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The map label for this gene is argE

Identifier: 209696161

GI number: 209696161

Start: 2985996

End: 2987132

Strand: Reverse

Name: argE

Synonym: VSAL_I2755

Alternate gene names: 209696161

Gene position: 2987132-2985996 (Counterclockwise)

Preceding gene: 209696165

Following gene: 209696160

Centisome position: 89.83

GC content: 40.46

Gene sequence:

>1137_bases
ATGAAAATACCAGAATTTAAAGAATATTATCAACAGCTCATCTCAACCTCTTCAATCAGCTCTACAGACTCAAGCTGGGA
TGAAGGTAATGCAAAAGTCATACATAAATTAGCACAGTGGTGTGAAGATTTAGGCTGTGAAGTTGAAATTGAAGAAATAG
AGAAAGGAAAACTCAACCTATTGGCTAAATTAGGTTCAGGAGAAGGCGGGTTATTACTCGCAGGACACACCGATACCGTC
CCTTATGATCAAGGTCGTTGGAACTACGACCCTCACACTCTAACCGAAGCCAACGATCGATTTTATGGGCTTGGAACCGC
TGATATGAAAGGCTTCTTTGCCTTTATCTTAGAGGCAATAAAAAACATCAATTGGAAAGACCAATCTAAGCCACTTTATA
TTTTGGCCACCTGTGATGAAGAAACAACCATGCTTGGCGCCCGCCATTTCGCCTCAAACACTAGCATCCAACCGGATTAC
TGTATTATTGGTGAACCAACAAACTTAATGCCTATTCGTGGTCATAAAGGCCATGTCGCCAACGCCGTTCGTGTTACCGG
TAAATCTGGTCATTCATCAAACCCGGCTTATGGTGTTAATGCGTTAGAAATCATGAATGAAATCATGTTTGCTTTAATGA
ATTTAAAAAATAAATTAGTTAAGGAATACCACAACCCTGGTTTTTCTATTCCTTATCCAACCCTTAATCTTGGCCATATC
CATGGCGGTGATAGCCCGAATCGTATTTGCGGCTGTTGTGAACTTCATTATGACGTACGCCCATTACCGGGAATTAGCCT
TGATGGATTAGATAATATGCTGCGTGATGCATTGAAAGACGTCGAAGAAAAATGGCCAGGAAGAATTGAAATAACCCCGT
TGCATGAACCTATCCCAGGTTATGAATGCAGCGCTGATAGCCCTATCGTAACAAGTGTTGCTGAGATTTGTGGCCAAGAA
GTAGAAACCGTTAATTACTGTACTGAAGCTCCTTTCTTACAAGATCTTTGTCCAACATTAGTGTTAGGTCCGGGTTCCAT
TGAACAAGCGCACCAACCTGATGAATTTTTAGCATTTTCATTCATTGACCCGACAATCAATATATTGAGCAAATTAATGT
ATAAACATTGCTTTTAA

Upstream 100 bases:

>100_bases
CATTAAAATTAAACTAAACTGTATTTCTATTCACTTATTGTGATTTAATATGTGTTTTACAGGGTTCTCTCTTTTGTGTC
AACAGTGGATGTATGAATAA

Downstream 100 bases:

>100_bases
TCTGAAATAAATTTACAACACTCATTAAAAGCAAATCAATATTCGATGATCTACGGCAATGTATCGTTTAAAAAATCATC
GTTTATTCTTCAAAGTTTGA

Product: acetylornithine deacetylase

Products: NA

Alternate protein names: AO; Acetylornithinase; N-acetylornithinase; NAO

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MKIPEFKEYYQQLISTSSISSTDSSWDEGNAKVIHKLAQWCEDLGCEVEIEEIEKGKLNLLAKLGSGEGGLLLAGHTDTV
PYDQGRWNYDPHTLTEANDRFYGLGTADMKGFFAFILEAIKNINWKDQSKPLYILATCDEETTMLGARHFASNTSIQPDY
CIIGEPTNLMPIRGHKGHVANAVRVTGKSGHSSNPAYGVNALEIMNEIMFALMNLKNKLVKEYHNPGFSIPYPTLNLGHI
HGGDSPNRICGCCELHYDVRPLPGISLDGLDNMLRDALKDVEEKWPGRIEITPLHEPIPGYECSADSPIVTSVAEICGQE
VETVNYCTEAPFLQDLCPTLVLGPGSIEQAHQPDEFLAFSFIDPTINILSKLMYKHCF

Sequences:

>Translated_378_residues
MKIPEFKEYYQQLISTSSISSTDSSWDEGNAKVIHKLAQWCEDLGCEVEIEEIEKGKLNLLAKLGSGEGGLLLAGHTDTV
PYDQGRWNYDPHTLTEANDRFYGLGTADMKGFFAFILEAIKNINWKDQSKPLYILATCDEETTMLGARHFASNTSIQPDY
CIIGEPTNLMPIRGHKGHVANAVRVTGKSGHSSNPAYGVNALEIMNEIMFALMNLKNKLVKEYHNPGFSIPYPTLNLGHI
HGGDSPNRICGCCELHYDVRPLPGISLDGLDNMLRDALKDVEEKWPGRIEITPLHEPIPGYECSADSPIVTSVAEICGQE
VETVNYCTEAPFLQDLCPTLVLGPGSIEQAHQPDEFLAFSFIDPTINILSKLMYKHCF
>Mature_378_residues
MKIPEFKEYYQQLISTSSISSTDSSWDEGNAKVIHKLAQWCEDLGCEVEIEEIEKGKLNLLAKLGSGEGGLLLAGHTDTV
PYDQGRWNYDPHTLTEANDRFYGLGTADMKGFFAFILEAIKNINWKDQSKPLYILATCDEETTMLGARHFASNTSIQPDY
CIIGEPTNLMPIRGHKGHVANAVRVTGKSGHSSNPAYGVNALEIMNEIMFALMNLKNKLVKEYHNPGFSIPYPTLNLGHI
HGGDSPNRICGCCELHYDVRPLPGISLDGLDNMLRDALKDVEEKWPGRIEITPLHEPIPGYECSADSPIVTSVAEICGQE
VETVNYCTEAPFLQDLCPTLVLGPGSIEQAHQPDEFLAFSFIDPTINILSKLMYKHCF

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. ArgE subfamily

Homologues:

Organism=Escherichia coli, GI1790395, Length=379, Percent_Identity=56.7282321899736, Blast_Score=476, Evalue=1e-135,
Organism=Escherichia coli, GI1789236, Length=353, Percent_Identity=24.929178470255, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788816, Length=292, Percent_Identity=26.7123287671233, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17551016, Length=295, Percent_Identity=28.4745762711864, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGE_ALISL (B6EMN5)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002264091.1
- ProteinModelPortal:   B6EMN5
- MEROPS:   M20.974
- GeneID:   6988999
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I2755
- HOGENOM:   HBG728841
- OMA:   RICGQCA
- ProtClustDB:   PRK05111
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_01108
- InterPro:   IPR010169
- InterPro:   IPR001261
- InterPro:   IPR002933
- InterPro:   IPR011650
- TIGRFAMs:   TIGR01892

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20; SSF55031 Peptidase_M20_dimer

EC number: =3.5.1.16

Molecular weight: Translated: 41952; Mature: 41952

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00758 ARGE_DAPE_CPG2_1; PS00759 ARGE_DAPE_CPG2_2

Important sites: ACT_SITE 78-78 ACT_SITE 140-140

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIPEFKEYYQQLISTSSISSTDSSWDEGNAKVIHKLAQWCEDLGCEVEIEEIEKGKLNL
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEHHHHCCCCEEE
LAKLGSGEGGLLLAGHTDTVPYDQGRWNYDPHTLTEANDRFYGLGTADMKGFFAFILEAI
EEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHH
KNINWKDQSKPLYILATCDEETTMLGARHFASNTSIQPDYCIIGEPTNLMPIRGHKGHVA
HCCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEECCCCCEEEECCCCCCCC
NAVRVTGKSGHSSNPAYGVNALEIMNEIMFALMNLKNKLVKEYHNPGFSIPYPTLNLGHI
CEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECEE
HGGDSPNRICGCCELHYDVRPLPGISLDGLDNMLRDALKDVEEKWPGRIEITPLHEPIPG
CCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
YECSADSPIVTSVAEICGQEVETVNYCTEAPFLQDLCPTLVLGPGSIEQAHQPDEFLAFS
CCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCHHHHHCHHEEECCCCCCCCCCCCCEEEEE
FIDPTINILSKLMYKHCF
ECCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIPEFKEYYQQLISTSSISSTDSSWDEGNAKVIHKLAQWCEDLGCEVEIEEIEKGKLNL
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEHHHHCCCCEEE
LAKLGSGEGGLLLAGHTDTVPYDQGRWNYDPHTLTEANDRFYGLGTADMKGFFAFILEAI
EEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHH
KNINWKDQSKPLYILATCDEETTMLGARHFASNTSIQPDYCIIGEPTNLMPIRGHKGHVA
HCCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEECCCCCEEEECCCCCCCC
NAVRVTGKSGHSSNPAYGVNALEIMNEIMFALMNLKNKLVKEYHNPGFSIPYPTLNLGHI
CEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECEE
HGGDSPNRICGCCELHYDVRPLPGISLDGLDNMLRDALKDVEEKWPGRIEITPLHEPIPG
CCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
YECSADSPIVTSVAEICGQEVETVNYCTEAPFLQDLCPTLVLGPGSIEQAHQPDEFLAFS
CCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCHHHHHCHHEEECCCCCCCCCCCCCEEEEE
FIDPTINILSKLMYKHCF
ECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA