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The map label for this gene is apt

Identifier: 209694643

GI number: 209694643

Start: 1179452

End: 1179997

Strand: Direct

Name: apt

Synonym: VSAL_I1084

Alternate gene names: 209694643

Gene position: 1179452-1179997 (Clockwise)

Preceding gene: 209694642

Following gene: 209694644

Centisome position: 35.47

GC content: 40.66

Gene sequence:

>546_bases
ATGTCTACAGAAACATTAGAACTTATCAAAAATAGCATTAAATCTGTTCCTGATTATCCAAAAGCAGGCATCATGTTCCG
TGATGTTACAAGCTTGATGGAAGATCCAAAAGCTTACCAAGCAACGATTCAGTTATTGGTTGAAAAGTACAAGCAAGGTG
GTTTTACCAAGATCGTTGGAACTGAAGCTCGTGGTTTCTTATTTGGTGCTCCTTTGGCACTAGAATTAGGTGTTGGTTTT
GTCCCAGTTCGTAAACCGGGTAAATTGCCACGTCCAACGATTGCACAAACGTATGATCTTGAATACGGAACAGATACGTT
AGAAATTCACACAGACGCAATTGTTGAAGGTGATAAGGTTCTTGTTGTTGATGATTTACTTGCAACTGGCGGAACCATCG
AAGCAACAGTGAAACTTATTCGCCAACTTGGTGGTGATGTTCAGCACGCTGCATTTGTTATCAACCTTCCAGAAATTGGT
GGTGAAACGCGTTTAGAAGGCTTAGGTCTAAACGTGTACAGTATTTGTGAGTTTCCTGGTCACTAA

Upstream 100 bases:

>100_bases
AATACCGTCGTCCTAACTTGCTCATAGTGAAGAAAGTGAATACCATTAGTCGGTTAATTTTTTAAGATACCGGCTATCGG
TACAATTAGGTCTTTAAACC

Downstream 100 bases:

>100_bases
TTCTTCATATACACAATAAATGTAATGAGATCTCTCTATCAATGAAGATCTCATTTTTTTGCTGTGCTACGATTTAGATC
TATTTTATTTTGGGCTGTAT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 181; Mature: 180

Protein sequence:

>181_residues
MSTETLELIKNSIKSVPDYPKAGIMFRDVTSLMEDPKAYQATIQLLVEKYKQGGFTKIVGTEARGFLFGAPLALELGVGF
VPVRKPGKLPRPTIAQTYDLEYGTDTLEIHTDAIVEGDKVLVVDDLLATGGTIEATVKLIRQLGGDVQHAAFVINLPEIG
GETRLEGLGLNVYSICEFPGH

Sequences:

>Translated_181_residues
MSTETLELIKNSIKSVPDYPKAGIMFRDVTSLMEDPKAYQATIQLLVEKYKQGGFTKIVGTEARGFLFGAPLALELGVGF
VPVRKPGKLPRPTIAQTYDLEYGTDTLEIHTDAIVEGDKVLVVDDLLATGGTIEATVKLIRQLGGDVQHAAFVINLPEIG
GETRLEGLGLNVYSICEFPGH
>Mature_180_residues
STETLELIKNSIKSVPDYPKAGIMFRDVTSLMEDPKAYQATIQLLVEKYKQGGFTKIVGTEARGFLFGAPLALELGVGFV
PVRKPGKLPRPTIAQTYDLEYGTDTLEIHTDAIVEGDKVLVVDDLLATGGTIEATVKLIRQLGGDVQHAAFVINLPEIGG
ETRLEGLGLNVYSICEFPGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=168, Percent_Identity=43.452380952381, Blast_Score=144, Evalue=4e-35,
Organism=Homo sapiens, GI71773201, Length=133, Percent_Identity=48.1203007518797, Blast_Score=127, Evalue=4e-30,
Organism=Escherichia coli, GI1786675, Length=180, Percent_Identity=74.4444444444444, Blast_Score=272, Evalue=9e-75,
Organism=Caenorhabditis elegans, GI17509087, Length=164, Percent_Identity=42.6829268292683, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=163, Percent_Identity=41.1042944785276, Blast_Score=116, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320649, Length=161, Percent_Identity=39.1304347826087, Blast_Score=93, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17136334, Length=179, Percent_Identity=41.340782122905, Blast_Score=131, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_ALISL (B6EJ41)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002262571.1
- ProteinModelPortal:   B6EJ41
- GeneID:   6986837
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I1084
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19604; Mature: 19473

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTETLELIKNSIKSVPDYPKAGIMFRDVTSLMEDPKAYQATIQLLVEKYKQGGFTKIVG
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEC
TEARGFLFGAPLALELGVGFVPVRKPGKLPRPTIAQTYDLEYGTDTLEIHTDAIVEGDKV
CCCCCEEEECCEEEECCCCEEECCCCCCCCCCCCCEEEECCCCCCEEEEEECEEECCCEE
LVVDDLLATGGTIEATVKLIRQLGGDVQHAAFVINLPEIGGETRLEGLGLNVYSICEFPG
EEEECHHHCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEECCCCCEEECCCCC
H
C
>Mature Secondary Structure 
STETLELIKNSIKSVPDYPKAGIMFRDVTSLMEDPKAYQATIQLLVEKYKQGGFTKIVG
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEC
TEARGFLFGAPLALELGVGFVPVRKPGKLPRPTIAQTYDLEYGTDTLEIHTDAIVEGDKV
CCCCCEEEECCEEEECCCCEEECCCCCCCCCCCCCEEEECCCCCCEEEEEECEEECCCEE
LVVDDLLATGGTIEATVKLIRQLGGDVQHAAFVINLPEIGGETRLEGLGLNVYSICEFPG
EEEECHHHCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEECCCCCEEECCCCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA