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The map label for this gene is eif6

Identifier: 21226909

GI number: 21226909

Start: 958725

End: 959384

Strand: Direct

Name: eif6

Synonym: MM_0807

Alternate gene names: 21226909

Gene position: 958725-959384 (Clockwise)

Preceding gene: 21226908

Following gene: 21226910

Centisome position: 23.4

GC content: 47.73

Gene sequence:

>660_bases
ATGATTCGAACAGTGGATATCTACGATACCTCGATTATAGGGGTATTTGCAACCTGTACAGAAGATCTTGCTCTCGTTCC
TCCTCTTACAAAGCCGGAGGTCTGCACTATACTCGAAGAGGCTCTGGATGTAAGGGTAGTTGAAACTCTTATAAACGGAA
GCACTGTGGTAGGAGCCCTTTCAAGGGGCAACTCAAATGGGTTTTTACTTCCATACGGGTCCAGTGTCGAGGAGATGCAG
AAAAGGACAGGTGTTCCTGCAGGCATACTTCCGGACAGGCTGAATGCAGTTGGAAACATTGTGCTTGCAAACGACTCTGC
AGCCCTTGTTCACCCAGAGCTTTCAGACAGAGCTCTCGAAATTATCGCCAGAACCCTCAAGGTAGAGGTTTACAGGGGAA
CAATTGCCGGGATAAAGAATGTAGGGATGGCAGGAGTCGTTACAAATAAAGGGCTTCTTGTACACCCTAAAGTGACCGTT
TCGGAAAGAGAGGCTCTGGAAGAGATCTTCGGGCTTCCGGTAAATATAGGAACTACTAATTTCGGAACCCAGATGCTTGG
TTCAGGTCTGCTTGCAAATTCAAAGAACTTTGTAGCGGGCTCAGAGACAACAGGACCGGAACTCGGAAGAATTGAAGAAG
CCCTTGGGTTCCTGGAGTGA

Upstream 100 bases:

>100_bases
CCCCCTCTATCAATCAGGGTAAGGGCTGTCAAATTCGCAGATGGTGAAGTACAGGCAGAGCTTGCCCAGTAAATAACCGT
TAAAGCGAAAATCAAAGAAT

Downstream 100 bases:

>100_bases
GCATCATCATCCATCTGTTCCAGAAAAAAGTTACAGCAAGAGAGTGGTAATGATGAAGAGTTTTATTGTTAAAGGTAAAT
TTAAAGCAGGAAATTCCTGG

Product: translation initiation factor IF-6

Products: NA

Alternate protein names: aIF-6

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MIRTVDIYDTSIIGVFATCTEDLALVPPLTKPEVCTILEEALDVRVVETLINGSTVVGALSRGNSNGFLLPYGSSVEEMQ
KRTGVPAGILPDRLNAVGNIVLANDSAALVHPELSDRALEIIARTLKVEVYRGTIAGIKNVGMAGVVTNKGLLVHPKVTV
SEREALEEIFGLPVNIGTTNFGTQMLGSGLLANSKNFVAGSETTGPELGRIEEALGFLE

Sequences:

>Translated_219_residues
MIRTVDIYDTSIIGVFATCTEDLALVPPLTKPEVCTILEEALDVRVVETLINGSTVVGALSRGNSNGFLLPYGSSVEEMQ
KRTGVPAGILPDRLNAVGNIVLANDSAALVHPELSDRALEIIARTLKVEVYRGTIAGIKNVGMAGVVTNKGLLVHPKVTV
SEREALEEIFGLPVNIGTTNFGTQMLGSGLLANSKNFVAGSETTGPELGRIEEALGFLE
>Mature_219_residues
MIRTVDIYDTSIIGVFATCTEDLALVPPLTKPEVCTILEEALDVRVVETLINGSTVVGALSRGNSNGFLLPYGSSVEEMQ
KRTGVPAGILPDRLNAVGNIVLANDSAALVHPELSDRALEIIARTLKVEVYRGTIAGIKNVGMAGVVTNKGLLVHPKVTV
SEREALEEIFGLPVNIGTTNFGTQMLGSGLLANSKNFVAGSETTGPELGRIEEALGFLE

Specific function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex

COG id: COG1976

COG function: function code J; Translation initiation factor 6 (eIF-6)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-6 family

Homologues:

Organism=Homo sapiens, GI4504771, Length=214, Percent_Identity=33.6448598130841, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI31563378, Length=214, Percent_Identity=33.6448598130841, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI31563374, Length=100, Percent_Identity=36, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17506075, Length=219, Percent_Identity=31.0502283105023, Blast_Score=103, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6325273, Length=207, Percent_Identity=35.2657004830918, Blast_Score=123, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21492634, Length=219, Percent_Identity=35.1598173515982, Blast_Score=124, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF6_METMA (Q8PYQ3)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_632831.1
- ProteinModelPortal:   Q8PYQ3
- SMR:   Q8PYQ3
- GeneID:   1479149
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_0807
- NMPDR:   fig|192952.1.peg.807
- HOGENOM:   HBG589638
- OMA:   QFENSNE
- ProtClustDB:   PRK04046
- BioCyc:   MMAZ192952:MM0807-MONOMER
- HAMAP:   MF_00032
- InterPro:   IPR002769
- PANTHER:   PTHR10784
- PIRSF:   PIRSF006413
- SMART:   SM00654
- TIGRFAMs:   TIGR00323

Pfam domain/function: PF01912 eIF-6

EC number: NA

Molecular weight: Translated: 23115; Mature: 23115

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRTVDIYDTSIIGVFATCTEDLALVPPLTKPEVCTILEEALDVRVVETLINGSTVVGAL
CCEEEEECCCHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEE
SRGNSNGFLLPYGSSVEEMQKRTGVPAGILPDRLNAVGNIVLANDSAALVHPELSDRALE
ECCCCCCEEEECCCCHHHHHHHCCCCCCCCHHHHHHHCCEEEECCCCEEECCCHHHHHHH
IIARTLKVEVYRGTIAGIKNVGMAGVVTNKGLLVHPKVTVSEREALEEIFGLPVNIGTTN
HHHHHHHEEEEECHHHHHHHCCEEEEEECCCEEECCCCCHHHHHHHHHHHCCCEECCCCC
FGTQMLGSGLLANSKNFVAGSETTGPELGRIEEALGFLE
CCHHHHCCCCCCCCCCEECCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MIRTVDIYDTSIIGVFATCTEDLALVPPLTKPEVCTILEEALDVRVVETLINGSTVVGAL
CCEEEEECCCHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEE
SRGNSNGFLLPYGSSVEEMQKRTGVPAGILPDRLNAVGNIVLANDSAALVHPELSDRALE
ECCCCCCEEEECCCCHHHHHHHCCCCCCCCHHHHHHHCCEEEECCCCEEECCCHHHHHHH
IIARTLKVEVYRGTIAGIKNVGMAGVVTNKGLLVHPKVTVSEREALEEIFGLPVNIGTTN
HHHHHHHEEEEECHHHHHHHCCEEEEEECCCEEECCCCCHHHHHHHHHHHCCCEECCCCC
FGTQMLGSGLLANSKNFVAGSETTGPELGRIEEALGFLE
CCHHHHCCCCCCCCCCEECCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824