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The map label for this gene is msrB

Identifier: 21227736

GI number: 21227736

Start: 1948868

End: 1949290

Strand: Direct

Name: msrB

Synonym: MM_1634

Alternate gene names: 21227736

Gene position: 1948868-1949290 (Clockwise)

Preceding gene: 21227735

Following gene: 21227737

Centisome position: 47.58

GC content: 45.86

Gene sequence:

>423_bases
TTGGCACAGAACAAAATCGAGAAATCCGAAGAAGACTGGAAGAGTGTTCTAACACCCGAACAATACCATGTTTTGAGGCA
GAAAGGCACAGAAAGACCATTTTCTGGCAACCTGTACTACAACAAAGAAAAAGGAATCTATACCTGTGCTGCATGTGGGC
AGGAGCTCTTTTCCTCTGATACCAAGTTTGAATCCGGGACTGGCTGGCCGAGTTTCTATGATGTGATTTCCAGCGACAGG
GTCCGGCTTCATGAAGATAACAGCTATTTCATGAAAAGGATAGAGGTTGTCTGCTCTCGCTGCGGAAGCCACCTCGGGCA
TGTATTTGAAGACGGGCCTGAACCTACTGGGCAACGCTACTGCATCAACTCTGTCTCTCTTGGTTTCACAAAGGAAGAAG
ATACAGGGAAAGAAAAAGAATAA

Upstream 100 bases:

>100_bases
CTTTCACTTTCCTGTAATTAAAACTTTCCGGATAGATCTGCCTTGACTTCCGATATAATTAAGTCAAATCAGGTTTACAT
AACATAAAGGGGGTTTACGA

Downstream 100 bases:

>100_bases
AACATGACTCATCTGGCATAAGAACACCAGAGCCCCGTAATTGCGATCTTCAGGGAATCTGGGTAAGGAAAAGGAGGGCC
TGATAATTTGAACCTCACTA

Product: methionine sulfoxide reductase B

Products: NA

Alternate protein names: Peptide-methionine (R)-S-oxide reductase

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MAQNKIEKSEEDWKSVLTPEQYHVLRQKGTERPFSGNLYYNKEKGIYTCAACGQELFSSDTKFESGTGWPSFYDVISSDR
VRLHEDNSYFMKRIEVVCSRCGSHLGHVFEDGPEPTGQRYCINSVSLGFTKEEDTGKEKE

Sequences:

>Translated_140_residues
MAQNKIEKSEEDWKSVLTPEQYHVLRQKGTERPFSGNLYYNKEKGIYTCAACGQELFSSDTKFESGTGWPSFYDVISSDR
VRLHEDNSYFMKRIEVVCSRCGSHLGHVFEDGPEPTGQRYCINSVSLGFTKEEDTGKEKE
>Mature_139_residues
AQNKIEKSEEDWKSVLTPEQYHVLRQKGTERPFSGNLYYNKEKGIYTCAACGQELFSSDTKFESGTGWPSFYDVISSDRV
RLHEDNSYFMKRIEVVCSRCGSHLGHVFEDGPEPTGQRYCINSVSLGFTKEEDTGKEKE

Specific function: Unknown

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrB Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI301336164, Length=132, Percent_Identity=53.030303030303, Blast_Score=162, Evalue=7e-41,
Organism=Homo sapiens, GI301336162, Length=132, Percent_Identity=53.030303030303, Blast_Score=162, Evalue=7e-41,
Organism=Homo sapiens, GI73089054, Length=132, Percent_Identity=53.030303030303, Blast_Score=162, Evalue=7e-41,
Organism=Homo sapiens, GI37620216, Length=132, Percent_Identity=53.030303030303, Blast_Score=162, Evalue=8e-41,
Organism=Homo sapiens, GI117606353, Length=136, Percent_Identity=49.2647058823529, Blast_Score=133, Evalue=5e-32,
Organism=Homo sapiens, GI7706511, Length=107, Percent_Identity=40.1869158878505, Blast_Score=75, Evalue=3e-14,
Organism=Escherichia coli, GI1788077, Length=126, Percent_Identity=50.7936507936508, Blast_Score=142, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17553450, Length=141, Percent_Identity=48.936170212766, Blast_Score=129, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI115532676, Length=141, Percent_Identity=48.936170212766, Blast_Score=129, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6319816, Length=132, Percent_Identity=43.9393939393939, Blast_Score=124, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24645799, Length=130, Percent_Identity=50.7692307692308, Blast_Score=145, Evalue=7e-36,
Organism=Drosophila melanogaster, GI45553335, Length=130, Percent_Identity=50.7692307692308, Blast_Score=145, Evalue=9e-36,
Organism=Drosophila melanogaster, GI21356369, Length=130, Percent_Identity=50.7692307692308, Blast_Score=145, Evalue=9e-36,
Organism=Drosophila melanogaster, GI221378664, Length=134, Percent_Identity=50, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI221378662, Length=141, Percent_Identity=47.5177304964539, Blast_Score=142, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24645801, Length=141, Percent_Identity=46.8085106382979, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24645804, Length=141, Percent_Identity=46.8085106382979, Blast_Score=139, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRB_METMA (Q8PWF5)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_633658.1
- HSSP:   P54155
- ProteinModelPortal:   Q8PWF5
- SMR:   Q8PWF5
- GeneID:   1479976
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_1634
- NMPDR:   fig|192952.1.peg.1634
- HOGENOM:   HBG715255
- OMA:   FYDVISS
- ProtClustDB:   PRK00222
- BioCyc:   MMAZ192952:MM1634-MONOMER
- BRENDA:   1.8.4.12
- HAMAP:   MF_01400
- InterPro:   IPR002579
- InterPro:   IPR011057
- Gene3D:   G3DSA:2.170.150.20
- TIGRFAMs:   TIGR00357

Pfam domain/function: PF01641 SelR; SSF51316 Mss4_like

EC number: =1.8.4.12

Molecular weight: Translated: 16038; Mature: 15907

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: ACT_SITE 121-121

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQNKIEKSEEDWKSVLTPEQYHVLRQKGTERPFSGNLYYNKEKGIYTCAACGQELFSSD
CCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEECCCCEEHHHHHHHHHHCCC
TKFESGTGWPSFYDVISSDRVRLHEDNSYFMKRIEVVCSRCGSHLGHVFEDGPEPTGQRY
CCCCCCCCCHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
CINSVSLGFTKEEDTGKEKE
ECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AQNKIEKSEEDWKSVLTPEQYHVLRQKGTERPFSGNLYYNKEKGIYTCAACGQELFSSD
CCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEECCCCEEHHHHHHHHHHCCC
TKFESGTGWPSFYDVISSDRVRLHEDNSYFMKRIEVVCSRCGSHLGHVFEDGPEPTGQRY
CCCCCCCCCHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
CINSVSLGFTKEEDTGKEKE
ECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824