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The map label for this gene is 21227421

Identifier: 21227421

GI number: 21227421

Start: 1572566

End: 1574071

Strand: Direct

Name: 21227421

Synonym: MM_1319

Alternate gene names: NA

Gene position: 1572566-1574071 (Clockwise)

Preceding gene: 21227420

Following gene: 21227430

Centisome position: 38.39

GC content: 45.48

Gene sequence:

>1506_bases
ATGGATCCTGAACGAAATTCTTACAGTTCATCTCAGGAGTCAATACACTCTATGGACAAACCTATAGAATCTAAGGAAGG
CAATGTTTCTGTTGGGAAGTTTAAACTTTCTGACTCTTCAATCAACAATCCAGAAGAAATCATTTCTGTGCCGTCATCTA
CAACAGAAATCGAAAAGGTCGAAATGAAGCCCGGTAGGGGGGAAGGACTTAACCCCGAGCTTCTTCCTGCTTCAGTTTCG
GAACTGTTAATTCCTTCTCCTTTCCAGCCTCAAATCCCGGACGGAAACAATTCATCTGTTGAGTTTCACCCTTCAAAAGT
TGTGCTTATAGGCACGGCACACGTTTCCGAAAAGAGTGTGAATGAGGTAAGAAGCGCAATCAGAAATCTTAAACCCGATA
TCGTAGCTGTTGAGCTTTGCAGGGCACGTTACGATTCTCTTAAAGGAAATGTTCCGGAAACAAATCAGGTTCCAATAAAG
GAAATTCTCACCGAAGGAAAAGTGTATTACTACCTTGTCCACTGGCTGCTTGCTTATGTGCAGAAAAAGATCGGTGAAGA
CATGGGTGTAAAGCCCGGTTCCGAGATGATTTCCGCAATTGAAGAAGCAGAAGCCTCAGGAGCTAAAATAGCTCTAATTG
ACAGGGATATTCAGGTGACTCTCCAGCGTTTCTGGGGCCGCATGAAATTTACTGAGAAAATAAAGATGCTGGGTTCTCTT
ATAGGCGGCCTGATAGGAATAGGAAAAGGAGCAGAAATCGACATAGACCAGATAACTCAACAGGATGTTGTCACAGCCCT
CGTTAGCGAGCTCAGAGAATTTGCCCCAACTGCAGCTGAAACTCTCATAGATGAAAGGGACGCATACCTTGCAGGGAGCA
TTCTCAGGACGGCTGCTGGTGGAAACAAAACCATTGTTGCGGTAATCGGAGCAGGACATAAACCAGGTGTAATTAACTAC
CTGGAGAACCCAAAGAGCCTTCCTCCTCTTAATTCTCTTATGCAGATTCCGAAGAAACGATTTGGAATTGGCAAAATTAT
CGGTTTTGCCTTTGTAGGTCTTATTATCGGGTTTTTTTTGCTGCTCCTGCTTTCGGGCGTTCCACTGAAACTCCTTTTGA
TAGCTTTCGGATGGTGGTTCATTATCACAGGAACCCTGAGTGCAATCGGCACTCTGCTCGCAGGCGGCCATCCTTACTCA
GTCCTGACCGCCTTTTCGGTTGCCTGGCTGACCACTCTTCACCCTTTAATTGCTGCGGGCTGGTTTGCTGGAATTGTAGA
AGCAAGACAGCGAAACCCTACCGCCGCAGATATAAAAGCCCTTGCAGGGATAGAAACTTTCAGGGAAATGTTCAAAAACA
GGTTTATGCGAGTCCTCCTTGTCGCTAGCTTTGCTAACATAGGGAGTATGACAGGTACTTTCCTCGGAGCCTATGTTATG
ATACGGGTTACCGGCCTTGATCCAAGAGATATTCTACTTTCCGGGTTCAACGCTCTAGGACTCTAA

Upstream 100 bases:

>100_bases
CCAATACATATTTATCTAATACATATTTATCCGGCACTGCTAATCTGCTGTAACAAAGAGACTGATTATGAATAAATATG
AAATCACAGATTCTCAGGAA

Downstream 100 bases:

>100_bases
AATAGGACTCTAAAATAATCCTATGGATAAAAGCAGATCTGAGAGTCAGATTTTCTGCTTTCATAACTTTTATCCTTTTG
CAATTTTGAAGCGATTTTTA

Product: pheromone shutdown protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MDPERNSYSSSQESIHSMDKPIESKEGNVSVGKFKLSDSSINNPEEIISVPSSTTEIEKVEMKPGRGEGLNPELLPASVS
ELLIPSPFQPQIPDGNNSSVEFHPSKVVLIGTAHVSEKSVNEVRSAIRNLKPDIVAVELCRARYDSLKGNVPETNQVPIK
EILTEGKVYYYLVHWLLAYVQKKIGEDMGVKPGSEMISAIEEAEASGAKIALIDRDIQVTLQRFWGRMKFTEKIKMLGSL
IGGLIGIGKGAEIDIDQITQQDVVTALVSELREFAPTAAETLIDERDAYLAGSILRTAAGGNKTIVAVIGAGHKPGVINY
LENPKSLPPLNSLMQIPKKRFGIGKIIGFAFVGLIIGFFLLLLLSGVPLKLLLIAFGWWFIITGTLSAIGTLLAGGHPYS
VLTAFSVAWLTTLHPLIAAGWFAGIVEARQRNPTAADIKALAGIETFREMFKNRFMRVLLVASFANIGSMTGTFLGAYVM
IRVTGLDPRDILLSGFNALGL

Sequences:

>Translated_501_residues
MDPERNSYSSSQESIHSMDKPIESKEGNVSVGKFKLSDSSINNPEEIISVPSSTTEIEKVEMKPGRGEGLNPELLPASVS
ELLIPSPFQPQIPDGNNSSVEFHPSKVVLIGTAHVSEKSVNEVRSAIRNLKPDIVAVELCRARYDSLKGNVPETNQVPIK
EILTEGKVYYYLVHWLLAYVQKKIGEDMGVKPGSEMISAIEEAEASGAKIALIDRDIQVTLQRFWGRMKFTEKIKMLGSL
IGGLIGIGKGAEIDIDQITQQDVVTALVSELREFAPTAAETLIDERDAYLAGSILRTAAGGNKTIVAVIGAGHKPGVINY
LENPKSLPPLNSLMQIPKKRFGIGKIIGFAFVGLIIGFFLLLLLSGVPLKLLLIAFGWWFIITGTLSAIGTLLAGGHPYS
VLTAFSVAWLTTLHPLIAAGWFAGIVEARQRNPTAADIKALAGIETFREMFKNRFMRVLLVASFANIGSMTGTFLGAYVM
IRVTGLDPRDILLSGFNALGL
>Mature_501_residues
MDPERNSYSSSQESIHSMDKPIESKEGNVSVGKFKLSDSSINNPEEIISVPSSTTEIEKVEMKPGRGEGLNPELLPASVS
ELLIPSPFQPQIPDGNNSSVEFHPSKVVLIGTAHVSEKSVNEVRSAIRNLKPDIVAVELCRARYDSLKGNVPETNQVPIK
EILTEGKVYYYLVHWLLAYVQKKIGEDMGVKPGSEMISAIEEAEASGAKIALIDRDIQVTLQRFWGRMKFTEKIKMLGSL
IGGLIGIGKGAEIDIDQITQQDVVTALVSELREFAPTAAETLIDERDAYLAGSILRTAAGGNKTIVAVIGAGHKPGVINY
LENPKSLPPLNSLMQIPKKRFGIGKIIGFAFVGLIIGFFLLLLLSGVPLKLLLIAFGWWFIITGTLSAIGTLLAGGHPYS
VLTAFSVAWLTTLHPLIAAGWFAGIVEARQRNPTAADIKALAGIETFREMFKNRFMRVLLVASFANIGSMTGTFLGAYVM
IRVTGLDPRDILLSGFNALGL

Specific function: Unknown

COG id: COG1916

COG function: function code S; Uncharacterized homolog of PrgY (pheromone shutdown protein)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI33342278, Length=219, Percent_Identity=30.1369863013699, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71988206, Length=264, Percent_Identity=27.6515151515151, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI71988217, Length=264, Percent_Identity=27.6515151515151, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24646455, Length=278, Percent_Identity=28.0575539568345, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21357445, Length=278, Percent_Identity=28.0575539568345, Blast_Score=89, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002816
- InterPro:   IPR005230 [H]

Pfam domain/function: PF01963 TraB [H]

EC number: NA

Molecular weight: Translated: 54313; Mature: 54313

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPERNSYSSSQESIHSMDKPIESKEGNVSVGKFKLSDSSINNPEEIISVPSSTTEIEKV
CCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCHHHHEECCCCCCCHHEE
EMKPGRGEGLNPELLPASVSELLIPSPFQPQIPDGNNSSVEFHPSKVVLIGTAHVSEKSV
EECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCCCHHHH
NEVRSAIRNLKPDIVAVELCRARYDSLKGNVPETNQVPIKEILTEGKVYYYLVHWLLAYV
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHH
QKKIGEDMGVKPGSEMISAIEEAEASGAKIALIDRDIQVTLQRFWGRMKFTEKIKMLGSL
HHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
IGGLIGIGKGAEIDIDQITQQDVVTALVSELREFAPTAAETLIDERDAYLAGSILRTAAG
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
GNKTIVAVIGAGHKPGVINYLENPKSLPPLNSLMQIPKKRFGIGKIIGFAFVGLIIGFFL
CCCEEEEEEECCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLLLSGVPLKLLLIAFGWWFIITGTLSAIGTLLAGGHPYSVLTAFSVAWLTTLHPLIAAG
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
WFAGIVEARQRNPTAADIKALAGIETFREMFKNRFMRVLLVASFANIGSMTGTFLGAYVM
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
IRVTGLDPRDILLSGFNALGL
EEEECCCHHHHHHHCHHHHCC
>Mature Secondary Structure
MDPERNSYSSSQESIHSMDKPIESKEGNVSVGKFKLSDSSINNPEEIISVPSSTTEIEKV
CCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCHHHHEECCCCCCCHHEE
EMKPGRGEGLNPELLPASVSELLIPSPFQPQIPDGNNSSVEFHPSKVVLIGTAHVSEKSV
EECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCCCHHHH
NEVRSAIRNLKPDIVAVELCRARYDSLKGNVPETNQVPIKEILTEGKVYYYLVHWLLAYV
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHH
QKKIGEDMGVKPGSEMISAIEEAEASGAKIALIDRDIQVTLQRFWGRMKFTEKIKMLGSL
HHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
IGGLIGIGKGAEIDIDQITQQDVVTALVSELREFAPTAAETLIDERDAYLAGSILRTAAG
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
GNKTIVAVIGAGHKPGVINYLENPKSLPPLNSLMQIPKKRFGIGKIIGFAFVGLIIGFFL
CCCEEEEEEECCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLLLSGVPLKLLLIAFGWWFIITGTLSAIGTLLAGGHPYSVLTAFSVAWLTTLHPLIAAG
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
WFAGIVEARQRNPTAADIKALAGIETFREMFKNRFMRVLLVASFANIGSMTGTFLGAYVM
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
IRVTGLDPRDILLSGFNALGL
EEEECCCHHHHHHHCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]