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The map label for this gene is tyrP-A [H]

Identifier: 212223788

GI number: 212223788

Start: 597575

End: 598681

Strand: Reverse

Name: tyrP-A [H]

Synonym: TON_0640

Alternate gene names: 212223788

Gene position: 598681-597575 (Counterclockwise)

Preceding gene: 212223789

Following gene: 212223786

Centisome position: 32.4

GC content: 54.83

Gene sequence:

>1107_bases
ATGAAAAAGCTCACGCTGGCAGAGGCAAGTGCTATACTCATTGGGACTCAAATCGGGGCGGGTGTTCTGGGCTTGCCGTA
CGCGCTTAAGAATGCGGGCTTTGCCGGAATAGCAATTATCGTCGCCGTTGGCATTCTCACACTCCTCACAGCCCTTTTCG
TGCTTGAGCTGGCCGTCCAGAGGGGAGGAACGCTTACTTCACTTGCGCGAGAGACGCTTGGGAAGGCGGGCGGCTGGCTG
ATGCTCGCGAGCATATCCGTTCTCAGCTATGGAGCTCTCATAGCCTACATCGCTGGAAGCGGTGACATACTATCCTCTCT
GCTTGGAATTGACAGATCCATCTGCGCTATATTTTTCTGGATGATTATGAGCGGGATCGTGCTCATGGGCCTCAAAGCAT
CGGGCGAGGCAGAGCTGATGTTCAACTTCCTCCTGCTTGGTGCGCTGGCAGTTGCAGTGGCTTTGATGCTGCCGAGGGTG
AACGTTGAGAACATGGCAACGGTAGATACCTCCGCCCTGGTCTCCGGGATAGGTGTCGCCATCTTTGCCTACGTAAGTCA
CATGGTTGTTCCCGAGATGTATAAGGGGCTCGAAAGCGTGGAGAAGACCAAAAAGGCCGTCCTCATAGGTTATCTTGTAC
CGATGGCATTCTACGCTCTCTTTGTCTTTGCCTTCGTTGGTGCGCTAGGAGGGAACACCCCTCAGCTGGCCACGTCGGCT
CTCGAAGACTACTATGGTGGCTTAGGCAAGGTGCTCGGTCTTATCCTTCCGCTCGCGGCCATAAGCACGAGCTACATCGG
CATAGGCTTCGCCCAGATGGACAACCTTCGCGAGGCCTTCAAGCTTGACAAGAGAAGTGCATGGCTCCTGACGGTGGTTC
CGCCCCTGCTGATATACTTTGCCGGTCTGAAGAGCTTCGTCAGCGCCCTCTGGCTCGCTGGAACATTCGGCGGCCTTCTC
TACGCGGGAATCCTGCCGGTGGCGATGTACGTCAAAACGAAGAAGGTCTGCCCGCCGAAGTGTGTGAGGATTCCACACGG
CGTTGCTTACTTTGTTGGAGCGATTTTCTTCCTAGTTTTCATATATTCAGTGGTGTCACTGGTCTGA

Upstream 100 bases:

>100_bases
CAAGTCTGTTCTCTACTCTTTTTCAGGTACCAGTGGCGAACACCTTTTTTCAGAGCAACGCTTAAATTCATGAACCTTTC
TTCATCTCTCGGTGATGGTC

Downstream 100 bases:

>100_bases
ACCTTTCTTTTTATTCCCTAGGGCAGGTATTCATATATGGAGAACTAGAAAAGGATAAATTGGAGAGATTCACTTCAAAA
TCCCAAGGCTCTGGTTCGTC

Product: aromatic amino acid permease

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease 1 [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MKKLTLAEASAILIGTQIGAGVLGLPYALKNAGFAGIAIIVAVGILTLLTALFVLELAVQRGGTLTSLARETLGKAGGWL
MLASISVLSYGALIAYIAGSGDILSSLLGIDRSICAIFFWMIMSGIVLMGLKASGEAELMFNFLLLGALAVAVALMLPRV
NVENMATVDTSALVSGIGVAIFAYVSHMVVPEMYKGLESVEKTKKAVLIGYLVPMAFYALFVFAFVGALGGNTPQLATSA
LEDYYGGLGKVLGLILPLAAISTSYIGIGFAQMDNLREAFKLDKRSAWLLTVVPPLLIYFAGLKSFVSALWLAGTFGGLL
YAGILPVAMYVKTKKVCPPKCVRIPHGVAYFVGAIFFLVFIYSVVSLV

Sequences:

>Translated_368_residues
MKKLTLAEASAILIGTQIGAGVLGLPYALKNAGFAGIAIIVAVGILTLLTALFVLELAVQRGGTLTSLARETLGKAGGWL
MLASISVLSYGALIAYIAGSGDILSSLLGIDRSICAIFFWMIMSGIVLMGLKASGEAELMFNFLLLGALAVAVALMLPRV
NVENMATVDTSALVSGIGVAIFAYVSHMVVPEMYKGLESVEKTKKAVLIGYLVPMAFYALFVFAFVGALGGNTPQLATSA
LEDYYGGLGKVLGLILPLAAISTSYIGIGFAQMDNLREAFKLDKRSAWLLTVVPPLLIYFAGLKSFVSALWLAGTFGGLL
YAGILPVAMYVKTKKVCPPKCVRIPHGVAYFVGAIFFLVFIYSVVSLV
>Mature_368_residues
MKKLTLAEASAILIGTQIGAGVLGLPYALKNAGFAGIAIIVAVGILTLLTALFVLELAVQRGGTLTSLARETLGKAGGWL
MLASISVLSYGALIAYIAGSGDILSSLLGIDRSICAIFFWMIMSGIVLMGLKASGEAELMFNFLLLGALAVAVALMLPRV
NVENMATVDTSALVSGIGVAIFAYVSHMVVPEMYKGLESVEKTKKAVLIGYLVPMAFYALFVFAFVGALGGNTPQLATSA
LEDYYGGLGKVLGLILPLAAISTSYIGIGFAQMDNLREAFKLDKRSAWLLTVVPPLLIYFAGLKSFVSALWLAGTFGGLL
YAGILPVAMYVKTKKVCPPKCVRIPHGVAYFVGAIFFLVFIYSVVSLV

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=384, Percent_Identity=27.34375, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 38733; Mature: 38733

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLTLAEASAILIGTQIGAGVLGLPYALKNAGFAGIAIIVAVGILTLLTALFVLELAVQ
CCCCHHHHHHHHEEECHHCCCHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGGTLTSLARETLGKAGGWLMLASISVLSYGALIAYIAGSGDILSSLLGIDRSICAIFFW
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHH
MIMSGIVLMGLKASGEAELMFNFLLLGALAVAVALMLPRVNVENMATVDTSALVSGIGVA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
IFAYVSHMVVPEMYKGLESVEKTKKAVLIGYLVPMAFYALFVFAFVGALGGNTPQLATSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LEDYYGGLGKVLGLILPLAAISTSYIGIGFAQMDNLREAFKLDKRSAWLLTVVPPLLIYF
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
AGLKSFVSALWLAGTFGGLLYAGILPVAMYVKTKKVCPPKCVRIPHGVAYFVGAIFFLVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHH
IYSVVSLV
HHHHHHHC
>Mature Secondary Structure
MKKLTLAEASAILIGTQIGAGVLGLPYALKNAGFAGIAIIVAVGILTLLTALFVLELAVQ
CCCCHHHHHHHHEEECHHCCCHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGGTLTSLARETLGKAGGWLMLASISVLSYGALIAYIAGSGDILSSLLGIDRSICAIFFW
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHH
MIMSGIVLMGLKASGEAELMFNFLLLGALAVAVALMLPRVNVENMATVDTSALVSGIGVA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
IFAYVSHMVVPEMYKGLESVEKTKKAVLIGYLVPMAFYALFVFAFVGALGGNTPQLATSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LEDYYGGLGKVLGLILPLAAISTSYIGIGFAQMDNLREAFKLDKRSAWLLTVVPPLLIYF
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
AGLKSFVSALWLAGTFGGLLYAGILPVAMYVKTKKVCPPKCVRIPHGVAYFVGAIFFLVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHH
IYSVVSLV
HHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]