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The map label for this gene is purL [H]

Identifier: 21226962

GI number: 21226962

Start: 1014013

End: 1016007

Strand: Direct

Name: purL [H]

Synonym: MM_0860

Alternate gene names: 21226962

Gene position: 1014013-1016007 (Clockwise)

Preceding gene: 21226961

Following gene: 21226963

Centisome position: 24.75

GC content: 49.67

Gene sequence:

>1995_bases
GTGATTATCGGTCCCGGAGACGATGCTGCAATCATCAAATTCGAAGACGGATATGTGCTTGCTATAGGAATGGAAAGCCA
CAACCACCCTTCATATGTGGACCCGTATAACGGGGCAGCTACCGGTGTGGGAGGCATTGTAAGAGACATAATTTCCATGG
GAGCCCGCCCAATAGCCCTTATGGACCCGCTCTACTTCGGGCCTCTGGACACCCCTAAAAACCTTTTCCTTTTCGAGCAG
ATAATAAAAGGAATCGCAGGATACGGGAACTGCATAGGAGTGCCCGTGGTTAATGGTGAGACCTTTTTTGACAGGAGATA
CAGCGGAAACCCGCTGGTAAACGTTGTTGCAGTCGGGCTCTGCAAAGAAGAAAAAGTTATGACTTCCCGCTCCCAGAAAG
CAGGAAACAAGCTCATTCTTGCAGGTTCAAGCACGGGAAAAGACGGGCTGGGTGGAGCTTCCTTTGCTTCCAGAGACCTC
TCGGAATCAGCCGAAGCCGAAGATCGCCCAAGCGTCCAGGTAGGAGACCCCTATACAGAAAAGCTTGTTATGGAAATGAC
CCTGGAAGCCATAGATAAAGGGTACATAAAGTCCTGCAAAGACCTCGGAGCTGCAGGGCTTGGGGGAGCGAGTTCGGAAC
TGGCTGCTAAAGGAGGACTGGGAGCCTATATTATTGCAGACGCAGTCCCGCAGCGCGAACCCGAAATGAATGCTTATGAG
ATCCTGCTTGCCGAATCTCAGGAACGTATGGTCTTTGAGGTAGCCCCTGAAGATGTGGATGCAGTCCTTGCCCTTGTGCA
GAAATATGATCTGAACGGGGCTGTGATCGGGCACCTCACAGAAAAGCCCAATTACACTGTTGAGTTCAGAGGCGAAATCG
TGGCTGACATCCCTATAGGTTTCCTTACGGGAGGAGCCCCGACCTGTGAAAAGCCTTCAGAGGCTCCCATACACAGGGAA
GAAGGCAAAAAGCCGGAAACCCCTGAGGACCTGAAAGCAGCTTTCATGAAAGTCCTGTCTTCACACAACATTGCCTCAAA
GGAATGGATCTACAGGCAGTATGACCATGAAGTCCAGCTAAGGACAGTTGTCAAACCAGGAGAAGATTCCGGAGTGCTCA
GAATTACAGATAAAAAAGGAATTGCACTTTCCTGCGGCTGCCAGCCCAGAGCAACTCTTCTTGACCCCTATACAGGAGGA
AGAACTGCAATCATTGAAAACGCCATGAACCTTGCAGTAAAAGGTGCTGAAGGGCTTGCCATTGTGAACTGCCTCAACTT
TGGAAACCCTGAAAACCCCGAAACCTACTGGCAGTTCAAAAACGCCGTACTCGGGCTCGGAGACGCAGCAAGGGAGCTTT
CAATCCCGGTTGTAGGAGGAAATGTTTCCCTTTATAATGAAAGCGATGAGTTCAGGACTGCAATCCCCCCAACCCCTTCA
ATAGGAATGATCGGAAAAGTTGACCTCGAAACGCCTCTCCCATCGGGCTTCTTTGCAAAAACCGGAGACAGCATTATACT
TGTAGGAGAAACAGTTCCTGAAATGGGAGGTTCGGAGTACTATTCCTGCATGGGAGCTGGCAATGCCGGAAAAGTACCTG
AGGTACCAAAAAACGCCCCTGAAATAATAAAAGCCGTAATTGAAGCTGTTAAGAGCGGAAAACTGAATTCTGCACACGAC
ATTTCCCTCGGAGGAATCGGTGCAGGGCTTGCAAGGATGTGCAAAAACATGGGCGGAAAAGTAGACGTTAGCGAGATTGC
TGGCGGGATGAAGGAAGACGAGTTCCTGTTCTCAGAAGCCCCCGCAAGGGCGCTGCTTGCAACAGCTGAACCGGAAGCCG
TCCAGGAACTCCTTAAAGGTGTGCCCCATGCCGTAATAGGCACGGTTGGTGGAGATGCCCTTGAGATAAAAGGTAAAGAT
TTCGAGCTCTTCATCTCTTTAGAAGAAATCAAAAATGCACATGAAAGCCTTACTAAATTTATGATGATGGGATGA

