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The map label for this gene is proC [H]

Identifier: 212224278

GI number: 212224278

Start: 1038640

End: 1039023

Strand: Reverse

Name: proC [H]

Synonym: TON_1129

Alternate gene names: 212224278

Gene position: 1039023-1038640 (Counterclockwise)

Preceding gene: 212224292

Following gene: 212224276

Centisome position: 56.24

GC content: 56.51

Gene sequence:

>384_bases
ATGCCCAACATAGCCGTTCTCGTCAAGGAGTCTTTTACGGCATACGCCATCGACCTAAAGGGTGACGACCTGAAAACCGT
TGAGAACCTATTTCCTGCCTTTGGAGAGTGCATAAAGGTTGGGGAGGAGCACATGGACGCCATAATGGGACTCGATGGTT
TCGGACAGGCCTACGTGACGGTGTTCCTTGAGGCGATGGTCTACGGCCGCTTAAGGGTTGGTCTGCCGAGGGAAATTGCC
TGGCTCGCCGTCCTCCAGACCCTCCTCGAGACGACGAAGCTCCTCATGGAGACGGACAGACATCCGGCCGAGGTGAAGGG
AGGGGATGATAACCCCGCTGGGACTACGATAGACGGCGTCTTTGAGCTCGAGGAAGAAGGGTGA

Upstream 100 bases:

>100_bases
TGGGGAAAAGCTCGACGGAAAGCTGCTGATATTGCTGGCCGCTGGCATAGGGCTCGAATACATAGAGAGAAAAGTTCCGA
AGGCTAAGGTGGTCAGGGCG

Downstream 100 bases:

>100_bases
GGATGGCGGTGGTGAAGGCCATAGACGCGGCGACCAGAAAGTCGAGGATACTCTCGAAAAGGCCTAAAATCCGTTGAAGC
TCACAACCTCTTCAAGCTTT

Product: P5CR

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 127; Mature: 126

Protein sequence:

>127_residues
MPNIAVLVKESFTAYAIDLKGDDLKTVENLFPAFGECIKVGEEHMDAIMGLDGFGQAYVTVFLEAMVYGRLRVGLPREIA
WLAVLQTLLETTKLLMETDRHPAEVKGGDDNPAGTTIDGVFELEEEG

Sequences:

>Translated_127_residues
MPNIAVLVKESFTAYAIDLKGDDLKTVENLFPAFGECIKVGEEHMDAIMGLDGFGQAYVTVFLEAMVYGRLRVGLPREIA
WLAVLQTLLETTKLLMETDRHPAEVKGGDDNPAGTTIDGVFELEEEG
>Mature_126_residues
PNIAVLVKESFTAYAIDLKGDDLKTVENLFPAFGECIKVGEEHMDAIMGLDGFGQAYVTVFLEAMVYGRLRVGLPREIAW
LAVLQTLLETTKLLMETDRHPAEVKGGDDNPAGTTIDGVFELEEEG

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=129, Percent_Identity=34.8837209302326, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI24797097, Length=129, Percent_Identity=35.6589147286822, Blast_Score=83, Evalue=5e-17,
Organism=Homo sapiens, GI24797095, Length=129, Percent_Identity=35.6589147286822, Blast_Score=83, Evalue=6e-17,
Organism=Homo sapiens, GI21361454, Length=129, Percent_Identity=35.6589147286822, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1786585, Length=129, Percent_Identity=34.1085271317829, Blast_Score=77, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17569021, Length=129, Percent_Identity=35.6589147286822, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320861, Length=117, Percent_Identity=29.0598290598291, Blast_Score=64, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24648116, Length=127, Percent_Identity=35.4330708661417, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24647700, Length=129, Percent_Identity=31.0077519379845, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21358587, Length=129, Percent_Identity=31.0077519379845, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 13919; Mature: 13788

Theoretical pI: Translated: 4.08; Mature: 4.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNIAVLVKESFTAYAIDLKGDDLKTVENLFPAFGECIKVGEEHMDAIMGLDGFGQAYVT
CCCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
VFLEAMVYGRLRVGLPREIAWLAVLQTLLETTKLLMETDRHPAEVKGGDDNPAGTTIDGV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCE
FELEEEG
EEECCCC
>Mature Secondary Structure 
PNIAVLVKESFTAYAIDLKGDDLKTVENLFPAFGECIKVGEEHMDAIMGLDGFGQAYVT
CCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
VFLEAMVYGRLRVGLPREIAWLAVLQTLLETTKLLMETDRHPAEVKGGDDNPAGTTIDGV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCE
FELEEEG
EEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]