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The map label for this gene is cofD

Identifier: 21227976

GI number: 21227976

Start: 2226908

End: 2227819

Strand: Direct

Name: cofD

Synonym: MM_1874

Alternate gene names: 21227976

Gene position: 2226908-2227819 (Clockwise)

Preceding gene: 21227972

Following gene: 21227977

Centisome position: 54.36

GC content: 48.25

Gene sequence:

>912_bases
ATGATTATATTTTCAGGCGGCACCGGAACTCCCAAACTCCTTGACGGGCTCAAGGAAATCCTCCCTGAGGAGGAACTGAC
TGTTGTTGTAAACACTGCCGAAGACCTCTGGGTTTCTGGGAACCTGATCTCTCCAGACCTTGATACGGTGCTCTATCTTT
TCTCAGACCAGATTGACAGGAAGAGGTGGTGGGGCATAGAAAATGATACCTTCGGGACTTATGAGCGTATGAAGGAGCTC
GGCATTGAAGAAGGACTGAAGCTAGGAGACAGGGACAGGGCAACCCATATTATCCGCTCGAACATTATCCGGGACGGGGC
GTCCCTTACGGATTCAACAGTGAAGCTTTCATCCCTTTTTGGGATCAAAGCAAATATCCTGCCAATGTCCGATGATCCTG
TTTCCACTTATATAGAAACTGCTGAAGGAATTATGCATTTCCAGGACTTCTGGATTGGAAAACGTGGAGAGCCAGATGTG
CGTGGAGTTGATATCAGGGGAGTTTCCGAAGCTTCCATTTCTCCTAAAGTGCTCGAAGCCTTTGAGAAGGAAGAAAATAT
CCTTATAGGGCCGAGCAACCCTATCACGAGTATAGGCCCGATTATTTCCCTCCCCGGGATGAGGGAACTGTTGAAAAAGA
AAAAGGTCGTTGCAGTTAGCCCGATTATTGGGAATGCCCCTGTCAGCGGCCCTGCTGGAAAACTGATGCCTGCCTGCGGG
ATTGAAGTCTCTTCCATGGGAGTTGCTGAATACTACCAGGATTTTCTTGATGTTTTCGTTTTTGATGAAAGGGATCGTGC
AGATGAGTTCGCATTTGAAAGGCTTGGCTGCCATGCTTCACGGGCAGACACCCTGATGACCTCTACTGAGAAGAGCAAAG
AACTGGCAGAGATTGTGGTTCAGGCTTTTTGA

Upstream 100 bases:

>100_bases
TATTACTTTGATGCTATTACTTAAGATGTAAATTACAGGGCACCTGCTGCCCGAATGCTATATAATAATTCGGAAACAGG
GATTAGAAACAGGTAATATC

Downstream 100 bases:

>100_bases
CAATATTGTATGCCCTTCTTAACTTTTCCTTTTTAACTCCCTTTTCTCTTTTGTTTTTCACCTCTTTCTCTTTTGTTTTT
CACCTCTTTCTCTTTTGTTT

Product: LPPG:FO 2-phospho-L-lactate transferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MIIFSGGTGTPKLLDGLKEILPEEELTVVVNTAEDLWVSGNLISPDLDTVLYLFSDQIDRKRWWGIENDTFGTYERMKEL
GIEEGLKLGDRDRATHIIRSNIIRDGASLTDSTVKLSSLFGIKANILPMSDDPVSTYIETAEGIMHFQDFWIGKRGEPDV
RGVDIRGVSEASISPKVLEAFEKEENILIGPSNPITSIGPIISLPGMRELLKKKKVVAVSPIIGNAPVSGPAGKLMPACG
IEVSSMGVAEYYQDFLDVFVFDERDRADEFAFERLGCHASRADTLMTSTEKSKELAEIVVQAF

Sequences:

