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The map label for this gene is neuC [H]

Identifier: 209696406

GI number: 209696406

Start: 3263835

End: 3265001

Strand: Direct

Name: neuC [H]

Synonym: VSAL_I3013

Alternate gene names: 209696406

Gene position: 3263835-3265001 (Clockwise)

Preceding gene: 209696405

Following gene: 209696407

Centisome position: 98.16

GC content: 37.28

Gene sequence:

>1167_bases
ATGAAAAGACTACTTTATATCACAGGCTCTAGAGCTGAATACGGCATTATGAAGCGACTATTACTGGCACTAAAAGATGA
CAGTGAGATTGAATTAACCATAGTTGCTACTGGTATGCACTGCGACGAGAAATATGGCTTAACTTATCAAGTAATCGAAA
ATGATGGGTTTGTTATTGATAAGTTGATTGATATTCATATCAACACTGAAAATAACGCCAATATTTTAGCTTCAATGTCT
ATCTGTCAGGCTGAATTTGGTCAGTATTTTCAAGACAATAAATTTGATGCTGTAATGATATTAGGTGATCGCTATGAGAT
ATTCTCTGTTGCGATAGCTGTAGCTATGCATAACTTACCTATCATTCATTTACACGGTGGTGAGAAAACATTGGGCAATT
ATGATGAGTTTATACGTCATGCTATTACCAAAATGAGTAAATTGCATTTAGCTTCTACAGAAGAGTATCGTCAGCGTATT
ATTCAAATGGGCGAGCATCCTGATAGTGTATTTAACATTGGTGCATTAGGGGCAGAAAACAGCCTACTAATGGATTTACC
GACAAAACAGATGTTAGAAAATCGTTTTGGATCACTGCAAAATCCTTATTTTATGGTGGTATTCCATCCTGAAACCTTAA
CGGACACACCGCTTGCTGAACAGATGAACGCATTACTCTTGGCGCTTAAAACATTAACACTAAAGTACGACCTTATTTTT
ATTGGTTCAAACTCAGACACCGGTGCTGATGAAATTACAGTTAAAGTTAAGGCGTTCTGCGATGAGACGAACTCTCGCTA
TATGACGTCTGTTAAGCCTGAAGAATATTTAGCACTAAATAAGTATGCACAAGGCCTAATTGGCAACTCATCATCTGGTT
TAATCGAAGTGCCTTCATTAAAAGTGCCGACGATTAATATCGGAGAACGGCAGAAAGGTCGCGTACGAGGTGACACGGTC
ATTGATTGTGAATGTACAGCTGAGGCTATTTTAGCTTCGGTTACGGATAGCCAGTCGGTAGTATTTCAACATACAGTACA
GAAGGCTGCTAATCCATATTATCAACAAGCAGTATTAGAAAATGCTTTGACTGAAATTAAACAGTTTATGCAGTCATCAG
TACCATTATGTAAAGATTTTTACGATCTAAACATAAATAATCAGTGA

Upstream 100 bases:

>100_bases
ACCAATTTGGTAATTTACCAGCAGAATTTACACATGATGGTTTACATTTTTCTCCAGAAGCATATCAACAATTAGAGCAA
GAAATAGCGGAAGCCCTGTA

Downstream 100 bases:

>100_bases
TAGGTTGCTGTTTATGAGTTTATTAAAGGGCGCCCGAGTTTATCTGGTGTCAAATATATTAAATGCCATTATTCCTTTTT
TATTATTACCAATTTTAACA

Product: polysialic acid biosynthesis protein P7

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MKRLLYITGSRAEYGIMKRLLLALKDDSEIELTIVATGMHCDEKYGLTYQVIENDGFVIDKLIDIHINTENNANILASMS
ICQAEFGQYFQDNKFDAVMILGDRYEIFSVAIAVAMHNLPIIHLHGGEKTLGNYDEFIRHAITKMSKLHLASTEEYRQRI
IQMGEHPDSVFNIGALGAENSLLMDLPTKQMLENRFGSLQNPYFMVVFHPETLTDTPLAEQMNALLLALKTLTLKYDLIF
IGSNSDTGADEITVKVKAFCDETNSRYMTSVKPEEYLALNKYAQGLIGNSSSGLIEVPSLKVPTINIGERQKGRVRGDTV
IDCECTAEAILASVTDSQSVVFQHTVQKAANPYYQQAVLENALTEIKQFMQSSVPLCKDFYDLNINNQ

Sequences:

>Translated_388_residues
MKRLLYITGSRAEYGIMKRLLLALKDDSEIELTIVATGMHCDEKYGLTYQVIENDGFVIDKLIDIHINTENNANILASMS
ICQAEFGQYFQDNKFDAVMILGDRYEIFSVAIAVAMHNLPIIHLHGGEKTLGNYDEFIRHAITKMSKLHLASTEEYRQRI
IQMGEHPDSVFNIGALGAENSLLMDLPTKQMLENRFGSLQNPYFMVVFHPETLTDTPLAEQMNALLLALKTLTLKYDLIF
IGSNSDTGADEITVKVKAFCDETNSRYMTSVKPEEYLALNKYAQGLIGNSSSGLIEVPSLKVPTINIGERQKGRVRGDTV
IDCECTAEAILASVTDSQSVVFQHTVQKAANPYYQQAVLENALTEIKQFMQSSVPLCKDFYDLNINNQ
>Mature_388_residues
MKRLLYITGSRAEYGIMKRLLLALKDDSEIELTIVATGMHCDEKYGLTYQVIENDGFVIDKLIDIHINTENNANILASMS
ICQAEFGQYFQDNKFDAVMILGDRYEIFSVAIAVAMHNLPIIHLHGGEKTLGNYDEFIRHAITKMSKLHLASTEEYRQRI
IQMGEHPDSVFNIGALGAENSLLMDLPTKQMLENRFGSLQNPYFMVVFHPETLTDTPLAEQMNALLLALKTLTLKYDLIF
IGSNSDTGADEITVKVKAFCDETNSRYMTSVKPEEYLALNKYAQGLIGNSSSGLIEVPSLKVPTINIGERQKGRVRGDTV
IDCECTAEAILASVTDSQSVVFQHTVQKAANPYYQQAVLENALTEIKQFMQSSVPLCKDFYDLNINNQ

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI190014632, Length=394, Percent_Identity=29.6954314720812, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI298566312, Length=394, Percent_Identity=29.6954314720812, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI4885285, Length=394, Percent_Identity=29.6954314720812, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI298566325, Length=362, Percent_Identity=29.0055248618785, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI298566315, Length=172, Percent_Identity=29.0697674418605, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: NA

Molecular weight: Translated: 43491; Mature: 43491

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLLYITGSRAEYGIMKRLLLALKDDSEIELTIVATGMHCDEKYGLTYQVIENDGFVID
CCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCEEEEECCCCEEEE
KLIDIHINTENNANILASMSICQAEFGQYFQDNKFDAVMILGDRYEIFSVAIAVAMHNLP
EEEEEEEECCCCCEEEEEHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCC
IIHLHGGEKTLGNYDEFIRHAITKMSKLHLASTEEYRQRIIQMGEHPDSVFNIGALGAEN
EEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHEEEECCCCCC
SLLMDLPTKQMLENRFGSLQNPYFMVVFHPETLTDTPLAEQMNALLLALKTLTLKYDLIF
CEEEECCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEEEEEEE
IGSNSDTGADEITVKVKAFCDETNSRYMTSVKPEEYLALNKYAQGLIGNSSSGLIEVPSL
EECCCCCCCCEEEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCEEECCCE
KVPTINIGERQKGRVRGDTVIDCECTAEAILASVTDSQSVVFQHTVQKAANPYYQQAVLE
ECCEEECCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHH
NALTEIKQFMQSSVPLCKDFYDLNINNQ
HHHHHHHHHHHHCCCHHHHHEEECCCCC
>Mature Secondary Structure
MKRLLYITGSRAEYGIMKRLLLALKDDSEIELTIVATGMHCDEKYGLTYQVIENDGFVID
CCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCEEEEECCCCEEEE
KLIDIHINTENNANILASMSICQAEFGQYFQDNKFDAVMILGDRYEIFSVAIAVAMHNLP
EEEEEEEECCCCCEEEEEHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCC
IIHLHGGEKTLGNYDEFIRHAITKMSKLHLASTEEYRQRIIQMGEHPDSVFNIGALGAEN
EEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHEEEECCCCCC
SLLMDLPTKQMLENRFGSLQNPYFMVVFHPETLTDTPLAEQMNALLLALKTLTLKYDLIF
CEEEECCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEEEEEEE
IGSNSDTGADEITVKVKAFCDETNSRYMTSVKPEEYLALNKYAQGLIGNSSSGLIEVPSL
EECCCCCCCCEEEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCEEECCCE
KVPTINIGERQKGRVRGDTVIDCECTAEAILASVTDSQSVVFQHTVQKAANPYYQQAVLE
ECCEEECCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHH
NALTEIKQFMQSSVPLCKDFYDLNINNQ
HHHHHHHHHHHHCCCHHHHHEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]