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The map label for this gene is tpx [C]

Identifier: 21227878

GI number: 21227878

Start: 2119785

End: 2120249

Strand: Reverse

Name: tpx [C]

Synonym: MM_1776

Alternate gene names: 21227878

Gene position: 2120249-2119785 (Counterclockwise)

Preceding gene: 21227880

Following gene: 21227876

Centisome position: 51.76

GC content: 41.51

Gene sequence:

>465_bases
ATGACAGACGAAATACGAGTAGGGGAAACTATCCAGGACTTCCGTCTAAGAGACCAGAAGAGAGAAGAAATACATCTTTA
TGACCTGAAAGGCAAGAAAGTCCTCCTGTCCTTCCACCCTCTTGCCTGGACACAGGTCTGCGCACAGCAAATGAAGTCAC
TTGAAGAAAATTATGAGCTTTTTACAGAACTCAACACTGTACCCCTTGGTATAAGTGTGGATCCCATACCTTCAAAGAAA
GCCTGGGCAAGAGAGCTTGGAATCAACCACATTAAATTACTTTCGGACTTCTGGCCTCATGGGGAAGTTGCCAGAACCTG
CGGGATATTCAGGGGAAAAGAAGGTGTCTCAGAAAGAGCTAATATAATTATTGATGAAAATCGGCAAGTGATTTATTTCA
AGAAATATCTAGGGCATGAGCTTCCTGATATAAAGGAGATTATAGAAGTTCTGAAAAACAAATAA

Upstream 100 bases:

>100_bases
CACTACTAACTTACAAATTCATCAGTAACTTATAAAGCTATTAATAATTAAAATAGAAAAACAAATATTAAATTGAGGAA
AAAATAAACTGGGGAAATTT

Downstream 100 bases:

>100_bases
GGTCTAAAAAGGAAATTTCTGAAAACCTGCCCGATGACAGCCCTGAAAAAGAGGTTTTAAACAAGGAAAACAAAAAGCCG
CCGGAGGGATTTGAACCCTC

Product: Thiol-specific antioxidant protein

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MTDEIRVGETIQDFRLRDQKREEIHLYDLKGKKVLLSFHPLAWTQVCAQQMKSLEENYELFTELNTVPLGISVDPIPSKK
AWARELGINHIKLLSDFWPHGEVARTCGIFRGKEGVSERANIIIDENRQVIYFKKYLGHELPDIKEIIEVLKNK

Sequences:

>Translated_154_residues
MTDEIRVGETIQDFRLRDQKREEIHLYDLKGKKVLLSFHPLAWTQVCAQQMKSLEENYELFTELNTVPLGISVDPIPSKK
AWARELGINHIKLLSDFWPHGEVARTCGIFRGKEGVSERANIIIDENRQVIYFKKYLGHELPDIKEIIEVLKNK
>Mature_153_residues
TDEIRVGETIQDFRLRDQKREEIHLYDLKGKKVLLSFHPLAWTQVCAQQMKSLEENYELFTELNTVPLGISVDPIPSKKA
WARELGINHIKLLSDFWPHGEVARTCGIFRGKEGVSERANIIIDENRQVIYFKKYLGHELPDIKEIIEVLKNK

Specific function: Has Antioxidant Activity. Could Remove Peroxides Or H(2)O(2) Within The Catalase- And Peroxidase-Deficient Periplasmic Space. [C]

COG id: COG1225

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Caenorhabditis elegans, GI193204376, Length=155, Percent_Identity=28.3870967741935, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32565831, Length=155, Percent_Identity=28.3870967741935, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17738015, Length=157, Percent_Identity=31.2101910828025, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 17959; Mature: 17828

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDEIRVGETIQDFRLRDQKREEIHLYDLKGKKVLLSFHPLAWTQVCAQQMKSLEENYEL
CCCCCCCCCHHHHHHHCCCCCCEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHH
FTELNTVPLGISVDPIPSKKAWARELGINHIKLLSDFWPHGEVARTCGIFRGKEGVSERA
HHHCCCCCCCEEECCCCCHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCC
NIIIDENRQVIYFKKYLGHELPDIKEIIEVLKNK
CEEEECCCCEEEEEHHCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TDEIRVGETIQDFRLRDQKREEIHLYDLKGKKVLLSFHPLAWTQVCAQQMKSLEENYEL
CCCCCCCCHHHHHHHCCCCCCEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHH
FTELNTVPLGISVDPIPSKKAWARELGINHIKLLSDFWPHGEVARTCGIFRGKEGVSERA
HHHCCCCCCCEEECCCCCHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCC
NIIIDENRQVIYFKKYLGHELPDIKEIIEVLKNK
CEEEECCCCEEEEEHHCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]