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The map label for this gene is srp54

Identifier: 212223269

GI number: 212223269

Start: 95093

End: 96439

Strand: Reverse

Name: srp54

Synonym: TON_0123

Alternate gene names: 212223269

Gene position: 96439-95093 (Counterclockwise)

Preceding gene: 212223276

Following gene: 212223268

Centisome position: 5.22

GC content: 50.11

Gene sequence:

>1347_bases
ATGGCCCTAGAAAAGCTTGGAAAGGCACTCAACAATGCCCTGAGAAAGCTCGCCCGTTCAAGCACCGTTGATGAGGCGAC
GATTAAGGAAGTAGTGCGAGACATTCAAAGGGCACTCATTCAGGCCGACGTTAACGTTAGACTCGTTCTCGACTTAACCA
AGAGGATAGAAAAAAGGGCTCTGGAGGAAGAGCCTCCCACGGGAGTTTCAAAGAAGGAGCACATAATTAAAATAGTCTAC
GAGGAACTGACGAAGTTCCTTGGCACGGAAGCTAAGCCCATCGAGATAAAGGAGAAGCCGACGGTTCTGCTGACTGTGGG
TATCCAGGGTTCCGGTAAAACGACCAGCATCGCAAAACTCGCCAGATACTTCCAGAAGAGGGGCTATAAAGTCGGTCTCG
TATGTTCAGATACCTGGCGTCCAGGAGCTTACCAGCAACTCAAACAGCTTGTTGAACCCTTCGGCATAGAGGTTTTCGGT
GATCCCGAGGAGAAAGATGCAATAAAGCTCGCAAAGGAAGGCGTCGAGCACTTCAGAGAGAAGGGCGTCGACATAATCAT
CGTGGATTCAGCAGGAAGGCACAAGGAGGAGAAAAGCCTCATAGAGGAGATGAAACAGATAAGCGCAGCCATAAAGCCCC
ACGAGGTAATCCTTGTCATAGACGGAACCATCGGTCAGCAGGCTTACAATCAAGCGCTGGCCTTTAAAGAGGCCACTCCA
ATAGGCTCAATAATTGTTACAAAGCTCGATGGTTCCGCCAAGGGTGGTGGAGCGCTCTCGGCGGTTGCAGCAACTGGGGC
ACCCATAAAGTTCATCGGTGTGGGCGAGAGAATTGATGATTTAGAGCCCTTCGACCCCAAGAGGTTCGTCTCAAGGCTCC
TTGGTCTGGGTGACATTCAGGGCCTTCTCGAAAAATTTGAGGAACTCCAGAAGCAGCAGGAATTCAGGGAGGAAGACTTA
GAGAAGTTCCTTAAGGGCAAGTTCAACCTCAAGGACATGTACGCCCAGCTTGAGGCTATGCAGAAGATGGGCCCGCTGAA
GCAGATACTCCAGATGATTCCGGGAATGGGCTACTCCCTGCCGGACGATGCTGTCAGGGTTGGAGAGGAAAGGTTGAAGA
AGTTCAAGGTCATAATGGACTCAATGACCGAGGAAGAACTCGAGCATCCTGAGATAATCAACTACTCAAGGATAAAGAGG
ATTGCCCGCGGTTCAGGAACGAGCATCCAAGAGGTAAGAGAGCTCCTTCACCAGTACAATCAAATGAAGAAGATGTTTAA
GAGCATGGATAAAAGGAAACTCTCCAAGATGGCCCGCAAGTTTAACCTCGGGGGGTTTGGGCTATGA

Upstream 100 bases:

>100_bases
ATTTAACCGGGTCGTTTTTGCCAAAAGAATACATCAGAACGGGGAAAAGCAACCCAACCGTTTATAAACTTTGGAAACCC
CATCACTACGGTGGGAGAAG

Downstream 100 bases:

>100_bases
TAGAAGCCTTCGTGCTAGTTGTTGTTAAGCCCGGGACTGAGGAAAAGGTCTACAACGCCCTGGCGGGGGAAAAACACATT
AAGGAAATATACCGCGTCTA

Product: signal recognition particle protein Srp54

Products: NA

Alternate protein names: SRP54

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MALEKLGKALNNALRKLARSSTVDEATIKEVVRDIQRALIQADVNVRLVLDLTKRIEKRALEEEPPTGVSKKEHIIKIVY
EELTKFLGTEAKPIEIKEKPTVLLTVGIQGSGKTTSIAKLARYFQKRGYKVGLVCSDTWRPGAYQQLKQLVEPFGIEVFG
DPEEKDAIKLAKEGVEHFREKGVDIIIVDSAGRHKEEKSLIEEMKQISAAIKPHEVILVIDGTIGQQAYNQALAFKEATP
IGSIIVTKLDGSAKGGGALSAVAATGAPIKFIGVGERIDDLEPFDPKRFVSRLLGLGDIQGLLEKFEELQKQQEFREEDL
EKFLKGKFNLKDMYAQLEAMQKMGPLKQILQMIPGMGYSLPDDAVRVGEERLKKFKVIMDSMTEEELEHPEIINYSRIKR
IARGSGTSIQEVRELLHQYNQMKKMFKSMDKRKLSKMARKFNLGGFGL

Sequences:

>Translated_448_residues
MALEKLGKALNNALRKLARSSTVDEATIKEVVRDIQRALIQADVNVRLVLDLTKRIEKRALEEEPPTGVSKKEHIIKIVY
EELTKFLGTEAKPIEIKEKPTVLLTVGIQGSGKTTSIAKLARYFQKRGYKVGLVCSDTWRPGAYQQLKQLVEPFGIEVFG
DPEEKDAIKLAKEGVEHFREKGVDIIIVDSAGRHKEEKSLIEEMKQISAAIKPHEVILVIDGTIGQQAYNQALAFKEATP
IGSIIVTKLDGSAKGGGALSAVAATGAPIKFIGVGERIDDLEPFDPKRFVSRLLGLGDIQGLLEKFEELQKQQEFREEDL
EKFLKGKFNLKDMYAQLEAMQKMGPLKQILQMIPGMGYSLPDDAVRVGEERLKKFKVIMDSMTEEELEHPEIINYSRIKR
IARGSGTSIQEVRELLHQYNQMKKMFKSMDKRKLSKMARKFNLGGFGL
>Mature_447_residues
ALEKLGKALNNALRKLARSSTVDEATIKEVVRDIQRALIQADVNVRLVLDLTKRIEKRALEEEPPTGVSKKEHIIKIVYE
ELTKFLGTEAKPIEIKEKPTVLLTVGIQGSGKTTSIAKLARYFQKRGYKVGLVCSDTWRPGAYQQLKQLVEPFGIEVFGD
PEEKDAIKLAKEGVEHFREKGVDIIIVDSAGRHKEEKSLIEEMKQISAAIKPHEVILVIDGTIGQQAYNQALAFKEATPI
GSIIVTKLDGSAKGGGALSAVAATGAPIKFIGVGERIDDLEPFDPKRFVSRLLGLGDIQGLLEKFEELQKQQEFREEDLE
KFLKGKFNLKDMYAQLEAMQKMGPLKQILQMIPGMGYSLPDDAVRVGEERLKKFKVIMDSMTEEELEHPEIINYSRIKRI
ARGSGTSIQEVRELLHQYNQMKKMFKSMDKRKLSKMARKFNLGGFGL

Specific function: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family

Homologues:

Organism=Homo sapiens, GI4507215, Length=440, Percent_Identity=45, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI226371618, Length=378, Percent_Identity=47.6190476190476, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI89061728, Length=147, Percent_Identity=57.1428571428571, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI23308697, Length=283, Percent_Identity=25.0883392226148, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI295424842, Length=283, Percent_Identity=25.0883392226148, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1788963, Length=427, Percent_Identity=35.8313817330211, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI1789874, Length=268, Percent_Identity=35.8208955223881, Blast_Score=158, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17539958, Length=438, Percent_Identity=43.37899543379, Blast_Score=364, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI193206261, Length=215, Percent_Identity=28.3720930232558, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325345, Length=450, Percent_Identity=44.2222222222222, Blast_Score=349, Evalue=5e-97,
Organism=Saccharomyces cerevisiae, GI6320498, Length=316, Percent_Identity=26.8987341772152, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17647949, Length=439, Percent_Identity=43.7357630979499, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=25.4545454545455, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SRP54_THEON (B6YSS1)

Other databases:

- EMBL:   CP000855
- RefSeq:   YP_002306505.1
- GeneID:   7017775
- GenomeReviews:   CP000855_GR
- KEGG:   ton:TON_0123
- HOGENOM:   HBG562580
- OMA:   SKKEHII
- ProtClustDB:   PRK00771
- HAMAP:   MF_00306
- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004125
- InterPro:   IPR022941
- Gene3D:   G3DSA:1.20.120.140
- Gene3D:   G3DSA:1.10.260.30
- SMART:   SM00382
- SMART:   SM00962
- SMART:   SM00963

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB; SSF47446 Signal_recog_particle_SRP54_M; SSF47364 SRP54

EC number: NA

Molecular weight: Translated: 50278; Mature: 50147

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALEKLGKALNNALRKLARSSTVDEATIKEVVRDIQRALIQADVNVRLVLDLTKRIEKRA
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHH
LEEEPPTGVSKKEHIIKIVYEELTKFLGTEAKPIEIKEKPTVLLTVGIQGSGKTTSIAKL
HCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEEEEECCCCCHHHHHHH
ARYFQKRGYKVGLVCSDTWRPGAYQQLKQLVEPFGIEVFGDPEEKDAIKLAKEGVEHFRE
HHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHH
KGVDIIIVDSAGRHKEEKSLIEEMKQISAAIKPHEVILVIDGTIGQQAYNQALAFKEATP
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCC
IGSIIVTKLDGSAKGGGALSAVAATGAPIKFIGVGERIDDLEPFDPKRFVSRLLGLGDIQ
CCCEEEEECCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCHHHH
GLLEKFEELQKQQEFREEDLEKFLKGKFNLKDMYAQLEAMQKMGPLKQILQMIPGMGYSL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCC
PDDAVRVGEERLKKFKVIMDSMTEEELEHPEIINYSRIKRIARGSGTSIQEVRELLHQYN
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
QMKKMFKSMDKRKLSKMARKFNLGGFGL
HHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ALEKLGKALNNALRKLARSSTVDEATIKEVVRDIQRALIQADVNVRLVLDLTKRIEKRA
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHH
LEEEPPTGVSKKEHIIKIVYEELTKFLGTEAKPIEIKEKPTVLLTVGIQGSGKTTSIAKL
HCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEEEEECCCCCHHHHHHH
ARYFQKRGYKVGLVCSDTWRPGAYQQLKQLVEPFGIEVFGDPEEKDAIKLAKEGVEHFRE
HHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHH
KGVDIIIVDSAGRHKEEKSLIEEMKQISAAIKPHEVILVIDGTIGQQAYNQALAFKEATP
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCC
IGSIIVTKLDGSAKGGGALSAVAATGAPIKFIGVGERIDDLEPFDPKRFVSRLLGLGDIQ
CCCEEEEECCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCHHHH
GLLEKFEELQKQQEFREEDLEKFLKGKFNLKDMYAQLEAMQKMGPLKQILQMIPGMGYSL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCC
PDDAVRVGEERLKKFKVIMDSMTEEELEHPEIINYSRIKRIARGSGTSIQEVRELLHQYN
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
QMKKMFKSMDKRKLSKMARKFNLGGFGL
HHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA