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The map label for this gene is yrbE [H]

Identifier: 21227282

GI number: 21227282

Start: 1400103

End: 1402277

Strand: Reverse

Name: yrbE [H]

Synonym: MM_1180

Alternate gene names: 21227282

Gene position: 1402277-1400103 (Counterclockwise)

Preceding gene: 21227283

Following gene: 21227281

Centisome position: 34.23

GC content: 46.53

Gene sequence:

>2175_bases
ATGATAAGGAGCTTCAGTATGAAACAGGTTGTCCTGAATCTTAAAGATGGAGATTTGACGGTTGAAGACGTCCCAATTCC
CACTTTAAAAGGCAGTGGTGTGCTTGTCCGCAACTATTATTCCGTCATTAGCGCAGGCACTGAATCCGGCCTTGTGGATC
TTGCTGATAAATCCCTTATTGGAAAAGCAAGGGCAAGGCCAGATCTCGCAATGAAAGTAATAAACAAAGCGAAACAGGAC
GGCCCGATTTCAGCATTCCAGCAGGCTATGGGAAGGCTTGAAAAACGTGAACCTCTTGGCTACAGTAGTGCAGGAACTGT
AATTTCTGTAAGCGAAGATATAGCATCCATAAAAGTTGGAGACAGGGTAGCATGTGCTGGCGCAGGTTATGCCAACCATG
CAGATGTCGCATTTGTTCCGAAGAACCTCTGCGTAAAAGTCCCGGACAACGTTGACCTTAAAAATGCCTGTTTCACAACT
GTGGGCTCAATTGCAATGCAGGGGGTCCGTAACGCCGATGTAAGAGTAGGGGAGAATGTTGTTGTTGTCGGCCTGGGTCT
GATTGGCCTGATTACCGTACAGATTCTGAAAGCCTCAGGCTGCCGCGTCTTCGGAATAGACCTTGATGAATCCAAAGTAA
AACTTGCAAAAGAGCTTGGAGCAGACTTTGCCCTTTCTAGAAATACTCCCAATATAGAGGAAAGTGTCAGGCAGTTCTCC
CGTGGAATCGGTGCTGATGTAACAATCATTGCAGCTGCAACAAGGTCAAACGATCCTGTGGACTTCGCTGGAAAAATAAC
CCGTGAGCGCGGAAAAGTGGTAATTGTAGGCCTTGTAGGCATGGACATCCCGCGTGAAGAGTATTACAATAAAGAAATTG
AACTTCGCGTATCCCGTTCCTACGGCCCTGGCCGTTACGACCGCGCCTATGAAGAATTCGGCAGGGACTACCCGGCCCCT
TACGTCCGCTGGACCGAAAACCGTAATATGCAGGCTTTTCTGGATCTTCTCTCCATGAAAAAAATCTCCATGGACCCTAT
TATCTCCCACGAATTTGCAATCGAGCAAGCTCCGGACGCTTATGATATCATAGAACAGAGAAAACCCTACCTCGGCATAG
TCCTCAGGTACGACACGAACAGGGAAATTGAAGATAAAATCGTGCTTAAAGCTCCCGAATCAAAGCCATTCCCGAGTGGA
ACTCCGGTTGTCGGAGTTATAGGTGCAGGGATCTTTGCAACAAGCACCCTCCTTCCGAACCTCTCGAAAATAGACGGCAT
AAAATTAAAAGGCCTCTCTGCAGCAACCGGGATCAGTTGTGAATCCGTTGCCAAAAAATACGGCTTTGGATACTGCACTT
CCGATTATCACAAAATCATGGAAGACCCTGAAATCAACTGCGTGAGCATAGTAACCCGAAACAGCCTTCATGCTCCCCTG
GTAATCGAAGCCCTCAAACACGGCAAAAACGTCCTTGTGGAAAAGCCTCTCGCTCTCAATGAAGAAGAACTTGAAGCTGT
CAGAGCTGCCTGGGAAAAACACGGAGGTCTTGTAATGGTCGGCTTCAACCGCCGCTATTCCGAACTAGGCATGAAACTCA
GGGATTTCTTCAAAAAACGTTCCCAGCCAATGGTAGCCCTCTACCGCGTAAACGCCGAGTCCATCCCAAAAGATCACTGG
ATCTATGACAATTCCGAAGGTGGAAGTCGCATCATCACCGAATGCTGTCATTTCATTGATTTCCTGCAGTATATTATAGG
CTCTTCTCCCACAGAAGTCTACGCCCGAAAAATCGAACCCGAAATTAAAAGCCCCGAAGACAACGAAAACGTTTCAATTA
CCATTTCTTTTGAAGATGGCTCAATAGGGACTATAATATACACTACCCACGGAGACAGCTCTCTGTCCAAAGAGCGTGCA
GAATTCTTTGCAGACGGGATGGCTGGAGTTATCACGGATTTCAAGCAGCTTGAAATGGTAAAGGGTGGGAAGAAAGAGAA
GATTGCAAAGAGAATGGTAACAGAGAAAGGGCATAAGAATGAGTTTGAGAAGTTTCTTGAGATGGTGAAGAAGGGTTCTT
CAGAGTATAATTTTGAAGGAAACGTTTTGACTACTTTGGTGACGCTAAAGGCTGTAGACTCGTTGCAGAACAACTCCCCA
GTGAAAATATTCTGA

