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The map label for this gene is exoI [H]

Identifier: 209695999

GI number: 209695999

Start: 2782932

End: 2784740

Strand: Direct

Name: exoI [H]

Synonym: VSAL_I2583

Alternate gene names: 209695999

Gene position: 2782932-2784740 (Clockwise)

Preceding gene: 209695998

Following gene: 209696000

Centisome position: 83.69

GC content: 40.74

Gene sequence:

>1809_bases
ATGATGGATTATCGTGTAGATCTTGCTGTTTTGTCTGAAAAAGACAACCTAAGTCGTTTTGGTTTAACATTACATAATTT
AAGTGATGTAGATCTTCATCATTGGCAGCTTCATTTCACCATTGATCGCTTCATCGCACCAAACAGCAACACCCAAGGAA
AACTTGAGCAAGTCGGTAGTTTCTGCAAGTTAACTCCCGAAGAAAAACAAGTACTAAAAGCGAACAACCATTATTATATC
GAATTTACGATTGCGACGGCCCCGTTCCGCTTTATTTCTGATGGGCTTGATGATGCGAGTATTTTTATTACTCAAGATGA
TAAAAACTATTTTTTAGATGTCTCTATTTCTCCTATCGTTTTAGCATCACCTTACTCAGAGAGAACTCAAATACCAAGAG
TCGCTCCGGCTGAATTATCATTAATACCAAAACCGGAATCGGTTCAACGTCTTGATGGGCAATTTGTTTTAAGCAATAAA
ACGTCATTAGAAATTCAGACGCATTTAGCCAATGGTGCCTCACAATGGCTTATTGAGGAGCTCGCAGCAATAACATCTCA
AGAGTTCGCCATCAAAAATACCGGTAATATTGTTTTTATGTCTAATCCAACATTGGATAAAGGCGCATACCAACTTACCG
TTACAGAAAGTACCGTACAAATTAAAGCTGGCTCAAACGAAGGTTTTTCTCATGGGTGTGCCACCTTATTGCAGCTCGTA
AGTGAACAAAATCAAACAATTCCATGTGTAAAAATAAGCGACCAACCTCGCTTTCATTACCGCGGAATGATGATCGATTG
TGCAAGGCACTTCCACCCTCTTGAGAGAGTTAAACGACTTATCAATCAGTTAGCCCAGTATAAATTTAATGTTTTTCACT
GGCACCTAACGGATGACGAAGGTTGGCGTGTTGAAATTAAAGCATTTCCAGAATTAACTGACATCGGCGCATGGCGCGGC
CCTGAAGAAACTCTAGAACCTCAATATACCCACGTAGCAAAAAAACACGGCGGATTTTACTCACAAGAAGAAATCAAAGA
GGTCATCGCTTATGCCGACATGCGTGGTATCACCGTTATTCCTGAAATTGATATTCCGGGACACTGCCGTGCAGCAATCA
AAGCATTACCTCATTTATTGGTTGATAAAGACGATCATTCAAACTACCGCAGTATTCAGCATTACACCGATAATGTTTTA
TCTCCTGCGATTGAAGGTACTTACACCTTTATTGATACTGTACTTGAAGAAATTGCGGCGTTATTTCCAGCCCCTTACAT
TCACATAGGTGCAGATGAAGTACCTAAAGGTGTCTGGACTGACAGTGAAAAGTGTCAAGCATTAATGGCCAAACAAGGTT
ATCGCGATCCCGTTGAACTTCAAGGTCATCTACTTCGTCATGCTGAAACAAAATTAAAGCAGCTCGGTAAAAGAATGTTG
GGATGGGAAGAGGCGCAACACGGAAATAAAGTCAGTAAAGACACGGTTATTTACTCTTGGTTAAGCGAAGAAGCGGCACT
TAACTGTGCAAAACAAGGCTTTGATGTGGTACTTCAACCTGGACAAACGACTTACCTAGATATGGCTCAAGATTATGCTC
CTGAAGAGCCAGGAGTAGATTGGGCTAATGTACTTCCTCTTGAAGATGCATATAACTATGAACCACTAGCAGAACTTGCT
GATAACGACCCTATTCGTAAACGAATTCTTGGTATTCAATGCGCGCTTTGGTGTGAAATCATCAATAACCAAGAGCGTAT
GGATTACATGATTTTCCCACGCCTTTTAGCGATGTCTGAAGGGATGTAG

Upstream 100 bases:

>100_bases
CCAATATTTAGTACAACCACAATTTGATGCTATTGAAGGTGGCATCCTGATGGCAGGAAAAGCAGAACATAACCTGTTCT
AGCATTATATTAAGGAAGAT

Downstream 100 bases:

>100_bases
ACACAAAAACAACACAGAAACTGGACAGACTTTTTATCAAAGTTAAATGGACGATTACCAACCCTAACACGTCAGGGTAT
TAATTTCCGTCAACCATAAG

Product: beta-hexosaminidase (beta-N-acetylglucosaminidase)

Products: NA

Alternate protein names: Beta-N-acetylhexosaminidase; N-acetyl-beta-glucosaminidase [H]

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MMDYRVDLAVLSEKDNLSRFGLTLHNLSDVDLHHWQLHFTIDRFIAPNSNTQGKLEQVGSFCKLTPEEKQVLKANNHYYI
EFTIATAPFRFISDGLDDASIFITQDDKNYFLDVSISPIVLASPYSERTQIPRVAPAELSLIPKPESVQRLDGQFVLSNK
TSLEIQTHLANGASQWLIEELAAITSQEFAIKNTGNIVFMSNPTLDKGAYQLTVTESTVQIKAGSNEGFSHGCATLLQLV
SEQNQTIPCVKISDQPRFHYRGMMIDCARHFHPLERVKRLINQLAQYKFNVFHWHLTDDEGWRVEIKAFPELTDIGAWRG
PEETLEPQYTHVAKKHGGFYSQEEIKEVIAYADMRGITVIPEIDIPGHCRAAIKALPHLLVDKDDHSNYRSIQHYTDNVL
SPAIEGTYTFIDTVLEEIAALFPAPYIHIGADEVPKGVWTDSEKCQALMAKQGYRDPVELQGHLLRHAETKLKQLGKRML
GWEEAQHGNKVSKDTVIYSWLSEEAALNCAKQGFDVVLQPGQTTYLDMAQDYAPEEPGVDWANVLPLEDAYNYEPLAELA
DNDPIRKRILGIQCALWCEIINNQERMDYMIFPRLLAMSEGM

Sequences:

>Translated_602_residues
MMDYRVDLAVLSEKDNLSRFGLTLHNLSDVDLHHWQLHFTIDRFIAPNSNTQGKLEQVGSFCKLTPEEKQVLKANNHYYI
EFTIATAPFRFISDGLDDASIFITQDDKNYFLDVSISPIVLASPYSERTQIPRVAPAELSLIPKPESVQRLDGQFVLSNK
TSLEIQTHLANGASQWLIEELAAITSQEFAIKNTGNIVFMSNPTLDKGAYQLTVTESTVQIKAGSNEGFSHGCATLLQLV
SEQNQTIPCVKISDQPRFHYRGMMIDCARHFHPLERVKRLINQLAQYKFNVFHWHLTDDEGWRVEIKAFPELTDIGAWRG
PEETLEPQYTHVAKKHGGFYSQEEIKEVIAYADMRGITVIPEIDIPGHCRAAIKALPHLLVDKDDHSNYRSIQHYTDNVL
SPAIEGTYTFIDTVLEEIAALFPAPYIHIGADEVPKGVWTDSEKCQALMAKQGYRDPVELQGHLLRHAETKLKQLGKRML
GWEEAQHGNKVSKDTVIYSWLSEEAALNCAKQGFDVVLQPGQTTYLDMAQDYAPEEPGVDWANVLPLEDAYNYEPLAELA
DNDPIRKRILGIQCALWCEIINNQERMDYMIFPRLLAMSEGM
>Mature_602_residues
MMDYRVDLAVLSEKDNLSRFGLTLHNLSDVDLHHWQLHFTIDRFIAPNSNTQGKLEQVGSFCKLTPEEKQVLKANNHYYI
EFTIATAPFRFISDGLDDASIFITQDDKNYFLDVSISPIVLASPYSERTQIPRVAPAELSLIPKPESVQRLDGQFVLSNK
TSLEIQTHLANGASQWLIEELAAITSQEFAIKNTGNIVFMSNPTLDKGAYQLTVTESTVQIKAGSNEGFSHGCATLLQLV
SEQNQTIPCVKISDQPRFHYRGMMIDCARHFHPLERVKRLINQLAQYKFNVFHWHLTDDEGWRVEIKAFPELTDIGAWRG
PEETLEPQYTHVAKKHGGFYSQEEIKEVIAYADMRGITVIPEIDIPGHCRAAIKALPHLLVDKDDHSNYRSIQHYTDNVL
SPAIEGTYTFIDTVLEEIAALFPAPYIHIGADEVPKGVWTDSEKCQALMAKQGYRDPVELQGHLLRHAETKLKQLGKRML
GWEEAQHGNKVSKDTVIYSWLSEEAALNCAKQGFDVVLQPGQTTYLDMAQDYAPEEPGVDWANVLPLEDAYNYEPLAELA
DNDPIRKRILGIQCALWCEIINNQERMDYMIFPRLLAMSEGM

Specific function: Hydrolyzes rapidly p-nitrophenyl-N-acetyl-beta-D- glucosaminide (PNP-beta-GlcNAc) and 4-methylumbelliferyl-beta- GlcNAc, and slightly active on p-nitrophenyl-beta-GalNAc. Hydrolyzes aryl-N-acetyl-beta-D-glucosaminide (aryl-beta-GlcNAc), aryl-beta-GalNAc a

COG id: COG3525

COG function: function code G; N-acetyl-beta-hexosaminidase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 20 family [H]

Homologues:

Organism=Homo sapiens, GI189181666, Length=407, Percent_Identity=29.7297297297297, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI4504373, Length=404, Percent_Identity=28.4653465346535, Blast_Score=156, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17569815, Length=469, Percent_Identity=27.0788912579957, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24653074, Length=502, Percent_Identity=26.4940239043825, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45551090, Length=502, Percent_Identity=26.4940239043825, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI281365639, Length=417, Percent_Identity=23.021582733813, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24657474, Length=417, Percent_Identity=23.021582733813, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24657468, Length=419, Percent_Identity=22.9116945107399, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI17647501, Length=419, Percent_Identity=22.9116945107399, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI17933586, Length=460, Percent_Identity=22.8260869565217, Blast_Score=109, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015882
- InterPro:   IPR001540
- InterPro:   IPR015883
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00728 Glyco_hydro_20; PF02838 Glyco_hydro_20b [H]

EC number: =3.2.1.52 [H]

Molecular weight: Translated: 68264; Mature: 68264

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDYRVDLAVLSEKDNLSRFGLTLHNLSDVDLHHWQLHFTIDRFIAPNSNTQGKLEQVGS
CCCEEEEEEEECCCCCCHHHCEEEECCCCCCEEEEEEEEEEEEEECCCCCCCCHHHHHCH
FCKLTPEEKQVLKANNHYYIEFTIATAPFRFISDGLDDASIFITQDDKNYFLDVSISPIV
HHCCCCHHHHHHCCCCEEEEEEEEECCCHHHHHCCCCCCEEEEEECCCCEEEEEECCCEE
LASPYSERTQIPRVAPAELSLIPKPESVQRLDGQFVLSNKTSLEIQTHLANGASQWLIEE
EECCCHHHCCCCCCCCCCEEECCCCHHHHHCCCEEEEECCCEEEEEEECCCCHHHHHHHH
LAAITSQEFAIKNTGNIVFMSNPTLDKGAYQLTVTESTVQIKAGSNEGFSHGCATLLQLV
HHHHCCCCEEEECCCCEEEEECCCCCCCEEEEEEECCEEEEEECCCCCCHHHHHHHHHHH
SEQNQTIPCVKISDQPRFHYRGMMIDCARHFHPLERVKRLINQLAQYKFNVFHWHLTDDE
HCCCCCCCEEEECCCCCEEECCCHHHHHHHCCHHHHHHHHHHHHHHCEEEEEEEEEECCC
GWRVEIKAFPELTDIGAWRGPEETLEPQYTHVAKKHGGFYSQEEIKEVIAYADMRGITVI
CCEEEEEECCCHHHCCCCCCCHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEE
PEIDIPGHCRAAIKALPHLLVDKDDHSNYRSIQHYTDNVLSPAIEGTYTFIDTVLEEIAA
ECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHH
LFPAPYIHIGADEVPKGVWTDSEKCQALMAKQGYRDPVELQGHLLRHAETKLKQLGKRML
HCCCCEEEECCHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GWEEAQHGNKVSKDTVIYSWLSEEAALNCAKQGFDVVLQPGQTTYLDMAQDYAPEEPGVD
CCHHHHCCCCCCCCCEEEEHHHHHHHHHHHHCCCEEEECCCCCEEHHHHHHCCCCCCCCC
WANVLPLEDAYNYEPLAELADNDPIRKRILGIQCALWCEIINNQERMDYMIFPRLLAMSE
HHHEEECHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
GM
CC
>Mature Secondary Structure
MMDYRVDLAVLSEKDNLSRFGLTLHNLSDVDLHHWQLHFTIDRFIAPNSNTQGKLEQVGS
CCCEEEEEEEECCCCCCHHHCEEEECCCCCCEEEEEEEEEEEEEECCCCCCCCHHHHHCH
FCKLTPEEKQVLKANNHYYIEFTIATAPFRFISDGLDDASIFITQDDKNYFLDVSISPIV
HHCCCCHHHHHHCCCCEEEEEEEEECCCHHHHHCCCCCCEEEEEECCCCEEEEEECCCEE
LASPYSERTQIPRVAPAELSLIPKPESVQRLDGQFVLSNKTSLEIQTHLANGASQWLIEE
EECCCHHHCCCCCCCCCCEEECCCCHHHHHCCCEEEEECCCEEEEEEECCCCHHHHHHHH
LAAITSQEFAIKNTGNIVFMSNPTLDKGAYQLTVTESTVQIKAGSNEGFSHGCATLLQLV
HHHHCCCCEEEECCCCEEEEECCCCCCCEEEEEEECCEEEEEECCCCCCHHHHHHHHHHH
SEQNQTIPCVKISDQPRFHYRGMMIDCARHFHPLERVKRLINQLAQYKFNVFHWHLTDDE
HCCCCCCCEEEECCCCCEEECCCHHHHHHHCCHHHHHHHHHHHHHHCEEEEEEEEEECCC
GWRVEIKAFPELTDIGAWRGPEETLEPQYTHVAKKHGGFYSQEEIKEVIAYADMRGITVI
CCEEEEEECCCHHHCCCCCCCHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEE
PEIDIPGHCRAAIKALPHLLVDKDDHSNYRSIQHYTDNVLSPAIEGTYTFIDTVLEEIAA
ECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHH
LFPAPYIHIGADEVPKGVWTDSEKCQALMAKQGYRDPVELQGHLLRHAETKLKQLGKRML
HCCCCEEEECCHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GWEEAQHGNKVSKDTVIYSWLSEEAALNCAKQGFDVVLQPGQTTYLDMAQDYAPEEPGVD
CCHHHHCCCCCCCCCEEEEHHHHHHHHHHHHCCCEEEECCCCCEEHHHHHHCCCCCCCCC
WANVLPLEDAYNYEPLAELADNDPIRKRILGIQCALWCEIINNQERMDYMIFPRLLAMSE
HHHEEECHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
GM
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969205 [H]