Click here to switch to the map view.

The map label for this gene is rpoK

Identifier: 21227861

GI number: 21227861

Start: 2099746

End: 2099997

Strand: Direct

Name: rpoK

Synonym: MM_1759

Alternate gene names: 21227861

Gene position: 2099746-2099997 (Clockwise)

Preceding gene: 21227860

Following gene: 21227862

Centisome position: 51.26

GC content: 46.03

Gene sequence:

>252_bases
ATGTCAAATTTATCATGCTTCTCGATTATCGGAACTCATCGGAGCGTTTTTAAGTTTAAGGGTGATCTGTTGGTCAAGGA
AAATTATACCCGGTTCGAGCGTGCACGAATTGTAGGTGCAAGAGCATTGCAGATTGCAATGGGGGCTCCTGTCCTGGTTG
AAGATGACGGGCGGCTGGACCCCCTGGGTGTAGCCATTGAAGAGTTGAAGGCCGGAGTTATTCCTATAACGGTTAAACGT
AAAAAAAGCTAA

Upstream 100 bases:

>100_bases
TGGTCCATCCTTCGGCGTTCGGGACGCCGGAACCTGAGTTCGAATCTCAGCGGTCCCATTTTCCCTTTCAAGGGTACTGG
TTTTAAGGTGTGTACTGAAT

Downstream 100 bases:

>100_bases
AAACGTAATTGGGATACTTTCAGACGCTGAATGAATTTTATTGTTGATTCTATATATTATGAGGTGACTTTATGGAGGAA
ATTGAGCAGACAGGGCAGGA

Product: DNA-directed RNA polymerase subunit K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 83; Mature: 82

Protein sequence:

>83_residues
MSNLSCFSIIGTHRSVFKFKGDLLVKENYTRFERARIVGARALQIAMGAPVLVEDDGRLDPLGVAIEELKAGVIPITVKR
KKS

Sequences:

>Translated_83_residues
MSNLSCFSIIGTHRSVFKFKGDLLVKENYTRFERARIVGARALQIAMGAPVLVEDDGRLDPLGVAIEELKAGVIPITVKR
KKS
>Mature_82_residues
SNLSCFSIIGTHRSVFKFKGDLLVKENYTRFERARIVGARALQIAMGAPVLVEDDGRLDPLGVAIEELKAGVIPITVKRK
KS

Specific function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

COG id: COG1758

COG function: function code K; DNA-directed RNA polymerase, subunit K/omega

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the archaeal rpoK/eukaryotic RPB6 RNA polymerase subunit family

Homologues:

Organism=Homo sapiens, GI11527390, Length=51, Percent_Identity=60.7843137254902, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17531543, Length=51, Percent_Identity=62.7450980392157, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17864588, Length=51, Percent_Identity=58.8235294117647, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPOK_METMA (Q8PW42)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_633783.1
- ProteinModelPortal:   Q8PW42
- SMR:   Q8PW42
- GeneID:   1480101
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_1759
- NMPDR:   fig|192952.1.peg.1759
- HOGENOM:   HBG646526
- OMA:   VIPITVK
- ProtClustDB:   PRK01099
- BioCyc:   MMAZ192952:MM1759-MONOMER
- BRENDA:   2.7.7.6
- HAMAP:   MF_00192
- InterPro:   IPR020708
- InterPro:   IPR006111
- InterPro:   IPR006110
- InterPro:   IPR012293
- Gene3D:   G3DSA:3.90.940.10
- PANTHER:   PTHR10773

Pfam domain/function: PF01192 RNA_pol_Rpb6; SSF63562 RNA_pol_omega

EC number: =2.7.7.6

Molecular weight: Translated: 9143; Mature: 9012

Theoretical pI: Translated: 10.48; Mature: 10.48

Prosite motif: PS01111 RNA_POL_K_14KD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLSCFSIIGTHRSVFKFKGDLLVKENYTRFERARIVGARALQIAMGAPVLVEDDGRLD
CCCCCEEEEECCCCEEEEECCCEEEECCCCHHHHHHHHCHHEEEEECCCCEEEECCCCCC
PLGVAIEELKAGVIPITVKRKKS
HHHHHHHHHCCCEEEEEEEECCC
>Mature Secondary Structure 
SNLSCFSIIGTHRSVFKFKGDLLVKENYTRFERARIVGARALQIAMGAPVLVEDDGRLD
CCCCEEEEECCCCEEEEECCCEEEECCCCHHHHHHHHCHHEEEEECCCCEEEECCCCCC
PLGVAIEELKAGVIPITVKRKKS
HHHHHHHHHCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824