Upstream 100 bases:

>100_bases
AATAATTTTCCCGACTTATTCATGACTTCGGAAGTGCTGGACTGTTTGAGTTATTCAATACACAGAGAAATTAAAAAATG
AAATTAACTTTATAAATATC

Downstream 100 bases:

>100_bases
AACCAACGTAGAAAGGAGATATTATGAGGATATTGGAAGTTTCAAACTATTTTAAGCCCTCCTGGGAAACTGGTGGAGTC
ACTAAGGTAAACTATGAATT

Product: oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 724; Mature: 724

Protein sequence:

>724_residues
MIRSFSMKQVVLNLKDGDLTVEDVPIPTLKGSGVLVRNYYSVISAGTESGLVDLADKSLIGKARARPDLAMKVINKAKQD
GPISAFQQAMGRLEKREPLGYSSAGTVISVSEDIASIKVGDRVACAGAGYANHADVAFVPKNLCVKVPDNVDLKNACFTT
VGSIAMQGVRNADVRVGENVVVVGLGLIGLITVQILKASGCRVFGIDLDESKVKLAKELGADFALSRNTPNIEESVRQFS
RGIGADVTIIAAATRSNDPVDFAGKITRERGKVVIVGLVGMDIPREEYYNKEIELRVSRSYGPGRYDRAYEEFGRDYPAP
YVRWTENRNMQAFLDLLSMKKISMDPIISHEFAIEQAPDAYDIIEQRKPYLGIVLRYDTNREIEDKIVLKAPESKPFPSG
TPVVGVIGAGIFATSTLLPNLSKIDGIKLKGLSAATGISCESVAKKYGFGYCTSDYHKIMEDPEINCVSIVTRNSLHAPL
VIEALKHGKNVLVEKPLALNEEELEAVRAAWEKHGGLVMVGFNRRYSELGMKLRDFFKKRSQPMVALYRVNAESIPKDHW
IYDNSEGGSRIITECCHFIDFLQYIIGSSPTEVYARKIEPEIKSPEDNENVSITISFEDGSIGTIIYTTHGDSSLSKERA
EFFADGMAGVITDFKQLEMVKGGKKEKIAKRMVTEKGHKNEFEKFLEMVKKGSSEYNFEGNVLTTLVTLKAVDSLQNNSP
VKIF

Sequences:

>Translated_724_residues
MIRSFSMKQVVLNLKDGDLTVEDVPIPTLKGSGVLVRNYYSVISAGTESGLVDLADKSLIGKARARPDLAMKVINKAKQD
GPISAFQQAMGRLEKREPLGYSSAGTVISVSEDIASIKVGDRVACAGAGYANHADVAFVPKNLCVKVPDNVDLKNACFTT
VGSIAMQGVRNADVRVGENVVVVGLGLIGLITVQILKASGCRVFGIDLDESKVKLAKELGADFALSRNTPNIEESVRQFS
RGIGADVTIIAAATRSNDPVDFAGKITRERGKVVIVGLVGMDIPREEYYNKEIELRVSRSYGPGRYDRAYEEFGRDYPAP
YVRWTENRNMQAFLDLLSMKKISMDPIISHEFAIEQAPDAYDIIEQRKPYLGIVLRYDTNREIEDKIVLKAPESKPFPSG
TPVVGVIGAGIFATSTLLPNLSKIDGIKLKGLSAATGISCESVAKKYGFGYCTSDYHKIMEDPEINCVSIVTRNSLHAPL
VIEALKHGKNVLVEKPLALNEEELEAVRAAWEKHGGLVMVGFNRRYSELGMKLRDFFKKRSQPMVALYRVNAESIPKDHW
IYDNSEGGSRIITECCHFIDFLQYIIGSSPTEVYARKIEPEIKSPEDNENVSITISFEDGSIGTIIYTTHGDSSLSKERA
EFFADGMAGVITDFKQLEMVKGGKKEKIAKRMVTEKGHKNEFEKFLEMVKKGSSEYNFEGNVLTTLVTLKAVDSLQNNSP
VKIF
>Mature_724_residues
MIRSFSMKQVVLNLKDGDLTVEDVPIPTLKGSGVLVRNYYSVISAGTESGLVDLADKSLIGKARARPDLAMKVINKAKQD
GPISAFQQAMGRLEKREPLGYSSAGTVISVSEDIASIKVGDRVACAGAGYANHADVAFVPKNLCVKVPDNVDLKNACFTT
VGSIAMQGVRNADVRVGENVVVVGLGLIGLITVQILKASGCRVFGIDLDESKVKLAKELGADFALSRNTPNIEESVRQFS
RGIGADVTIIAAATRSNDPVDFAGKITRERGKVVIVGLVGMDIPREEYYNKEIELRVSRSYGPGRYDRAYEEFGRDYPAP
YVRWTENRNMQAFLDLLSMKKISMDPIISHEFAIEQAPDAYDIIEQRKPYLGIVLRYDTNREIEDKIVLKAPESKPFPSG
TPVVGVIGAGIFATSTLLPNLSKIDGIKLKGLSAATGISCESVAKKYGFGYCTSDYHKIMEDPEINCVSIVTRNSLHAPL
VIEALKHGKNVLVEKPLALNEEELEAVRAAWEKHGGLVMVGFNRRYSELGMKLRDFFKKRSQPMVALYRVNAESIPKDHW
IYDNSEGGSRIITECCHFIDFLQYIIGSSPTEVYARKIEPEIKSPEDNENVSITISFEDGSIGTIIYTTHGDSSLSKERA
EFFADGMAGVITDFKQLEMVKGGKKEKIAKRMVTEKGHKNEFEKFLEMVKKGSSEYNFEGNVLTTLVTLKAVDSLQNNSP
VKIF

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gfo/idh/mocA family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=314, Percent_Identity=23.5668789808917, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1788073, Length=213, Percent_Identity=27.2300469483568, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI87082125, Length=300, Percent_Identity=23.3333333333333, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1787572, Length=269, Percent_Identity=27.8810408921933, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=257, Percent_Identity=26.0700389105058, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562878, Length=164, Percent_Identity=29.8780487804878, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319955, Length=300, Percent_Identity=25.3333333333333, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=300, Percent_Identity=25.3333333333333, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17737897, Length=301, Percent_Identity=23.2558139534884, Blast_Score=67, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000683
- InterPro:   IPR004104 [H]

Pfam domain/function: PF01408 GFO_IDH_MocA; PF02894 GFO_IDH_MocA_C [H]

EC number: NA

Molecular weight: Translated: 79690; Mature: 79690

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRSFSMKQVVLNLKDGDLTVEDVPIPTLKGSGVLVRNYYSVISAGTESGLVDLADKSLI
CCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCEEHHHHHHHHHCCCCCCEEEHHHHHHH
GKARARPDLAMKVINKAKQDGPISAFQQAMGRLEKREPLGYSSAGTVISVSEDIASIKVG
HHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHEECC
DRVACAGAGYANHADVAFVPKNLCVKVPDNVDLKNACFTTVGSIAMQGVRNADVRVGENV
CEEEECCCCCCCCCCEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCE
VVVGLGLIGLITVQILKASGCRVFGIDLDESKVKLAKELGADFALSRNTPNIEESVRQFS
EEEHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCEEECCCCCCHHHHHHHHH
RGIGADVTIIAAATRSNDPVDFAGKITRERGKVVIVGLVGMDIPREEYYNKEIELRVSRS
CCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCEEEEEEECCCCCHHHHCCCEEEEEEECC
YGPGRYDRAYEEFGRDYPAPYVRWTENRNMQAFLDLLSMKKISMDPIISHEFAIEQAPDA
CCCCHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCH
YDIIEQRKPYLGIVLRYDTNREIEDKIVLKAPESKPFPSGTPVVGVIGAGIFATSTLLPN
HHHHHHCCCEEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
LSKIDGIKLKGLSAATGISCESVAKKYGFGYCTSDYHKIMEDPEINCVSIVTRNSLHAPL
CHHCCCEEEECCCHHCCCCHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEECCCCCCHH
VIEALKHGKNVLVEKPLALNEEELEAVRAAWEKHGGLVMVGFNRRYSELGMKLRDFFKKR
HHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHC
SQPMVALYRVNAESIPKDHWIYDNSEGGSRIITECCHFIDFLQYIIGSSPTEVYARKIEP
CCCEEEEEEECHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
EIKSPEDNENVSITISFEDGSIGTIIYTTHGDSSLSKERAEFFADGMAGVITDFKQLEMV
CCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
KGGKKEKIAKRMVTEKGHKNEFEKFLEMVKKGSSEYNFEGNVLTTLVTLKAVDSLQNNSP
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
VKIF
EEEC
>Mature Secondary Structure
MIRSFSMKQVVLNLKDGDLTVEDVPIPTLKGSGVLVRNYYSVISAGTESGLVDLADKSLI
CCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCEEHHHHHHHHHCCCCCCEEEHHHHHHH
GKARARPDLAMKVINKAKQDGPISAFQQAMGRLEKREPLGYSSAGTVISVSEDIASIKVG
HHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHEECC
DRVACAGAGYANHADVAFVPKNLCVKVPDNVDLKNACFTTVGSIAMQGVRNADVRVGENV
CEEEECCCCCCCCCCEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCE
VVVGLGLIGLITVQILKASGCRVFGIDLDESKVKLAKELGADFALSRNTPNIEESVRQFS
EEEHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCEEECCCCCCHHHHHHHHH
RGIGADVTIIAAATRSNDPVDFAGKITRERGKVVIVGLVGMDIPREEYYNKEIELRVSRS
CCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCEEEEEEECCCCCHHHHCCCEEEEEEECC
YGPGRYDRAYEEFGRDYPAPYVRWTENRNMQAFLDLLSMKKISMDPIISHEFAIEQAPDA
CCCCHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCH
YDIIEQRKPYLGIVLRYDTNREIEDKIVLKAPESKPFPSGTPVVGVIGAGIFATSTLLPN
HHHHHHCCCEEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
LSKIDGIKLKGLSAATGISCESVAKKYGFGYCTSDYHKIMEDPEINCVSIVTRNSLHAPL
CHHCCCEEEECCCHHCCCCHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEECCCCCCHH
VIEALKHGKNVLVEKPLALNEEELEAVRAAWEKHGGLVMVGFNRRYSELGMKLRDFFKKR
HHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHC
SQPMVALYRVNAESIPKDHWIYDNSEGGSRIITECCHFIDFLQYIIGSSPTEVYARKIEP
CCCEEEEEEECHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
EIKSPEDNENVSITISFEDGSIGTIIYTTHGDSSLSKERAEFFADGMAGVITDFKQLEMV
CCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
KGGKKEKIAKRMVTEKGHKNEFEKFLEMVKKGSSEYNFEGNVLTTLVTLKAVDSLQNNSP
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
VKIF
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9025289 [H]