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The map label for this gene is livH [H]

Identifier: 212223305

GI number: 212223305

Start: 136183

End: 137088

Strand: Reverse

Name: livH [H]

Synonym: TON_0159

Alternate gene names: 212223305

Gene position: 137088-136183 (Counterclockwise)

Preceding gene: 212223306

Following gene: 212223304

Centisome position: 7.42

GC content: 52.98

Gene sequence:

>906_bases
ATGGGTGTTCTTGAAGGTGCGCTGACCTACGCCAACCTGTTGGCCCTCTTGGCCCTAGGGCTCACGCTCACCTACATAAC
CACTGGAGTTCCAAACTTTGCCCACGGTTCCTTCGCGGTGATAGGTTCGTATCTAGCGTACACGCTCTACGTAGGGCTCG
GGCTCAACCCCTACTTGGCTCTCATTCCGGCTCCTATTACAGGAGGTCTATTTGGTATAGCTGTCTACCTGCTCACGCTG
AAGCCCTTAATCCGAAAAGGTGCTTCGGTTGATATGCTGATGATGGCCACACTGGCGGTGGACATTATCCTATACGGCCT
ACTCGGTGCCTATTCAGACGTCATAAGTTCTGCATTCAAGAGAAACGCTAGCAAATTTGTCTTTACGAACGCTGACTTTG
CTGTGTCAGGAATTCCCGGCAGGTTAGTCGTTTCCAGCCTCCTTGTAGTTGCGACGCTCGTCGCACTCTACATCCTGCTG
TACCGCACCAAGTTCGGAACCGCTCTAAGGGCGTCGATGGAAAACCCTGCCCTAGCCGAAGCAATGGGGATAGACGTCGA
GAGGACGAGGCTGTTTTCCTGGTTTCTGGCGGCGGCACTGGCGGGCATGGTTGGTGCAGTCTTGCCCTTCCTTCAGGAGA
CAGTACCCGGAACTGGAGGCTTTATAATAGTGTCAGTCTTCGCGGCCAGTATAGTCGGTGGACTAAAGAACATCAGCGGT
GGTCTCATTGGCGGGTACATAATAGGCCTTTCCGAGTCACTTGTTACCTTCGGTCTCTCAGACGTTCTCGGGACTGGGAT
TCTCGTCTACGGAAAGGTGGTTTCTCTCATGATAATGATAGCCGTACTACTTCTGATGCCCGAGGGGATTACCGGCACAA
AGGTCTGGAGGAGGTTGATGAGATGA

Upstream 100 bases:

>100_bases
CTTATAACGGATGATAAATTCCAGAGACACTTCCTCGGCATAATTGAGGACGTTGAAATCGTTGGGGAAAAGACGGAAAA
GCTTGAGGCGGGTGATGTCG

Downstream 100 bases:

>100_bases
TCATGGAACTGCTCCAGCTCATACTCGTCTGGATTGGGATATATGCGGTAGTAAACATAAGCCTGAACATTGAGTACGGT
TACACAGGAATACCAAACTT

Product: branched-chain amino acid transport ATP-binding protein livH

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MGVLEGALTYANLLALLALGLTLTYITTGVPNFAHGSFAVIGSYLAYTLYVGLGLNPYLALIPAPITGGLFGIAVYLLTL
KPLIRKGASVDMLMMATLAVDIILYGLLGAYSDVISSAFKRNASKFVFTNADFAVSGIPGRLVVSSLLVVATLVALYILL
YRTKFGTALRASMENPALAEAMGIDVERTRLFSWFLAAALAGMVGAVLPFLQETVPGTGGFIIVSVFAASIVGGLKNISG
GLIGGYIIGLSESLVTFGLSDVLGTGILVYGKVVSLMIMIAVLLLMPEGITGTKVWRRLMR

Sequences:

>Translated_301_residues
MGVLEGALTYANLLALLALGLTLTYITTGVPNFAHGSFAVIGSYLAYTLYVGLGLNPYLALIPAPITGGLFGIAVYLLTL
KPLIRKGASVDMLMMATLAVDIILYGLLGAYSDVISSAFKRNASKFVFTNADFAVSGIPGRLVVSSLLVVATLVALYILL
YRTKFGTALRASMENPALAEAMGIDVERTRLFSWFLAAALAGMVGAVLPFLQETVPGTGGFIIVSVFAASIVGGLKNISG
GLIGGYIIGLSESLVTFGLSDVLGTGILVYGKVVSLMIMIAVLLLMPEGITGTKVWRRLMR
>Mature_300_residues
GVLEGALTYANLLALLALGLTLTYITTGVPNFAHGSFAVIGSYLAYTLYVGLGLNPYLALIPAPITGGLFGIAVYLLTLK
PLIRKGASVDMLMMATLAVDIILYGLLGAYSDVISSAFKRNASKFVFTNADFAVSGIPGRLVVSSLLVVATLVALYILLY
RTKFGTALRASMENPALAEAMGIDVERTRLFSWFLAAALAGMVGAVLPFLQETVPGTGGFIIVSVFAASIVGGLKNISGG
LIGGYIIGLSESLVTFGLSDVLGTGILVYGKVVSLMIMIAVLLLMPEGITGTKVWRRLMR

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=298, Percent_Identity=28.1879194630872, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 31557; Mature: 31426

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVLEGALTYANLLALLALGLTLTYITTGVPNFAHGSFAVIGSYLAYTLYVGLGLNPYLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHH
LIPAPITGGLFGIAVYLLTLKPLIRKGASVDMLMMATLAVDIILYGLLGAYSDVISSAFK
EECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNASKFVFTNADFAVSGIPGRLVVSSLLVVATLVALYILLYRTKFGTALRASMENPALAE
CCCCCEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
AMGIDVERTRLFSWFLAAALAGMVGAVLPFLQETVPGTGGFIIVSVFAASIVGGLKNISG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
GLIGGYIIGLSESLVTFGLSDVLGTGILVYGKVVSLMIMIAVLLLMPEGITGTKVWRRLM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
R
C
>Mature Secondary Structure 
GVLEGALTYANLLALLALGLTLTYITTGVPNFAHGSFAVIGSYLAYTLYVGLGLNPYLA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHH
LIPAPITGGLFGIAVYLLTLKPLIRKGASVDMLMMATLAVDIILYGLLGAYSDVISSAFK
EECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNASKFVFTNADFAVSGIPGRLVVSSLLVVATLVALYILLYRTKFGTALRASMENPALAE
CCCCCEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
AMGIDVERTRLFSWFLAAALAGMVGAVLPFLQETVPGTGGFIIVSVFAASIVGGLKNISG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
GLIGGYIIGLSESLVTFGLSDVLGTGILVYGKVVSLMIMIAVLLLMPEGITGTKVWRRLM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]