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The map label for this gene is mfnA [H]

Identifier: 212224861

GI number: 212224861

Start: 1575839

End: 1576990

Strand: Reverse

Name: mfnA [H]

Synonym: TON_1710

Alternate gene names: 212224861

Gene position: 1576990-1575839 (Counterclockwise)

Preceding gene: 212224862

Following gene: 212224859

Centisome position: 85.35

GC content: 53.73

Gene sequence:

>1152_bases
ATGTTCCCGAGGAAAGGCGCGAGCGAGGAAGAAGTTTTAGCAGAGCTGGAGGAGAAAACGGCGGAGGATTTAACCTTCGA
TTCCGGACGGATTTTAGGTTCAATGTGCACATATCCCCATCCCTTCGCTCGGAAGGTAATCTCCCTCTACATCGACAGAA
ACCTCGGCGACCCCGGCCTTCACGTCGGCAGTCAGAAGATTGAGGAAGAAGCCATCCAGATGCTCTCCAACCTTCTCGGC
CTTGAGAAGGGCTACGGGAACATAGTCTCCGGAGGAACTGAGGCCAACATCTTGGCCGTTAGAGCCTTCCGCAACCTCGC
CGACGTCGAAAAGCCGGAGCTAATCCTCCCAAGGAGCGCCCACTTCTCCTTCCTCAAGGCGAGCGAGATGCTCAGCGTCA
AGCTTGTCTGGGCCGAGCTTAAAGAGGACTACTCCGTCGATGTCAATGATGTCGAAAGAAAGATAACGGACAACACGATA
GGCATCGTTGGTATAGCCGGAACCACTGGTCTAGGAGTAGTTGACGACATTCCTGCCTTGAGTGACCTAGCCATTGACTA
CGGTCTTCCTCTGCACGTTGATGCAGCTTTTGGAGGCTTCGTCATACCCTTCGCAAAGGAGCTGGGTTATGACCTACCCG
ACTTCGACTTCAGGCTTAAAGGCGTTCAGAGCATAACCATAGACCCCCACAAGATGGGTATGGTGCCCATCCCGGCAGGT
GGGATAATATTCAGGAAGAAGAAGTTCCTAGAGGCCATAAGTGTTCCCGCCCCCTACTTGGCGGGAGGCAAAGTGTGGCA
GGCAACAATAACCGGAACACGGCCTGGAGCAAACGCTCTGGCTGTGTGGGCCATGATAAAGCACCTCGGCTTCGAGGGCT
ACAAGGAGGTAGTGAAGGGGGCAATGGAGCTGAGCAGATGGTTCGCGGGAGAGCTGAAAAAGATACCCGGCGTTTACCTC
ATCAGGGAGCCCATGCTCAACATAGTCTCCTTTGGCACAACGAACCTGGAAGAAGTCGAGGAGAAGCTCAAAAGGCGCGG
CTGGGGAATAAGCGCCCATCGTGGTTACATTAGGATCGTCATGATGCCCCACGTTAGAAGAGAACACCTAGAGGAGTTTC
TAAGGGATCTGCAGGAAATCATCACTCGGTGA

Upstream 100 bases:

>100_bases
ATGATGACAGCCTTAACGACGCCGCTGTTCTTTAAGACCTACATCAAAAGGGCAAAAGCTTAAATTGAGGGGTGTGGAGT
AGTGCCAGGCTGGTGAGACC

Downstream 100 bases:

>100_bases
CTCCCTTTATGTCCACGTGAACGAAGGCCCTGTCAACGTCCTCTATCTCCTCGATGCGCTCCCTCACTTCTTCGCTGATG
TCATGAGCTTCCTTCAGCGT

Product: L-tyrosine decarboxylase

Products: NA

Alternate protein names: TDC [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MFPRKGASEEEVLAELEEKTAEDLTFDSGRILGSMCTYPHPFARKVISLYIDRNLGDPGLHVGSQKIEEEAIQMLSNLLG
LEKGYGNIVSGGTEANILAVRAFRNLADVEKPELILPRSAHFSFLKASEMLSVKLVWAELKEDYSVDVNDVERKITDNTI
GIVGIAGTTGLGVVDDIPALSDLAIDYGLPLHVDAAFGGFVIPFAKELGYDLPDFDFRLKGVQSITIDPHKMGMVPIPAG
GIIFRKKKFLEAISVPAPYLAGGKVWQATITGTRPGANALAVWAMIKHLGFEGYKEVVKGAMELSRWFAGELKKIPGVYL
IREPMLNIVSFGTTNLEEVEEKLKRRGWGISAHRGYIRIVMMPHVRREHLEEFLRDLQEIITR

Sequences:

>Translated_383_residues
MFPRKGASEEEVLAELEEKTAEDLTFDSGRILGSMCTYPHPFARKVISLYIDRNLGDPGLHVGSQKIEEEAIQMLSNLLG
LEKGYGNIVSGGTEANILAVRAFRNLADVEKPELILPRSAHFSFLKASEMLSVKLVWAELKEDYSVDVNDVERKITDNTI
GIVGIAGTTGLGVVDDIPALSDLAIDYGLPLHVDAAFGGFVIPFAKELGYDLPDFDFRLKGVQSITIDPHKMGMVPIPAG
GIIFRKKKFLEAISVPAPYLAGGKVWQATITGTRPGANALAVWAMIKHLGFEGYKEVVKGAMELSRWFAGELKKIPGVYL
IREPMLNIVSFGTTNLEEVEEKLKRRGWGISAHRGYIRIVMMPHVRREHLEEFLRDLQEIITR
>Mature_383_residues
MFPRKGASEEEVLAELEEKTAEDLTFDSGRILGSMCTYPHPFARKVISLYIDRNLGDPGLHVGSQKIEEEAIQMLSNLLG
LEKGYGNIVSGGTEANILAVRAFRNLADVEKPELILPRSAHFSFLKASEMLSVKLVWAELKEDYSVDVNDVERKITDNTI
GIVGIAGTTGLGVVDDIPALSDLAIDYGLPLHVDAAFGGFVIPFAKELGYDLPDFDFRLKGVQSITIDPHKMGMVPIPAG
GIIFRKKKFLEAISVPAPYLAGGKVWQATITGTRPGANALAVWAMIKHLGFEGYKEVVKGAMELSRWFAGELKKIPGVYL
IREPMLNIVSFGTTNLEEVEEKLKRRGWGISAHRGYIRIVMMPHVRREHLEEFLRDLQEIITR

Specific function: Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine [H]

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31982936, Length=395, Percent_Identity=31.6455696202532, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI194294551, Length=331, Percent_Identity=26.5861027190332, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1789934, Length=371, Percent_Identity=24.5283018867925, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787769, Length=371, Percent_Identity=24.5283018867925, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17543922, Length=388, Percent_Identity=31.4432989690722, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17557272, Length=335, Percent_Identity=31.3432835820896, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25148342, Length=333, Percent_Identity=31.2312312312312, Blast_Score=149, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6320500, Length=352, Percent_Identity=31.8181818181818, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6323905, Length=311, Percent_Identity=24.7588424437299, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355963, Length=365, Percent_Identity=30.1369863013699, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24654344, Length=365, Percent_Identity=30.1369863013699, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI21356415, Length=276, Percent_Identity=27.8985507246377, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: 3820 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115
- InterPro:   IPR020931 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.25 [H]

Molecular weight: Translated: 42432; Mature: 42432

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPRKGASEEEVLAELEEKTAEDLTFDSGRILGSMCTYPHPFARKVISLYIDRNLGDPGL
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCC
HVGSQKIEEEAIQMLSNLLGLEKGYGNIVSGGTEANILAVRAFRNLADVEKPELILPRSA
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEECCCCC
HFSFLKASEMLSVKLVWAELKEDYSVDVNDVERKITDNTIGIVGIAGTTGLGVVDDIPAL
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCHHCCCCH
SDLAIDYGLPLHVDAAFGGFVIPFAKELGYDLPDFDFRLKGVQSITIDPHKMGMVPIPAG
HHHHHHCCCCEEEECCCCCCHHHHHHHCCCCCCCCCEEECCCEEEEECHHHCCEEECCCC
GIIFRKKKFLEAISVPAPYLAGGKVWQATITGTRPGANALAVWAMIKHLGFEGYKEVVKG
CEEHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHH
AMELSRWFAGELKKIPGVYLIREPMLNIVSFGTTNLEEVEEKLKRRGWGISAHRGYIRIV
HHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEEE
MMPHVRREHLEEFLRDLQEIITR
ECCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFPRKGASEEEVLAELEEKTAEDLTFDSGRILGSMCTYPHPFARKVISLYIDRNLGDPGL
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCC
HVGSQKIEEEAIQMLSNLLGLEKGYGNIVSGGTEANILAVRAFRNLADVEKPELILPRSA
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEECCCCC
HFSFLKASEMLSVKLVWAELKEDYSVDVNDVERKITDNTIGIVGIAGTTGLGVVDDIPAL
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCHHCCCCH
SDLAIDYGLPLHVDAAFGGFVIPFAKELGYDLPDFDFRLKGVQSITIDPHKMGMVPIPAG
HHHHHHCCCCEEEECCCCCCHHHHHHHCCCCCCCCCEEECCCEEEEECHHHCCEEECCCC
GIIFRKKKFLEAISVPAPYLAGGKVWQATITGTRPGANALAVWAMIKHLGFEGYKEVVKG
CEEHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHH
AMELSRWFAGELKKIPGVYLIREPMLNIVSFGTTNLEEVEEKLKRRGWGISAHRGYIRIV
HHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEEE
MMPHVRREHLEEFLRDLQEIITR
ECCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA