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The map label for this gene is nrdZ [H]

Identifier: 209694807

GI number: 209694807

Start: 1377116

End: 1379269

Strand: Reverse

Name: nrdZ [H]

Synonym: VSAL_I1270

Alternate gene names: 209694807

Gene position: 1379269-1377116 (Counterclockwise)

Preceding gene: 209694809

Following gene: 209694806

Centisome position: 41.48

GC content: 41.64

Gene sequence:

>2154_bases
ATGCCACAATCTAAAAATGCGACAGTTTCCCTAGCGAATCCCACTGAAATTGCTTACCAATCGACCTCAATGGACATTTG
GGAGAGTAAATATTGTCTTAAAAACAAACAAGGCAATCGTGTTGATCTTTCCATGGACGATACCTTTAAACGCGTTGCCA
AAGCTCTGTCTGATTTAGAACAACCCGCAGAACAAAAACAATGGAATGAACAATTCTTATGGGCATTGCGTAATGGTGCA
ATCCCGGCTGGACGCATCACATCAAATGCAGGTGCCTTCGAACATAAACCGGCAACATCAACCATTAACTGTACCGTTTC
TGGCACCATCGTTGACTCTATGGATGACATTTTAGGAAAAGTACACGAAGCTGGGTTAACGCTTAAAGCTGGCTGCGGTA
TTGGGTACGACTTTTCAACATTACGTCCTCGTGGCGCATTTGTGTCTGGTGCTGGCGCTTACACGTCAGGCCCTCTATCG
TTCATGGATATCTACGATAAAATGTGTTTTACCGTCTCTTCTGCTGGTGGACGCCGTGGCGCACAAATGGGCACCATGGA
TATTCGACACCCTGACGTTATCGACTTTATTCGAGCAAAACGGGAAGATGGCCGCCTACGCCAATTTAACTTGTCACTGC
TCATTACCGAAGATTTTGTAGAAGCAGTTAAAAATCAAAACGATTGGCAACTGATTTTTCCAATTACACTAAAAGAAGCG
AAATTAGATCACATGGATCTATACAGCGATAACAGTGTGGTATGGGCTGACTGGCCAGTAAAAGAAGGGTTCGCAGAAAA
CGAAGAAGGCTTAGTTGCTTGTAAGGTCTATCGTACGATGCCAGCTCAAAATCTGTGGAACATCATAATGACATCAACGT
ATGATTACGCAGAACCTGGCTTTATTCTAATCGACAAAGTAAACCAGATGAACAACAACTGGTTCTGTGAAGAAATAAGA
GCAACAAACCCTTGTGGTGAACAGCCTCTTCCTCCTTATGGAGCTTGTTTATTAGGATCGATTAATTTGACTAAGTTTGT
CCGTAATCCATTTACTGACACTGCTTTTTTTGATTGGGATGCTTATCGTAATGTCGTTTCTATCTTCACTCGCATGCTTG
ATAACGTTGTTGAAATTAATCAGTTACCACTAGAGCAACAACGTCATGAGATCATGCATAAACGTCGTCATGGCATGGGT
TTCTTAGGCCTTGGTTCAACATTAACGATGCTACAACACAAATATGGCAGTATTGAATCCATTGGGTTTACGGAACAAGT
TGCTCAAGAAATGGCGGTTACTGGTTGGAAGTCAGGACTCGATTTAGCCGCGGAGAAAGGCTCTGCACCAATCATGGAAG
AAAGCTTTATCGTGACAGCAAAAATGCTTCGCCAACGCCCTGAGATGGCTGAGGATGGCATTAAACTGGGTGATAAAGTA
AAAGGAAAAGTATTGCATGCTAAGTACAGTCGTTACATGCAACAGTTGGCAATCATTGAACCAAAACTCGTCGCTAAGAT
CATTGAACAAGGTGTTCGTTTTACCCACCACAGTTCTATTGCACCAACAGGCACCATCTCATTATCTCTTGCTAATAATG
CAAGTAATGGCATAGAGCCAAGCTTTGCACACCATTACACTCGTAATGTCATTAAGACAGGTAAAAAATCAAAAGAAAGT
GTTGATGTCTACAGCTATGAATTATTAGCATACCGTGCATTAATTAACGACAAAGCAATGCCATACAGTACTAATGAAGA
AAATAAGCTACCTGATTATTTTATTACTGCTGACGACATAACCCCTCAGCAACATGTTGCTGTACAGGCTGCGGCTCAGA
AATGGATTGATTCATCGATTTCTAAAACAGCGAACATACCAACAGACTTCCCATTCGAAGAGTTCAAAGACATTTATATG
GATGCTTACGACAAAGGATTGAAGGGCTGTACAACTTTCCGCTTTAACCCTGAAGTATTCCAAGGGGTTCTCGTTAAAGA
AGAAGACCTAGAAAATACAACGTATTGCTTTACGCTAGAAGATGGCTCGACATTAGAAGCAAAAGGCAACGAAAAAATTG
AGTACGATGGTGAGATGCATACCGCCGCTAATTTATATGATGCGCTAAAAGAAGGTTACTACGGTAAATTTTAA

Upstream 100 bases:

>100_bases
CTTTGTCAAGACTTGAAGATCATATTATATAATGGTTTGATCCCCCCTCCTGAGTTTTGCATTCCATTTTCTATCTTTAT
GACGCAGTAAGGTCTTCTAC

Downstream 100 bases:

>100_bases
TTTACCGCCCTCATCCAATTCAATATAACTAAATAATAAAAATTAGGGAGCATCCCTCCCTATTTAAAGATTAAGAAGGG
TTTACCATGGTCAAGAAAAT

Product: ribonucleotide reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 717; Mature: 716

Protein sequence:

>717_residues
MPQSKNATVSLANPTEIAYQSTSMDIWESKYCLKNKQGNRVDLSMDDTFKRVAKALSDLEQPAEQKQWNEQFLWALRNGA
IPAGRITSNAGAFEHKPATSTINCTVSGTIVDSMDDILGKVHEAGLTLKAGCGIGYDFSTLRPRGAFVSGAGAYTSGPLS
FMDIYDKMCFTVSSAGGRRGAQMGTMDIRHPDVIDFIRAKREDGRLRQFNLSLLITEDFVEAVKNQNDWQLIFPITLKEA
KLDHMDLYSDNSVVWADWPVKEGFAENEEGLVACKVYRTMPAQNLWNIIMTSTYDYAEPGFILIDKVNQMNNNWFCEEIR
ATNPCGEQPLPPYGACLLGSINLTKFVRNPFTDTAFFDWDAYRNVVSIFTRMLDNVVEINQLPLEQQRHEIMHKRRHGMG
FLGLGSTLTMLQHKYGSIESIGFTEQVAQEMAVTGWKSGLDLAAEKGSAPIMEESFIVTAKMLRQRPEMAEDGIKLGDKV
KGKVLHAKYSRYMQQLAIIEPKLVAKIIEQGVRFTHHSSIAPTGTISLSLANNASNGIEPSFAHHYTRNVIKTGKKSKES
VDVYSYELLAYRALINDKAMPYSTNEENKLPDYFITADDITPQQHVAVQAAAQKWIDSSISKTANIPTDFPFEEFKDIYM
DAYDKGLKGCTTFRFNPEVFQGVLVKEEDLENTTYCFTLEDGSTLEAKGNEKIEYDGEMHTAANLYDALKEGYYGKF

Sequences:

