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The map label for this gene is hisI [H]

Identifier: 209694690

GI number: 209694690

Start: 1243108

End: 1243728

Strand: Direct

Name: hisI [H]

Synonym: VSAL_I1140

Alternate gene names: 209694690

Gene position: 1243108-1243728 (Clockwise)

Preceding gene: 209694689

Following gene: 209694691

Centisome position: 37.38

GC content: 41.55

Gene sequence:

>621_bases
ATGAGCCAACAAGATTTTGCAACACGTATTGATTGGGAAAAAGTGGACGGCTTAGTACCTGCAATTATTCAAGACTTTAG
TTCAAGCCAAGTATTGATGATGGGCTACATGAACAAAGACGCGTTATCAAAAACGTTAGAGACAAAGAAAGTTACTTTTT
TCTCTCGCACTAAGAATCGTTTATGGACTAAAGGTGAAGAATCAGGCGATAGCTTAAATTTGGTTAATATCTCTTTAGAT
TGTGATAACGATACATTACTTATCAAAGTTAAACCTGTTGGTCCAACGTGCCACACAGGGACAACTACTTGTTGGGATAG
CGATAAAACAGAAGAAAGCCAATTAGTTTGGCTTCATCAGTTGGAACAGCTACTTGCCGAGCGTAAGAATGCTGATCCTG
ACTCCTCTTACACAGCAAGTCTCTACGCCCGTGGCACCAAACGTATTTCGCAGAAAGTTGGCGAAGAGGGCGTTGAAGTT
GCGCTTGCAGCGACGTCGGGTGACAAGGCGGAGCTAGTGTGTGAATCAGCAGATTTGATGTATCACTTGTTTGTTCTGCT
TCAAGACCAAGGCTTGTCGTTTGATGATGTGATTAATAAATTGAAAGAACGTCATACGTAA

Upstream 100 bases:

>100_bases
ACGTGGACGGTGCTTTAGCAGCATCGGTATTCCATAAGCAAATCATCAATATTGGTGAATTAAAAGAATATTTAGCACAA
CAAAAAATAGAGGTACGCCG

Downstream 100 bases:

>100_bases
AATAACGATTATTTGATAATATTTAAGTTAATACTCAGTTATTAGCTTTTTTATATGTAACTTCTTAACTTTAGTCTCAT
AAATTTAATGTGAATTGAAT

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MSQQDFATRIDWEKVDGLVPAIIQDFSSSQVLMMGYMNKDALSKTLETKKVTFFSRTKNRLWTKGEESGDSLNLVNISLD
CDNDTLLIKVKPVGPTCHTGTTTCWDSDKTEESQLVWLHQLEQLLAERKNADPDSSYTASLYARGTKRISQKVGEEGVEV
ALAATSGDKAELVCESADLMYHLFVLLQDQGLSFDDVINKLKERHT

Sequences:

>Translated_206_residues
MSQQDFATRIDWEKVDGLVPAIIQDFSSSQVLMMGYMNKDALSKTLETKKVTFFSRTKNRLWTKGEESGDSLNLVNISLD
CDNDTLLIKVKPVGPTCHTGTTTCWDSDKTEESQLVWLHQLEQLLAERKNADPDSSYTASLYARGTKRISQKVGEEGVEV
ALAATSGDKAELVCESADLMYHLFVLLQDQGLSFDDVINKLKERHT
>Mature_205_residues
SQQDFATRIDWEKVDGLVPAIIQDFSSSQVLMMGYMNKDALSKTLETKKVTFFSRTKNRLWTKGEESGDSLNLVNISLDC
DNDTLLIKVKPVGPTCHTGTTTCWDSDKTEESQLVWLHQLEQLLAERKNADPDSSYTASLYARGTKRISQKVGEEGVEVA
LAATSGDKAELVCESADLMYHLFVLLQDQGLSFDDVINKLKERHT

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=196, Percent_Identity=64.7959183673469, Blast_Score=267, Evalue=4e-73,
Organism=Saccharomyces cerevisiae, GI6319819, Length=207, Percent_Identity=30.9178743961353, Blast_Score=89, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 23070; Mature: 22939

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQQDFATRIDWEKVDGLVPAIIQDFSSSQVLMMGYMNKDALSKTLETKKVTFFSRTKNR
CCCCHHHHHCCHHHHHCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHEEEEEHHCHH
LWTKGEESGDSLNLVNISLDCDNDTLLIKVKPVGPTCHTGTTTCWDSDKTEESQLVWLHQ
CCCCCCCCCCCEEEEEEEEECCCCEEEEEEECCCCCCCCCCCEECCCCCCCCHHHHHHHH
LEQLLAERKNADPDSSYTASLYARGTKRISQKVGEEGVEVALAATSGDKAELVCESADLM
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECHHHHH
YHLFVLLQDQGLSFDDVINKLKERHT
HHHHHHHHCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SQQDFATRIDWEKVDGLVPAIIQDFSSSQVLMMGYMNKDALSKTLETKKVTFFSRTKNR
CCCHHHHHCCHHHHHCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHEEEEEHHCHH
LWTKGEESGDSLNLVNISLDCDNDTLLIKVKPVGPTCHTGTTTCWDSDKTEESQLVWLHQ
CCCCCCCCCCCEEEEEEEEECCCCEEEEEEECCCCCCCCCCCEECCCCCCCCHHHHHHHH
LEQLLAERKNADPDSSYTASLYARGTKRISQKVGEEGVEVALAATSGDKAELVCESADLM
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECHHHHH
YHLFVLLQDQGLSFDDVINKLKERHT
HHHHHHHHCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]