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The map label for this gene is gltA [H]

Identifier: 21227629

GI number: 21227629

Start: 1821031

End: 1822098

Strand: Reverse

Name: gltA [H]

Synonym: MM_1527

Alternate gene names: 21227629

Gene position: 1822098-1821031 (Counterclockwise)

Preceding gene: 161485674

Following gene: 21227628

Centisome position: 44.48

GC content: 44.01

Gene sequence:

>1068_bases
ATGAATAAAAATATATGTTTCATAGACGGGCTGGAGGGCATTCTGAAGTACAGGGACGTCGATATTAACGAACTGATCGA
CCTGCCCTATGACGCAGTTTCCTATCTGCTGATTAAGGGAGAGCTCTCCGAAGAAAAGGAACTTGCCGAATACTCAGCCC
GCCTGCATGCGGAACGAGGAATCAACAGGGAGGTTATGGACGTTATCCGCATGTGCAATTTAAATATCGACTCTATGGAA
GCTCTTCTCACTGTCGTTTCTTTTATATCGCAATTTGATCCGGACCTGTATGATAATTCTCTAGAAGGAAATATGAGAAA
AGCCATAAGGTTAATTGCCGTGGTCCCAACTATTGTTGCTGCTTATTATAGAACGGCAAATGGAAAGGAACCTGTTCCCC
CCGATCCTTCCCTTGCCCATGGAGCTAATTTTCTGTACATGATAAAAGGAAGCAAGCCAGACCCTCTGGAAGCTGAAGTC
ATGGAAAAGGACTTTATTCTCAGCGCTGAGCATGAGCTAAATGCTTCAACTTTCTCCTCCAGGGTTACAGCTTCAACCAT
GTCCGACCTTTATTCTGCTGTTGTTTCCGGGCTCTGCACACTCAAAGGTCCTCTTCACGGAGGAGCAAGGTCAGAAGTTA
TGACCATGATTGAAACAATCGGCAGCCCTGAGAATGCCGAGAAATTTGTCCTTGAAAAAATCGAAAAGCGAGAGAAAATA
ATGGGCTTCGGGCATAGAGTCTACAAGACATATGACCCCAGGGGCACAATATTTAAGCAGCTTTCCAGGAGACTCGCTGA
AGCTAAAGGCGATATGCACTGGTATGAGACAGCCGAAGCAATAGAGAATGCTGTTATACGCGAGCTTGTGGAAAAGAGGG
GAAAACCGATTTATCCCAACATTGATTTTTATTCAGGAGTCATTTATAAATATATGGAAATCCCCCCTCAGCTTGCAACC
TCAATCTTTGCAATAGGAAGAATCTCAGGCTGGATAGCTCATTGTTTTGATCAGTATGAAAAGAAAAAGATCATAAGGCC
CAGGATCTTCATGCTGGATGAGTGTTAA

Upstream 100 bases:

>100_bases
CCCAAAAAGTCCTTCGTGTTTAAATATTTCACGTATAATCAGAGGATTCCCCATTTCAAAATTTTTTGAAAATCCTCTAG
GCATAACTGCGAGGTAGAAA

Downstream 100 bases:

>100_bases
GACCCTGAGAGAGCCCTGTTATGCCTGAAAACCGGCAGAAGTTATCGAAATTGAAATAAGCTCATAGAGTCAGAATCCAG
CATATAATATACAGGATCTG

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MNKNICFIDGLEGILKYRDVDINELIDLPYDAVSYLLIKGELSEEKELAEYSARLHAERGINREVMDVIRMCNLNIDSME
ALLTVVSFISQFDPDLYDNSLEGNMRKAIRLIAVVPTIVAAYYRTANGKEPVPPDPSLAHGANFLYMIKGSKPDPLEAEV
MEKDFILSAEHELNASTFSSRVTASTMSDLYSAVVSGLCTLKGPLHGGARSEVMTMIETIGSPENAEKFVLEKIEKREKI
MGFGHRVYKTYDPRGTIFKQLSRRLAEAKGDMHWYETAEAIENAVIRELVEKRGKPIYPNIDFYSGVIYKYMEIPPQLAT
SIFAIGRISGWIAHCFDQYEKKKIIRPRIFMLDEC

Sequences:

>Translated_355_residues
MNKNICFIDGLEGILKYRDVDINELIDLPYDAVSYLLIKGELSEEKELAEYSARLHAERGINREVMDVIRMCNLNIDSME
ALLTVVSFISQFDPDLYDNSLEGNMRKAIRLIAVVPTIVAAYYRTANGKEPVPPDPSLAHGANFLYMIKGSKPDPLEAEV
MEKDFILSAEHELNASTFSSRVTASTMSDLYSAVVSGLCTLKGPLHGGARSEVMTMIETIGSPENAEKFVLEKIEKREKI
MGFGHRVYKTYDPRGTIFKQLSRRLAEAKGDMHWYETAEAIENAVIRELVEKRGKPIYPNIDFYSGVIYKYMEIPPQLAT
SIFAIGRISGWIAHCFDQYEKKKIIRPRIFMLDEC
>Mature_355_residues
MNKNICFIDGLEGILKYRDVDINELIDLPYDAVSYLLIKGELSEEKELAEYSARLHAERGINREVMDVIRMCNLNIDSME
ALLTVVSFISQFDPDLYDNSLEGNMRKAIRLIAVVPTIVAAYYRTANGKEPVPPDPSLAHGANFLYMIKGSKPDPLEAEV
MEKDFILSAEHELNASTFSSRVTASTMSDLYSAVVSGLCTLKGPLHGGARSEVMTMIETIGSPENAEKFVLEKIEKREKI
MGFGHRVYKTYDPRGTIFKQLSRRLAEAKGDMHWYETAEAIENAVIRELVEKRGKPIYPNIDFYSGVIYKYMEIPPQLAT
SIFAIGRISGWIAHCFDQYEKKKIIRPRIFMLDEC

Specific function: Catalyzes The Synthesis Of 2-Methylcitrate From Propionyl-CoA And Oxaloacetate. Also Catalyzes The Condensation Of Oxaloacetate With Acetyl-CoA But With A Lower Specificity. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=324, Percent_Identity=22.2222222222222, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786527, Length=350, Percent_Identity=33.4285714285714, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1786939, Length=361, Percent_Identity=33.2409972299169, Blast_Score=194, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI17555174, Length=330, Percent_Identity=23.9393939393939, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319850, Length=346, Percent_Identity=24.5664739884393, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6324328, Length=343, Percent_Identity=23.9067055393586, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24640126, Length=347, Percent_Identity=24.4956772334294, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24640124, Length=347, Percent_Identity=24.4956772334294, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21356863, Length=342, Percent_Identity=25.1461988304094, Blast_Score=85, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 40217; Mature: 40217

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKNICFIDGLEGILKYRDVDINELIDLPYDAVSYLLIKGELSEEKELAEYSARLHAERG
CCCCEEEECCHHHHHHHCCCCHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
INREVMDVIRMCNLNIDSMEALLTVVSFISQFDPDLYDNSLEGNMRKAIRLIAVVPTIVA
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AYYRTANGKEPVPPDPSLAHGANFLYMIKGSKPDPLEAEVMEKDFILSAEHELNASTFSS
HHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHEEECCCCCCHHHHHH
RVTASTMSDLYSAVVSGLCTLKGPLHGGARSEVMTMIETIGSPENAEKFVLEKIEKREKI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
MGFGHRVYKTYDPRGTIFKQLSRRLAEAKGDMHWYETAEAIENAVIRELVEKRGKPIYPN
HHCCHHHHEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IDFYSGVIYKYMEIPPQLATSIFAIGRISGWIAHCFDQYEKKKIIRPRIFMLDEC
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCC
>Mature Secondary Structure
MNKNICFIDGLEGILKYRDVDINELIDLPYDAVSYLLIKGELSEEKELAEYSARLHAERG
CCCCEEEECCHHHHHHHCCCCHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
INREVMDVIRMCNLNIDSMEALLTVVSFISQFDPDLYDNSLEGNMRKAIRLIAVVPTIVA
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AYYRTANGKEPVPPDPSLAHGANFLYMIKGSKPDPLEAEVMEKDFILSAEHELNASTFSS
HHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHEEECCCCCCHHHHHH
RVTASTMSDLYSAVVSGLCTLKGPLHGGARSEVMTMIETIGSPENAEKFVLEKIEKREKI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
MGFGHRVYKTYDPRGTIFKQLSRRLAEAKGDMHWYETAEAIENAVIRELVEKRGKPIYPN
HHCCHHHHEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IDFYSGVIYKYMEIPPQLATSIFAIGRISGWIAHCFDQYEKKKIIRPRIFMLDEC
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8532683; 9254593 [H]