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The map label for this gene is arcA [H]

Identifier: 209695976

GI number: 209695976

Start: 2740146

End: 2740865

Strand: Direct

Name: arcA [H]

Synonym: VSAL_I2558

Alternate gene names: 209695976

Gene position: 2740146-2740865 (Clockwise)

Preceding gene: 209695971

Following gene: 209695979

Centisome position: 82.41

GC content: 40.69

Gene sequence:

>720_bases
ATGCAAACCCCTCAGATCCTAATCGTTGAAGATGAACACGTTACTCGTAATACACTAAAAAGCATTTTTGAAGCAGAAGG
CTACAATGTATTCGAAGCAAGCGATGGTGAAGAAATGCACACTGTGCTTTCTGAACAACAGCTTAATCTTGTGATTATGG
ACATCAACCTTCCAGGAAAAAATGGCCTTCTTCTTGCTCGTGAACTTCGCGAACGTGGTGATATGGCTCTTATGTTCCTT
ACAGGTAGAGACAATGAAGTTGATAAGATTTTAGGATTAGAAATCGGTGCTGATGATTACATCACAAAACCATTTAATCC
TCGCGAGCTGACTATTCGTGCACGTAACTTATTGACTCGTTCAATGAATCAAAGCACAGCCGTTGAAGATAAAAAACTGG
TTGAGCGTTATACATTCAATGGTTGGACTGTTGAAATCAACAGCCGCTCTCTAGTTAGCCCAAGCGGTGAAAGCTACAAG
CTTCCTCGCTCTGAATTCCGTGCCTTACTTCACTTCTGTGAAAACCCAGGTAAAATTCAGACTCGTGCTGACTTATTGAA
AAAAATGACAGGCCGTGAGCTAAAACCTCATGATCGTACTGTTGATGTAACTATTCGTCGCATCCGTAAGCATTTTGAAT
CAGTAACAGATACTCCTGAGATTATCGCTACTATTCATGGTGAAGGTTACCGTTTTTGTGGTGATCTAGAAGAGTTATAA

Upstream 100 bases:

>100_bases
CTACGATTGAAGAGTCTATTTCCTATTTGTAAATTTTTTATTATAGAATTAACACCGTTAATTCTACTTTTGACTTTAAT
CAGTTAGTTAGGTACCGCCC

Downstream 100 bases:

>100_bases
TAGTTAACTCTTTCTGAAATAAAAATGCCCCGCTCTATTTAGATAGACGGGGCATTTTTGTATCCGGTATTAAATTAATA
CACAGTATCAACCGAAACAT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MQTPQILIVEDEHVTRNTLKSIFEAEGYNVFEASDGEEMHTVLSEQQLNLVIMDINLPGKNGLLLARELRERGDMALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTRSMNQSTAVEDKKLVERYTFNGWTVEINSRSLVSPSGESYK
LPRSEFRALLHFCENPGKIQTRADLLKKMTGRELKPHDRTVDVTIRRIRKHFESVTDTPEIIATIHGEGYRFCGDLEEL

Sequences:

>Translated_239_residues
MQTPQILIVEDEHVTRNTLKSIFEAEGYNVFEASDGEEMHTVLSEQQLNLVIMDINLPGKNGLLLARELRERGDMALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTRSMNQSTAVEDKKLVERYTFNGWTVEINSRSLVSPSGESYK
LPRSEFRALLHFCENPGKIQTRADLLKKMTGRELKPHDRTVDVTIRRIRKHFESVTDTPEIIATIHGEGYRFCGDLEEL
>Mature_239_residues
MQTPQILIVEDEHVTRNTLKSIFEAEGYNVFEASDGEEMHTVLSEQQLNLVIMDINLPGKNGLLLARELRERGDMALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTRSMNQSTAVEDKKLVERYTFNGWTVEINSRSLVSPSGESYK
LPRSEFRALLHFCENPGKIQTRADLLKKMTGRELKPHDRTVDVTIRRIRKHFESVTDTPEIIATIHGEGYRFCGDLEEL

Specific function: Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expres

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790863, Length=238, Percent_Identity=83.6134453781513, Blast_Score=419, Evalue=1e-119,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=40.343347639485, Blast_Score=178, Evalue=3e-46,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=33.6206896551724, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1788394, Length=233, Percent_Identity=33.4763948497854, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786599, Length=232, Percent_Identity=34.051724137931, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI2367329, Length=233, Percent_Identity=32.618025751073, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790860, Length=241, Percent_Identity=31.1203319502075, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=32.4561403508772, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI87082012, Length=233, Percent_Identity=31.3304721030043, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI1787375, Length=229, Percent_Identity=29.6943231441048, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=28.3898305084746, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=29.9559471365639, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1790552, Length=234, Percent_Identity=30.7692307692308, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=26.8722466960352, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=37.6237623762376, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27392; Mature: 27392

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTPQILIVEDEHVTRNTLKSIFEAEGYNVFEASDGEEMHTVLSEQQLNLVIMDINLPGK
CCCCCEEEEECCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCCEEEEEEECCCC
NGLLLARELRERGDMALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTR
CCEEEHHHHHHCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEEHHHHHHHH
SMNQSTAVEDKKLVERYTFNGWTVEINSRSLVSPSGESYKLPRSEFRALLHFCENPGKIQ
HCCCHHHHHHHHHHHHHCCCCEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCC
TRADLLKKMTGRELKPHDRTVDVTIRRIRKHFESVTDTPEIIATIHGEGYRFCGDLEEL
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEECCCCCCC
>Mature Secondary Structure
MQTPQILIVEDEHVTRNTLKSIFEAEGYNVFEASDGEEMHTVLSEQQLNLVIMDINLPGK
CCCCCEEEEECCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCCEEEEEEECCCC
NGLLLARELRERGDMALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLTR
CCEEEHHHHHHCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEEHHHHHHHH
SMNQSTAVEDKKLVERYTFNGWTVEINSRSLVSPSGESYKLPRSEFRALLHFCENPGKIQ
HCCCHHHHHHHHHHHHHCCCCEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCC
TRADLLKKMTGRELKPHDRTVDVTIRRIRKHFESVTDTPEIIATIHGEGYRFCGDLEEL
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]