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The map label for this gene is mtaD [H]

Identifier: 212224109

GI number: 212224109

Start: 883181

End: 884443

Strand: Reverse

Name: mtaD [H]

Synonym: TON_0960

Alternate gene names: 212224109

Gene position: 884443-883181 (Counterclockwise)

Preceding gene: 212224111

Following gene: 212224106

Centisome position: 47.87

GC content: 54.08

Gene sequence:

>1263_bases
ATGTTTGCGCTCATTGGTACGGTGGTCGATGCTGAAAAGGTTCTGAAAAATCATGCAGTTTTGGTTGATGGAACCGAGGT
AATCAACGTTATTCCCAGAGATAAGCTTGGAGAATATGGAGTTGATGAAATCTACGGTGGAGAGGGTTATCTCGTTCTGC
CGGGTCTAGTTAACACCCACACCCACGTAGCCATGGCCAAACTCCGTGGACTCGGCGAGGATCTGCCAATAGAGCGCTGG
CTCAAGGAGGTAATCTGGCCCACTGAGCTCACCTGGACGCCCGAGGAAATCCGCCGCTGGGCGCTCCTTGGAATGGCGGA
GGCTTTAGCTAACGGCTCCACGACGATAAACGACCACTACTTCTTTGCCGATGAGATAGCCGGGACCGCTCGGGAGCTTG
GAATACGCGCCTTCATCGGCCAGACGGTGATGGACCTGGTGGACTTTCCCCTCGCGGAGCCTGAAAAGGGCTTCAAGTTC
TTCAAGCACTGGGAAGGAAAAGACGAACTCGTCAAACCCGCTTTAGCTCCCCACGCAACGAATACGGTCTCACTTGAGCT
CATGCGAGAAATCGGTGCCTTTGCCCGCGAGAGAAACGCTTTACTCCACGTCCATCTCTCCCAGAGCAGGGAGGAGGTCA
GGACCGTTAAGGAGCGCTACGGACTAACTCCCGTGGAATACCTTGCTGAGGCCGGCGTTCTCCATGAAAACCTCATTGGC
GTGCACGGGATATACCTGAGCGATGGGGAAGTTAAGCTCTACTCCCAAAGCGGAGCCACTCTCGTCCATTGCTCCCTCAG
TATGGCGAAGCTTGAGGCAAGGATAGCTCCGATAATTGAGCTTTACACCGCAGGGACGAACATAGCGCTGGGCAACGACT
CTCCGAACCCCGTTGGCGTTATGGACATGTTCACTGAAATGCGCTTTGCGGCAGTGCTTAACAAGGTCTGGAGAAAGAGA
ACGGACGTGGCCAGCACGAGGGAGGTTTTCAGCTGGGCCACCATTGGTGGAGCCAGCGCTCTGAAGCTTAAAGCCGGACT
GATAAAACCCGGCTACCTGGCTGACCTTGTGCTCATAAACGCGAGGAAACCCCAGTTCCTGCCCGGGGAGAACGTTTACT
CCCATCTCGTCTACTCCACAAGGGGAAGCGATGTAGAGCTTGTGATAGTGAACGGAGAGATAGTCTACAGAAACGGCGTA
TTCACGAAGCTTGGAAAAACGCTGGAAGAATTATGGGAAGAGCTCAGACCTTCCGAACGATGA

Upstream 100 bases:

>100_bases
CTACTTTTCCCTTTTCTGCATTTAAATCCTTTGGGCGATTTTATGTCGTTGTGTCAAAATTTTTAAGTATCCAGATGGCA
TATATTCAAAGGGTGATGGG

Downstream 100 bases:

>100_bases
GTTTGACACCATCAACGTTGATTACCTTGACGGTGTCCCCTATCTTCAGCCTATCCTCGCTGAGGGCTATCCACTTATCG
CCCTCGAGCTCGACGAGGTA

Product: metal-dependent amidohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MFALIGTVVDAEKVLKNHAVLVDGTEVINVIPRDKLGEYGVDEIYGGEGYLVLPGLVNTHTHVAMAKLRGLGEDLPIERW
LKEVIWPTELTWTPEEIRRWALLGMAEALANGSTTINDHYFFADEIAGTARELGIRAFIGQTVMDLVDFPLAEPEKGFKF
FKHWEGKDELVKPALAPHATNTVSLELMREIGAFARERNALLHVHLSQSREEVRTVKERYGLTPVEYLAEAGVLHENLIG
VHGIYLSDGEVKLYSQSGATLVHCSLSMAKLEARIAPIIELYTAGTNIALGNDSPNPVGVMDMFTEMRFAAVLNKVWRKR
TDVASTREVFSWATIGGASALKLKAGLIKPGYLADLVLINARKPQFLPGENVYSHLVYSTRGSDVELVIVNGEIVYRNGV
FTKLGKTLEELWEELRPSER

Sequences:

>Translated_420_residues
MFALIGTVVDAEKVLKNHAVLVDGTEVINVIPRDKLGEYGVDEIYGGEGYLVLPGLVNTHTHVAMAKLRGLGEDLPIERW
LKEVIWPTELTWTPEEIRRWALLGMAEALANGSTTINDHYFFADEIAGTARELGIRAFIGQTVMDLVDFPLAEPEKGFKF
FKHWEGKDELVKPALAPHATNTVSLELMREIGAFARERNALLHVHLSQSREEVRTVKERYGLTPVEYLAEAGVLHENLIG
VHGIYLSDGEVKLYSQSGATLVHCSLSMAKLEARIAPIIELYTAGTNIALGNDSPNPVGVMDMFTEMRFAAVLNKVWRKR
TDVASTREVFSWATIGGASALKLKAGLIKPGYLADLVLINARKPQFLPGENVYSHLVYSTRGSDVELVIVNGEIVYRNGV
FTKLGKTLEELWEELRPSER
>Mature_420_residues
MFALIGTVVDAEKVLKNHAVLVDGTEVINVIPRDKLGEYGVDEIYGGEGYLVLPGLVNTHTHVAMAKLRGLGEDLPIERW
LKEVIWPTELTWTPEEIRRWALLGMAEALANGSTTINDHYFFADEIAGTARELGIRAFIGQTVMDLVDFPLAEPEKGFKF
FKHWEGKDELVKPALAPHATNTVSLELMREIGAFARERNALLHVHLSQSREEVRTVKERYGLTPVEYLAEAGVLHENLIG
VHGIYLSDGEVKLYSQSGATLVHCSLSMAKLEARIAPIIELYTAGTNIALGNDSPNPVGVMDMFTEMRFAAVLNKVWRKR
TDVASTREVFSWATIGGASALKLKAGLIKPGYLADLVLINARKPQFLPGENVYSHLVYSTRGSDVELVIVNGEIVYRNGV
FTKLGKTLEELWEELRPSER

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=350, Percent_Identity=29.7142857142857, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI87082177, Length=409, Percent_Identity=25.4278728606357, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1789249, Length=378, Percent_Identity=25.6613756613757, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17540282, Length=414, Percent_Identity=23.9130434782609, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6319963, Length=356, Percent_Identity=25, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24643849, Length=333, Percent_Identity=26.1261261261261, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 46618; Mature: 46618

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFALIGTVVDAEKVLKNHAVLVDGTEVINVIPRDKLGEYGVDEIYGGEGYLVLPGLVNTH
CCEEEHHHHHHHHHHHCCEEEEECHHHEEECCCCCCCCCCCHHEECCCCEEECCCCCCCH
THVAMAKLRGLGEDLPIERWLKEVIWPTELTWTPEEIRRWALLGMAEALANGSTTINDHY
HHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCE
FFADEIAGTARELGIRAFIGQTVMDLVDFPLAEPEKGFKFFKHWEGKDELVKPALAPHAT
EEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHCCCCCCCCC
NTVSLELMREIGAFARERNALLHVHLSQSREEVRTVKERYGLTPVEYLAEAGVLHENLIG
CHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHCCE
VHGIYLSDGEVKLYSQSGATLVHCSLSMAKLEARIAPIIELYTAGTNIALGNDSPNPVGV
EEEEEEECCCEEEEECCCCEEEEECHHHHHHHHHHHHHHHEEECCCEEEECCCCCCCCHH
MDMFTEMRFAAVLNKVWRKRTDVASTREVFSWATIGGASALKLKAGLIKPGYLADLVLIN
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHEEEEEEE
ARKPQFLPGENVYSHLVYSTRGSDVELVIVNGEIVYRNGVFTKLGKTLEELWEELRPSER
CCCCCCCCCCHHHHHHEEECCCCCEEEEEECCEEEEECCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFALIGTVVDAEKVLKNHAVLVDGTEVINVIPRDKLGEYGVDEIYGGEGYLVLPGLVNTH
CCEEEHHHHHHHHHHHCCEEEEECHHHEEECCCCCCCCCCCHHEECCCCEEECCCCCCCH
THVAMAKLRGLGEDLPIERWLKEVIWPTELTWTPEEIRRWALLGMAEALANGSTTINDHY
HHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCE
FFADEIAGTARELGIRAFIGQTVMDLVDFPLAEPEKGFKFFKHWEGKDELVKPALAPHAT
EEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHCCCCCCCCC
NTVSLELMREIGAFARERNALLHVHLSQSREEVRTVKERYGLTPVEYLAEAGVLHENLIG
CHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHCCE
VHGIYLSDGEVKLYSQSGATLVHCSLSMAKLEARIAPIIELYTAGTNIALGNDSPNPVGV
EEEEEEECCCEEEEECCCCEEEEECHHHHHHHHHHHHHHHEEECCCEEEECCCCCCCCHH
MDMFTEMRFAAVLNKVWRKRTDVASTREVFSWATIGGASALKLKAGLIKPGYLADLVLIN
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHEEEEEEE
ARKPQFLPGENVYSHLVYSTRGSDVELVIVNGEIVYRNGVFTKLGKTLEELWEELRPSER
CCCCCCCCCCHHHHHHEEECCCCCEEEEEECCEEEEECCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA