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The map label for this gene is ppiB [H]

Identifier: 209694786

GI number: 209694786

Start: 1353653

End: 1354150

Strand: Reverse

Name: ppiB [H]

Synonym: VSAL_I1244

Alternate gene names: 209694786

Gene position: 1354150-1353653 (Counterclockwise)

Preceding gene: 209694787

Following gene: 209694785

Centisome position: 40.72

GC content: 37.15

Gene sequence:

>498_bases
ATGATTATTTTAACTACCAACTTTGGCGATATTCATATTGAGCTTAATAAAGAAAAAGCACCGGTTAGCTCAAAGAACTT
TTTAAAGTACTGCCAAGACGGTTTTTATGAAGGTACAATTTTTCATCGCGTGATTAAAGGTTTTATGATCCAAGGCGGCG
GGTTTACTGCTGATATGCAAGAGAAAGAAATGCGCGCCCCTATTGTTAATGAAGCAAACCGTGGTTTAAAAAACTTAAAT
GGTACAATCGCGATGGCTCGTACCGATGCGCCTCACTCTGCAACCAGTGAGTTTTTTATTAACATCGCTAATAATACCTT
TCTTGATCACACGGCAACAACCAATACGGGTTGGGGCTATACCGTGTTTGGTGAAGTCACTATTGGTATGGACGTAGTTA
AGAAAATTGCCAAAATAAAAACAAAATCAATGGGTGAATTTGATGATGTTCCAAAAGAGAGTATCATTATTGAAAAAGTG
ACTATTATTGAAGAGTAA

Upstream 100 bases:

>100_bases
CTGATTCTCGTTTTATGAATAATGCCTTTTCTATATAGCTTGAAGAGGTAAATGCGTATACTGTCGCTCCTTAATTTTTA
ACTTACACGGTTACTGAAAG

Downstream 100 bases:

>100_bases
CAAACGCATTACTCTCCCTTAAATAACACTAAAAACGGTGCTAATTATAGCGCCGTTTTAGATCCCCCTAATGCAATTTT
CTGGGATAAACCAATATTAA

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MIILTTNFGDIHIELNKEKAPVSSKNFLKYCQDGFYEGTIFHRVIKGFMIQGGGFTADMQEKEMRAPIVNEANRGLKNLN
GTIAMARTDAPHSATSEFFINIANNTFLDHTATTNTGWGYTVFGEVTIGMDVVKKIAKIKTKSMGEFDDVPKESIIIEKV
TIIEE

Sequences:

>Translated_165_residues
MIILTTNFGDIHIELNKEKAPVSSKNFLKYCQDGFYEGTIFHRVIKGFMIQGGGFTADMQEKEMRAPIVNEANRGLKNLN
GTIAMARTDAPHSATSEFFINIANNTFLDHTATTNTGWGYTVFGEVTIGMDVVKKIAKIKTKSMGEFDDVPKESIIIEKV
TIIEE
>Mature_165_residues
MIILTTNFGDIHIELNKEKAPVSSKNFLKYCQDGFYEGTIFHRVIKGFMIQGGGFTADMQEKEMRAPIVNEANRGLKNLN
GTIAMARTDAPHSATSEFFINIANNTFLDHTATTNTGWGYTVFGEVTIGMDVVKKIAKIKTKSMGEFDDVPKESIIIEKV
TIIEE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI22547212, Length=165, Percent_Identity=32.7272727272727, Blast_Score=80, Evalue=7e-16,
Organism=Homo sapiens, GI7657473, Length=165, Percent_Identity=32.7272727272727, Blast_Score=80, Evalue=7e-16,
Organism=Homo sapiens, GI22547215, Length=162, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI19557636, Length=162, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI24308049, Length=163, Percent_Identity=33.1288343558282, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI64276486, Length=129, Percent_Identity=35.6589147286822, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI7706339, Length=157, Percent_Identity=34.3949044585987, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI5174637, Length=155, Percent_Identity=32.258064516129, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI5031987, Length=142, Percent_Identity=35.2112676056338, Blast_Score=67, Evalue=7e-12,
Organism=Escherichia coli, GI1786736, Length=164, Percent_Identity=57.9268292682927, Blast_Score=196, Evalue=5e-52,
Organism=Escherichia coli, GI1789763, Length=163, Percent_Identity=52.1472392638037, Blast_Score=181, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17532641, Length=164, Percent_Identity=32.3170731707317, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71980594, Length=142, Percent_Identity=38.0281690140845, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71980590, Length=142, Percent_Identity=38.0281690140845, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17539496, Length=161, Percent_Identity=32.2981366459627, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17506311, Length=163, Percent_Identity=33.1288343558282, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71997782, Length=129, Percent_Identity=34.1085271317829, Blast_Score=73, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17539498, Length=141, Percent_Identity=34.7517730496454, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17565860, Length=148, Percent_Identity=33.1081081081081, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323562, Length=161, Percent_Identity=33.5403726708075, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17986117, Length=163, Percent_Identity=30.0613496932515, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI19922376, Length=171, Percent_Identity=29.2397660818713, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922912, Length=154, Percent_Identity=34.4155844155844, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45549139, Length=142, Percent_Identity=36.6197183098592, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24652460, Length=141, Percent_Identity=31.2056737588652, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17647301, Length=155, Percent_Identity=33.5483870967742, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24664125, Length=157, Percent_Identity=33.1210191082803, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357783, Length=157, Percent_Identity=33.1210191082803, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357249, Length=129, Percent_Identity=31.7829457364341, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18371; Mature: 18371

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIILTTNFGDIHIELNKEKAPVSSKNFLKYCQDGFYEGTIFHRVIKGFMIQGGGFTADMQ
CEEEEECCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHEECCCCCCCCCC
EKEMRAPIVNEANRGLKNLNGTIAMARTDAPHSATSEFFINIANNTFLDHTATTNTGWGY
HHHHCCCCHHHHHCCHHHCCCEEEEEECCCCCCCCCEEEEEECCCEEECCCCCCCCCCCE
TVFGEVTIGMDVVKKIAKIKTKSMGEFDDVPKESIIIEKVTIIEE
EEEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MIILTTNFGDIHIELNKEKAPVSSKNFLKYCQDGFYEGTIFHRVIKGFMIQGGGFTADMQ
CEEEEECCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHEECCCCCCCCCC
EKEMRAPIVNEANRGLKNLNGTIAMARTDAPHSATSEFFINIANNTFLDHTATTNTGWGY
HHHHCCCCHHHHHCCHHHCCCEEEEEECCCCCCCCCEEEEEECCCEEECCCCCCCCCCCE
TVFGEVTIGMDVVKKIAKIKTKSMGEFDDVPKESIIIEKVTIIEE
EEEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]