Click here to switch to the map view.

The map label for this gene is bcc [H]

Identifier: 212223184

GI number: 212223184

Start: 34369

End: 34833

Strand: Reverse

Name: bcc [H]

Synonym: TON_0039

Alternate gene names: 212223184

Gene position: 34833-34369 (Counterclockwise)

Preceding gene: 212223185

Following gene: 212223183

Centisome position: 1.89

GC content: 53.76

Gene sequence:

>465_bases
ATGGCTAAGGTTAAGGTCATCGTTGACGGTGTTGAATACGAGGTTGAGGTTGAAGAGCTTGGAATGGGCCGTTTTAAAGT
CTCCTTCGAGGACAAGAGCTACGAGGTCGAGGCAAAGGGGCTCGGAATAGACCTGAGCGCAATAAGCGAGCCGGCAGCTA
CCCCAGCCCGCATCAGCGCTCCTGCCGTTCCGAGTGCTCCCGTTCCGGTTTCAGCGCCCGCTGCTCCGGCCCCAGCGCCA
GCTCCTGTTGGTGAGGGGGTTGTGACGGCTCCCATGCCGGGTAAGATTCTTAGAATACTCGTTAAAGAAGGTGATCAAGT
CAAAACCGGTCAGGGACTACTCATCCTCGAGGCAATGAAAATGGAAAACGAAATCCCAGCACCAAAAGACGGAACAATAA
AGAAAATCCTCATCAAAGAAGGCCAAACCGTCGACACCGGACAACCACTAATCGAACTCGGGTGA

Upstream 100 bases:

>100_bases
CCTTCAAGAGGAAGGTTTCTGACTCTTGGCGCCTCTACGGCATCCAGACAACTATGGAAGATGTTGAGGACTTCAATTAC
GAGAAAGGGAAGTGGTGAAG

Downstream 100 bases:

>100_bases
TGGAGAATGGCCGGACTGGAGCAGGCAATAATCGAATTCATCGAGAGCATGGGGCTTCTCCATCTAACTGTTGGCAATGT
AATAATGATACTCGTCGGTC

Product: putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MAKVKVIVDGVEYEVEVEELGMGRFKVSFEDKSYEVEAKGLGIDLSAISEPAATPARISAPAVPSAPVPVSAPAAPAPAP
APVGEGVVTAPMPGKILRILVKEGDQVKTGQGLLILEAMKMENEIPAPKDGTIKKILIKEGQTVDTGQPLIELG

Sequences:

>Translated_154_residues
MAKVKVIVDGVEYEVEVEELGMGRFKVSFEDKSYEVEAKGLGIDLSAISEPAATPARISAPAVPSAPVPVSAPAAPAPAP
APVGEGVVTAPMPGKILRILVKEGDQVKTGQGLLILEAMKMENEIPAPKDGTIKKILIKEGQTVDTGQPLIELG
>Mature_153_residues
AKVKVIVDGVEYEVEVEELGMGRFKVSFEDKSYEVEAKGLGIDLSAISEPAATPARISAPAVPSAPVPVSAPAAPAPAPA
PVGEGVVTAPMPGKILRILVKEGDQVKTGQGLLILEAMKMENEIPAPKDGTIKKILIKEGQTVDTGQPLIELG

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=64, Percent_Identity=48.4375, Blast_Score=73, Evalue=1e-13,
Organism=Escherichia coli, GI1789653, Length=142, Percent_Identity=32.3943661971831, Blast_Score=72, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17567343, Length=67, Percent_Identity=50.7462686567164, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71987519, Length=157, Percent_Identity=31.2101910828025, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: NA

Molecular weight: Translated: 16006; Mature: 15875

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVKVIVDGVEYEVEVEELGMGRFKVSFEDKSYEVEAKGLGIDLSAISEPAATPARISA
CCEEEEEEECCEEEEEHHHCCCCEEEEEECCCCEEEEECCCCEEHHHCCCCCCCCCEECC
PAVPSAPVPVSAPAAPAPAPAPVGEGVVTAPMPGKILRILVKEGDQVKTGQGLLILEAMK
CCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHEEHHCCCCEECCCCEEEEEEEH
MENEIPAPKDGTIKKILIKEGQTVDTGQPLIELG
HCCCCCCCCCCCEEEEEEECCCEECCCCCEEECC
>Mature Secondary Structure 
AKVKVIVDGVEYEVEVEELGMGRFKVSFEDKSYEVEAKGLGIDLSAISEPAATPARISA
CEEEEEEECCEEEEEHHHCCCCEEEEEECCCCEEEEECCCCEEHHHCCCCCCCCCEECC
PAVPSAPVPVSAPAAPAPAPAPVGEGVVTAPMPGKILRILVKEGDQVKTGQGLLILEAMK
CCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHEEHHCCCCEECCCCEEEEEEEH
MENEIPAPKDGTIKKILIKEGQTVDTGQPLIELG
HCCCCCCCCCCCEEEEEEECCCEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8431283; 12397186 [H]