTQSKMYSMPEKGNLKVGSDADIAIYDILPGQVDP
STEYAKVKKAFSAASYTLKSGEVVVKDGEIEETPKGKTYWVNAKIPESIDTAMQKDIDRKFRKYYTVSKSNYMVEDSYIQ
KPVEIGTEGVF

Specific function: Unknown

COG id: COG1229

COG function: function code C; Formylmethanofuran dehydrogenase subunit A

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013108
- InterPro:   IPR012027
- InterPro:   IPR011059 [H]

Pfam domain/function: PF07969 Amidohydro_3 [H]

EC number: 1.2.99.5

Molecular weight: Translated: 63217; Mature: 63086

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEILIKNASVCDPAQGINCETMDICIRDGKIVESVSGSAEVIDAEGRLTMAGGFDGHTH
CCCEEECCCCCCCCCCCCCCEEEEEEEECCCEEECCCCCCEEEECCCCEEEECCCCCCCC
SAGKINVGRFINPNDARKNPVPGLSGQVARTEKTRAQVGYNTPNTYAIGYRYAKLGYTTI
CCCEEEECCEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEEEEECCCHHHH
CEAAIPLLAARHTHEEFKEIPILDKMGLSLFGSNWQVMEYIRDKEPEKLAAYIAWGLKAS
HHHHHHHHHHHHCHHHHHHCCCHHHCCHHHCCCCHHHHHHHHCCCHHHHHHHHHHCCCCC
RGYGVKIVNPGGGEAWGWGRNVSGLYDPVPNFDVTPAEILLGLAEANERLQLPHSIHVHC
CCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEECCCCEEEEEE
NNLGKPGNYATTIETMKLLEKVKPSRDRQALHVTHVQFNAYAGTSWRDFETGAPMVADYI
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCHHHHHH
NGANHLTFDLGQVIFGPAVTMTADGPVEYANSRMLHEKWSNQDIELEDASGVVPLFYSPK
CCCCEEEEEHHHHHCCCEEEEECCCCHHHHCCHHHHHHCCCCCEEEECCCCEEEEEECCH
SFVNAVQWAIGLELALLVKDPWKVMFTTDSPNGGSFVNYPEAFTYLMSAKRREEVISGFS
HHHHHHHHHHCCEEEEEEECCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
KMALDRMVLPGIDRELDFYELAVMTRSTQSKMYSMPEKGNLKVGSDADIAIYDILPGQVD
HHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCEEECCCCCEEEEEECCCCCC
PSTEYAKVKKAFSAASYTLKSGEVVVKDGEIEETPKGKTYWVNAKIPESIDTAMQKDIDR
CCHHHHHHHHHHHHHHEEEECCCEEEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHH
KFRKYYTVSKSNYMVEDSYIQKPVEIGTEGVF
HHHHHEEECCCCEEEEHHHHCCCHHCCCCCCC
>Mature Secondary Structure 
SEILIKNASVCDPAQGINCETMDICIRDGKIVESVSGSAEVIDAEGRLTMAGGFDGHTH
CCEEECCCCCCCCCCCCCCEEEEEEEECCCEEECCCCCCEEEECCCCEEEECCCCCCCC
SAGKINVGRFINPNDARKNPVPGLSGQVARTEKTRAQVGYNTPNTYAIGYRYAKLGYTTI
CCCEEEECCEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEEEEECCCHHHH
CEAAIPLLAARHTHEEFKEIPILDKMGLSLFGSNWQVMEYIRDKEPEKLAAYIAWGLKAS
HHHHHHHHHHHHCHHHHHHCCCHHHCCHHHCCCCHHHHHHHHCCCHHHHHHHHHHCCCCC
RGYGVKIVNPGGGEAWGWGRNVSGLYDPVPNFDVTPAEILLGLAEANERLQLPHSIHVHC
CCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEECCCCEEEEEE
NNLGKPGNYATTIETMKLLEKVKPSRDRQALHVTHVQFNAYAGTSWRDFETGAPMVADYI
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCHHHHHH
NGANHLTFDLGQVIFGPAVTMTADGPVEYANSRMLHEKWSNQDIELEDASGVVPLFYSPK
CCCCEEEEEHHHHHCCCEEEEECCCCHHHHCCHHHHHHCCCCCEEEECCCCEEEEEECCH
SFVNAVQWAIGLELALLVKDPWKVMFTTDSPNGGSFVNYPEAFTYLMSAKRREEVISGFS
HHHHHHHHHHCCEEEEEEECCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
KMALDRMVLPGIDRELDFYELAVMTRSTQSKMYSMPEKGNLKVGSDADIAIYDILPGQVD
HHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCEEECCCCCEEEEEECCCCCC
PSTEYAKVKKAFSAASYTLKSGEVVVKDGEIEETPKGKTYWVNAKIPESIDTAMQKDIDR
CCHHHHHHHHHHHHHHEEEECCCEEEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHH
KFRKYYTVSKSNYMVEDSYIQKPVEIGTEGVF
HHHHHEEECCCCEEEEHHHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: formylmethanofuran; H2O; acceptor

Specific reaction: formylmethanofuran + H2O + acceptor = CO2 + methanofuran + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]