Click here to switch to the map view.

The map label for this gene is gltP [H]

Identifier: 212224050

GI number: 212224050

Start: 831224

End: 832498

Strand: Reverse

Name: gltP [H]

Synonym: TON_0901

Alternate gene names: 212224050

Gene position: 832498-831224 (Counterclockwise)

Preceding gene: 212224051

Following gene: 212224049

Centisome position: 45.06

GC content: 53.96

Gene sequence:

>1275_bases
ATGGGAAGGGGGATATTGAGAACATATCTTGAAATTCCTGTGCTTTACAAGATCCTCGCTGGGCTCGTGCTGGGTGTTAT
CTTCGGTATGCTGCTTCCAGAGTATTCAGCAGCCCTAAAGCCGCTCGGAGACCTATTTGTGAGACTCCTGAAGATGCTAG
TGATGCCCATAATACTGTTCTCACTGATAGTTGGCGCCGCCAGTATCAATCCATCGCGGCTCGGAAGGGTTGGCGTCAAG
ATAATCCTCTATTACCTGGCCACATCGGCATTCGCAGTGTTCTTTGGCCTGCTGATGGGCAACCTCTTCAAGCCAGGAAC
TGGAATCGAGCTCGGAACAGGCTCTGGAAAGGCTATAGAGGCAGAGGCTCCGTCACTCGTCCAGACGCTCCTCAACATCG
TTCCGACCAACCCCTTCGCAGCCCTTTCAAGTGGCCAGGTTCTGCCTACGATATTCTTCGCCATAGTCTTTGGAATAGCC
ATCAGCTACCTCATGAACAGTGAAGATGAAAGGATCAGAAGCTCAGCTGAGACGCTCTTCAGAGTTATGGATGCCGCCGC
CGAGGCGATGTACAAGATAGTCGCCGGTGTCATGCAGTACGCTCCAATAGGTGTCTTTGCCCTGATTTACTACGTCATCG
GCCAGTTCGGCCCGAACGTCGCCGGACCACTCGTCAAGGTTGTCGTAGCGGTTTATCTTGGCCTCATCCTCCAGATACTC
TTGGTCTACGGCGTCCTGCTCAAGGTCTTCGGCATCGACCCGTTTAAGTTCCTTAAGAAGGCAAAGGACGCTATGATTAC
TGCCTTTGTTACTAGGAGCTCCAGCGGAACTTTACCCGTCACAATGCGCGTTGCCGAGGAGGAGATGGGCGTTGACAAGG
GCATATTCTCCTTCACCCTGCCCCTTGGCGCGACGATAAACATGGACGGAACTGCGCTCTACCAGGGTGTCACGGTGCTC
TTCGTTGCGAACGCAATAGGCCAGCCGCTGACACTTGAGCAGCAGCTCGTGGTCATCCTCACGGCTGTACTTGCCTCGAT
TGGAACCGCTGGCGTTCCGGGTGCGGGGGCTATAATGCTGGCCATGGTGCTCCAGAGCGTTGGCCTCGAACTCGTGGAGG
GAAGTCCTGTAGCTTTGGCTTATGCCATGATACTCGGAATCGACGCAATACTTGACATGGGCAGAACTATGGTAAACGTC
ACCGGCGATCTGGCTGGAACCACCATAGTCGCCAAGACCGAAGGCGAAATGGACTCTTCCAAGTGGACGAGCTGA

Upstream 100 bases:

>100_bases
TTCCACGATTTTCTGTCATATTGTCAACTTTTTTTGGTAAAAGTTAATATAATGTCGCTATTAATGCTATTTCGACGTCA
TTCTTAAAGAGGTGAAGCCA

Downstream 100 bases:

>100_bases
ACTCTTTGCTCCTTTCACTTTTTCTAGTTTTAGATGGCCTTTTATTCTGGCTTTTCTGAGATAAAGTTAAATACCCAGGG
GTCTAATGCTATCTACACAT

Product: proton/glutamate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MGRGILRTYLEIPVLYKILAGLVLGVIFGMLLPEYSAALKPLGDLFVRLLKMLVMPIILFSLIVGAASINPSRLGRVGVK
IILYYLATSAFAVFFGLLMGNLFKPGTGIELGTGSGKAIEAEAPSLVQTLLNIVPTNPFAALSSGQVLPTIFFAIVFGIA
ISYLMNSEDERIRSSAETLFRVMDAAAEAMYKIVAGVMQYAPIGVFALIYYVIGQFGPNVAGPLVKVVVAVYLGLILQIL
LVYGVLLKVFGIDPFKFLKKAKDAMITAFVTRSSSGTLPVTMRVAEEEMGVDKGIFSFTLPLGATINMDGTALYQGVTVL
FVANAIGQPLTLEQQLVVILTAVLASIGTAGVPGAGAIMLAMVLQSVGLELVEGSPVALAYAMILGIDAILDMGRTMVNV
TGDLAGTTIVAKTEGEMDSSKWTS

Sequences:

>Translated_424_residues
MGRGILRTYLEIPVLYKILAGLVLGVIFGMLLPEYSAALKPLGDLFVRLLKMLVMPIILFSLIVGAASINPSRLGRVGVK
IILYYLATSAFAVFFGLLMGNLFKPGTGIELGTGSGKAIEAEAPSLVQTLLNIVPTNPFAALSSGQVLPTIFFAIVFGIA
ISYLMNSEDERIRSSAETLFRVMDAAAEAMYKIVAGVMQYAPIGVFALIYYVIGQFGPNVAGPLVKVVVAVYLGLILQIL
LVYGVLLKVFGIDPFKFLKKAKDAMITAFVTRSSSGTLPVTMRVAEEEMGVDKGIFSFTLPLGATINMDGTALYQGVTVL
FVANAIGQPLTLEQQLVVILTAVLASIGTAGVPGAGAIMLAMVLQSVGLELVEGSPVALAYAMILGIDAILDMGRTMVNV
TGDLAGTTIVAKTEGEMDSSKWTS
>Mature_423_residues
GRGILRTYLEIPVLYKILAGLVLGVIFGMLLPEYSAALKPLGDLFVRLLKMLVMPIILFSLIVGAASINPSRLGRVGVKI
ILYYLATSAFAVFFGLLMGNLFKPGTGIELGTGSGKAIEAEAPSLVQTLLNIVPTNPFAALSSGQVLPTIFFAIVFGIAI
SYLMNSEDERIRSSAETLFRVMDAAAEAMYKIVAGVMQYAPIGVFALIYYVIGQFGPNVAGPLVKVVVAVYLGLILQILL
VYGVLLKVFGIDPFKFLKKAKDAMITAFVTRSSSGTLPVTMRVAEEEMGVDKGIFSFTLPLGATINMDGTALYQGVTVLF
VANAIGQPLTLEQQLVVILTAVLASIGTAGVPGAGAIMLAMVLQSVGLELVEGSPVALAYAMILGIDAILDMGRTMVNVT
GDLAGTTIVAKTEGEMDSSKWTS

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=453, Percent_Identity=30.242825607064, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI66773030, Length=472, Percent_Identity=31.1440677966102, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI21314632, Length=428, Percent_Identity=30.3738317757009, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI40254478, Length=480, Percent_Identity=30.4166666666667, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI5032093, Length=424, Percent_Identity=32.311320754717, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI4827012, Length=304, Percent_Identity=33.5526315789474, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI223468564, Length=279, Percent_Identity=34.4086021505376, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI223468566, Length=279, Percent_Identity=34.4086021505376, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI262359914, Length=431, Percent_Identity=27.1461716937355, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI194239697, Length=270, Percent_Identity=34.4444444444444, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI301601644, Length=195, Percent_Identity=36.9230769230769, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1790514, Length=427, Percent_Identity=34.6604215456674, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI1789947, Length=424, Percent_Identity=30.188679245283, Blast_Score=214, Evalue=7e-57,
Organism=Escherichia coli, GI1788024, Length=423, Percent_Identity=29.5508274231678, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1789473, Length=386, Percent_Identity=27.4611398963731, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71983106, Length=461, Percent_Identity=32.5379609544469, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71983099, Length=461, Percent_Identity=32.5379609544469, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71996953, Length=454, Percent_Identity=32.15859030837, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI193206505, Length=445, Percent_Identity=31.9101123595506, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17537407, Length=438, Percent_Identity=31.9634703196347, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17541374, Length=417, Percent_Identity=30.9352517985612, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI193206654, Length=415, Percent_Identity=28.6746987951807, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24583025, Length=410, Percent_Identity=28.780487804878, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI17137668, Length=410, Percent_Identity=28.780487804878, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24583023, Length=410, Percent_Identity=28.780487804878, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI281360483, Length=482, Percent_Identity=28.2157676348548, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI17137666, Length=482, Percent_Identity=28.2157676348548, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI281360481, Length=482, Percent_Identity=28.2157676348548, Blast_Score=121, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 44793; Mature: 44662

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCC
>Mature Secondary Structure 
GRGILRTYLEIPVLYKILAGLVLGVIFGMLLPEYSAALKPLGDLFVRLLKMLVMPIILF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLIVGAASINPSRLGRVGVKIILYYLATSAFAVFFGLLMGNLFKPGTGIELGTGSGKAIE
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEC
AEAPSLVQTLLNIVPTNPFAALSSGQVLPTIFFAIVFGIAISYLMNSEDERIRSSAETLF
CCCHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
RVMDAAAEAMYKIVAGVMQYAPIGVFALIYYVIGQFGPNVAGPLVKVVVAVYLGLILQIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LVYGVLLKVFGIDPFKFLKKAKDAMITAFVTRSSSGTLPVTMRVAEEEMGVDKGIFSFTL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCCCCEEEEEECHHHCCCCCCHHHEEE
PLGATINMDGTALYQGVTVLFVANAIGQPLTLEQQLVVILTAVLASIGTAGVPGAGAIML
CCCCEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AMVLQSVGLELVEGSPVALAYAMILGIDAILDMGRTMVNVTGDLAGTTIVAKTEGEMDSS
HHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHCCHHHEEECCCCCCCEEEEECCCCCCCC
KWTS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]