Upstream 100 bases:

>100_bases
CCCTTGTAGAACAGGGCTGTTTTTAAATCTGTGGAGTGAGCACTGCTCCTATCGATCAAGTGCCCCTCTCCTGAAAACCT
TTACAACCACGGGCGAAAAC

Downstream 100 bases:

>100_bases
TTAACCTCATCCCATTTCTTTTTTCTTTTCAGTTAAGTGTTCTTATCAGCCTGAAGGGCATCTTTTAATTCAATATATTT
TTTATTTTGTCATATCTTTT

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 664; Mature: 664

Protein sequence:

>664_residues
MIIGPGDDAAIIKFEDGYVLAIGMESHNHPSYVDPYNGAATGVGGIVRDIISMGARPIALMDPLYFGPLDTPKNLFLFEQ
IIKGIAGYGNCIGVPVVNGETFFDRRYSGNPLVNVVAVGLCKEEKVMTSRSQKAGNKLILAGSSTGKDGLGGASFASRDL
SESAEAEDRPSVQVGDPYTEKLVMEMTLEAIDKGYIKSCKDLGAAGLGGASSELAAKGGLGAYIIADAVPQREPEMNAYE
ILLAESQERMVFEVAPEDVDAVLALVQKYDLNGAVIGHLTEKPNYTVEFRGEIVADIPIGFLTGGAPTCEKPSEAPIHRE
EGKKPETPEDLKAAFMKVLSSHNIASKEWIYRQYDHEVQLRTVVKPGEDSGVLRITDKKGIALSCGCQPRATLLDPYTGG
RTAIIENAMNLAVKGAEGLAIVNCLNFGNPENPETYWQFKNAVLGLGDAARELSIPVVGGNVSLYNESDEFRTAIPPTPS
IGMIGKVDLETPLPSGFFAKTGDSIILVGETVPEMGGSEYYSCMGAGNAGKVPEVPKNAPEIIKAVIEAVKSGKLNSAHD
ISLGGIGAGLARMCKNMGGKVDVSEIAGGMKEDEFLFSEAPARALLATAEPEAVQELLKGVPHAVIGTVGGDALEIKGKD
FELFISLEEIKNAHESLTKFMMMG

Sequences:

>Translated_664_residues
MIIGPGDDAAIIKFEDGYVLAIGMESHNHPSYVDPYNGAATGVGGIVRDIISMGARPIALMDPLYFGPLDTPKNLFLFEQ
IIKGIAGYGNCIGVPVVNGETFFDRRYSGNPLVNVVAVGLCKEEKVMTSRSQKAGNKLILAGSSTGKDGLGGASFASRDL
SESAEAEDRPSVQVGDPYTEKLVMEMTLEAIDKGYIKSCKDLGAAGLGGASSELAAKGGLGAYIIADAVPQREPEMNAYE
ILLAESQERMVFEVAPEDVDAVLALVQKYDLNGAVIGHLTEKPNYTVEFRGEIVADIPIGFLTGGAPTCEKPSEAPIHRE
EGKKPETPEDLKAAFMKVLSSHNIASKEWIYRQYDHEVQLRTVVKPGEDSGVLRITDKKGIALSCGCQPRATLLDPYTGG
RTAIIENAMNLAVKGAEGLAIVNCLNFGNPENPETYWQFKNAVLGLGDAARELSIPVVGGNVSLYNESDEFRTAIPPTPS
IGMIGKVDLETPLPSGFFAKTGDSIILVGETVPEMGGSEYYSCMGAGNAGKVPEVPKNAPEIIKAVIEAVKSGKLNSAHD
ISLGGIGAGLARMCKNMGGKVDVSEIAGGMKEDEFLFSEAPARALLATAEPEAVQELLKGVPHAVIGTVGGDALEIKGKD
FELFISLEEIKNAHESLTKFMMMG
>Mature_664_residues
MIIGPGDDAAIIKFEDGYVLAIGMESHNHPSYVDPYNGAATGVGGIVRDIISMGARPIALMDPLYFGPLDTPKNLFLFEQ
IIKGIAGYGNCIGVPVVNGETFFDRRYSGNPLVNVVAVGLCKEEKVMTSRSQKAGNKLILAGSSTGKDGLGGASFASRDL
SESAEAEDRPSVQVGDPYTEKLVMEMTLEAIDKGYIKSCKDLGAAGLGGASSELAAKGGLGAYIIADAVPQREPEMNAYE
ILLAESQERMVFEVAPEDVDAVLALVQKYDLNGAVIGHLTEKPNYTVEFRGEIVADIPIGFLTGGAPTCEKPSEAPIHRE
EGKKPETPEDLKAAFMKVLSSHNIASKEWIYRQYDHEVQLRTVVKPGEDSGVLRITDKKGIALSCGCQPRATLLDPYTGG
RTAIIENAMNLAVKGAEGLAIVNCLNFGNPENPETYWQFKNAVLGLGDAARELSIPVVGGNVSLYNESDEFRTAIPPTPS
IGMIGKVDLETPLPSGFFAKTGDSIILVGETVPEMGGSEYYSCMGAGNAGKVPEVPKNAPEIIKAVIEAVKSGKLNSAHD
ISLGGIGAGLARMCKNMGGKVDVSEIAGGMKEDEFLFSEAPARALLATAEPEAVQELLKGVPHAVIGTVGGDALEIKGKD
FELFISLEEIKNAHESLTKFMMMG

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=693, Percent_Identity=24.0981240981241, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI48994899, Length=332, Percent_Identity=28.6144578313253, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17553022, Length=476, Percent_Identity=26.4705882352941, Blast_Score=86, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6321498, Length=625, Percent_Identity=25.12, Blast_Score=100, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 70407; Mature: 70407

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIGPGDDAAIIKFEDGYVLAIGMESHNHPSYVDPYNGAATGVGGIVRDIISMGARPIAL
CEECCCCCEEEEEECCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
MDPLYFGPLDTPKNLFLFEQIIKGIAGYGNCIGVPVVNGETFFDRRYSGNPLVNVVAVGL
ECCCEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCHHCCCCCCCCCEEEEEEEEC
CKEEKVMTSRSQKAGNKLILAGSSTGKDGLGGASFASRDLSESAEAEDRPSVQVGDPYTE
CCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEECCCHHH
KLVMEMTLEAIDKGYIKSCKDLGAAGLGGASSELAAKGGLGAYIIADAVPQREPEMNAYE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCCCCCCEEE
ILLAESQERMVFEVAPEDVDAVLALVQKYDLNGAVIGHLTEKPNYTVEFRGEIVADIPIG
EEEECCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCEEEECCEE
FLTGGAPTCEKPSEAPIHREEGKKPETPEDLKAAFMKVLSSHNIASKEWIYRQYDHEVQL
EECCCCCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEE
RTVVKPGEDSGVLRITDKKGIALSCGCQPRATLLDPYTGGRTAIIENAMNLAVKGAEGLA
EEEECCCCCCCEEEEECCCCEEEECCCCCCCEEECCCCCCCHHHHHHHHHHEEECCCCEE
IVNCLNFGNPENPETYWQFKNAVLGLGDAARELSIPVVGGNVSLYNESDEFRTAIPPTPS
EEEEECCCCCCCCHHHHHHHHHHEECCCCHHHEEEEEECCCEEEECCCCCCEECCCCCCC
IGMIGKVDLETPLPSGFFAKTGDSIILVGETVPEMGGSEYYSCMGAGNAGKVPEVPKNAP
CCCEEEEECCCCCCCCCEECCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCH
EIIKAVIEAVKSGKLNSAHDISLGGIGAGLARMCKNMGGKVDVSEIAGGMKEDEFLFSEA
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEHHHHCCCCCCCHHHHHCC
PARALLATAEPEAVQELLKGVPHAVIGTVGGDALEIKGKDFELFISLEEIKNAHESLTKF
CCHHEEECCCHHHHHHHHHCCCCEEEECCCCCEEEECCCCEEEEEEHHHHHHHHHHHHHH
MMMG
HHCC
>Mature Secondary Structure
MIIGPGDDAAIIKFEDGYVLAIGMESHNHPSYVDPYNGAATGVGGIVRDIISMGARPIAL
CEECCCCCEEEEEECCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
MDPLYFGPLDTPKNLFLFEQIIKGIAGYGNCIGVPVVNGETFFDRRYSGNPLVNVVAVGL
ECCCEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCHHCCCCCCCCCEEEEEEEEC
CKEEKVMTSRSQKAGNKLILAGSSTGKDGLGGASFASRDLSESAEAEDRPSVQVGDPYTE
CCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEECCCHHH
KLVMEMTLEAIDKGYIKSCKDLGAAGLGGASSELAAKGGLGAYIIADAVPQREPEMNAYE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCCCCCCEEE
ILLAESQERMVFEVAPEDVDAVLALVQKYDLNGAVIGHLTEKPNYTVEFRGEIVADIPIG
EEEECCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCEEEECCEE
FLTGGAPTCEKPSEAPIHREEGKKPETPEDLKAAFMKVLSSHNIASKEWIYRQYDHEVQL
EECCCCCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEE
RTVVKPGEDSGVLRITDKKGIALSCGCQPRATLLDPYTGGRTAIIENAMNLAVKGAEGLA
EEEECCCCCCCEEEEECCCCEEEECCCCCCCEEECCCCCCCHHHHHHHHHHEEECCCCEE
IVNCLNFGNPENPETYWQFKNAVLGLGDAARELSIPVVGGNVSLYNESDEFRTAIPPTPS
EEEEECCCCCCCCHHHHHHHHHHEECCCCHHHEEEEEECCCEEEECCCCCCEECCCCCCC
IGMIGKVDLETPLPSGFFAKTGDSIILVGETVPEMGGSEYYSCMGAGNAGKVPEVPKNAP
CCCEEEEECCCCCCCCCEECCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCH
EIIKAVIEAVKSGKLNSAHDISLGGIGAGLARMCKNMGGKVDVSEIAGGMKEDEFLFSEA
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEHHHHCCCCCCCHHHHHCC
PARALLATAEPEAVQELLKGVPHAVIGTVGGDALEIKGKDFELFISLEEIKNAHESLTKF
CCHHEEECCCHHHHHHHHHCCCCEEEECCCCCEEEECCCCEEEEEEHHHHHHHHHHHHHH
MMMG
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12125824 [H]