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The map label for this gene is phr [H]

Identifier: 21226954

GI number: 21226954

Start: 1005507

End: 1006901

Strand: Reverse

Name: phr [H]

Synonym: MM_0852

Alternate gene names: 21226954

Gene position: 1006901-1005507 (Counterclockwise)

Preceding gene: 21226955

Following gene: 21226953

Centisome position: 24.58

GC content: 44.73

Gene sequence:

>1395_bases
TTGATTATGAATCCGAAACGTATCAGGGCTCTTAAATCAGGGAAACAGGGGGACGGACCTGTTGTTTACTGGATGAGTCG
GGACCAGAGGGCTGAAGATAATTGGGCTCTTCTCTTTTCACGGGCAATAGCAAAAGAAGCTAATGTGCCTGTAGTAGTGG
TTTTTTGCCTGACGGATGAGTTTTTAGAGGCTGGTATCAGGCAGTATGAATTCATGCTCAAAGGGCTTCAGGAACTTGAG
GTTTCACTTTCCCGTAAAAAGATTCCGTCTTTCTTCCTGAGAGGGGATCCCGGAGAAAAAATTTCCCGGTTTGTAAAAGA
CTATAATGCCGGGACTCTTGTTACGGACTTCAGCCCGCTCCGCATAAAAAACCAGTGGATAGAAAAAGTTATTTCCGGCA
TTTCAATCCCGTTTTTTGAGGTTGACGCCCATAATGTTGTTCCCTGCTGGGAGGCTTCTCAAAAACATGAGTATGCAGCG
CATACTTTCCGCCCGAAACTCTATGCTCTTCTTCCAGAGTTTCTTGAAGAATTCCCTGAACTTGAGCCTAATTCTGTAAC
TCCCGAGCTTTCAGCCGGTGCCGGCATGGTGGAGACTTTATCGGACGTACTGGAAACCGGAGTTAAAGCCCTTCTTCCTG
AGAGAGCCTTACTTAAAAATAAGGATCCTCTTTTTGAACCTTGGCACTTCGAGCCCGGAGAAAAAGCTGCAAAAAAGGTA
ATGGAGAGTTTTATTGCAGACAGGCTTGATTCGTACGGGGCGCTGAGAAATGACCCGACAAAAAATATGCTTTCAAATCT
CTCGCCCTATCTTCATTTCGGGCAGATATCTTCCCAGAGGGTTGTGCTTGAAGTGGAAAAGGCAGAAAGTAACCCCGGGT
CAAAGAAAGCTTTTCTGGATGAGATTCTTATATGGAAGGAGATTTCGGACAATTTCTGTTATTATAACCCAGGATACGAT
GGGTTTGAAAGCTTTCCATCCTGGGCAAAGGAATCTTTAAACGCCCACAGGAATGATGTGAGGAGTCATATCTACACCCT
TGAAGAGTTCGAAGCAGGAAAAACACATGACCCACTCTGGAACGCGAGTCAGATGGAACTTCTCAGTACAGGGAAAATGC
ACGGTTACATGCGCATGTACTGGGCAAAAAAAATTCTGGAATGGAGCGAATCTCCCGAAAAAGCCCTTGAAATTGCAATC
TGCCTGAACGACAGGTATGAACTTGACGGAAGAGACCCCAATGGATATGCCGGAATTGCCTGGAGTATCGGAGGAGTCCA
TGACAGGGCATGGGGGGAGAGAGAAGTTACAGGAAAAATCAGATATATGAGTTATGAAGGCTGCAAAAGAAAATTTGACG
TTAAATTATATATTGAAAAATATTCAGCTTTGTAG

Upstream 100 bases:

>100_bases
GTCTCAGTTTAAGTCCCAGTTTAAGTCCCAGTTTAATTTTTAGTCTAAGTTTTCATTTTTACAGTTCAGGTGTTAGTTCT
TTATCTGCGGAGCCCCAGAA

Downstream 100 bases:

>100_bases
AATTCCCTGAGTTTATCCAGAGAGCCTTCATAACTTTTTTATTCGCAGTATACCATCAGATTTCAACTTTTATCTATATG
TCTCCAGGCTTACAAAAGTT

Product: deoxyribodipyrimidine photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MIMNPKRIRALKSGKQGDGPVVYWMSRDQRAEDNWALLFSRAIAKEANVPVVVVFCLTDEFLEAGIRQYEFMLKGLQELE
VSLSRKKIPSFFLRGDPGEKISRFVKDYNAGTLVTDFSPLRIKNQWIEKVISGISIPFFEVDAHNVVPCWEASQKHEYAA
HTFRPKLYALLPEFLEEFPELEPNSVTPELSAGAGMVETLSDVLETGVKALLPERALLKNKDPLFEPWHFEPGEKAAKKV
MESFIADRLDSYGALRNDPTKNMLSNLSPYLHFGQISSQRVVLEVEKAESNPGSKKAFLDEILIWKEISDNFCYYNPGYD
GFESFPSWAKESLNAHRNDVRSHIYTLEEFEAGKTHDPLWNASQMELLSTGKMHGYMRMYWAKKILEWSESPEKALEIAI
CLNDRYELDGRDPNGYAGIAWSIGGVHDRAWGEREVTGKIRYMSYEGCKRKFDVKLYIEKYSAL

Sequences:

>Translated_464_residues
MIMNPKRIRALKSGKQGDGPVVYWMSRDQRAEDNWALLFSRAIAKEANVPVVVVFCLTDEFLEAGIRQYEFMLKGLQELE
VSLSRKKIPSFFLRGDPGEKISRFVKDYNAGTLVTDFSPLRIKNQWIEKVISGISIPFFEVDAHNVVPCWEASQKHEYAA
HTFRPKLYALLPEFLEEFPELEPNSVTPELSAGAGMVETLSDVLETGVKALLPERALLKNKDPLFEPWHFEPGEKAAKKV
MESFIADRLDSYGALRNDPTKNMLSNLSPYLHFGQISSQRVVLEVEKAESNPGSKKAFLDEILIWKEISDNFCYYNPGYD
GFESFPSWAKESLNAHRNDVRSHIYTLEEFEAGKTHDPLWNASQMELLSTGKMHGYMRMYWAKKILEWSESPEKALEIAI
CLNDRYELDGRDPNGYAGIAWSIGGVHDRAWGEREVTGKIRYMSYEGCKRKFDVKLYIEKYSAL
>Mature_464_residues
MIMNPKRIRALKSGKQGDGPVVYWMSRDQRAEDNWALLFSRAIAKEANVPVVVVFCLTDEFLEAGIRQYEFMLKGLQELE
VSLSRKKIPSFFLRGDPGEKISRFVKDYNAGTLVTDFSPLRIKNQWIEKVISGISIPFFEVDAHNVVPCWEASQKHEYAA
HTFRPKLYALLPEFLEEFPELEPNSVTPELSAGAGMVETLSDVLETGVKALLPERALLKNKDPLFEPWHFEPGEKAAKKV
MESFIADRLDSYGALRNDPTKNMLSNLSPYLHFGQISSQRVVLEVEKAESNPGSKKAFLDEILIWKEISDNFCYYNPGYD
GFESFPSWAKESLNAHRNDVRSHIYTLEEFEAGKTHDPLWNASQMELLSTGKMHGYMRMYWAKKILEWSESPEKALEIAI
CLNDRYELDGRDPNGYAGIAWSIGGVHDRAWGEREVTGKIRYMSYEGCKRKFDVKLYIEKYSAL

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Drosophila melanogaster, GI24586398, Length=463, Percent_Identity=47.3002159827214, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24586396, Length=463, Percent_Identity=47.3002159827214, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24586404, Length=158, Percent_Identity=58.2278481012658, Blast_Score=216, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008148
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 53158; Mature: 53158

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMNPKRIRALKSGKQGDGPVVYWMSRDQRAEDNWALLFSRAIAKEANVPVVVVFCLTDE
CCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCHH
FLEAGIRQYEFMLKGLQELEVSLSRKKIPSFFLRGDPGEKISRFVKDYNAGTLVTDFSPL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCEEEECCCCH
RIKNQWIEKVISGISIPFFEVDAHNVVPCWEASQKHEYAAHTFRPKLYALLPEFLEEFPE
HHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHCCC
LEPNSVTPELSAGAGMVETLSDVLETGVKALLPERALLKNKDPLFEPWHFEPGEKAAKKV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHHH
MESFIADRLDSYGALRNDPTKNMLSNLSPYLHFGQISSQRVVLEVEKAESNPGSKKAFLD
HHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEECCCCCCEEEEEEECCCCCCCHHHHHHH
EILIWKEISDNFCYYNPGYDGFESFPSWAKESLNAHRNDVRSHIYTLEEFEAGKTHDPLW
HHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NASQMELLSTGKMHGYMRMYWAKKILEWSESPEKALEIAICLNDRYELDGRDPNGYAGIA
CCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHEEEEEEECCCEEECCCCCCCCEEEE
WSIGGVHDRAWGEREVTGKIRYMSYEGCKRKFDVKLYIEKYSAL
EECCCCCCCCCCCCCCCEEEEEEEHHCCCCCCCEEEEEEHHCCC
>Mature Secondary Structure
MIMNPKRIRALKSGKQGDGPVVYWMSRDQRAEDNWALLFSRAIAKEANVPVVVVFCLTDE
CCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCHH
FLEAGIRQYEFMLKGLQELEVSLSRKKIPSFFLRGDPGEKISRFVKDYNAGTLVTDFSPL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCEEEECCCCH
RIKNQWIEKVISGISIPFFEVDAHNVVPCWEASQKHEYAAHTFRPKLYALLPEFLEEFPE
HHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHCCC
LEPNSVTPELSAGAGMVETLSDVLETGVKALLPERALLKNKDPLFEPWHFEPGEKAAKKV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHHH
MESFIADRLDSYGALRNDPTKNMLSNLSPYLHFGQISSQRVVLEVEKAESNPGSKKAFLD
HHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEECCCCCCEEEEEEECCCCCCCHHHHHHH
EILIWKEISDNFCYYNPGYDGFESFPSWAKESLNAHRNDVRSHIYTLEEFEAGKTHDPLW
HHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NASQMELLSTGKMHGYMRMYWAKKILEWSESPEKALEIAICLNDRYELDGRDPNGYAGIA
CCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHEEEEEEECCCEEECCCCCCCCEEEE
WSIGGVHDRAWGEREVTGKIRYMSYEGCKRKFDVKLYIEKYSAL
EECCCCCCCCCCCCCCCEEEEEEEHHCCCCCCCEEEEEEHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2668276 [H]