>Translated_717_residues
MPQSKNATVSLANPTEIAYQSTSMDIWESKYCLKNKQGNRVDLSMDDTFKRVAKALSDLEQPAEQKQWNEQFLWALRNGA
IPAGRITSNAGAFEHKPATSTINCTVSGTIVDSMDDILGKVHEAGLTLKAGCGIGYDFSTLRPRGAFVSGAGAYTSGPLS
FMDIYDKMCFTVSSAGGRRGAQMGTMDIRHPDVIDFIRAKREDGRLRQFNLSLLITEDFVEAVKNQNDWQLIFPITLKEA
KLDHMDLYSDNSVVWADWPVKEGFAENEEGLVACKVYRTMPAQNLWNIIMTSTYDYAEPGFILIDKVNQMNNNWFCEEIR
ATNPCGEQPLPPYGACLLGSINLTKFVRNPFTDTAFFDWDAYRNVVSIFTRMLDNVVEINQLPLEQQRHEIMHKRRHGMG
FLGLGSTLTMLQHKYGSIESIGFTEQVAQEMAVTGWKSGLDLAAEKGSAPIMEESFIVTAKMLRQRPEMAEDGIKLGDKV
KGKVLHAKYSRYMQQLAIIEPKLVAKIIEQGVRFTHHSSIAPTGTISLSLANNASNGIEPSFAHHYTRNVIKTGKKSKES
VDVYSYELLAYRALINDKAMPYSTNEENKLPDYFITADDITPQQHVAVQAAAQKWIDSSISKTANIPTDFPFEEFKDIYM
DAYDKGLKGCTTFRFNPEVFQGVLVKEEDLENTTYCFTLEDGSTLEAKGNEKIEYDGEMHTAANLYDALKEGYYGKF
>Mature_716_residues
PQSKNATVSLANPTEIAYQSTSMDIWESKYCLKNKQGNRVDLSMDDTFKRVAKALSDLEQPAEQKQWNEQFLWALRNGAI
PAGRITSNAGAFEHKPATSTINCTVSGTIVDSMDDILGKVHEAGLTLKAGCGIGYDFSTLRPRGAFVSGAGAYTSGPLSF
MDIYDKMCFTVSSAGGRRGAQMGTMDIRHPDVIDFIRAKREDGRLRQFNLSLLITEDFVEAVKNQNDWQLIFPITLKEAK
LDHMDLYSDNSVVWADWPVKEGFAENEEGLVACKVYRTMPAQNLWNIIMTSTYDYAEPGFILIDKVNQMNNNWFCEEIRA
TNPCGEQPLPPYGACLLGSINLTKFVRNPFTDTAFFDWDAYRNVVSIFTRMLDNVVEINQLPLEQQRHEIMHKRRHGMGF
LGLGSTLTMLQHKYGSIESIGFTEQVAQEMAVTGWKSGLDLAAEKGSAPIMEESFIVTAKMLRQRPEMAEDGIKLGDKVK
GKVLHAKYSRYMQQLAIIEPKLVAKIIEQGVRFTHHSSIAPTGTISLSLANNASNGIEPSFAHHYTRNVIKTGKKSKESV
DVYSYELLAYRALINDKAMPYSTNEENKLPDYFITADDITPQQHVAVQAAAQKWIDSSISKTANIPTDFPFEEFKDIYMD
AYDKGLKGCTTFRFNPEVFQGVLVKEEDLENTTYCFTLEDGSTLEAKGNEKIEYDGEMHTAANLYDALKEGYYGKF

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=472, Percent_Identity=23.9406779661017, Blast_Score=113, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17555242, Length=452, Percent_Identity=23.0088495575221, Blast_Score=112, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6320914, Length=371, Percent_Identity=23.989218328841, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6322123, Length=380, Percent_Identity=23.6842105263158, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17352481, Length=472, Percent_Identity=24.5762711864407, Blast_Score=120, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 80451; Mature: 80320

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQSKNATVSLANPTEIAYQSTSMDIWESKYCLKNKQGNRVDLSMDDTFKRVAKALSDLE
CCCCCCCEEEECCCCCEEEECCCCHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHH
QPAEQKQWNEQFLWALRNGAIPAGRITSNAGAFEHKPATSTINCTVSGTIVDSMDDILGK
CHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCEEEEEEECEEHHHHHHHHHH
VHEAGLTLKAGCGIGYDFSTLRPRGAFVSGAGAYTSGPLSFMDIYDKMCFTVSSAGGRRG
HHHCCCEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHEEECCCCCCC
AQMGTMDIRHPDVIDFIRAKREDGRLRQFNLSLLITEDFVEAVKNQNDWQLIFPITLKEA
CCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEEEEEEHHHHHHHCCCCCCEEEEEEEECCC
KLDHMDLYSDNSVVWADWPVKEGFAENEEGLVACKVYRTMPAQNLWNIIMTSTYDYAEPG
CCCHHEEECCCCEEEECCCCCCCCCCCCCCEEEEEEEHHCCHHHHHHHHHCCCCCCCCCC
FILIDKVNQMNNNWFCEEIRATNPCGEQPLPPYGACLLGSINLTKFVRNPFTDTAFFDWD
EEEEECHHHCCCCEEHHHHCCCCCCCCCCCCCCCHHHCCCCHHHHHHCCCCCCCEEECHH
AYRNVVSIFTRMLDNVVEINQLPLEQQRHEIMHKRRHGMGFLGLGSTLTMLQHKYGSIES
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCCC
IGFTEQVAQEMAVTGWKSGLDLAAEKGSAPIMEESFIVTAKMLRQRPEMAEDGIKLGDKV
CCCHHHHHHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCCHH
KGKVLHAKYSRYMQQLAIIEPKLVAKIIEQGVRFTHHSSIAPTGTISLSLANNASNGIEP
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEECCCCCCCCEEEEEEECCCCCCCCC
SFAHHYTRNVIKTGKKSKESVDVYSYELLAYRALINDKAMPYSTNEENKLPDYFITADDI
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCC
TPQQHVAVQAAAQKWIDSSISKTANIPTDFPFEEFKDIYMDAYDKGLKGCTTFRFNPEVF
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECHHHH
QGVLVKEEDLENTTYCFTLEDGSTLEAKGNEKIEYDGEMHTAANLYDALKEGYYGKF
HCEEEECCCCCCCEEEEEECCCCEEECCCCCCEEECCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PQSKNATVSLANPTEIAYQSTSMDIWESKYCLKNKQGNRVDLSMDDTFKRVAKALSDLE
CCCCCCEEEECCCCCEEEECCCCHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHH
QPAEQKQWNEQFLWALRNGAIPAGRITSNAGAFEHKPATSTINCTVSGTIVDSMDDILGK
CHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCEEEEEEECEEHHHHHHHHHH
VHEAGLTLKAGCGIGYDFSTLRPRGAFVSGAGAYTSGPLSFMDIYDKMCFTVSSAGGRRG
HHHCCCEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHEEECCCCCCC
AQMGTMDIRHPDVIDFIRAKREDGRLRQFNLSLLITEDFVEAVKNQNDWQLIFPITLKEA
CCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEEEEEEHHHHHHHCCCCCCEEEEEEEECCC
KLDHMDLYSDNSVVWADWPVKEGFAENEEGLVACKVYRTMPAQNLWNIIMTSTYDYAEPG
CCCHHEEECCCCEEEECCCCCCCCCCCCCCEEEEEEEHHCCHHHHHHHHHCCCCCCCCCC
FILIDKVNQMNNNWFCEEIRATNPCGEQPLPPYGACLLGSINLTKFVRNPFTDTAFFDWD
EEEEECHHHCCCCEEHHHHCCCCCCCCCCCCCCCHHHCCCCHHHHHHCCCCCCCEEECHH
AYRNVVSIFTRMLDNVVEINQLPLEQQRHEIMHKRRHGMGFLGLGSTLTMLQHKYGSIES
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCCC
IGFTEQVAQEMAVTGWKSGLDLAAEKGSAPIMEESFIVTAKMLRQRPEMAEDGIKLGDKV
CCCHHHHHHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCCHH
KGKVLHAKYSRYMQQLAIIEPKLVAKIIEQGVRFTHHSSIAPTGTISLSLANNASNGIEP
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEECCCCCCCCEEEEEEECCCCCCCCC
SFAHHYTRNVIKTGKKSKESVDVYSYELLAYRALINDKAMPYSTNEENKLPDYFITADDI
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCC
TPQQHVAVQAAAQKWIDSSISKTANIPTDFPFEEFKDIYMDAYDKGLKGCTTFRFNPEVF
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECHHHH
QGVLVKEEDLENTTYCFTLEDGSTLEAKGNEKIEYDGEMHTAANLYDALKEGYYGKF
HCEEEECCCCCCCEEEEEECCCCEEECCCCCCEEECCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]