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The map label for this gene is trxC [H]

Identifier: 209695312

GI number: 209695312

Start: 1981008

End: 1981442

Strand: Reverse

Name: trxC [H]

Synonym: VSAL_I1845

Alternate gene names: 209695312

Gene position: 1981442-1981008 (Counterclockwise)

Preceding gene: 209695313

Following gene: 209695306

Centisome position: 59.59

GC content: 40.92

Gene sequence:

>435_bases
ATGTCGCAATTTCAATCTCGATGCCCTTCTTGCCAAGGCATAAACCGTCTTCCTATCGAACGTATTAACGACAAACCTAC
TTGTGGTCGCTGTAAGGAACTCTTGTTAGATGGAAAACCATTAGAAGGCACTAGTGAAAACTTATCCGCATTATTAGACA
GCGAACAACCTATTGTTATCGATTTTTGGGCACCTTGGTGTAATCCGTGTGTCGGCTTCTCACCTGTTTTTGAAGACGTT
GCCGCTGAACGTAATGGCCAAGTTCGTTGTGTGAAAGTAAATACTGAAGCCCAACAACAAATTGCAGCACAATATCAAAT
TCGTTCAATTCCAACGATCATGGTTTTCAAAAATGGAGAACGTGTAGATATGATCAATGGTGCATTGCCAAAAGGTCAGT
TTGATCAGTGGTTAAACCAAGCACTACTTAAATAG

Upstream 100 bases:

>100_bases
GGGGCTATTTGCTCCTTTTTTATTGAGTTTCGTATTATCTACCCCCATTATTTCTTTATGCTCACAAACTACTTCATGTA
GAAAATAATAAAGGAATAAC

Downstream 100 bases:

>100_bases
TCAGTCACAACCCTTAAAAGATCAAAAAAAGCCCCTTTACTGGATAACCAATAAAGGGGCTTACATTTCTATTTATCTAT
TTATCAAATACACATTAATT

Product: thioredoxin 2

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 144; Mature: 143

Protein sequence:

>144_residues
MSQFQSRCPSCQGINRLPIERINDKPTCGRCKELLLDGKPLEGTSENLSALLDSEQPIVIDFWAPWCNPCVGFSPVFEDV
AAERNGQVRCVKVNTEAQQQIAAQYQIRSIPTIMVFKNGERVDMINGALPKGQFDQWLNQALLK

Sequences:

>Translated_144_residues
MSQFQSRCPSCQGINRLPIERINDKPTCGRCKELLLDGKPLEGTSENLSALLDSEQPIVIDFWAPWCNPCVGFSPVFEDV
AAERNGQVRCVKVNTEAQQQIAAQYQIRSIPTIMVFKNGERVDMINGALPKGQFDQWLNQALLK
>Mature_143_residues
SQFQSRCPSCQGINRLPIERINDKPTCGRCKELLLDGKPLEGTSENLSALLDSEQPIVIDFWAPWCNPCVGFSPVFEDVA
AERNGQVRCVKVNTEAQQQIAAQYQIRSIPTIMVFKNGERVDMINGALPKGQFDQWLNQALLK

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=32.6086956521739, Blast_Score=75, Evalue=3e-14,
Organism=Escherichia coli, GI1788936, Length=135, Percent_Identity=58.5185185185185, Blast_Score=181, Evalue=2e-47,
Organism=Escherichia coli, GI87082331, Length=92, Percent_Identity=39.1304347826087, Blast_Score=84, Evalue=3e-18,
Organism=Escherichia coli, GI87081747, Length=86, Percent_Identity=36.046511627907, Blast_Score=72, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=92, Percent_Identity=33.695652173913, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17507705, Length=82, Percent_Identity=40.2439024390244, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=73, Percent_Identity=30.1369863013699, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115532378, Length=101, Percent_Identity=31.6831683168317, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=75, Percent_Identity=29.3333333333333, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI115532380, Length=68, Percent_Identity=33.8235294117647, Blast_Score=62, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=90, Percent_Identity=32.2222222222222, Blast_Score=61, Evalue=7e-11,
Organism=Drosophila melanogaster, GI28573567, Length=92, Percent_Identity=32.6086956521739, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 16153; Mature: 16022

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQFQSRCPSCQGINRLPIERINDKPTCGRCKELLLDGKPLEGTSENLSALLDSEQPIVI
CCCHHHHCCCCCCCCCCCHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEE
DFWAPWCNPCVGFSPVFEDVAAERNGQVRCVKVNTEAQQQIAAQYQIRSIPTIMVFKNGE
EECCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCC
RVDMINGALPKGQFDQWLNQALLK
EEEECCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SQFQSRCPSCQGINRLPIERINDKPTCGRCKELLLDGKPLEGTSENLSALLDSEQPIVI
CCHHHHCCCCCCCCCCCHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEE
DFWAPWCNPCVGFSPVFEDVAAERNGQVRCVKVNTEAQQQIAAQYQIRSIPTIMVFKNGE
EECCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCC
RVDMINGALPKGQFDQWLNQALLK
EEEECCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]