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The map label for this gene is gabT [C]

Identifier: 21226149

GI number: 21226149

Start: 61663

End: 63090

Strand: Reverse

Name: gabT [C]

Synonym: MM_0047

Alternate gene names: 21226149

Gene position: 63090-61663 (Counterclockwise)

Preceding gene: 21226150

Following gene: 21226145

Centisome position: 1.54

GC content: 49.65

Gene sequence:

>1428_bases
GTGGAAGGGGAGAGGTTTTTGAATCACAGGACTCCGGAAGAGCTTGAAAAATGGAAGAATACCGGCAAAACGGAAGGATC
AGAAGACTCAATGAAAGAACTGGAAACAGAATTCAATTCTTTTGAACAGGAAGTCGGGCTGCTCGATACTGTCGGCCCGA
AAGCCAGGGAGATAATAGGGCAGGACTGCAACATGGTGTCTGCATGTGTGTCCCGCCCCTATCCTCTGGTTGTTGACAGG
GCGAAAGGTTCCGTAGTCAGGGATATTGACGGAAAAGAGTACATAGATTTTGTTGCAGGGATTGCTGTCATGAACGCGGG
CTACTCAAATCCCGAGGTCCAAGCTGCAATTTCCGCACAGCTTGAAAAAATGGTCCACTGCGGATACGGGGACTTTTTTG
CCGAGCCCCCCCTGAAACTTGCAAAAAAGCTGAGGGATCTTTCTGGTTACTCAAAAGTCTTTTACTGTAACAGCGGAGCT
GAGTCTATAGAGGCTGCAATGAAACTTTCCCTCTGGAAAACAAAGCGCCAGAACTTTATCTCTTTTTACAATGCTTTTCA
CGGCCGGACACTCGGAGCCCTCTCCCTTACATGCTCTAAAGTCAGGCACAAAGAGCATTTCCCTACCATCCGTACCGTAC
ACACTGACTATGCCTACTGCTACCGCTGTCCTCTGAACCTCGATTATCCTTCCTGCGGGATCGAATGTGCAAAGCAGATT
GAAAACCTGGTTTTCCGGAGAGAGCTAAGCCCGGAAGACACTGCCGCAGTCTTTGTTGAACCGATCCAGGGAGAAGGAGG
ATATATAGTCCCTCCTGTAGAGTTTCATAAGGAGGTAAGGAGGATCTGTACGGATAACGATGTTCTTCTCGTGGCTGACG
AAGTCCAGACGGGCTGTTTCAGGACAGGTCCTTTCCTTGCCATGGAAAATTTTGAGGTAAGGGCTGACATTACCTGCCTT
GCAAAAGCCCTGGGTTCAGGTCTTCCCATAGGCGCAATGCTTGCAGACAATGAGCTCATGGACTGGCCTCCCGGAGTCCA
CTCAAATACCTTCGGAGGAAATCTCCTTTCCTCAGCCGCAGCCCTTGCTTCCCTTGAATTCCTGGAAAAAGAGAACACAG
AAAACCATGTCCGGGAAATGGGCGCTCATATCCGGCACCGCCTCAGGGAGCTTCAGGAAAATTTCCCCTGCATAGGAGAT
GTCAGGGGTCTCGGACTCATGACAGGCGTGGAAATCGTAAAACCGGATAAATCCATAGACCCTGTCAGGAGGGATAAAAT
AATCAGGGAGGCTTTTAAGGATGGAGTCCTGCTCCTTCCCTGCGGAGACTCCGTAATCCGTTTCTCTCCTCCCCTTGTTA
TGACTGACGAAGAAGCCGACCTCGGGCTCGATAAATTTGAAAAGGCACTGAAAAAAGCGGTGAGATGA

Upstream 100 bases:

>100_bases
AAGCTGGAACAGAGGCGATTAAAGAATTCACCGAGGTAAAAGCCGTATATATAGATTACAGCGGCAGGCTACAAAAAGCC
CAGATAGATACAGAATAAAA

Downstream 100 bases:

>100_bases
AGTTAAATTAGATGCAGTGAGATGAAGTTAAATAAAGATGCATCATGAAAGTGCGGTAAATGCAGTATATAATTTTTACA
TAACCTCATGCTGGCTACTT

Product: acetylornithine aminotransferase

Products: succinate semialdehyde; L-glutamate

Alternate protein names: ORF B [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MEGERFLNHRTPEELEKWKNTGKTEGSEDSMKELETEFNSFEQEVGLLDTVGPKAREIIGQDCNMVSACVSRPYPLVVDR
AKGSVVRDIDGKEYIDFVAGIAVMNAGYSNPEVQAAISAQLEKMVHCGYGDFFAEPPLKLAKKLRDLSGYSKVFYCNSGA
ESIEAAMKLSLWKTKRQNFISFYNAFHGRTLGALSLTCSKVRHKEHFPTIRTVHTDYAYCYRCPLNLDYPSCGIECAKQI
ENLVFRRELSPEDTAAVFVEPIQGEGGYIVPPVEFHKEVRRICTDNDVLLVADEVQTGCFRTGPFLAMENFEVRADITCL
AKALGSGLPIGAMLADNELMDWPPGVHSNTFGGNLLSSAAALASLEFLEKENTENHVREMGAHIRHRLRELQENFPCIGD
VRGLGLMTGVEIVKPDKSIDPVRRDKIIREAFKDGVLLLPCGDSVIRFSPPLVMTDEEADLGLDKFEKALKKAVR

Sequences:

>Translated_475_residues
MEGERFLNHRTPEELEKWKNTGKTEGSEDSMKELETEFNSFEQEVGLLDTVGPKAREIIGQDCNMVSACVSRPYPLVVDR
AKGSVVRDIDGKEYIDFVAGIAVMNAGYSNPEVQAAISAQLEKMVHCGYGDFFAEPPLKLAKKLRDLSGYSKVFYCNSGA
ESIEAAMKLSLWKTKRQNFISFYNAFHGRTLGALSLTCSKVRHKEHFPTIRTVHTDYAYCYRCPLNLDYPSCGIECAKQI
ENLVFRRELSPEDTAAVFVEPIQGEGGYIVPPVEFHKEVRRICTDNDVLLVADEVQTGCFRTGPFLAMENFEVRADITCL
AKALGSGLPIGAMLADNELMDWPPGVHSNTFGGNLLSSAAALASLEFLEKENTENHVREMGAHIRHRLRELQENFPCIGD
VRGLGLMTGVEIVKPDKSIDPVRRDKIIREAFKDGVLLLPCGDSVIRFSPPLVMTDEEADLGLDKFEKALKKAVR
>Mature_475_residues
MEGERFLNHRTPEELEKWKNTGKTEGSEDSMKELETEFNSFEQEVGLLDTVGPKAREIIGQDCNMVSACVSRPYPLVVDR
AKGSVVRDIDGKEYIDFVAGIAVMNAGYSNPEVQAAISAQLEKMVHCGYGDFFAEPPLKLAKKLRDLSGYSKVFYCNSGA
ESIEAAMKLSLWKTKRQNFISFYNAFHGRTLGALSLTCSKVRHKEHFPTIRTVHTDYAYCYRCPLNLDYPSCGIECAKQI
ENLVFRRELSPEDTAAVFVEPIQGEGGYIVPPVEFHKEVRRICTDNDVLLVADEVQTGCFRTGPFLAMENFEVRADITCL
AKALGSGLPIGAMLADNELMDWPPGVHSNTFGGNLLSSAAALASLEFLEKENTENHVREMGAHIRHRLRELQENFPCIGD
VRGLGLMTGVEIVKPDKSIDPVRRDKIIREAFKDGVLLLPCGDSVIRFSPPLVMTDEEADLGLDKFEKALKKAVR

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=397, Percent_Identity=32.4937027707809, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI13994255, Length=424, Percent_Identity=29.9528301886792, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI284507298, Length=312, Percent_Identity=34.6153846153846, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI24119277, Length=409, Percent_Identity=27.1393643031785, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI37574042, Length=440, Percent_Identity=25.2272727272727, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI226442705, Length=440, Percent_Identity=24.7727272727273, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI188536080, Length=463, Percent_Identity=26.5658747300216, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI38679950, Length=463, Percent_Identity=26.5658747300216, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI38679946, Length=463, Percent_Identity=26.5658747300216, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI226442709, Length=382, Percent_Identity=25.130890052356, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1789016, Length=432, Percent_Identity=33.7962962962963, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1788044, Length=412, Percent_Identity=35.9223300970874, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1787560, Length=404, Percent_Identity=34.9009900990099, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI145693181, Length=401, Percent_Identity=35.9102244389027, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1789759, Length=415, Percent_Identity=32.7710843373494, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1786991, Length=420, Percent_Identity=29.7619047619048, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1786349, Length=386, Percent_Identity=26.4248704663212, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI32564660, Length=425, Percent_Identity=28.7058823529412, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI25144271, Length=406, Percent_Identity=29.8029556650246, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71992977, Length=427, Percent_Identity=27.4004683840749, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI25144274, Length=292, Percent_Identity=31.8493150684932, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17541228, Length=462, Percent_Identity=25.5411255411255, Blast_Score=115, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6324432, Length=421, Percent_Identity=34.916864608076, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6323470, Length=430, Percent_Identity=32.5581395348837, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6324386, Length=431, Percent_Identity=27.6102088167053, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6321456, Length=448, Percent_Identity=27.0089285714286, Blast_Score=114, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21357415, Length=424, Percent_Identity=29.9528301886792, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI161085790, Length=429, Percent_Identity=31.002331002331, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI28574759, Length=432, Percent_Identity=30.5555555555556, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI21356575, Length=439, Percent_Identity=29.3849658314351, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI281366494, Length=493, Percent_Identity=26.9776876267748, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24667139, Length=493, Percent_Identity=26.9776876267748, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24667143, Length=493, Percent_Identity=26.9776876267748, Blast_Score=131, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.19

Molecular weight: Translated: 52928; Mature: 52928

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGERFLNHRTPEELEKWKNTGKTEGSEDSMKELETEFNSFEQEVGLLDTVGPKAREIIG
CCCCHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHC
QDCNMVSACVSRPYPLVVDRAKGSVVRDIDGKEYIDFVAGIAVMNAGYSNPEVQAAISAQ
CCCHHHHHHHCCCCCEEEECCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LEKMVHCGYGDFFAEPPLKLAKKLRDLSGYSKVFYCNSGAESIEAAMKLSLWKTKRQNFI
HHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
SFYNAFHGRTLGALSLTCSKVRHKEHFPTIRTVHTDYAYCYRCPLNLDYPSCGIECAKQI
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCCCCCCCHHHHHHHHH
ENLVFRRELSPEDTAAVFVEPIQGEGGYIVPPVEFHKEVRRICTDNDVLLVADEVQTGCF
HHHHHHHCCCCCCCEEEEEEEEECCCCEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCC
RTGPFLAMENFEVRADITCLAKALGSGLPIGAMLADNELMDWPPGVHSNTFGGNLLSSAA
CCCCEEEECCCEEHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
ALASLEFLEKENTENHVREMGAHIRHRLRELQENFPCIGDVRGLGLMTGVEIVKPDKSID
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHCCEEECCCCCCC
PVRRDKIIREAFKDGVLLLPCGDSVIRFSPPLVMTDEEADLGLDKFEKALKKAVR
HHHHHHHHHHHHHCCEEEEECCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MEGERFLNHRTPEELEKWKNTGKTEGSEDSMKELETEFNSFEQEVGLLDTVGPKAREIIG
CCCCHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHC
QDCNMVSACVSRPYPLVVDRAKGSVVRDIDGKEYIDFVAGIAVMNAGYSNPEVQAAISAQ
CCCHHHHHHHCCCCCEEEECCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LEKMVHCGYGDFFAEPPLKLAKKLRDLSGYSKVFYCNSGAESIEAAMKLSLWKTKRQNFI
HHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
SFYNAFHGRTLGALSLTCSKVRHKEHFPTIRTVHTDYAYCYRCPLNLDYPSCGIECAKQI
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCCCCCCCHHHHHHHHH
ENLVFRRELSPEDTAAVFVEPIQGEGGYIVPPVEFHKEVRRICTDNDVLLVADEVQTGCF
HHHHHHHCCCCCCCEEEEEEEEECCCCEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCC
RTGPFLAMENFEVRADITCLAKALGSGLPIGAMLADNELMDWPPGVHSNTFGGNLLSSAA
CCCCEEEECCCEEHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
ALASLEFLEKENTENHVREMGAHIRHRLRELQENFPCIGDVRGLGLMTGVEIVKPDKSID
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHCCEEECCCCCCC
PVRRDKIIREAFKDGVLLLPCGDSVIRFSPPLVMTDEEADLGLDKFEKALKKAVR
HHHHHHHHHHHHHCCEEEEECCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal 5'-phosphate lysine-residue [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 3.3 {4-aminobutanoate}} 1.1 {4-aminobutanoate}} 1.3 {2-oxoglutarate}} 0.7 {2-oxoglutarate}} [C]

Substrates: 4-aminobutanoate; 2-oxoglutarate

Specific reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: 2-Oxoglutarate; Lysyl reagents; SH-group reagents [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA