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The map label for this gene is tyrS [H]

Identifier: 212224130

GI number: 212224130

Start: 904321

End: 905448

Strand: Reverse

Name: tyrS [H]

Synonym: TON_0981

Alternate gene names: 212224130

Gene position: 905448-904321 (Counterclockwise)

Preceding gene: 212224138

Following gene: 212224129

Centisome position: 49.01

GC content: 52.93

Gene sequence:

>1128_bases
ATGGACATAGGGAGGAAGATAGAGCTGATAACCAAGAGGCCCACGGAGGAGCTACTGACCGTTGAGAACCTGAGACATCT
TTTGGAGATAGGTGCCCCAATGCAGCACTACATCGGCTTTGAAATAAGCGGTTACATTCACCTGGGAACTGGTTTGATGG
CTGGTGCCAAGATAGCAGATCTTCAGAAAGCGGGGATAAAGACGAGGATTTTCCTTGCTGACTGGCACAGCTGGATAAAC
GACAAGCTCGGCGGCGATTTGGAGATCATCCAGAAAGTCGCTCTGACGTACTTCAAGGAGGGTATGAAGCAGAGTATAAA
GGTCATGGGCGGCGATCCTGATAAGGTTGAATTCGTGCTAGCGAGTGAAATCCTTGAGAAGGGCGACTACTGGCAGACGG
TTATAGACATCTCCAAGAACGTTACCCTGGCGAGAATGATGCGCTCCATAACCATTATGGGCCGCCAGATGGGAGAGGCC
ATAGACTTTGCCAAGCTCATATACCCCGCTATGCAGGTGGCTGACATCTTCTACCAGGGCGTCACCATAGCACACGCCGG
AATGGATCAGAGGAAGGCTCATGTCATAGCTATTGAAGTCGCCCAGAAGCTTAAGTACCACGCAATAGAGCACAATGGTG
AGAAGCTGAAGCCCGTTGCTCTTCACCACCACCTCCTGCTCGGCCTTCAGGAGCCGCCGGTGTGGCCGATAGAGAGCGAG
GAGCAGTACAAGGAGCTCAAGACCCAGATGAAGATGAGCAAGAGCAAGCCTTATTCGGCCGTCTTCATCCACGACACTCC
CGAGGAGATCAAGCAGAAGCTCAGGAAGGCCTTCTGCCCGGCCAGGGAGGTTAAGTACAACCCCGTTCTTGACTGGGCTG
AGTACATCATCTTCCGCGAGGAGCCGACGGAGTTCACAATCCACAGGCCGGCCAAGTTTGGTGGCGATGTTACCTACACG
ACCTTTGAGGAGCTCAAGCGGGACTTCGCTGAAGGAAAGCTTCATCCGCTCGACCTCAAGAACGCAGTGGCTGAGTACCT
AATTGAGCTGCTCAAGCCGGTCAGAGACTACTTCGAGAAGCATCCAGAGCCTCTCGAACTCATGAGGGAGATAAAGATTA
CCCGCTGA

Upstream 100 bases:

>100_bases
GTGGAGAGTTATAAATCTTATGAATCGGAACTTTAACAGGCCTGAAAAACTTCCGTAAAGTCCTTAAAGGCTTAGGATAT
TCTGGCTTTAGGTGGTGAGC

Downstream 100 bases:

>100_bases
CTCCCTTTTTCTTTTGGTGAGTGACATGCCGGGGATAGACGAAAAGGATAAAGAAATTCTCAGAATCCTGAGGAAGGAGG
GTAGGATAACCCTCACAGAG

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MDIGRKIELITKRPTEELLTVENLRHLLEIGAPMQHYIGFEISGYIHLGTGLMAGAKIADLQKAGIKTRIFLADWHSWIN
DKLGGDLEIIQKVALTYFKEGMKQSIKVMGGDPDKVEFVLASEILEKGDYWQTVIDISKNVTLARMMRSITIMGRQMGEA
IDFAKLIYPAMQVADIFYQGVTIAHAGMDQRKAHVIAIEVAQKLKYHAIEHNGEKLKPVALHHHLLLGLQEPPVWPIESE
EQYKELKTQMKMSKSKPYSAVFIHDTPEEIKQKLRKAFCPAREVKYNPVLDWAEYIIFREEPTEFTIHRPAKFGGDVTYT
TFEELKRDFAEGKLHPLDLKNAVAEYLIELLKPVRDYFEKHPEPLELMREIKITR

Sequences:

>Translated_375_residues
MDIGRKIELITKRPTEELLTVENLRHLLEIGAPMQHYIGFEISGYIHLGTGLMAGAKIADLQKAGIKTRIFLADWHSWIN
DKLGGDLEIIQKVALTYFKEGMKQSIKVMGGDPDKVEFVLASEILEKGDYWQTVIDISKNVTLARMMRSITIMGRQMGEA
IDFAKLIYPAMQVADIFYQGVTIAHAGMDQRKAHVIAIEVAQKLKYHAIEHNGEKLKPVALHHHLLLGLQEPPVWPIESE
EQYKELKTQMKMSKSKPYSAVFIHDTPEEIKQKLRKAFCPAREVKYNPVLDWAEYIIFREEPTEFTIHRPAKFGGDVTYT
TFEELKRDFAEGKLHPLDLKNAVAEYLIELLKPVRDYFEKHPEPLELMREIKITR
>Mature_375_residues
MDIGRKIELITKRPTEELLTVENLRHLLEIGAPMQHYIGFEISGYIHLGTGLMAGAKIADLQKAGIKTRIFLADWHSWIN
DKLGGDLEIIQKVALTYFKEGMKQSIKVMGGDPDKVEFVLASEILEKGDYWQTVIDISKNVTLARMMRSITIMGRQMGEA
IDFAKLIYPAMQVADIFYQGVTIAHAGMDQRKAHVIAIEVAQKLKYHAIEHNGEKLKPVALHHHLLLGLQEPPVWPIESE
EQYKELKTQMKMSKSKPYSAVFIHDTPEEIKQKLRKAFCPAREVKYNPVLDWAEYIIFREEPTEFTIHRPAKFGGDVTYT
TFEELKRDFAEGKLHPLDLKNAVAEYLIELLKPVRDYFEKHPEPLELMREIKITR

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507947, Length=353, Percent_Identity=29.7450424929178, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71992775, Length=345, Percent_Identity=27.2463768115942, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321624, Length=371, Percent_Identity=30.188679245283, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21357223, Length=332, Percent_Identity=28.0120481927711, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002307
- InterPro:   IPR015624 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 43134; Mature: 43134

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIGRKIELITKRPTEELLTVENLRHLLEIGAPMQHYIGFEISGYIHLGTGLMAGAKIAD
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHCCEEEEEEEEECCCHHCCCHHHH
LQKAGIKTRIFLADWHSWINDKLGGDLEIIQKVALTYFKEGMKQSIKVMGGDPDKVEFVL
HHHCCCEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ASEILEKGDYWQTVIDISKNVTLARMMRSITIMGRQMGEAIDFAKLIYPAMQVADIFYQG
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VTIAHAGMDQRKAHVIAIEVAQKLKYHAIEHNGEKLKPVALHHHLLLGLQEPPVWPIESE
CCEEECCCCCCCHHEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCH
EQYKELKTQMKMSKSKPYSAVFIHDTPEEIKQKLRKAFCPAREVKYNPVLDWAEYIIFRE
HHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCHHHCCCCCHHHHHHHEEECC
EPTEFTIHRPAKFGGDVTYTTFEELKRDFAEGKLHPLDLKNAVAEYLIELLKPVRDYFEK
CCCCEEEECCHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
HPEPLELMREIKITR
CCCHHHHHHHHCCCC
>Mature Secondary Structure
MDIGRKIELITKRPTEELLTVENLRHLLEIGAPMQHYIGFEISGYIHLGTGLMAGAKIAD
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHCCEEEEEEEEECCCHHCCCHHHH
LQKAGIKTRIFLADWHSWINDKLGGDLEIIQKVALTYFKEGMKQSIKVMGGDPDKVEFVL
HHHCCCEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ASEILEKGDYWQTVIDISKNVTLARMMRSITIMGRQMGEAIDFAKLIYPAMQVADIFYQG
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VTIAHAGMDQRKAHVIAIEVAQKLKYHAIEHNGEKLKPVALHHHLLLGLQEPPVWPIESE
CCEEECCCCCCCHHEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCH
EQYKELKTQMKMSKSKPYSAVFIHDTPEEIKQKLRKAFCPAREVKYNPVLDWAEYIIFRE
HHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCHHHCCCCCHHHHHHHEEECC
EPTEFTIHRPAKFGGDVTYTTFEELKRDFAEGKLHPLDLKNAVAEYLIELLKPVRDYFEK
CCCCEEEECCHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
HPEPLELMREIKITR
CCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA