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The map label for this gene is sbm [H]

Identifier: 212224225

GI number: 212224225

Start: 993251

End: 993691

Strand: Reverse

Name: sbm [H]

Synonym: TON_1076

Alternate gene names: 212224225

Gene position: 993691-993251 (Counterclockwise)

Preceding gene: 212224227

Following gene: 212224224

Centisome position: 53.78

GC content: 49.89

Gene sequence:

>441_bases
ATGGTCGAGCGCTCAAAGGTTAGGGTCGTTATCGCCAAGCCCGGTCTTGATGGCCATGATAGAGGCGCCAAGGTCGTTGC
GAGGGCGCTGAGAGATGCAGGGTATGAAGTCATTTACACGGGTATAAGACAGACTCCGGAACAGATAGTTGAGACAGTCA
TACAGGAAGATGCCGCCGTACTGGGAATAAGCATTCTCTCAGGTGCACATATGGTTCTAATACCTAAGATCCTCAAGCTC
CTTGAGGAAAGGGGTCTTAAGCTGAACGAGGATATCGTTGTTTTTGCCGGTGGAATAATCCCGCCCGACGATGCCGAGGA
ACTCAAAAAGATGGGTGTTGCGGAAGTGTTTGGACCGGGGACGCCGCTTCAGAAGACTATTGATTTCATTGATAGGGCCG
TAGAGAACCTCAAGCGCTTTAGGGAAGGCTTAACTTTATAA

Upstream 100 bases:

>100_bases
ATTAAAAAGACTTCTGGACAAAATATCCAATGTAAAGTCCAACCTTTAGTTTTGACAATCTTTAAATACTATCCGGAACA
AAATCCTTCCGGTGGTTGAA

Downstream 100 bases:

>100_bases
TTTCTTTCTTGGATAATTTGTCCGAGTGATGACGATGATAGACGACCTGATCGAACGCATGCTCCAGGGAGATAAGCGCG
CCACGGCCAGGCTGATAACC

Product: methylmalony-CoA mutase

Products: succinyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MVERSKVRVVIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPEQIVETVIQEDAAVLGISILSGAHMVLIPKILKL
LEERGLKLNEDIVVFAGGIIPPDDAEELKKMGVAEVFGPGTPLQKTIDFIDRAVENLKRFREGLTL

Sequences:

>Translated_146_residues
MVERSKVRVVIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPEQIVETVIQEDAAVLGISILSGAHMVLIPKILKL
LEERGLKLNEDIVVFAGGIIPPDDAEELKKMGVAEVFGPGTPLQKTIDFIDRAVENLKRFREGLTL
>Mature_146_residues
MVERSKVRVVIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPEQIVETVIQEDAAVLGISILSGAHMVLIPKILKL
LEERGLKLNEDIVVFAGGIIPPDDAEELKKMGVAEVFGPGTPLQKTIDFIDRAVENLKRFREGLTL

Specific function: Unknown

COG id: COG2185

COG function: function code I; Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=137, Percent_Identity=40.1459854014599, Blast_Score=103, Evalue=6e-23,
Organism=Escherichia coli, GI1789284, Length=120, Percent_Identity=45, Blast_Score=111, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25144500, Length=116, Percent_Identity=45.6896551724138, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: 5.4.99.2

Molecular weight: Translated: 15967; Mature: 15967

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVERSKVRVVIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPEQIVETVIQEDAAV
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHH
LGISILSGAHMVLIPKILKLLEERGLKLNEDIVVFAGGIIPPDDAEELKKMGVAEVFGPG
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHCCHHHHCCCC
TPLQKTIDFIDRAVENLKRFREGLTL
CCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVERSKVRVVIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPEQIVETVIQEDAAV
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHH
LGISILSGAHMVLIPKILKLLEERGLKLNEDIVVFAGGIIPPDDAEELKKMGVAEVFGPG
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHCCHHHHCCCC
TPLQKTIDFIDRAVENLKRFREGLTL
CCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-methylmalonyl-CoA

Specific reaction: (R)-methylmalonyl-CoA = succinyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1355087; 9278503 [H]