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The map label for this gene is adk

Identifier: 212223929

GI number: 212223929

Start: 726320

End: 726994

Strand: Reverse

Name: adk

Synonym: TON_0780

Alternate gene names: 212223929

Gene position: 726994-726320 (Counterclockwise)

Preceding gene: 212223931

Following gene: 212223928

Centisome position: 39.35

GC content: 50.81

Gene sequence:

>675_bases
ATGAACATCCTGATCTTCGGACCACCTGGGAGCGGCAAATCAACCCACTCGAGGACGATAACGGAGCGCTATGGGCTGAC
GTATATCTCCTCAGGGGACATGATACGGGCGGAGATTGAAAAGGGAAGCGAGCTCGGGAAGGAGCTGAAGAAATATCTCG
CAAAAGGGGAGCTCATTCCGGACATCGTCGTCAATACCCTTGTGATTTCTCGCTTAAGGCGCGACAGGAACAACTTCATC
ATCGATGGCTACCCCAGAACGGCAGAGCAGGTTCTCGCGCTTGAGAACTACCTATACGACCACGGCATAAGGATAGACGT
GGCGATGGAGATTTTCATCTCTAAGGAGGAAAGTGTTGAGCGCATCTCTGGGAGAAGGATATGTCCCAAGTGCGGTGCCG
TTTACCATCTTCGGTACAGACCCCCAAAGGTTCCCGGTAAATGTGACCTATGTGGCTCCCAGCTCATCCAGAGAGAGGAC
GACAGGTCAGAAATAGTGGCGAAGCGCTATGACCTCTACGTCAAGAACATGGAGCCGATAATCAAGTTCTACAAGAAGCA
GGGCATCTACGTTAGGGTTGATGGTCACGGCAGTATAAACGAAGTCTGGGAAAGGATAAGACCACTCCTCGACTACATAC
ACAACCGCGAAAAGAAACGGAAAGAAAACGAGTAA

Upstream 100 bases:

>100_bases
GTATGCGTAGCCGGATGCCCGAACAAAGCCTGTGCTCAGTTTCATGGCCACCACCGTAATTGTTTTATCACTCAGGAGAT
AAATAACTAGCGGTGAGAAA

Downstream 100 bases:

>100_bases
AGTTTTTAGTCCTCTTCTTCCAAACTTTTTTAGGTGGTCTTATGAAGGTCAAGTTCTATGCGACATTTCGTGAACTCATC
GGAAGGAAGGAGATAGAGGT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MNILIFGPPGSGKSTHSRTITERYGLTYISSGDMIRAEIEKGSELGKELKKYLAKGELIPDIVVNTLVISRLRRDRNNFI
IDGYPRTAEQVLALENYLYDHGIRIDVAMEIFISKEESVERISGRRICPKCGAVYHLRYRPPKVPGKCDLCGSQLIQRED
DRSEIVAKRYDLYVKNMEPIIKFYKKQGIYVRVDGHGSINEVWERIRPLLDYIHNREKKRKENE

Sequences:

>Translated_224_residues
MNILIFGPPGSGKSTHSRTITERYGLTYISSGDMIRAEIEKGSELGKELKKYLAKGELIPDIVVNTLVISRLRRDRNNFI
IDGYPRTAEQVLALENYLYDHGIRIDVAMEIFISKEESVERISGRRICPKCGAVYHLRYRPPKVPGKCDLCGSQLIQRED
DRSEIVAKRYDLYVKNMEPIIKFYKKQGIYVRVDGHGSINEVWERIRPLLDYIHNREKKRKENE
>Mature_224_residues
MNILIFGPPGSGKSTHSRTITERYGLTYISSGDMIRAEIEKGSELGKELKKYLAKGELIPDIVVNTLVISRLRRDRNNFI
IDGYPRTAEQVLALENYLYDHGIRIDVAMEIFISKEESVERISGRRICPKCGAVYHLRYRPPKVPGKCDLCGSQLIQRED
DRSEIVAKRYDLYVKNMEPIIKFYKKQGIYVRVDGHGSINEVWERIRPLLDYIHNREKKRKENE

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=205, Percent_Identity=35.1219512195122, Blast_Score=144, Evalue=5e-35,
Organism=Homo sapiens, GI4502013, Length=205, Percent_Identity=35.1219512195122, Blast_Score=144, Evalue=6e-35,
Organism=Homo sapiens, GI19923437, Length=211, Percent_Identity=35.5450236966825, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI310110345, Length=211, Percent_Identity=36.0189573459716, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI53832003, Length=211, Percent_Identity=36.0189573459716, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI8051579, Length=211, Percent_Identity=36.0189573459716, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI53832001, Length=211, Percent_Identity=36.0189573459716, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI4502011, Length=217, Percent_Identity=30.8755760368664, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI7706497, Length=222, Percent_Identity=26.5765765765766, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI28144897, Length=222, Percent_Identity=26.5765765765766, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI28144899, Length=222, Percent_Identity=26.5765765765766, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI22749187, Length=207, Percent_Identity=24.1545893719807, Blast_Score=74, Evalue=7e-14,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=39.63133640553, Blast_Score=161, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17552384, Length=221, Percent_Identity=37.10407239819, Blast_Score=153, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17537943, Length=207, Percent_Identity=29.4685990338164, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17567503, Length=215, Percent_Identity=28.3720930232558, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17550688, Length=207, Percent_Identity=27.536231884058, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25147457, Length=215, Percent_Identity=27.906976744186, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17533833, Length=217, Percent_Identity=23.0414746543779, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=207, Percent_Identity=37.6811594202899, Blast_Score=161, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=39.3939393939394, Blast_Score=145, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6322828, Length=210, Percent_Identity=23.8095238095238, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI22026816, Length=217, Percent_Identity=36.405529953917, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI17737899, Length=209, Percent_Identity=37.3205741626794, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24645822, Length=209, Percent_Identity=37.3205741626794, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24663208, Length=224, Percent_Identity=25.4464285714286, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17647141, Length=224, Percent_Identity=25.4464285714286, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221459597, Length=210, Percent_Identity=25.2380952380952, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21356893, Length=210, Percent_Identity=25.2380952380952, Blast_Score=81, Evalue=7e-16,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_THEON (B6YVU5)

Other databases:

- EMBL:   CP000855
- RefSeq:   YP_002307165.1
- GeneID:   7017083
- GenomeReviews:   CP000855_GR
- KEGG:   ton:TON_0780
- HOGENOM:   HBG630208
- OMA:   MEPIIKF
- ProtClustDB:   PRK00279
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 26002; Mature: 26002

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILIFGPPGSGKSTHSRTITERYGLTYISSGDMIRAEIEKGSELGKELKKYLAKGELIP
CEEEEECCCCCCCCCCHHHHHHHHCEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCCCH
DIVVNTLVISRLRRDRNNFIIDGYPRTAEQVLALENYLYDHGIRIDVAMEIFISKEESVE
HHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEEEEECCHHHHH
RISGRRICPKCGAVYHLRYRPPKVPGKCDLCGSQLIQREDDRSEIVAKRYDLYVKNMEPI
HHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHH
IKFYKKQGIYVRVDGHGSINEVWERIRPLLDYIHNREKKRKENE
HHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCHHHHHCCCC
>Mature Secondary Structure
MNILIFGPPGSGKSTHSRTITERYGLTYISSGDMIRAEIEKGSELGKELKKYLAKGELIP
CEEEEECCCCCCCCCCHHHHHHHHCEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCCCH
DIVVNTLVISRLRRDRNNFIIDGYPRTAEQVLALENYLYDHGIRIDVAMEIFISKEESVE
HHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEEEEECCHHHHH
RISGRRICPKCGAVYHLRYRPPKVPGKCDLCGSQLIQREDDRSEIVAKRYDLYVKNMEPI
HHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHH
IKFYKKQGIYVRVDGHGSINEVWERIRPLLDYIHNREKKRKENE
HHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA