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The map label for this gene is mvk [H]

Identifier: 21227864

GI number: 21227864

Start: 2101873

End: 2102778

Strand: Direct

Name: mvk [H]

Synonym: MM_1762

Alternate gene names: 21227864

Gene position: 2101873-2102778 (Clockwise)

Preceding gene: 21227863

Following gene: 21227865

Centisome position: 51.31

GC content: 46.91

Gene sequence:

>906_bases
ATGGTTTCATGTTCTGCGCCCGGGAAAATCTATCTTTTCGGAGAACATGCGGTTGTTTACGGAGAAACCGCAATAGCGTG
TGCAGTAGAGTTAAGGACCCGGGTGCGGGCGGAGTTAAATGACTCCATAACTATCCAGTCTCAGATCGGCAGGACAGGTC
TTGATTTTGAAAAACATCCCTATGTCTCTGCAGTGATTGAAAAAATGAGAAAATCTATCCCCATAAATGGTGTTTTTTTA
ACTGTTGATTCCGACATTCCTGTTGGGTCAGGGCTCGGCTCATCTGCTGCTGTTACGATTGCAAGCATAGGAGCTCTCAA
CGAACTTTTCGGATTCGGGCTTTCGCTTCAGGAAATTGCGAAACTGGGGCATGAAATTGAGATAAAAGTTCAGGGTGCAG
CGAGCCCTACTGACACCTATGTTTCTACTTTCGGAGGAGTCGTTACCATCCCTGAAAGGAGAAAGCTTAAGACTCCTGAC
TGTGGAATTGTTATAGGGGACACCGGAGTTTTTTCTTCTACAAAAGAGCTTGTGGCAAACGTCAGGCAGCTCCGCGAAAG
TTACCCTGATCTTATCGAACCTCTTATGACTTCTATTGGCAAAATCTCCAGAATCGGTGAGCAACTTGTACTTTCCGGGG
ACTATGCTTCTATTGGCAGGCTTATGAATGTAAATCAGGGACTGCTTGATGCACTTGGAGTTAATATCCTTGAGCTTTCA
CAGCTTATCTATTCTGCAAGGGCAGCAGGAGCTTTCGGGGCAAAAATTACTGGAGCAGGAGGCGGTGGTTGTATGGTTGC
GCTAACTGCACCGGAGAAATGTAATCAGGTAGCGGAAGCCGTTGCAGGTGCAGGGGGCAAAGTGACCATTACAAAACCCA
CGGAACAGGGGTTGAAGGTCGATTGA

Upstream 100 bases:

>100_bases
ATACTATTTTTACTTTTACTCATAGATACCCGTTCAGGGGTAAGGTTAATTACTTAACGTGCTCAAATTCAGCAAAATTG
AAAAACTGTTGAGGAATAAT

Downstream 100 bases:

>100_bases
ACCGGATTAATCGGAAGGTTTTTCCTGTAAAATAAGATTGCTTTTATTCCCATCTTTTCATCATTATTGTTGCAGAAATC
ATGATATCTGAATATAATTG

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MVSCSAPGKIYLFGEHAVVYGETAIACAVELRTRVRAELNDSITIQSQIGRTGLDFEKHPYVSAVIEKMRKSIPINGVFL
TVDSDIPVGSGLGSSAAVTIASIGALNELFGFGLSLQEIAKLGHEIEIKVQGAASPTDTYVSTFGGVVTIPERRKLKTPD
CGIVIGDTGVFSSTKELVANVRQLRESYPDLIEPLMTSIGKISRIGEQLVLSGDYASIGRLMNVNQGLLDALGVNILELS
QLIYSARAAGAFGAKITGAGGGGCMVALTAPEKCNQVAEAVAGAGGKVTITKPTEQGLKVD

Sequences:

>Translated_301_residues
MVSCSAPGKIYLFGEHAVVYGETAIACAVELRTRVRAELNDSITIQSQIGRTGLDFEKHPYVSAVIEKMRKSIPINGVFL
TVDSDIPVGSGLGSSAAVTIASIGALNELFGFGLSLQEIAKLGHEIEIKVQGAASPTDTYVSTFGGVVTIPERRKLKTPD
CGIVIGDTGVFSSTKELVANVRQLRESYPDLIEPLMTSIGKISRIGEQLVLSGDYASIGRLMNVNQGLLDALGVNILELS
QLIYSARAAGAFGAKITGAGGGGCMVALTAPEKCNQVAEAVAGAGGKVTITKPTEQGLKVD
>Mature_301_residues
MVSCSAPGKIYLFGEHAVVYGETAIACAVELRTRVRAELNDSITIQSQIGRTGLDFEKHPYVSAVIEKMRKSIPINGVFL
TVDSDIPVGSGLGSSAAVTIASIGALNELFGFGLSLQEIAKLGHEIEIKVQGAASPTDTYVSTFGGVVTIPERRKLKTPD
CGIVIGDTGVFSSTKELVANVRQLRESYPDLIEPLMTSIGKISRIGEQLVLSGDYASIGRLMNVNQGLLDALGVNILELS
QLIYSARAAGAFGAKITGAGGGGCMVALTAPEKCNQVAEAVAGAGGKVTITKPTEQGLKVD

Specific function: Galactose metabolism; first step. [C]

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI167001643, Length=341, Percent_Identity=30.791788856305, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI4557769, Length=341, Percent_Identity=30.791788856305, Blast_Score=92, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6323864, Length=356, Percent_Identity=24.7191011235955, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI78707210, Length=381, Percent_Identity=28.0839895013123, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 31413; Mature: 31413

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSCSAPGKIYLFGEHAVVYGETAIACAVELRTRVRAELNDSITIQSQIGRTGLDFEKHP
CCCCCCCCEEEEEECCEEEECCHHHHHHHHHHHHHHHHCCCCEEEEHHCCCCCCCCCCCC
YVSAVIEKMRKSIPINGVFLTVDSDIPVGSGLGSSAAVTIASIGALNELFGFGLSLQEIA
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
KLGHEIEIKVQGAASPTDTYVSTFGGVVTIPERRKLKTPDCGIVIGDTGVFSSTKELVAN
HCCCEEEEEEECCCCCCHHHHHHCCCEEECCCCCCCCCCCCCEEEECCCCCCCHHHHHHH
VRQLRESYPDLIEPLMTSIGKISRIGEQLVLSGDYASIGRLMNVNQGLLDALGVNILELS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHCCCHHHHHHHCCHHHHHH
QLIYSARAAGAFGAKITGAGGGGCMVALTAPEKCNQVAEAVAGAGGKVTITKPTEQGLKV
HHHHHHHCCCCCCCEEECCCCCCEEEEEECCHHHHHHHHHHHCCCCEEEEECCCCCCCCC
D
C
>Mature Secondary Structure
MVSCSAPGKIYLFGEHAVVYGETAIACAVELRTRVRAELNDSITIQSQIGRTGLDFEKHP
CCCCCCCCEEEEEECCEEEECCHHHHHHHHHHHHHHHHCCCCEEEEHHCCCCCCCCCCCC
YVSAVIEKMRKSIPINGVFLTVDSDIPVGSGLGSSAAVTIASIGALNELFGFGLSLQEIA
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
KLGHEIEIKVQGAASPTDTYVSTFGGVVTIPERRKLKTPDCGIVIGDTGVFSSTKELVAN
HCCCEEEEEEECCCCCCHHHHHHCCCEEECCCCCCCCCCCCCEEEECCCCCCCHHHHHHH
VRQLRESYPDLIEPLMTSIGKISRIGEQLVLSGDYASIGRLMNVNQGLLDALGVNILELS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHCCCHHHHHHHCCHHHHHH
QLIYSARAAGAFGAKITGAGGGGCMVALTAPEKCNQVAEAVAGAGGKVTITKPTEQGLKV
HHHHHHHCCCCCCCEEECCCCCCEEEEEECCHHHHHHHHHHHCCCCEEEEECCCCCCCCC
D
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA