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The map label for this gene is ubiE [H]

Identifier: 21226119

GI number: 21226119

Start: 19760

End: 20581

Strand: Reverse

Name: ubiE [H]

Synonym: MM_0017

Alternate gene names: 21226119

Gene position: 20581-19760 (Counterclockwise)

Preceding gene: 21226121

Following gene: 21226117

Centisome position: 0.5

GC content: 47.08

Gene sequence:

>822_bases
ATGAGTAAAATTGACTGGGATTCTCCTGAAGGTGCCGAAAGGTATGACCGAAACTGTGATCACCAGTTCCAGAAAGGACA
TGTACTGATAGAAATGATGGGAATAAAGAAAGGCGATTTCGTGCTCGACGTTGGCTGTGGAACAGGGAGGCAGGCCCTGA
ATGTCGCTGGAATTATTGGACCGGCTGGCAAACTCACGGGGATCGACCCTTCTTCATATCGGATTGAGCTTGCACGAAAA
AAGTTTGAGGGAGATTCATCCGGCAATGTCCGTTTTCTGGTAAGACAGGCTGAGAATCTCCAAGACATACCGGATAACTC
GATAAACCATGCATATTTCTGCTCCTCATTCCACTGGGTTGATGATAAGAAAACTGCCCTTAATGAAATATTTCGGGTGC
TCCGGCCAGGAGGCAAGGTCGGCATGACAACACTTGACAGAAACAGCCCCAACACGATGAAGGCGCTGATAGACCCCATT
CTTGCAAAATTTGGCATTGAAAGGCGTCATGAATGGCACAGGGGTATGAAAAAAGTAACTGCGCCTGAACTCCACGATCT
GCTTTCAGGAGCCGGCTTTACCAGCATCTCAATAGAGCCAAGAGCTGTCCCACGGAAGTATAATTCTCCAGAAGAGTTTT
TGCAGCACCCGGAAGAGAAGGACAGCTCCAGGGGGATTTTAAGGGACATTTCCAACGAGACCCTGGAAAAGCTCAGACAG
GAAATTACTGAAGAATTCAGGAAAGCTCAGACTCCGGAAGACATTGGTTTTGGAAATATTACGCTGTTTGCAATCGCAAC
AAAAGCGCAAGAAGGGATTTAA

Upstream 100 bases:

>100_bases
AGTAAGAGAAACCTCAAGTTGGATTGATAATGATTTATCTCTGCCAGAATGTCTGTTAAGATTCAAGAAGGTGAACGAAA
ATGAGTAAAGGTGAACGAAA

Downstream 100 bases:

>100_bases
AGGGATATAAAATAAATAACAGGGATTTCACCAGGTCTTTCACGGCTTAGAGATTATCCGAAAAGTAGTTACCTACTATA
ATTTTACAATATTCAATATT

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MSKIDWDSPEGAERYDRNCDHQFQKGHVLIEMMGIKKGDFVLDVGCGTGRQALNVAGIIGPAGKLTGIDPSSYRIELARK
KFEGDSSGNVRFLVRQAENLQDIPDNSINHAYFCSSFHWVDDKKTALNEIFRVLRPGGKVGMTTLDRNSPNTMKALIDPI
LAKFGIERRHEWHRGMKKVTAPELHDLLSGAGFTSISIEPRAVPRKYNSPEEFLQHPEEKDSSRGILRDISNETLEKLRQ
EITEEFRKAQTPEDIGFGNITLFAIATKAQEGI

Sequences:

>Translated_273_residues
MSKIDWDSPEGAERYDRNCDHQFQKGHVLIEMMGIKKGDFVLDVGCGTGRQALNVAGIIGPAGKLTGIDPSSYRIELARK
KFEGDSSGNVRFLVRQAENLQDIPDNSINHAYFCSSFHWVDDKKTALNEIFRVLRPGGKVGMTTLDRNSPNTMKALIDPI
LAKFGIERRHEWHRGMKKVTAPELHDLLSGAGFTSISIEPRAVPRKYNSPEEFLQHPEEKDSSRGILRDISNETLEKLRQ
EITEEFRKAQTPEDIGFGNITLFAIATKAQEGI
>Mature_272_residues
SKIDWDSPEGAERYDRNCDHQFQKGHVLIEMMGIKKGDFVLDVGCGTGRQALNVAGIIGPAGKLTGIDPSSYRIELARKK
FEGDSSGNVRFLVRQAENLQDIPDNSINHAYFCSSFHWVDDKKTALNEIFRVLRPGGKVGMTTLDRNSPNTMKALIDPIL
AKFGIERRHEWHRGMKKVTAPELHDLLSGAGFTSISIEPRAVPRKYNSPEEFLQHPEEKDSSRGILRDISNETLEKLRQE
ITEEFRKAQTPEDIGFGNITLFAIATKAQEGI

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014122
- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 30652; Mature: 30521

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIDWDSPEGAERYDRNCDHQFQKGHVLIEMMGIKKGDFVLDVGCGTGRQALNVAGIIG
CCCCCCCCCCCHHHHCCCCCCHHHCCCEEEEEECCCCCCEEEEECCCCCHHHHHHHEEEC
PAGKLTGIDPSSYRIELARKKFEGDSSGNVRFLVRQAENLQDIPDNSINHAYFCSSFHWV
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECHHCHHCCCCCCCCCEEEECCEEEC
DDKKTALNEIFRVLRPGGKVGMTTLDRNSPNTMKALIDPILAKFGIERRHEWHRGMKKVT
CCHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCC
APELHDLLSGAGFTSISIEPRAVPRKYNSPEEFLQHPEEKDSSRGILRDISNETLEKLRQ
CHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
EITEEFRKAQTPEDIGFGNITLFAIATKAQEGI
HHHHHHHHCCCCCCCCCCCEEEEEEECHHCCCC
>Mature Secondary Structure 
SKIDWDSPEGAERYDRNCDHQFQKGHVLIEMMGIKKGDFVLDVGCGTGRQALNVAGIIG
CCCCCCCCCCHHHHCCCCCCHHHCCCEEEEEECCCCCCEEEEECCCCCHHHHHHHEEEC
PAGKLTGIDPSSYRIELARKKFEGDSSGNVRFLVRQAENLQDIPDNSINHAYFCSSFHWV
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECHHCHHCCCCCCCCCEEEECCEEEC
DDKKTALNEIFRVLRPGGKVGMTTLDRNSPNTMKALIDPILAKFGIERRHEWHRGMKKVT
CCHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCC
APELHDLLSGAGFTSISIEPRAVPRKYNSPEEFLQHPEEKDSSRGILRDISNETLEKLRQ
CHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
EITEEFRKAQTPEDIGFGNITLFAIATKAQEGI
HHHHHHHHCCCCCCCCCCCEEEEEEECHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]