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The map label for this gene is trpC [H]

Identifier: 209694700

GI number: 209694700

Start: 1251897

End: 1253309

Strand: Reverse

Name: trpC [H]

Synonym: VSAL_I1151

Alternate gene names: 209694700

Gene position: 1253309-1251897 (Counterclockwise)

Preceding gene: 209694701

Following gene: 209694699

Centisome position: 37.69

GC content: 39.63

Gene sequence:

>1413_bases
ATGACACAGCAACTGTCTGAGCATATCTCAGTAGAAAACACACAAATGGCAGAAGTACTTGTAAAGATCGTCAAGGACAA
AGTCATTTGGGTTAGCGAACGCAAAGAAACTCAACCTCTTGATTCGTTCCAAAATGGCTTAACGGCATCTGATCGCAGCT
TTTACAAAGCATTAAAAACAGGCAACACTGAATTCATTCTTGAATGTAAAAAAGCCTCGCCATCTAAAGGGTTGATCCGT
CAAGATTTTGATCTCAATTACATCGCATCAGTGTATAACAATCATGCCAGTGCAATCTCAGTACTCACCGATGAGAAGTA
TTTCCAAGGCAGTTTTGATTTCTTGCCAATCATTCGTGACCAAGTCAATCAACCAATTCTATGCAAAGACTTCATGATTG
ACACTTATCAAGTTTATTTAGCTCGTCACTACGGCGCAGATGCAATTCTATTAATGCTTTCTGTTCTTGATGATGAACAA
TACTGTGAATTGGCGGCCGTCGCCCACTCTTTAAGTATGGGTATTTTAACCGAAGTCAGTAATGAAGAAGAGTTACATCG
TGCAGTGGCATTAGAAGCTCAGGTTATTGGTATTAATAACCGTAATCTTCGTGATTTATCTACCGACTTAAACCGTACCA
AAGAATTAGCACCTCTTCTCCCTAAAGACACAACCATCATTTCTGAATCGGGGATTTACAACCATCAGCAAGTGAAAGAC
TTAGCAAAGCACGCGACAGGATTTTTGATTGGCAGTTCATTAATGTCGGAAGAAAACCTAGAGCTTGCTGCACGAAAAGT
TATTTTAGGGGAGAACAAAGTCTGTGGCCTAACGTCAATAGAAGATGCGAAAGCGGTCTATAACGCAGGCGCGGTGTATG
GTGGATTAATCTTTGTTGAGAAATCACCTCGGTTTGTTTCTCTTGAAACAGCAAAAACCATCACCCAAGCCACCACATTA
AACTATGTGGGTGTATTTCAAAATGAAACGCTTAAAAACATCGTGAAGACAGCAAATGACTTATCTTTGTCCGTCATTCA
ACTTCATGGAAATGAGAGCGAAGATTACATTACTGAACTAAAACAACAATTACCAACAACATGCCAAGTGTGGAATGTTA
TTTCTGTGTCAGATGATGCCCAAAGCATTTCACTTCCACAAAGTGTTGCTGATAAAGTACTGGTAGATTGTAAGGTTGGT
TCTCAAACTGGAGGAACTGGTGTTAGTTTTGATTGGAATAAACTGCCACACAATAACATCATTCTTGCCGGTGGATTAAG
CCTTGAAAATACGAAAACAGCCTCACAATTAGGGTGCTTTGGACTCGATTTCAACTCTGGAGTAGAAACGACTCCAGGGA
AAAAAGATCATAAAAAATTAAGCGCCGTATTTAGCGCATTACGAAATTATTAA

Upstream 100 bases:

>100_bases
ATGAAGATTTAAAAGCCAATGCACAGAAAGCCATTGATGCAATGAACTCTGGCAAAGCATTTACATTAGTTCAGCAATTA
GCGGCACGAGGATAGAGAAG

Downstream 100 bases:

>100_bases
GGAAAATATCATGGCAAAATTAGATGCCTACTTCGGCGAATATGGTGGTCAATACGTACCACAAATTTTAGTTCCTGCAC
TTGATCAACTTGAGCAAGCC

Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MTQQLSEHISVENTQMAEVLVKIVKDKVIWVSERKETQPLDSFQNGLTASDRSFYKALKTGNTEFILECKKASPSKGLIR
QDFDLNYIASVYNNHASAISVLTDEKYFQGSFDFLPIIRDQVNQPILCKDFMIDTYQVYLARHYGADAILLMLSVLDDEQ
YCELAAVAHSLSMGILTEVSNEEELHRAVALEAQVIGINNRNLRDLSTDLNRTKELAPLLPKDTTIISESGIYNHQQVKD
LAKHATGFLIGSSLMSEENLELAARKVILGENKVCGLTSIEDAKAVYNAGAVYGGLIFVEKSPRFVSLETAKTITQATTL
NYVGVFQNETLKNIVKTANDLSLSVIQLHGNESEDYITELKQQLPTTCQVWNVISVSDDAQSISLPQSVADKVLVDCKVG
SQTGGTGVSFDWNKLPHNNIILAGGLSLENTKTASQLGCFGLDFNSGVETTPGKKDHKKLSAVFSALRNY

Sequences:

>Translated_470_residues
MTQQLSEHISVENTQMAEVLVKIVKDKVIWVSERKETQPLDSFQNGLTASDRSFYKALKTGNTEFILECKKASPSKGLIR
QDFDLNYIASVYNNHASAISVLTDEKYFQGSFDFLPIIRDQVNQPILCKDFMIDTYQVYLARHYGADAILLMLSVLDDEQ
YCELAAVAHSLSMGILTEVSNEEELHRAVALEAQVIGINNRNLRDLSTDLNRTKELAPLLPKDTTIISESGIYNHQQVKD
LAKHATGFLIGSSLMSEENLELAARKVILGENKVCGLTSIEDAKAVYNAGAVYGGLIFVEKSPRFVSLETAKTITQATTL
NYVGVFQNETLKNIVKTANDLSLSVIQLHGNESEDYITELKQQLPTTCQVWNVISVSDDAQSISLPQSVADKVLVDCKVG
SQTGGTGVSFDWNKLPHNNIILAGGLSLENTKTASQLGCFGLDFNSGVETTPGKKDHKKLSAVFSALRNY
>Mature_469_residues
TQQLSEHISVENTQMAEVLVKIVKDKVIWVSERKETQPLDSFQNGLTASDRSFYKALKTGNTEFILECKKASPSKGLIRQ
DFDLNYIASVYNNHASAISVLTDEKYFQGSFDFLPIIRDQVNQPILCKDFMIDTYQVYLARHYGADAILLMLSVLDDEQY
CELAAVAHSLSMGILTEVSNEEELHRAVALEAQVIGINNRNLRDLSTDLNRTKELAPLLPKDTTIISESGIYNHQQVKDL
AKHATGFLIGSSLMSEENLELAARKVILGENKVCGLTSIEDAKAVYNAGAVYGGLIFVEKSPRFVSLETAKTITQATTLN
YVGVFQNETLKNIVKTANDLSLSVIQLHGNESEDYITELKQQLPTTCQVWNVISVSDDAQSISLPQSVADKVLVDCKVGS
QTGGTGVSFDWNKLPHNNIILAGGLSLENTKTASQLGCFGLDFNSGVETTPGKKDHKKLSAVFSALRNY

Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain [H]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=462, Percent_Identity=58.2251082251082, Blast_Score=535, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6322638, Length=266, Percent_Identity=33.4586466165414, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6320210, Length=216, Percent_Identity=30.0925925925926, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS; PF00697 PRAI [H]

EC number: =4.1.1.48; =5.3.1.24 [H]

Molecular weight: Translated: 51799; Mature: 51668

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQLSEHISVENTQMAEVLVKIVKDKVIWVSERKETQPLDSFQNGLTASDRSFYKALKT
CCCHHHHHCCCCCHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHCCCCCCHHHHHHHHHC
GNTEFILECKKASPSKGLIRQDFDLNYIASVYNNHASAISVLTDEKYFQGSFDFLPIIRD
CCCEEEEEECCCCCCCCCEECCCCHHHHHHHHCCCCCEEEEEECCHHHCCCCCHHHHHHH
QVNQPILCKDFMIDTYQVYLARHYGADAILLMLSVLDDEQYCELAAVAHSLSMGILTEVS
HCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
NEEELHRAVALEAQVIGINNRNLRDLSTDLNRTKELAPLLPKDTTIISESGIYNHQQVKD
CHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHH
LAKHATGFLIGSSLMSEENLELAARKVILGENKVCGLTSIEDAKAVYNAGAVYGGLIFVE
HHHHHHHHHHHHHHHCCCCHHHHHHHHEECCCCEECCCCCHHHHHHHHCCCEEEEEEEEE
KSPRFVSLETAKTITQATTLNYVGVFQNETLKNIVKTANDLSLSVIQLHGNESEDYITEL
CCCCEEEEHHHHHHHHHHHEEEEEEECCHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHH
KQQLPTTCQVWNVISVSDDAQSISLPQSVADKVLVDCKVGSQTGGTGVSFDWNKLPHNNI
HHHCCCEEEEEEEEEECCCCHHCCCCHHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCE
ILAGGLSLENTKTASQLGCFGLDFNSGVETTPGKKDHKKLSAVFSALRNY
EEECCCCCCCCCCHHHHCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQQLSEHISVENTQMAEVLVKIVKDKVIWVSERKETQPLDSFQNGLTASDRSFYKALKT
CCHHHHHCCCCCHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHCCCCCCHHHHHHHHHC
GNTEFILECKKASPSKGLIRQDFDLNYIASVYNNHASAISVLTDEKYFQGSFDFLPIIRD
CCCEEEEEECCCCCCCCCEECCCCHHHHHHHHCCCCCEEEEEECCHHHCCCCCHHHHHHH
QVNQPILCKDFMIDTYQVYLARHYGADAILLMLSVLDDEQYCELAAVAHSLSMGILTEVS
HCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
NEEELHRAVALEAQVIGINNRNLRDLSTDLNRTKELAPLLPKDTTIISESGIYNHQQVKD
CHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHH
LAKHATGFLIGSSLMSEENLELAARKVILGENKVCGLTSIEDAKAVYNAGAVYGGLIFVE
HHHHHHHHHHHHHHHCCCCHHHHHHHHEECCCCEECCCCCHHHHHHHHCCCEEEEEEEEE
KSPRFVSLETAKTITQATTLNYVGVFQNETLKNIVKTANDLSLSVIQLHGNESEDYITEL
CCCCEEEEHHHHHHHHHHHEEEEEEECCHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHH
KQQLPTTCQVWNVISVSDDAQSISLPQSVADKVLVDCKVGSQTGGTGVSFDWNKLPHNNI
HHHCCCEEEEEEEEEECCCCHHCCCCHHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCE
ILAGGLSLENTKTASQLGCFGLDFNSGVETTPGKKDHKKLSAVFSALRNY
EEECCCCCCCCCCHHHHCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]