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The map label for this gene is nuoN [H]

Identifier: 212223412

GI number: 212223412

Start: 235919

End: 237484

Strand: Reverse

Name: nuoN [H]

Synonym: TON_0266

Alternate gene names: 212223412

Gene position: 237484-235919 (Counterclockwise)

Preceding gene: 212223413

Following gene: 212223411

Centisome position: 12.85

GC content: 49.49

Gene sequence:

>1566_bases
ATGGACGTGGTTGGACTAACTCCTGTGATTCCGGTCATCTTTGCCTTTGCACTCCCCCTGACTTCGATCATAGTTAAGGG
CAACAGGAAGATAATCCAAGCCTATGCACTGCTCGGCACGGGTTTAACCTTAATCAGTGCGCTCAAGCTTTTCGAACTAG
TGTACTCATCTGAAAAGCCGCCGATATATACTTTTGGCGGCTGGACTGCTCCAATTGGCATAATTTATGAGGTTGACAGA
ACTGGGGCACTTATAACTCTCCTCACCGCCGCGCTGATGTTCCTCATTGCGATTTACAGTTATCGCTACCTAGAGCACGA
GGAGGGTCTGGAGTGGTACTATACACTCTATTTAGGCTTGGAAGCTGGACTAATAGGTGTTTTACTAACTGGTGATGCCT
TCAACCTCTTCGTCATGATAGAAGTCACCAGCATCGCAGCATACGCCCTCGTAGCTTTCTACAGGGGAAGGAAGGACGCA
GTTCATGCTGCATTGAAGTATGCATTCATAGGTGCAATTGGTACTACAATGTACTTCTTAGCGCTTGGAATTCTCTACGG
GGCTTTTGGTACGGTTAATCTTGCTGATTTGAGTGCAAAGGTTCATGGTTTGAGTTTTCCAGTAACAGGTTCACCAGTTG
GTAATATTGTAATTGCTTCTGGTGTTGCTTTGGCTTTAGCTACGTGGGCTTTCCTCATAAAGGCAGCAATTGTTCCGAAC
CACTTCTGGCTTCCAGAAGCTCACCCAGCGGCACCAAGTCCAATCTCGGCAGTCTTGAGTGGTCTCGTAGTAAATGTTGG
AGTTTACGCTCTGATTAGATTCCTCTACACTGTTTACGGTGGTGAACTCACACCGGGTCTAGCAAAAATCGTTGGAACCT
TGGGGACAGTAGTCATAGCTCTCGGTGCGGTTTCGGCACTTTTCGGTGCACTCATGATGAACGCCCAGCGCGACGTCAAG
AAGCTCATTGCTTACTCCACGATAATGCACATGGGTTACCTGTTCATGGCCGTTGGCCTCGGCACCCAGCTTGGACTTCA
GGCGGCATTATTCCACATTATCAACCACGCAATTGCTAAAGCATTACTCTTCCTTGCTGCGGGCATGTTCATCCACGCCA
TCGGTTCAAGGGACATCAATGATATGGCTGGTTTGGGCAGACAGATGCCAATGGCAACTCTCGGACTCGCAATAGCAACC
CTCAGCCTCGTTGGAATCCCACCGTTCAACGTGTTCTTCAGCAAGCTGCTCCTCTTTGATGCGCTGATGGAGAAGAGCTT
AGCCTTGGCGATGGTTATCGTTGTCAGCTCAGTAACTGCACTCGTTGCCTACATGCGCGTCTTCTACAAGATATGGCTCG
GCAAGCCATCCAGAGAAGTGGCAGTGGGAGAATCTAAGAGCATGGCATTCGTGGTGCTCCTGCTGGCGGCTGCGGTTGTT
GTGATAGGTCTTGCCGCGCCGGTAATACTCCAGCACTACATCGAACCTGCCGCGACCCAGACGATGGACTACAAGCTTTA
CATCCAGACCGCCCTGGAGTATGCGTCAAGATTAAAACTCCTCTAA

Upstream 100 bases:

>100_bases
TGGATTGACGTGACGACTCTGGACCCTGAGACGGCTAAGGGAGAAATCTCGGCGGACTTTGAGAGATTTGCAAAGAGAAT
ACTGGAGTGAGGTGAGAGGC

Downstream 100 bases:

>100_bases
CCTCTCAATTTTTGGAGGTGTTGGAATGAGCATTGAGGCGGCAAAGCAGAGTCTTCTTCAGCGGATAAGGGAATTCTACG
GCGACAATTTGCTCTCCGTG

Product: putative monovalent cation/H+ antiporter subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MDVVGLTPVIPVIFAFALPLTSIIVKGNRKIIQAYALLGTGLTLISALKLFELVYSSEKPPIYTFGGWTAPIGIIYEVDR
TGALITLLTAALMFLIAIYSYRYLEHEEGLEWYYTLYLGLEAGLIGVLLTGDAFNLFVMIEVTSIAAYALVAFYRGRKDA
VHAALKYAFIGAIGTTMYFLALGILYGAFGTVNLADLSAKVHGLSFPVTGSPVGNIVIASGVALALATWAFLIKAAIVPN
HFWLPEAHPAAPSPISAVLSGLVVNVGVYALIRFLYTVYGGELTPGLAKIVGTLGTVVIALGAVSALFGALMMNAQRDVK
KLIAYSTIMHMGYLFMAVGLGTQLGLQAALFHIINHAIAKALLFLAAGMFIHAIGSRDINDMAGLGRQMPMATLGLAIAT
LSLVGIPPFNVFFSKLLLFDALMEKSLALAMVIVVSSVTALVAYMRVFYKIWLGKPSREVAVGESKSMAFVVLLLAAAVV
VIGLAAPVILQHYIEPAATQTMDYKLYIQTALEYASRLKLL

Sequences:

>Translated_521_residues
MDVVGLTPVIPVIFAFALPLTSIIVKGNRKIIQAYALLGTGLTLISALKLFELVYSSEKPPIYTFGGWTAPIGIIYEVDR
TGALITLLTAALMFLIAIYSYRYLEHEEGLEWYYTLYLGLEAGLIGVLLTGDAFNLFVMIEVTSIAAYALVAFYRGRKDA
VHAALKYAFIGAIGTTMYFLALGILYGAFGTVNLADLSAKVHGLSFPVTGSPVGNIVIASGVALALATWAFLIKAAIVPN
HFWLPEAHPAAPSPISAVLSGLVVNVGVYALIRFLYTVYGGELTPGLAKIVGTLGTVVIALGAVSALFGALMMNAQRDVK
KLIAYSTIMHMGYLFMAVGLGTQLGLQAALFHIINHAIAKALLFLAAGMFIHAIGSRDINDMAGLGRQMPMATLGLAIAT
LSLVGIPPFNVFFSKLLLFDALMEKSLALAMVIVVSSVTALVAYMRVFYKIWLGKPSREVAVGESKSMAFVVLLLAAAVV
VIGLAAPVILQHYIEPAATQTMDYKLYIQTALEYASRLKLL
>Mature_521_residues
MDVVGLTPVIPVIFAFALPLTSIIVKGNRKIIQAYALLGTGLTLISALKLFELVYSSEKPPIYTFGGWTAPIGIIYEVDR
TGALITLLTAALMFLIAIYSYRYLEHEEGLEWYYTLYLGLEAGLIGVLLTGDAFNLFVMIEVTSIAAYALVAFYRGRKDA
VHAALKYAFIGAIGTTMYFLALGILYGAFGTVNLADLSAKVHGLSFPVTGSPVGNIVIASGVALALATWAFLIKAAIVPN
HFWLPEAHPAAPSPISAVLSGLVVNVGVYALIRFLYTVYGGELTPGLAKIVGTLGTVVIALGAVSALFGALMMNAQRDVK
KLIAYSTIMHMGYLFMAVGLGTQLGLQAALFHIINHAIAKALLFLAAGMFIHAIGSRDINDMAGLGRQMPMATLGLAIAT
LSLVGIPPFNVFFSKLLLFDALMEKSLALAMVIVVSSVTALVAYMRVFYKIWLGKPSREVAVGESKSMAFVVLLLAAAVV
VIGLAAPVILQHYIEPAATQTMDYKLYIQTALEYASRLKLL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=354, Percent_Identity=27.683615819209, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI251831116, Length=315, Percent_Identity=25.0793650793651, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1788829, Length=436, Percent_Identity=31.651376146789, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1788827, Length=440, Percent_Identity=30.2272727272727, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1788831, Length=445, Percent_Identity=30.3370786516854, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1788613, Length=479, Percent_Identity=27.7661795407098, Blast_Score=132, Evalue=8e-32,
Organism=Escherichia coli, GI1788614, Length=404, Percent_Identity=27.7227722772277, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI2367154, Length=394, Percent_Identity=25.3807106598985, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI145693160, Length=403, Percent_Identity=24.5657568238213, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55716; Mature: 55716

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVVGLTPVIPVIFAFALPLTSIIVKGNRKIIQAYALLGTGLTLISALKLFELVYSSEKP
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PIYTFGGWTAPIGIIYEVDRTGALITLLTAALMFLIAIYSYRYLEHEEGLEWYYTLYLGL
CEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHEEHHH
EAGLIGVLLTGDAFNLFVMIEVTSIAAYALVAFYRGRKDAVHAALKYAFIGAIGTTMYFL
HCCCEEEEEECCCEEEEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ALGILYGAFGTVNLADLSAKVHGLSFPVTGSPVGNIVIASGVALALATWAFLIKAAIVPN
HHHHHHHHCCCCCHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
HFWLPEAHPAAPSPISAVLSGLVVNVGVYALIRFLYTVYGGELTPGLAKIVGTLGTVVIA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LGAVSALFGALMMNAQRDVKKLIAYSTIMHMGYLFMAVGLGTQLGLQAALFHIINHAIAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
ALLFLAAGMFIHAIGSRDINDMAGLGRQMPMATLGLAIATLSLVGIPPFNVFFSKLLLFD
HHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ALMEKSLALAMVIVVSSVTALVAYMRVFYKIWLGKPSREVAVGESKSMAFVVLLLAAAVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHH
VIGLAAPVILQHYIEPAATQTMDYKLYIQTALEYASRLKLL
HHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDVVGLTPVIPVIFAFALPLTSIIVKGNRKIIQAYALLGTGLTLISALKLFELVYSSEKP
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PIYTFGGWTAPIGIIYEVDRTGALITLLTAALMFLIAIYSYRYLEHEEGLEWYYTLYLGL
CEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHEEHHH
EAGLIGVLLTGDAFNLFVMIEVTSIAAYALVAFYRGRKDAVHAALKYAFIGAIGTTMYFL
HCCCEEEEEECCCEEEEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ALGILYGAFGTVNLADLSAKVHGLSFPVTGSPVGNIVIASGVALALATWAFLIKAAIVPN
HHHHHHHHCCCCCHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
HFWLPEAHPAAPSPISAVLSGLVVNVGVYALIRFLYTVYGGELTPGLAKIVGTLGTVVIA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LGAVSALFGALMMNAQRDVKKLIAYSTIMHMGYLFMAVGLGTQLGLQAALFHIINHAIAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
ALLFLAAGMFIHAIGSRDINDMAGLGRQMPMATLGLAIATLSLVGIPPFNVFFSKLLLFD
HHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ALMEKSLALAMVIVVSSVTALVAYMRVFYKIWLGKPSREVAVGESKSMAFVVLLLAAAVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHH
VIGLAAPVILQHYIEPAATQTMDYKLYIQTALEYASRLKLL
HHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA