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The map label for this gene is rhlB [C]

Identifier: 21227489

GI number: 21227489

Start: 1666819

End: 1669413

Strand: Reverse

Name: rhlB [C]

Synonym: MM_1387

Alternate gene names: 21227489

Gene position: 1669413-1666819 (Counterclockwise)

Preceding gene: 21227490

Following gene: 21227487

Centisome position: 40.75

GC content: 45.7

Gene sequence:

>2595_bases
ATGAAAGAAAGTCTTTTTCCTGAGAAACCGGAATGCATGAAGCATCCATTGATAAAGCCCGATACAGTTGAGCAGAGGCT
TTACCAGCTCAACCTTGCAGGAGAAGCCCTTAAGGGTTCAAGCCTTGTTGTACTTCCTACGGGACTTGGAAAAACCATAA
TAGCTCTTTTTGTAATTGCCTCCAGACTCCAGCGTTTCGGAGGAAAAGCCCTTATTCTCTCTCCTACGAAACCCCTTGTT
GAGCAGCACGCAGCTTTTTTCAAAAAGGTGATGGCTCTTCCCGAAGAAGAGGTTCTGGCTTTTACTGGCAGCATTTCCCC
TGCAGAGAGAGAAAGGCTATGGGAACAGGGAAAATTGATAGTATCAACCCCGCAGGTAATTGAAAACGACATCCTTACAA
GGCGGATCAGCCTCGAGAACGTTAGCCATATCACTTTTGACGAAGCCCACAGGGCAGTCGGAAACTATGCATATACCTTT
ATTGCGGAGAAGTATTTTGAGAGTGCGAAAAATCCGCATGTACTCGGAATTACAGCAAGCCCGGGAAGTTCGGATGAAAA
GATATCAGAGGTCTGTGAAGCCCTGCATGTCCAGAATGTAGCCGTGAAAACGGAAAAAGACAGAGATGTCCGCCCATATG
TGCAGGAAAAAGAAATCGAATGGCTCCAGGTTAATCTTCCCGCAGAGATGGCAGAAATCCGGAGCTATCTTGAGAAAATT
TTTGACGACAGGCTTGCAATTATCAGGAACCTGGGCTTTTCTGCAGGCAGCGGGAAATATGTCTCCAAAAAAGATCTGCT
GCTCCTCCAGAAAAAGCTTCAGGGAGAAATCAGGGTAGGAGGAGACCCTGCAGTCTTTTCTGCCATGTCCGTGGTCGCAG
AAATGATGAAGGTGAACCATGCAGTGGAAATGGTGGAAACCCAGGGGATAGAAGCCCTCAGAAAATACCTGGAAAAACTC
GACGCTGAAGCTTCTTCAAGCAAAGCGAGCAAGGCTGCAAAAAGGTTAATGGATGACCTCTATATGCGGAAGACCCTTTA
CCGGGCAAAAGAATGCGAGGTTGAACACCCAAAACTGGAGCTTGCGCGGAGAATCGTATGCGAGCAACTAGAAGGTAACC
CGGACTCGCGAGTAATTGTTTTTACAAACTACAGGGACAGCGCTGAAATGGTAGTTAACGCTCTTTCCAGAGTTTCCGGA
GTTAATCCTGTCCGTTTTGTGGGGCAGGGCTCTCGCCATAAGGATAAAGGGCTCACGCAAAAACAGCAGGTTGAAATCCT
TGAAAGGTTCAGGGCCGGGGAATATAATGCCCTGGTAGCCACATCGGTTGCTGAAGAAGGTCTTGACATTCCCGCCACAG
ACCTTGTTCTGTTTTACGAGCCTGTCCCCTCTGAGATAAGGAGCATCCAGCGCAAAGGCAGGACAGGCAGGCAGCATAAA
GGCAGAGTGACCGTTCTCGTGACAAAAGGCACAAGAGACGAGGCTTATTACTGGAGCAGCAAAAACAAGGAAAAAAGAAT
GCTGAACAGTATGCACGGACTTGAAGCTGTCCTGGGCCCGAAAAATGTCAAAAAAAGCTCTGAGCTTTCCGATTTTGACA
GTGTGTCTTTTATTTCAGACTCAAAACCGGAATCAAAACAAAACACAAAACTGGACTCTTACCCAGAATTTCAAGGAATT
GAAAGCGAAAGTATGGATAAAATCGAAAGCGGGAGCCTGGAAAATACTGAAGACTTCCCTATAACTGATTTTGGGGATCC
CGGAAAAACTGAGGGAAAAAACGGAAAAGATAGCGAGATAATTTCACACACGAAGGACATAAAACTGCAAAAAAATTCAG
ATGAGATTGGAAAGAAAGAAGAAAACGAGAAAGATTATGCAAACATAAAAGAAAAGCAAAAAACCCTTGTTGATTTCGGA
ACCGCATCAGGAGAAAGCTCAGACAGCCTCCTTAAAATTATAATCGACCACAGAGAAACAAAAAGCGGGGTTGCGAAAAC
TCTGGACAGACTCGGCATGGAACTCAGATTTATGGCTCTTGAAATCGGAGACTATATCGTGAGCGACCGCCTTGCAGTGG
AAAGGAAACGTACAGATGACTTTGCATGTTCCCTGATTGACGGAAAACGCAACCTTTTTGCCCAGCTCTCTGACCTGGCA
AGAGTTTATGAAAAACCTGTTCTGATAATTGAAGGGGAAGACCTTTTCACTTCAAGGCAGATTAACCCGAATGCTATTTA
TGGTTCCCTTGCATCCATTGCAATAGATTTTGGGGTATCCATCCTCTATTCCCGCGACGAAGAGGAAACCGCATCTATTT
TGAAAATACTTGCAAAGAGGGAGCAGACAGAAAATAAACGTGAAATCAACCCTCACGGGAAAAAGTCTGCCAGCACTCTT
GCAGAACAGCAGGAATACCTCATCTCTTCAATCTCGAACATCGGACCTAAAGCAGCCAGAAACCTTCTCTCGTATTTCGG
CTCGGTAGAGGCTGTTATGAGGGCTGATATCGAGGAGCTGAAGAAAGTAAAGCAAATAGGCCCAAAAACGGCGGCCAGAA
TCCGGGAAGTTCTTGAAAGCCCATATAAAGGATAA

Upstream 100 bases:

>100_bases
AAAGCCTACAGCAAAATATTTAATTTTTTATTACTTTTTTATAATTGAAATAAAGACCAGAAATAAATAAACCTGAAGAA
ATAAGCGATCCTGAATCAAA

Downstream 100 bases:

>100_bases
GCTGCAGGTTTCTTTTCTCTTTTCCAGCAGCATTTTATTTTCAGTGACAGGGCTTTTGCGGCCAAGTCTTTATAGGCATT
TAACAGGGCTTTATACGGGT

Product: Hef nuclease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 864; Mature: 864

Protein sequence:

>864_residues
MKESLFPEKPECMKHPLIKPDTVEQRLYQLNLAGEALKGSSLVVLPTGLGKTIIALFVIASRLQRFGGKALILSPTKPLV
EQHAAFFKKVMALPEEEVLAFTGSISPAERERLWEQGKLIVSTPQVIENDILTRRISLENVSHITFDEAHRAVGNYAYTF
IAEKYFESAKNPHVLGITASPGSSDEKISEVCEALHVQNVAVKTEKDRDVRPYVQEKEIEWLQVNLPAEMAEIRSYLEKI
FDDRLAIIRNLGFSAGSGKYVSKKDLLLLQKKLQGEIRVGGDPAVFSAMSVVAEMMKVNHAVEMVETQGIEALRKYLEKL
DAEASSSKASKAAKRLMDDLYMRKTLYRAKECEVEHPKLELARRIVCEQLEGNPDSRVIVFTNYRDSAEMVVNALSRVSG
VNPVRFVGQGSRHKDKGLTQKQQVEILERFRAGEYNALVATSVAEEGLDIPATDLVLFYEPVPSEIRSIQRKGRTGRQHK
GRVTVLVTKGTRDEAYYWSSKNKEKRMLNSMHGLEAVLGPKNVKKSSELSDFDSVSFISDSKPESKQNTKLDSYPEFQGI
ESESMDKIESGSLENTEDFPITDFGDPGKTEGKNGKDSEIISHTKDIKLQKNSDEIGKKEENEKDYANIKEKQKTLVDFG
TASGESSDSLLKIIIDHRETKSGVAKTLDRLGMELRFMALEIGDYIVSDRLAVERKRTDDFACSLIDGKRNLFAQLSDLA
RVYEKPVLIIEGEDLFTSRQINPNAIYGSLASIAIDFGVSILYSRDEEETASILKILAKREQTENKREINPHGKKSASTL
AEQQEYLISSISNIGPKAARNLLSYFGSVEAVMRADIEELKKVKQIGPKTAARIREVLESPYKG

Sequences:

>Translated_864_residues
MKESLFPEKPECMKHPLIKPDTVEQRLYQLNLAGEALKGSSLVVLPTGLGKTIIALFVIASRLQRFGGKALILSPTKPLV
EQHAAFFKKVMALPEEEVLAFTGSISPAERERLWEQGKLIVSTPQVIENDILTRRISLENVSHITFDEAHRAVGNYAYTF
IAEKYFESAKNPHVLGITASPGSSDEKISEVCEALHVQNVAVKTEKDRDVRPYVQEKEIEWLQVNLPAEMAEIRSYLEKI
FDDRLAIIRNLGFSAGSGKYVSKKDLLLLQKKLQGEIRVGGDPAVFSAMSVVAEMMKVNHAVEMVETQGIEALRKYLEKL
DAEASSSKASKAAKRLMDDLYMRKTLYRAKECEVEHPKLELARRIVCEQLEGNPDSRVIVFTNYRDSAEMVVNALSRVSG
VNPVRFVGQGSRHKDKGLTQKQQVEILERFRAGEYNALVATSVAEEGLDIPATDLVLFYEPVPSEIRSIQRKGRTGRQHK
GRVTVLVTKGTRDEAYYWSSKNKEKRMLNSMHGLEAVLGPKNVKKSSELSDFDSVSFISDSKPESKQNTKLDSYPEFQGI
ESESMDKIESGSLENTEDFPITDFGDPGKTEGKNGKDSEIISHTKDIKLQKNSDEIGKKEENEKDYANIKEKQKTLVDFG
TASGESSDSLLKIIIDHRETKSGVAKTLDRLGMELRFMALEIGDYIVSDRLAVERKRTDDFACSLIDGKRNLFAQLSDLA
RVYEKPVLIIEGEDLFTSRQINPNAIYGSLASIAIDFGVSILYSRDEEETASILKILAKREQTENKREINPHGKKSASTL
AEQQEYLISSISNIGPKAARNLLSYFGSVEAVMRADIEELKKVKQIGPKTAARIREVLESPYKG
>Mature_864_residues
MKESLFPEKPECMKHPLIKPDTVEQRLYQLNLAGEALKGSSLVVLPTGLGKTIIALFVIASRLQRFGGKALILSPTKPLV
EQHAAFFKKVMALPEEEVLAFTGSISPAERERLWEQGKLIVSTPQVIENDILTRRISLENVSHITFDEAHRAVGNYAYTF
IAEKYFESAKNPHVLGITASPGSSDEKISEVCEALHVQNVAVKTEKDRDVRPYVQEKEIEWLQVNLPAEMAEIRSYLEKI
FDDRLAIIRNLGFSAGSGKYVSKKDLLLLQKKLQGEIRVGGDPAVFSAMSVVAEMMKVNHAVEMVETQGIEALRKYLEKL
DAEASSSKASKAAKRLMDDLYMRKTLYRAKECEVEHPKLELARRIVCEQLEGNPDSRVIVFTNYRDSAEMVVNALSRVSG
VNPVRFVGQGSRHKDKGLTQKQQVEILERFRAGEYNALVATSVAEEGLDIPATDLVLFYEPVPSEIRSIQRKGRTGRQHK
GRVTVLVTKGTRDEAYYWSSKNKEKRMLNSMHGLEAVLGPKNVKKSSELSDFDSVSFISDSKPESKQNTKLDSYPEFQGI
ESESMDKIESGSLENTEDFPITDFGDPGKTEGKNGKDSEIISHTKDIKLQKNSDEIGKKEENEKDYANIKEKQKTLVDFG
TASGESSDSLLKIIIDHRETKSGVAKTLDRLGMELRFMALEIGDYIVSDRLAVERKRTDDFACSLIDGKRNLFAQLSDLA
RVYEKPVLIIEGEDLFTSRQINPNAIYGSLASIAIDFGVSILYSRDEEETASILKILAKREQTENKREINPHGKKSASTL
AEQQEYLISSISNIGPKAARNLLSYFGSVEAVMRADIEELKKVKQIGPKTAARIREVLESPYKG

Specific function: Can Carry Out ATP-Dependent Unwinding Of Double Stranded RNA. Has A Role In RNA Decay. Involved In The RNA Degradosome, A Multi-Enzyme Complex Important In RNA Processing And Messenger RNA Degradation. [C]

COG id: COG1111

COG function: function code L; ERCC4-like helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI74959747, Length=535, Percent_Identity=29.3457943925234, Blast_Score=238, Evalue=2e-62,
Organism=Homo sapiens, GI27881482, Length=516, Percent_Identity=27.1317829457364, Blast_Score=139, Evalue=9e-33,
Organism=Homo sapiens, GI149408122, Length=514, Percent_Identity=26.6536964980545, Blast_Score=117, Evalue=5e-26,
Organism=Homo sapiens, GI27886568, Length=169, Percent_Identity=31.3609467455621, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI4885217, Length=207, Percent_Identity=25.6038647342995, Blast_Score=67, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71982860, Length=535, Percent_Identity=25.7943925233645, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17539846, Length=225, Percent_Identity=28.8888888888889, Blast_Score=71, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322192, Length=593, Percent_Identity=25.8010118043845, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI116008407, Length=529, Percent_Identity=31.5689981096408, Blast_Score=249, Evalue=4e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR020819
- InterPro:   IPR006166
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR011335
- InterPro:   IPR010994 [H]

Pfam domain/function: PF00270 DEAD; PF02732 ERCC4; PF00271 Helicase_C; PF00633 HHH [H]

EC number: =3.6.4.13 [H]

Molecular weight: Translated: 96682; Mature: 96682

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKESLFPEKPECMKHPLIKPDTVEQRLYQLNLAGEALKGSSLVVLPTGLGKTIIALFVIA
CCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHH
SRLQRFGGKALILSPTKPLVEQHAAFFKKVMALPEEEVLAFTGSISPAERERLWEQGKLI
HHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHHCCCEE
VSTPQVIENDILTRRISLENVSHITFDEAHRAVGNYAYTFIAEKYFESAKNPHVLGITAS
EECHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
PGSSDEKISEVCEALHVQNVAVKTEKDRDVRPYVQEKEIEWLQVNLPAEMAEIRSYLEKI
CCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHCCCCCEEEEECCHHHHHHHHHHHHH
FDDRLAIIRNLGFSAGSGKYVSKKDLLLLQKKLQGEIRVGGDPAVFSAMSVVAEMMKVNH
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
AVEMVETQGIEALRKYLEKLDAEASSSKASKAAKRLMDDLYMRKTLYRAKECEVEHPKLE
HHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LARRIVCEQLEGNPDSRVIVFTNYRDSAEMVVNALSRVSGVNPVRFVGQGSRHKDKGLTQ
HHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCH
KQQVEILERFRAGEYNALVATSVAEEGLDIPATDLVLFYEPVPSEIRSIQRKGRTGRQHK
HHHHHHHHHHCCCCCCHHEEHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCC
GRVTVLVTKGTRDEAYYWSSKNKEKRMLNSMHGLEAVLGPKNVKKSSELSDFDSVSFISD
CCEEEEEECCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCC
SKPESKQNTKLDSYPEFQGIESESMDKIESGSLENTEDFPITDFGDPGKTEGKNGKDSEI
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
ISHTKDIKLQKNSDEIGKKEENEKDYANIKEKQKTLVDFGTASGESSDSLLKIIIDHRET
HHHHHCCEEECCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHH
KSGVAKTLDRLGMELRFMALEIGDYIVSDRLAVERKRTDDFACSLIDGKRNLFAQLSDLA
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCHHHHHHHHHHHH
RVYEKPVLIIEGEDLFTSRQINPNAIYGSLASIAIDFGVSILYSRDEEETASILKILAKR
HHHHCCEEEEECCCCEECCCCCCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHH
EQTENKREINPHGKKSASTLAEQQEYLISSISNIGPKAARNLLSYFGSVEAVMRADIEEL
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
KKVKQIGPKTAARIREVLESPYKG
HHHHHCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKESLFPEKPECMKHPLIKPDTVEQRLYQLNLAGEALKGSSLVVLPTGLGKTIIALFVIA
CCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHH
SRLQRFGGKALILSPTKPLVEQHAAFFKKVMALPEEEVLAFTGSISPAERERLWEQGKLI
HHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHHCCCEE
VSTPQVIENDILTRRISLENVSHITFDEAHRAVGNYAYTFIAEKYFESAKNPHVLGITAS
EECHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
PGSSDEKISEVCEALHVQNVAVKTEKDRDVRPYVQEKEIEWLQVNLPAEMAEIRSYLEKI
CCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHCCCCCEEEEECCHHHHHHHHHHHHH
FDDRLAIIRNLGFSAGSGKYVSKKDLLLLQKKLQGEIRVGGDPAVFSAMSVVAEMMKVNH
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
AVEMVETQGIEALRKYLEKLDAEASSSKASKAAKRLMDDLYMRKTLYRAKECEVEHPKLE
HHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LARRIVCEQLEGNPDSRVIVFTNYRDSAEMVVNALSRVSGVNPVRFVGQGSRHKDKGLTQ
HHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCH
KQQVEILERFRAGEYNALVATSVAEEGLDIPATDLVLFYEPVPSEIRSIQRKGRTGRQHK
HHHHHHHHHHCCCCCCHHEEHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCC
GRVTVLVTKGTRDEAYYWSSKNKEKRMLNSMHGLEAVLGPKNVKKSSELSDFDSVSFISD
CCEEEEEECCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCC
SKPESKQNTKLDSYPEFQGIESESMDKIESGSLENTEDFPITDFGDPGKTEGKNGKDSEI
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
ISHTKDIKLQKNSDEIGKKEENEKDYANIKEKQKTLVDFGTASGESSDSLLKIIIDHRET
HHHHHCCEEECCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHH
KSGVAKTLDRLGMELRFMALEIGDYIVSDRLAVERKRTDDFACSLIDGKRNLFAQLSDLA
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCHHHHHHHHHHHH
RVYEKPVLIIEGEDLFTSRQINPNAIYGSLASIAIDFGVSILYSRDEEETASILKILAKR
HHHHCCEEEEECCCCEECCCCCCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHH
EQTENKREINPHGKKSASTLAEQQEYLISSISNIGPKAARNLLSYFGSVEAVMRADIEEL
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
KKVKQIGPKTAARIREVLESPYKG
HHHHHCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]