>Translated_303_residues
MIIFSGGTGTPKLLDGLKEILPEEELTVVVNTAEDLWVSGNLISPDLDTVLYLFSDQIDRKRWWGIENDTFGTYERMKEL
GIEEGLKLGDRDRATHIIRSNIIRDGASLTDSTVKLSSLFGIKANILPMSDDPVSTYIETAEGIMHFQDFWIGKRGEPDV
RGVDIRGVSEASISPKVLEAFEKEENILIGPSNPITSIGPIISLPGMRELLKKKKVVAVSPIIGNAPVSGPAGKLMPACG
IEVSSMGVAEYYQDFLDVFVFDERDRADEFAFERLGCHASRADTLMTSTEKSKELAEIVVQAF
>Mature_303_residues
MIIFSGGTGTPKLLDGLKEILPEEELTVVVNTAEDLWVSGNLISPDLDTVLYLFSDQIDRKRWWGIENDTFGTYERMKEL
GIEEGLKLGDRDRATHIIRSNIIRDGASLTDSTVKLSSLFGIKANILPMSDDPVSTYIETAEGIMHFQDFWIGKRGEPDV
RGVDIRGVSEASISPKVLEAFEKEENILIGPSNPITSIGPIISLPGMRELLKKKKVVAVSPIIGNAPVSGPAGKLMPACG
IEVSSMGVAEYYQDFLDVFVFDERDRADEFAFERLGCHASRADTLMTSTEKSKELAEIVVQAF

Specific function: Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F42

COG id: COG0391

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CofD family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COFD_METMA (Q8PVT6)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_633898.1
- PDB:   3C3D
- PDB:   3C3E
- PDB:   3CGW
- PDBsum:   3C3D
- PDBsum:   3C3E
- PDBsum:   3CGW
- ProteinModelPortal:   Q8PVT6
- SMR:   Q8PVT6
- GeneID:   1480216
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_1874
- NMPDR:   fig|192952.1.peg.1874
- HOGENOM:   HBG374278
- OMA:   SNPITSI
- ProtClustDB:   PRK13606
- BioCyc:   MMAZ192952:MM1874-MONOMER
- HAMAP:   MF_01257
- InterPro:   IPR002882
- InterPro:   IPR010115
- TIGRFAMs:   TIGR01819

Pfam domain/function: PF01933 UPF0052

EC number: NA

Molecular weight: Translated: 33357; Mature: 33357

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIFSGGTGTPKLLDGLKEILPEEELTVVVNTAEDLWVSGNLISPDLDTVLYLFSDQIDR
CEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHH
KRWWGIENDTFGTYERMKELGIEEGLKLGDRDRATHIIRSNIIRDGASLTDSTVKLSSLF
HHHCCCCCCCCHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GIKANILPMSDDPVSTYIETAEGIMHFQDFWIGKRGEPDVRGVDIRGVSEASISPKVLEA
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHH
FEKEENILIGPSNPITSIGPIISLPGMRELLKKKKVVAVSPIIGNAPVSGPAGKLMPACG
HHCCCCEEECCCCCCCHHCCHHCCCCHHHHHHHCCEEEECCCCCCCCCCCCCCCCCHHCC
IEVSSMGVAEYYQDFLDVFVFDERDRADEFAFERLGCHASRADTLMTSTEKSKELAEIVV
CCHHHCCHHHHHHHHHHHEEECCCCCHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHH
QAF
HCC
>Mature Secondary Structure
MIIFSGGTGTPKLLDGLKEILPEEELTVVVNTAEDLWVSGNLISPDLDTVLYLFSDQIDR
CEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHH
KRWWGIENDTFGTYERMKELGIEEGLKLGDRDRATHIIRSNIIRDGASLTDSTVKLSSLF
HHHCCCCCCCCHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GIKANILPMSDDPVSTYIETAEGIMHFQDFWIGKRGEPDVRGVDIRGVSEASISPKVLEA
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHH
FEKEENILIGPSNPITSIGPIISLPGMRELLKKKKVVAVSPIIGNAPVSGPAGKLMPACG
HHCCCCEEECCCCCCCHHCCHHCCCCHHHHHHHCCEEEECCCCCCCCCCCCCCCCCHHCC
IEVSSMGVAEYYQDFLDVFVFDERDRADEFAFERLGCHASRADTLMTSTEKSKELAEIVV
CCHHHCCHHHHHHHHHHHEEECCCCCHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHH
QAF
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824