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The map label for this gene is strE [H]

Identifier: 21227269

GI number: 21227269

Start: 1386158

End: 1387123

Strand: Direct

Name: strE [H]

Synonym: MM_1167

Alternate gene names: 21227269

Gene position: 1386158-1387123 (Clockwise)

Preceding gene: 21227268

Following gene: 21227270

Centisome position: 33.84

GC content: 44.1

Gene sequence:

>966_bases
GTGACTCAATTGAAACTGCTTGTAACAGGCGGCTGCGGATTCATAGGCAGCAACTTTATCCGTTATATGCTGAAAAAATA
TCCGGACTATCAAATCGTAAACCTTGACAAACTGACCTATGCCGGAAATCCTGCCAACCTCAAAGACATTGAAAATAACC
CGAACTACTCTTTTGTCAAAGGCGACATCTGCGACCCTGTGGTTGTAAACGAAGTTATTAAAACAGCAGACCAGGTTGTC
CATTTCGCAGCCGAAAGCCACGTTGACCGTTCAATTGAAGACGGCTCGGTATTTGTCAGGACAAACGTGCTCGGGACAAA
TACCCTTCTCCAGAGTGCCCTTGCAAATAAGATAAAAAAATTCATTCATGTTTCCACAGATGAGGTTTACGGGAGCACCA
TGGAAGGTTCTTTTACAGAAACAGATAAACTGAACCCTTCAAGCCCCTATTCTTCAAGCAAAGCGGGCTCAGACCTCCTT
GCAATGTCTTACCATACAACCTATGGACTCCCGGTTTGCATAACCCGATGCACAAACAATTTTGGTCCCTACCAGTACCC
GGAAAAATTAATTCCATTTTTCATCAGCAGGTTAATGGAAGGAAAAAAAGTCCCTGTCTATGGTACAGGCATGAACATCC
GGGACTGGATCTACGTTGAAGACCACTGTTCTGCGATCGATTTTGTTCTCCACAAAGGAAGCGCCGGAGAAATATATAAT
ATAGACGGCGGAAACGAACTCACAAACCTTGAAATCACTCACAGGCTCCTTAAAATGCTTGGCAAGGACGAATCTTCAAT
AGAGTATGTTGAAGACCGAAAAGGCCACGATTTCCGCTACTCCCTTGACGGCAGCAAACTGGAAAAAATGGGCTGGAAAC
CCAGATATGATTTTGATACCGCTCTCGAAAAGACTGTCAGCTGGTATGTAGAAAATAAATGGTGGTGGGAACCATTAAAA
CGCTGA

Upstream 100 bases:

>100_bases
AAATATTTACTCATGAAATATTTACTCATGAAATAGTTATTCCCAAAATATTTACTCCAAAAATATTTACTCTTGAAAAT
TATCTATACCCCACAAAAAG

Downstream 100 bases:

>100_bases
TCATCGGCTCCAGCGGGATGCTCGGGTCAGACCTGTGCAAAGTCTTTCCCGATGCTGTTAAACTGACACACCATGACCTC
GACATCACAGACAGAGAGCA

Product: dTDP-glucose 4,6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MTQLKLLVTGGCGFIGSNFIRYMLKKYPDYQIVNLDKLTYAGNPANLKDIENNPNYSFVKGDICDPVVVNEVIKTADQVV
HFAAESHVDRSIEDGSVFVRTNVLGTNTLLQSALANKIKKFIHVSTDEVYGSTMEGSFTETDKLNPSSPYSSSKAGSDLL
AMSYHTTYGLPVCITRCTNNFGPYQYPEKLIPFFISRLMEGKKVPVYGTGMNIRDWIYVEDHCSAIDFVLHKGSAGEIYN
IDGGNELTNLEITHRLLKMLGKDESSIEYVEDRKGHDFRYSLDGSKLEKMGWKPRYDFDTALEKTVSWYVENKWWWEPLK
R

Sequences:

>Translated_321_residues
MTQLKLLVTGGCGFIGSNFIRYMLKKYPDYQIVNLDKLTYAGNPANLKDIENNPNYSFVKGDICDPVVVNEVIKTADQVV
HFAAESHVDRSIEDGSVFVRTNVLGTNTLLQSALANKIKKFIHVSTDEVYGSTMEGSFTETDKLNPSSPYSSSKAGSDLL
AMSYHTTYGLPVCITRCTNNFGPYQYPEKLIPFFISRLMEGKKVPVYGTGMNIRDWIYVEDHCSAIDFVLHKGSAGEIYN
IDGGNELTNLEITHRLLKMLGKDESSIEYVEDRKGHDFRYSLDGSKLEKMGWKPRYDFDTALEKTVSWYVENKWWWEPLK
R
>Mature_320_residues
TQLKLLVTGGCGFIGSNFIRYMLKKYPDYQIVNLDKLTYAGNPANLKDIENNPNYSFVKGDICDPVVVNEVIKTADQVVH
FAAESHVDRSIEDGSVFVRTNVLGTNTLLQSALANKIKKFIHVSTDEVYGSTMEGSFTETDKLNPSSPYSSSKAGSDLLA
MSYHTTYGLPVCITRCTNNFGPYQYPEKLIPFFISRLMEGKKVPVYGTGMNIRDWIYVEDHCSAIDFVLHKGSAGEIYNI
DGGNELTNLEITHRLLKMLGKDESSIEYVEDRKGHDFRYSLDGSKLEKMGWKPRYDFDTALEKTVSWYVENKWWWEPLKR

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=325, Percent_Identity=40.3076923076923, Blast_Score=268, Evalue=4e-72,
Organism=Homo sapiens, GI42516563, Length=314, Percent_Identity=22.9299363057325, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI4504031, Length=352, Percent_Identity=24.7159090909091, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI48994969, Length=341, Percent_Identity=44.8680351906158, Blast_Score=295, Evalue=4e-81,
Organism=Escherichia coli, GI1788353, Length=346, Percent_Identity=45.0867052023121, Blast_Score=292, Evalue=2e-80,
Organism=Escherichia coli, GI1786974, Length=343, Percent_Identity=25.0728862973761, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788366, Length=355, Percent_Identity=24.2253521126761, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788365, Length=341, Percent_Identity=20.5278592375367, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17568069, Length=322, Percent_Identity=37.888198757764, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI115532424, Length=321, Percent_Identity=32.0872274143302, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17539532, Length=317, Percent_Identity=23.9747634069401, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71982035, Length=345, Percent_Identity=25.2173913043478, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71982038, Length=347, Percent_Identity=25.0720461095101, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI133901786, Length=272, Percent_Identity=23.1617647058824, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI133901788, Length=272, Percent_Identity=23.1617647058824, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17539422, Length=272, Percent_Identity=23.1617647058824, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI133901790, Length=272, Percent_Identity=23.1617647058824, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17539424, Length=272, Percent_Identity=23.1617647058824, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=351, Percent_Identity=25.0712250712251, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21356223, Length=318, Percent_Identity=22.6415094339623, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI19923002, Length=349, Percent_Identity=27.5071633237822, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 36461; Mature: 36330

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLKLLVTGGCGFIGSNFIRYMLKKYPDYQIVNLDKLTYAGNPANLKDIENNPNYSFVK
CCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEHEEECCCCCCCCCCCCCCCEEEEE
GDICDPVVVNEVIKTADQVVHFAAESHVDRSIEDGSVFVRTNVLGTNTLLQSALANKIKK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
FIHVSTDEVYGSTMEGSFTETDKLNPSSPYSSSKAGSDLLAMSYHTTYGLPVCITRCTNN
HHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHCCC
FGPYQYPEKLIPFFISRLMEGKKVPVYGTGMNIRDWIYVEDHCSAIDFVLHKGSAGEIYN
CCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEECCCCCCEEHHEECCCCCCEEE
IDGGNELTNLEITHRLLKMLGKDESSIEYVEDRKGHDFRYSLDGSKLEKMGWKPRYDFDT
CCCCCCEEHHHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEECCCHHHHHCCCCCCCCHHH
ALEKTVSWYVENKWWWEPLKR
HHHHHHHHHCCCCEEHHHCCC
>Mature Secondary Structure 
TQLKLLVTGGCGFIGSNFIRYMLKKYPDYQIVNLDKLTYAGNPANLKDIENNPNYSFVK
CEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEHEEECCCCCCCCCCCCCCCEEEEE
GDICDPVVVNEVIKTADQVVHFAAESHVDRSIEDGSVFVRTNVLGTNTLLQSALANKIKK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
FIHVSTDEVYGSTMEGSFTETDKLNPSSPYSSSKAGSDLLAMSYHTTYGLPVCITRCTNN
HHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHCCC
FGPYQYPEKLIPFFISRLMEGKKVPVYGTGMNIRDWIYVEDHCSAIDFVLHKGSAGEIYN
CCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEECCCCCCEEHHEECCCCCCEEE
IDGGNELTNLEITHRLLKMLGKDESSIEYVEDRKGHDFRYSLDGSKLEKMGWKPRYDFDT
CCCCCCEEHHHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEECCCHHHHHCCCCCCCCHHH
ALEKTVSWYVENKWWWEPLKR
HHHHHHHHHCCCCEEHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1661369 [H]