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The map label for this gene is norM [H]

Identifier: 209694908

GI number: 209694908

Start: 1499112

End: 1500494

Strand: Reverse

Name: norM [H]

Synonym: VSAL_I1382

Alternate gene names: 209694908

Gene position: 1500494-1499112 (Counterclockwise)

Preceding gene: 209694910

Following gene: 209694906

Centisome position: 45.13

GC content: 42.37

Gene sequence:

>1383_bases
GTGCACAGATACCAAAAAGAAATCGTTCGCTTAATCAAGCTATCTACCCCTGTTCTAATTGCGAGTGTTGCTCAAACAGG
CATGGGGTTTGTCGATACAGTAATGGCAGGTGGCGTAAGTGCTACCGACATGGCAGCCGTTGCGATTGCAGCCAGTGTTT
GGCTGCCTGCTATATTATTTGGTGTTGGTTTACTAATGGCACTTGTGCCTGTTGTTGCTCAACTGAATGGTTCAGGAAAA
TCGAAAAAAATTCCTTTTGAGATCCATCAGGGCATTTATTTAGCCCTACTGATCTCTATTCCTATTATGGTTATCCTTTA
CAACGCCGGACATATCATTGCATTAATGAATGTTGAGCCTGAGTTATATGAAAAAACTAAAGGTTACTTACACGCCGTAT
TGTGGGCCGCACCTGCGTTTTTATTATTCCAAGCATTGCGCAGTTTCTGCGAAGGTTTGTCATTAACGATACCTGCAATG
GTCATTGGTTTTATCGGTCTTGCCGCTAACATCCCTCTAAACTGGATGTTTGTATATGGCAAGCTTGGTGCCCCTCCCCT
AGGTGGTGTTGGTTGTGGTATTGCAACCGCTATTGTCTACTGGCTGATGTTTGTTGCGATGATCATTTATACGTTTGTAG
CGCCAAAGCTACGCCGCGTAAACTTATATGAAAACTGGAACAAACCACAACTAAAAGAAATCTATCGCTTATTTAAGCTG
GGTCTTCCTGTTGCCTTGTCTATTTTCTTTGAAGTAACCTTATTTGCAGCGGTTGCTCTATTGGTTTCCCCATTAGGCTC
TACCGTTGTTGCTGCCCATCAGGTGGCGATTAACTTCTCTTCATTGATCTTTATGGTGCCAATGAGCATTGCGATTGCAG
TAAGTATTCGCGTAGGTCAAAAATTAGGTGAAAATGATCTTGAAGGAGCACGAATTGCAAGCTATTGCGGTTTGGCTTTT
GGTCTATTAATGGCATTTTGTACCGCTATTTTAACCGTACTTTTTCGCGAATCTATTGCTTATTTATACACAGACAACGT
CGAAGTAGTACATCTCGCGGTAAGCTTAATGTTATTGGCTGCGGTTTACCAATGTACTGATGCAGTGCAAGTTGTTGCTG
CTGGTGCATTGCGTGGCTATAAAGACATGACAGCAATCTTTAAACGTACGTTTATCTCTTATTGGATTGTCGGTTTGCCT
GCGGGATACATTCTAGGCATGACGGATTGGATCGTTGAGCCTATGGGTGTTTACGGTTTCTGGATTGGCTTTATTGGTGG
TTTAAGTACCGCTGCTATCCTATTAAGCTTACGTTTACGTTGGCTACAGAAAAACCCACAACACATCAATATGGAAGTCG
ATGAATTGCAAGTAATGCATTAA

Upstream 100 bases:

>100_bases
AGCACTCAATCAGACCCTTATATCTCTTTTTATTCGATCTCATGATCGGCTCTAAAAGTCATCGCTATAACCTTTACATA
TTAATATCCACGGTGAATCA

Downstream 100 bases:

>100_bases
TCCCATATTCAAAATAAAAATCCCCAAAGAGTACTTCTCCTTGGGGATTTTTATTATGTGAAGATCTATATTTATACCTA
CCAAATACCAACGGGGACGC

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter; Na(+)/drug antiporter [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MHRYQKEIVRLIKLSTPVLIASVAQTGMGFVDTVMAGGVSATDMAAVAIAASVWLPAILFGVGLLMALVPVVAQLNGSGK
SKKIPFEIHQGIYLALLISIPIMVILYNAGHIIALMNVEPELYEKTKGYLHAVLWAAPAFLLFQALRSFCEGLSLTIPAM
VIGFIGLAANIPLNWMFVYGKLGAPPLGGVGCGIATAIVYWLMFVAMIIYTFVAPKLRRVNLYENWNKPQLKEIYRLFKL
GLPVALSIFFEVTLFAAVALLVSPLGSTVVAAHQVAINFSSLIFMVPMSIAIAVSIRVGQKLGENDLEGARIASYCGLAF
GLLMAFCTAILTVLFRESIAYLYTDNVEVVHLAVSLMLLAAVYQCTDAVQVVAAGALRGYKDMTAIFKRTFISYWIVGLP
AGYILGMTDWIVEPMGVYGFWIGFIGGLSTAAILLSLRLRWLQKNPQHINMEVDELQVMH

Sequences:

>Translated_460_residues
MHRYQKEIVRLIKLSTPVLIASVAQTGMGFVDTVMAGGVSATDMAAVAIAASVWLPAILFGVGLLMALVPVVAQLNGSGK
SKKIPFEIHQGIYLALLISIPIMVILYNAGHIIALMNVEPELYEKTKGYLHAVLWAAPAFLLFQALRSFCEGLSLTIPAM
VIGFIGLAANIPLNWMFVYGKLGAPPLGGVGCGIATAIVYWLMFVAMIIYTFVAPKLRRVNLYENWNKPQLKEIYRLFKL
GLPVALSIFFEVTLFAAVALLVSPLGSTVVAAHQVAINFSSLIFMVPMSIAIAVSIRVGQKLGENDLEGARIASYCGLAF
GLLMAFCTAILTVLFRESIAYLYTDNVEVVHLAVSLMLLAAVYQCTDAVQVVAAGALRGYKDMTAIFKRTFISYWIVGLP
AGYILGMTDWIVEPMGVYGFWIGFIGGLSTAAILLSLRLRWLQKNPQHINMEVDELQVMH
>Mature_460_residues
MHRYQKEIVRLIKLSTPVLIASVAQTGMGFVDTVMAGGVSATDMAAVAIAASVWLPAILFGVGLLMALVPVVAQLNGSGK
SKKIPFEIHQGIYLALLISIPIMVILYNAGHIIALMNVEPELYEKTKGYLHAVLWAAPAFLLFQALRSFCEGLSLTIPAM
VIGFIGLAANIPLNWMFVYGKLGAPPLGGVGCGIATAIVYWLMFVAMIIYTFVAPKLRRVNLYENWNKPQLKEIYRLFKL
GLPVALSIFFEVTLFAAVALLVSPLGSTVVAAHQVAINFSSLIFMVPMSIAIAVSIRVGQKLGENDLEGARIASYCGLAF
GLLMAFCTAILTVLFRESIAYLYTDNVEVVHLAVSLMLLAAVYQCTDAVQVVAAGALRGYKDMTAIFKRTFISYWIVGLP
AGYILGMTDWIVEPMGVYGFWIGFIGGLSTAAILLSLRLRWLQKNPQHINMEVDELQVMH

Specific function: Multidrug efflux pump that functions as a Na(+)/drug antiporter [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=460, Percent_Identity=23.0434782608696, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI153792564, Length=442, Percent_Identity=24.4343891402715, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI38261960, Length=478, Percent_Identity=23.2217573221757, Blast_Score=96, Evalue=8e-20,
Organism=Escherichia coli, GI48994890, Length=453, Percent_Identity=57.6158940397351, Blast_Score=507, Evalue=1e-145,
Organism=Escherichia coli, GI226510954, Length=458, Percent_Identity=23.7991266375546, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320545, Length=426, Percent_Identity=23.2394366197183, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6321821, Length=324, Percent_Identity=25, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 50103; Mature: 50103

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRYQKEIVRLIKLSTPVLIASVAQTGMGFVDTVMAGGVSATDMAAVAIAASVWLPAILF
CCHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
GVGLLMALVPVVAQLNGSGKSKKIPFEIHQGIYLALLISIPIMVILYNAGHIIALMNVEP
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCH
ELYEKTKGYLHAVLWAAPAFLLFQALRSFCEGLSLTIPAMVIGFIGLAANIPLNWMFVYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEEEE
KLGAPPLGGVGCGIATAIVYWLMFVAMIIYTFVAPKLRRVNLYENWNKPQLKEIYRLFKL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEHHCCCCCCHHHHHHHHHHH
GLPVALSIFFEVTLFAAVALLVSPLGSTVVAAHQVAINFSSLIFMVPMSIAIAVSIRVGQ
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLGENDLEGARIASYCGLAFGLLMAFCTAILTVLFRESIAYLYTDNVEVVHLAVSLMLLA
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHH
AVYQCTDAVQVVAAGALRGYKDMTAIFKRTFISYWIVGLPAGYILGMTDWIVEPMGVYGF
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHH
WIGFIGGLSTAAILLSLRLRWLQKNPQHINMEVDELQVMH
HHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHEECC
>Mature Secondary Structure
MHRYQKEIVRLIKLSTPVLIASVAQTGMGFVDTVMAGGVSATDMAAVAIAASVWLPAILF
CCHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
GVGLLMALVPVVAQLNGSGKSKKIPFEIHQGIYLALLISIPIMVILYNAGHIIALMNVEP
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCH
ELYEKTKGYLHAVLWAAPAFLLFQALRSFCEGLSLTIPAMVIGFIGLAANIPLNWMFVYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEEEE
KLGAPPLGGVGCGIATAIVYWLMFVAMIIYTFVAPKLRRVNLYENWNKPQLKEIYRLFKL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEHHCCCCCCHHHHHHHHHHH
GLPVALSIFFEVTLFAAVALLVSPLGSTVVAAHQVAINFSSLIFMVPMSIAIAVSIRVGQ
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLGENDLEGARIASYCGLAFGLLMAFCTAILTVLFRESIAYLYTDNVEVVHLAVSLMLLA
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHH
AVYQCTDAVQVVAAGALRGYKDMTAIFKRTFISYWIVGLPAGYILGMTDWIVEPMGVYGF
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHH
WIGFIGGLSTAAILLSLRLRWLQKNPQHINMEVDELQVMH
HHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA